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dc.creatorUgrinović, Vukašin
dc.creatorPanić, Vesna
dc.creatorSpasojević, Pavle
dc.creatorSeslija, Sanja
dc.creatorBozic, Bojan
dc.creatorPetrović, Rada
dc.creatorJanaćković, Đorđe
dc.creatorVeljović, Đorđe
dc.date.accessioned2022-03-04T11:27:57Z
dc.date.available2022-03-04T11:27:57Z
dc.date.issued2022
dc.identifier.issn0032-3888
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/4984
dc.description.abstractHydrogels are promising materials for biomedical applications due to highly hydrated, porous, permeable structure with possibility to accommodate living cells, drugs, or bioactive factors. In this paper, we reported poly(methacrylic acid) (PMAA)/gelatin IPN hydrogels, synthesized by free-radical polymerization, with adjustable mechanical, structural, physicochemical, and biological characteristics. The influence of methacrylic acid (MAA), gelatin, and cross-linker in the precursor solution on hydrogels properties was investigated. The increasing concentration of MAA, gelatin, and cross-linker led to better mechanical properties, lower porosity, and water content. The compressive mechanical properties of hydrogels were significantly better in comparison to a single-network PMAA hydrogel, while the obtained compressive strength values up to 16 MPa were comparable with tough hydrogels. The increasing concentration of MAA and cross-linker reduced fatigue resistance and degradability, while the increase in gelatin content acted in the opposite way. Swelling tests in different pH conditions demonstrated strong pH-sensibility of the hydrogels, which was more pronounced as MAA concentration was higher, and gelatin and cross-linker concentrations were lower. In addition, the hydrogels strongly promoted the proliferation of human periodontal ligament stem cells and MRC-5 cells as assayed by MTT assay.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200026/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200135/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200178/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200287/RS//
dc.rightsrestrictedAccess
dc.sourcePolymer Engineering and Science
dc.subjectgelatinen
dc.subjectIPN hydrogelen
dc.subjectpoly(methacrylic acid)en
dc.subjecttissue engineeringen
dc.titleStrong and tough, pH sensible, interpenetrating network hydrogels based on gelatin and poly(methacrylic acid)en
dc.typearticle
dc.rights.licenseARR
dc.citation.rankM22~
dc.identifier.doi10.1002/pen.25870
dc.identifier.scopus2-s2.0-85122011824
dc.identifier.wos000734793000001
dc.type.versionpublishedVersion


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Приказ основних података о документу