Formulation and characterization of liposomal encapsulated systems of bioactive ingredients from traditional plant mountain germander (Teucrium montanum L.) for the incorporation into coffee drinks
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2022
Authors
Šeremet, DanijelaVugrinec, Kristina
Petrović, Predrag
Butorac, Ana
Kuzmić, Sunčica
Vojvodić Cebin, Aleksandra
Mandura, Ana
Lovrić, Marija
Pjanović, Rada
Komes, Draženka
Article (Published version)
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Conventional and innovative (microwave-assisted and subcritical water extraction) techniques were applied to investigate the bioactive content of traditional plant - Teucrium montanum. Verbascoside and echinacoside, identified and quantified using LC-MS/MS and HPLC-PAD, were found to be the predominant phenolics in all extracts. Infusion (30 degrees C, 30 min) was characterized with the highest total phenolic content and antioxidant capacity and was further used for encapsulation into liposomes. Formulation of liposomes with a high encapsulation efficiency of echinacoside (68.27%) and verbascoside (80.60%), satisfactory physical properties, including size (326.2 nm) and polydispersity index (0.34), was achieved, although determined zeta potential (-23.03 mV) indicated their instability. Formulated liposomes were successfully coated with pectin and alginate that was also proved by FTIR analysis. Liposomes coated with pectin showed the most desirable in vitro digestion release of verbasc...oside and echinacoside, while alginate as liposome surface layer proved to be more appropriate for their retention during storage time.
Keywords:
Extraction / Incorporation / Liposomes / Mountain germander / Teucrium montanum L.Source:
Food Chemistry, 2022, 370, 131257-Publisher:
- Elsevier Ltd.
DOI: 10.1016/j.foodchem.2021.131257
ISSN: 0308-8146
PubMed: 34788947
WoS: 000710508700005
Scopus: 2-s2.0-85117228377
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Šeremet, Danijela AU - Vugrinec, Kristina AU - Petrović, Predrag AU - Butorac, Ana AU - Kuzmić, Sunčica AU - Vojvodić Cebin, Aleksandra AU - Mandura, Ana AU - Lovrić, Marija AU - Pjanović, Rada AU - Komes, Draženka PY - 2022 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4987 AB - Conventional and innovative (microwave-assisted and subcritical water extraction) techniques were applied to investigate the bioactive content of traditional plant - Teucrium montanum. Verbascoside and echinacoside, identified and quantified using LC-MS/MS and HPLC-PAD, were found to be the predominant phenolics in all extracts. Infusion (30 degrees C, 30 min) was characterized with the highest total phenolic content and antioxidant capacity and was further used for encapsulation into liposomes. Formulation of liposomes with a high encapsulation efficiency of echinacoside (68.27%) and verbascoside (80.60%), satisfactory physical properties, including size (326.2 nm) and polydispersity index (0.34), was achieved, although determined zeta potential (-23.03 mV) indicated their instability. Formulated liposomes were successfully coated with pectin and alginate that was also proved by FTIR analysis. Liposomes coated with pectin showed the most desirable in vitro digestion release of verbascoside and echinacoside, while alginate as liposome surface layer proved to be more appropriate for their retention during storage time. PB - Elsevier Ltd. T2 - Food Chemistry T1 - Formulation and characterization of liposomal encapsulated systems of bioactive ingredients from traditional plant mountain germander (Teucrium montanum L.) for the incorporation into coffee drinks SP - 131257 VL - 370 DO - 10.1016/j.foodchem.2021.131257 ER -
@article{ author = "Šeremet, Danijela and Vugrinec, Kristina and Petrović, Predrag and Butorac, Ana and Kuzmić, Sunčica and Vojvodić Cebin, Aleksandra and Mandura, Ana and Lovrić, Marija and Pjanović, Rada and Komes, Draženka", year = "2022", abstract = "Conventional and innovative (microwave-assisted and subcritical water extraction) techniques were applied to investigate the bioactive content of traditional plant - Teucrium montanum. Verbascoside and echinacoside, identified and quantified using LC-MS/MS and HPLC-PAD, were found to be the predominant phenolics in all extracts. Infusion (30 degrees C, 30 min) was characterized with the highest total phenolic content and antioxidant capacity and was further used for encapsulation into liposomes. Formulation of liposomes with a high encapsulation efficiency of echinacoside (68.27%) and verbascoside (80.60%), satisfactory physical properties, including size (326.2 nm) and polydispersity index (0.34), was achieved, although determined zeta potential (-23.03 mV) indicated their instability. Formulated liposomes were successfully coated with pectin and alginate that was also proved by FTIR analysis. Liposomes coated with pectin showed the most desirable in vitro digestion release of verbascoside and echinacoside, while alginate as liposome surface layer proved to be more appropriate for their retention during storage time.", publisher = "Elsevier Ltd.", journal = "Food Chemistry", title = "Formulation and characterization of liposomal encapsulated systems of bioactive ingredients from traditional plant mountain germander (Teucrium montanum L.) for the incorporation into coffee drinks", pages = "131257", volume = "370", doi = "10.1016/j.foodchem.2021.131257" }
Šeremet, D., Vugrinec, K., Petrović, P., Butorac, A., Kuzmić, S., Vojvodić Cebin, A., Mandura, A., Lovrić, M., Pjanović, R.,& Komes, D.. (2022). Formulation and characterization of liposomal encapsulated systems of bioactive ingredients from traditional plant mountain germander (Teucrium montanum L.) for the incorporation into coffee drinks. in Food Chemistry Elsevier Ltd.., 370, 131257. https://doi.org/10.1016/j.foodchem.2021.131257
Šeremet D, Vugrinec K, Petrović P, Butorac A, Kuzmić S, Vojvodić Cebin A, Mandura A, Lovrić M, Pjanović R, Komes D. Formulation and characterization of liposomal encapsulated systems of bioactive ingredients from traditional plant mountain germander (Teucrium montanum L.) for the incorporation into coffee drinks. in Food Chemistry. 2022;370:131257. doi:10.1016/j.foodchem.2021.131257 .
Šeremet, Danijela, Vugrinec, Kristina, Petrović, Predrag, Butorac, Ana, Kuzmić, Sunčica, Vojvodić Cebin, Aleksandra, Mandura, Ana, Lovrić, Marija, Pjanović, Rada, Komes, Draženka, "Formulation and characterization of liposomal encapsulated systems of bioactive ingredients from traditional plant mountain germander (Teucrium montanum L.) for the incorporation into coffee drinks" in Food Chemistry, 370 (2022):131257, https://doi.org/10.1016/j.foodchem.2021.131257 . .