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dc.creatorBabić Radić, Marija M.
dc.creatorFilipovic, Vuk V.
dc.creatorVukomanovic, Marija
dc.creatorNikodinović-Runić, Jasmina
dc.creatorTomić, Simonida
dc.date.accessioned2022-03-04T11:30:13Z
dc.date.available2022-03-04T11:30:13Z
dc.date.issued2022
dc.identifier.issn2310-2861
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/5023
dc.description.abstractThe design and evaluation of novel 2-hydroxyethyl methacrylate/gelatin/alginate/graphene oxide hydrogels as innovative scaffolding biomaterials, which concurrently are the suitable drug delivery carrier, was proposed. The hydrogels were prepared by the adapted porogen leaching method; this is also the first time this method has been used to incorporate nanocolloidal graphene oxide through the hydrogel and simultaneously form porous structures. The effects of a material's composition on its chemical, morphological, mechanical, and swelling properties, as well as on cell viability and in vitro degradation, were assessed using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), measurements of Young's modulus, gravimetric method and MTT test, respectively. The engineered hydrogels show good swelling capacity, fully hydrophilic surfaces, tunable porosity (from 56 to 76%) and mechanical properties (from 1.69 to 4.78 MPa), curcumin entrapment efficiency above 99% and excellent curcumin release performances. In vitro cytotoxicity on healthy human fibroblast (MRC5 cells) by MTT test reveal that the materials are nontoxic and biocompatible, proposing novel hydrogels for in vivo clinical evaluation to optimize tissue regeneration treatments by coupling the hydrogels with cells and different active agents to create material/biofactor hybrids with new levels of biofunctionality.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172062/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/17014/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceGels
dc.subjectscaffolding biomaterialsen
dc.subjectgraphene oxide infused hydrogelsen
dc.subjectalginateen
dc.subjectgelatin based hydrogelsen
dc.subjectcurcumin releaseen
dc.titleDegradable 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Hydrogels Infused by Nanocolloidal Graphene Oxide as Promising Drug Delivery and Scaffolding Biomaterialsen
dc.typearticle
dc.rights.licenseBY
dc.citation.issue1
dc.citation.other8(1): -
dc.citation.rankM21~
dc.citation.spage22
dc.citation.volume8
dc.identifier.doi10.3390/gels8010022
dc.identifier.fulltexthttp://TechnoRep.tmf.bg.ac.rs/bitstream/id/7343/5019.pdf
dc.identifier.pmid35049557
dc.identifier.scopus2-s2.0-85121848351
dc.identifier.wos000748058700001
dc.type.versionpublishedVersion


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