Preparation of floating polymer-valsartan delivery systems using supercritical CO2
Samo za registrovane korisnike
2021
Autori
Milovanović, StojaDjuris, Jelena
Dapčević, Aleksandra
Lučić-Škorić, Marija
Medarevic, Đorđe
Pavlovic, Stefan M.
Ibric, Svetlana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
This study investigates pharmaceutical polymers (Soluplus((R)), HPMCAS, and Eudragit((R)) E100) and supercritical CO2-assisted process for preparation of floating valsartan delivery systems. Tested process (at pressure of 30 MPa and temperature of 100 degrees C during 2 h) enabled preparation of stable porous valsartan formulations which was confirmed with FESEM and mercury intrusion porosimetry analysis. The bulk density of obtained formulations was lower than 550 kg/m(3). FTIR, DSC, and PXRD analysis indicated that there was no chemical interaction between the drug and polymers and that amorphous solid dispersions were obtained. Formulations with Soluplus((R)) and HPMCAS retained its buoyancy in 0.1 M HCl for longer than 24 h, while formulation with Eudragit((R)) E100 retained its buoyancy up to 2 h. Controlled valsartan release was influenced by solubility of polymers in the tested release medium, which was confirmed by UV/VIS spectroscopy. The obtained results provided framework fo...r further development of floating drug delivery system using an environmental friendly process.
Ključne reči:
Eudragit((R)) E100 / HPMCAS / Soluplus((R)) / Supercritical CO2 / ValsartanIzvor:
Journal of Polymer Research, 2021, 28, 3Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200135 (Univerzitet u Beogradu, Tehnološko-metalurški fakultet) (RS-MESTD-inst-2020-200135)
DOI: 10.1007/s10965-021-02440-1
ISSN: 1022-9760
WoS: 000616723100002
Scopus: 2-s2.0-85100464987
Kolekcije
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Milovanović, Stoja AU - Djuris, Jelena AU - Dapčević, Aleksandra AU - Lučić-Škorić, Marija AU - Medarevic, Đorđe AU - Pavlovic, Stefan M. AU - Ibric, Svetlana PY - 2021 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4959 AB - This study investigates pharmaceutical polymers (Soluplus((R)), HPMCAS, and Eudragit((R)) E100) and supercritical CO2-assisted process for preparation of floating valsartan delivery systems. Tested process (at pressure of 30 MPa and temperature of 100 degrees C during 2 h) enabled preparation of stable porous valsartan formulations which was confirmed with FESEM and mercury intrusion porosimetry analysis. The bulk density of obtained formulations was lower than 550 kg/m(3). FTIR, DSC, and PXRD analysis indicated that there was no chemical interaction between the drug and polymers and that amorphous solid dispersions were obtained. Formulations with Soluplus((R)) and HPMCAS retained its buoyancy in 0.1 M HCl for longer than 24 h, while formulation with Eudragit((R)) E100 retained its buoyancy up to 2 h. Controlled valsartan release was influenced by solubility of polymers in the tested release medium, which was confirmed by UV/VIS spectroscopy. The obtained results provided framework for further development of floating drug delivery system using an environmental friendly process. T2 - Journal of Polymer Research T1 - Preparation of floating polymer-valsartan delivery systems using supercritical CO2 IS - 3 VL - 28 DO - 10.1007/s10965-021-02440-1 ER -
@article{ author = "Milovanović, Stoja and Djuris, Jelena and Dapčević, Aleksandra and Lučić-Škorić, Marija and Medarevic, Đorđe and Pavlovic, Stefan M. and Ibric, Svetlana", year = "2021", abstract = "This study investigates pharmaceutical polymers (Soluplus((R)), HPMCAS, and Eudragit((R)) E100) and supercritical CO2-assisted process for preparation of floating valsartan delivery systems. Tested process (at pressure of 30 MPa and temperature of 100 degrees C during 2 h) enabled preparation of stable porous valsartan formulations which was confirmed with FESEM and mercury intrusion porosimetry analysis. The bulk density of obtained formulations was lower than 550 kg/m(3). FTIR, DSC, and PXRD analysis indicated that there was no chemical interaction between the drug and polymers and that amorphous solid dispersions were obtained. Formulations with Soluplus((R)) and HPMCAS retained its buoyancy in 0.1 M HCl for longer than 24 h, while formulation with Eudragit((R)) E100 retained its buoyancy up to 2 h. Controlled valsartan release was influenced by solubility of polymers in the tested release medium, which was confirmed by UV/VIS spectroscopy. The obtained results provided framework for further development of floating drug delivery system using an environmental friendly process.", journal = "Journal of Polymer Research", title = "Preparation of floating polymer-valsartan delivery systems using supercritical CO2", number = "3", volume = "28", doi = "10.1007/s10965-021-02440-1" }
Milovanović, S., Djuris, J., Dapčević, A., Lučić-Škorić, M., Medarevic, Đ., Pavlovic, S. M.,& Ibric, S.. (2021). Preparation of floating polymer-valsartan delivery systems using supercritical CO2. in Journal of Polymer Research, 28(3). https://doi.org/10.1007/s10965-021-02440-1
Milovanović S, Djuris J, Dapčević A, Lučić-Škorić M, Medarevic Đ, Pavlovic SM, Ibric S. Preparation of floating polymer-valsartan delivery systems using supercritical CO2. in Journal of Polymer Research. 2021;28(3). doi:10.1007/s10965-021-02440-1 .
Milovanović, Stoja, Djuris, Jelena, Dapčević, Aleksandra, Lučić-Škorić, Marija, Medarevic, Đorđe, Pavlovic, Stefan M., Ibric, Svetlana, "Preparation of floating polymer-valsartan delivery systems using supercritical CO2" in Journal of Polymer Research, 28, no. 3 (2021), https://doi.org/10.1007/s10965-021-02440-1 . .