Приказ основних података о документу

dc.creatorMilovanović, Stoja
dc.creatorDjuris, Jelena
dc.creatorDapčević, Aleksandra
dc.creatorLučić-Škorić, Marija
dc.creatorMedarevic, Đorđe
dc.creatorPavlovic, Stefan M.
dc.creatorIbric, Svetlana
dc.date.accessioned2022-03-04T11:26:26Z
dc.date.available2022-03-04T11:26:26Z
dc.date.issued2021
dc.identifier.issn1022-9760
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/4959
dc.description.abstractThis study investigates pharmaceutical polymers (Soluplus((R)), HPMCAS, and Eudragit((R)) E100) and supercritical CO2-assisted process for preparation of floating valsartan delivery systems. Tested process (at pressure of 30 MPa and temperature of 100 degrees C during 2 h) enabled preparation of stable porous valsartan formulations which was confirmed with FESEM and mercury intrusion porosimetry analysis. The bulk density of obtained formulations was lower than 550 kg/m(3). FTIR, DSC, and PXRD analysis indicated that there was no chemical interaction between the drug and polymers and that amorphous solid dispersions were obtained. Formulations with Soluplus((R)) and HPMCAS retained its buoyancy in 0.1 M HCl for longer than 24 h, while formulation with Eudragit((R)) E100 retained its buoyancy up to 2 h. Controlled valsartan release was influenced by solubility of polymers in the tested release medium, which was confirmed by UV/VIS spectroscopy. The obtained results provided framework for further development of floating drug delivery system using an environmental friendly process.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200135/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Polymer Research
dc.subjectEudragit((R)) E100en
dc.subjectHPMCASen
dc.subjectSoluplus((R))en
dc.subjectSupercritical CO2en
dc.subjectValsartanen
dc.titlePreparation of floating polymer-valsartan delivery systems using supercritical CO2en
dc.typearticle
dc.rights.licenseARR
dc.citation.issue3
dc.citation.other28(3): -
dc.citation.rankM22
dc.citation.volume28
dc.identifier.doi10.1007/s10965-021-02440-1
dc.identifier.scopus2-s2.0-85100464987
dc.identifier.wos000616723100002
dc.type.versionpublishedVersion


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу