Selection of the suitable polymer for supercritical fluid assisted preparation of carvedilol solid dispersions
Authors
Djuris, JelenaMilovanovic, Stoja
Medarevic, Djordje
Dobricic, Vladimir
Dapčević, Aleksandra

Ibric, Svetlana
Article (Accepted Version)
Metadata
Show full item recordAbstract
Solid dispersions production is one of the substantial approaches for improvement of poor drug solubility. Additionally, supercritical fluid assisted method for preparation of solid dispersions can offer many advantages in comparison to the conventional melting or solvent-evaporation methods. Miscibility analysis provides valuable guidance for selection of the most appropriate polymeric carrier for dispersion of the drug of interest. In addition to the increased drug release rate, solid dispersions should have proper mechanical attributes in order to be successfully formulated in the final solid dosage form such as tablet. Therefore, several pharmaceutical grade polymers have been selected for development of BCS Class II drug carvedilol (CARV) solid dispersions. They were compared based on behavior in supercritical CO 2 and affinity towards CARV calculated from the miscibility analysis. By utilization of the supercritical CO 2 assisted method, solid dispersions of CARV with the selecte...d (co)polymers (polyvinylpyrrolidone (PVP), hydroxypropyl methylcellulose (HPMC), Soluplus® and Eudragit®) were obtained. Properties of the prepared CARV-polymer dispersions were observed by the polarizing and scanning electron microscopy and analyzed by differential scanning calorimetry and Fourier transform infrared spectroscopy. CARV was additionally characterized by X-ray powder diffraction. Furthermore, in vitro dissolution studies and dynamic compaction analysis were performed on the selected samples of solid dispersions. Among the studied polymers, PVP and HPMC have been identified as polymers with the highest affinity towards CARV, based on the calculated δ p values. This has been also confirmed with the highest dissolution efficiency of CARV-PVP and CARV-HPMC solid dispersions. Solid state characterization indicated that CARV was dispersed either molecularly, or in the amorphous form, depending on interactions with each polymer. Determination of CARV-PVP and CARV-HPMC mechanical properties revealed that CARV-PVP solid dispersion has superior compactibility and tabletability. Therefore, CARV-PVP solid dispersion has been highlighted as the most appropriate for the further development of tablets as the final dosage form. Presented study provides an example for efficient approach for development of poorly soluble drug solid dispersion with satisfactory tableting properties.
Keywords:
Carvedilol / Improved dissolution / Solid dispersion / Supercritical CO 2 / TabletabilitySource:
International Journal of Pharmaceutics, 2019, 554, 190-200Publisher:
- Elsevier B.V.
Funding / projects:
- Zero- to Three-Dimensional Nanostructures for Application in Electronics and Renewable Energy Sources: Synthesis, Characterization and Processing (RS-45007)
- Functional physiologically active plant materials with additional values for application in pharmaceutical and food industry (RS-45017)
- Advanced technologies for controlled release from solid drug delivery systems (RS-34007)
Note:
- This is the peer-reviewed version of the following article: Đuriš J, Milovanović S, Medarević Đ, Dobričić V, Dapčević A, Ibrić S. Selection of the suitable polymer for supercritical fluid assisted preparation of carvedilol solid dispersions. in International Journal of Pharmaceutics. 2019;554:190-200. https://doi.org/10.1016/j.ijpharm.2018.11.015
- Published version: http://technorep.tmf.bg.ac.rs/handle/123456789/4335
Related info:
DOI: 10.1016/j.ijpharm.2018.11.015
ISSN: 0378-5173
WoS: 000454421400019
Scopus: 2-s2.0-85056454143
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Djuris, Jelena AU - Milovanovic, Stoja AU - Medarevic, Djordje AU - Dobricic, Vladimir AU - Dapčević, Aleksandra AU - Ibric, Svetlana PY - 2019 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5030 AB - Solid dispersions production is one of the substantial approaches for improvement of poor drug solubility. Additionally, supercritical fluid assisted method for preparation of solid dispersions can offer many advantages in comparison to the conventional melting or solvent-evaporation methods. Miscibility analysis provides valuable guidance for selection of the most appropriate polymeric carrier for dispersion of the drug of interest. In addition to the increased drug release rate, solid dispersions should have proper mechanical attributes in order to be successfully formulated in the final solid dosage form such as tablet. Therefore, several pharmaceutical grade polymers have been selected for development of BCS Class II drug carvedilol (CARV) solid dispersions. They were compared based on behavior in supercritical CO 2 and affinity towards CARV calculated from the miscibility analysis. By utilization of the supercritical CO 2 assisted method, solid dispersions of CARV with the selected (co)polymers (polyvinylpyrrolidone (PVP), hydroxypropyl methylcellulose (HPMC), Soluplus® and Eudragit®) were obtained. Properties of the prepared CARV-polymer dispersions were observed by the polarizing and scanning electron microscopy and analyzed by differential scanning calorimetry and Fourier transform infrared spectroscopy. CARV was additionally characterized by X-ray powder diffraction. Furthermore, in vitro dissolution studies and dynamic compaction analysis were performed on the selected samples of solid dispersions. Among the studied polymers, PVP and HPMC have been identified as polymers with the highest affinity towards CARV, based on the calculated δ p values. This has been also confirmed with the highest dissolution efficiency of CARV-PVP and CARV-HPMC solid dispersions. Solid state characterization indicated that CARV was dispersed either molecularly, or in the amorphous form, depending on interactions with each polymer. Determination of CARV-PVP and CARV-HPMC mechanical properties revealed that CARV-PVP solid dispersion has superior compactibility and tabletability. Therefore, CARV-PVP solid dispersion has been highlighted as the most appropriate for the further development of tablets as the final dosage form. Presented study provides an example for efficient approach for development of poorly soluble drug solid dispersion with satisfactory tableting properties. PB - Elsevier B.V. T2 - International Journal of Pharmaceutics T1 - Selection of the suitable polymer for supercritical fluid assisted preparation of carvedilol solid dispersions EP - 200 SP - 190 VL - 554 DO - 10.1016/j.ijpharm.2018.11.015 ER -
@article{ author = "Djuris, Jelena and Milovanovic, Stoja and Medarevic, Djordje and Dobricic, Vladimir and Dapčević, Aleksandra and Ibric, Svetlana", year = "2019", abstract = "Solid dispersions production is one of the substantial approaches for improvement of poor drug solubility. Additionally, supercritical fluid assisted method for preparation of solid dispersions can offer many advantages in comparison to the conventional melting or solvent-evaporation methods. Miscibility analysis provides valuable guidance for selection of the most appropriate polymeric carrier for dispersion of the drug of interest. In addition to the increased drug release rate, solid dispersions should have proper mechanical attributes in order to be successfully formulated in the final solid dosage form such as tablet. Therefore, several pharmaceutical grade polymers have been selected for development of BCS Class II drug carvedilol (CARV) solid dispersions. They were compared based on behavior in supercritical CO 2 and affinity towards CARV calculated from the miscibility analysis. By utilization of the supercritical CO 2 assisted method, solid dispersions of CARV with the selected (co)polymers (polyvinylpyrrolidone (PVP), hydroxypropyl methylcellulose (HPMC), Soluplus® and Eudragit®) were obtained. Properties of the prepared CARV-polymer dispersions were observed by the polarizing and scanning electron microscopy and analyzed by differential scanning calorimetry and Fourier transform infrared spectroscopy. CARV was additionally characterized by X-ray powder diffraction. Furthermore, in vitro dissolution studies and dynamic compaction analysis were performed on the selected samples of solid dispersions. Among the studied polymers, PVP and HPMC have been identified as polymers with the highest affinity towards CARV, based on the calculated δ p values. This has been also confirmed with the highest dissolution efficiency of CARV-PVP and CARV-HPMC solid dispersions. Solid state characterization indicated that CARV was dispersed either molecularly, or in the amorphous form, depending on interactions with each polymer. Determination of CARV-PVP and CARV-HPMC mechanical properties revealed that CARV-PVP solid dispersion has superior compactibility and tabletability. Therefore, CARV-PVP solid dispersion has been highlighted as the most appropriate for the further development of tablets as the final dosage form. Presented study provides an example for efficient approach for development of poorly soluble drug solid dispersion with satisfactory tableting properties.", publisher = "Elsevier B.V.", journal = "International Journal of Pharmaceutics", title = "Selection of the suitable polymer for supercritical fluid assisted preparation of carvedilol solid dispersions", pages = "200-190", volume = "554", doi = "10.1016/j.ijpharm.2018.11.015" }
Djuris, J., Milovanovic, S., Medarevic, D., Dobricic, V., Dapčević, A.,& Ibric, S.. (2019). Selection of the suitable polymer for supercritical fluid assisted preparation of carvedilol solid dispersions. in International Journal of Pharmaceutics Elsevier B.V.., 554, 190-200. https://doi.org/10.1016/j.ijpharm.2018.11.015
Djuris J, Milovanovic S, Medarevic D, Dobricic V, Dapčević A, Ibric S. Selection of the suitable polymer for supercritical fluid assisted preparation of carvedilol solid dispersions. in International Journal of Pharmaceutics. 2019;554:190-200. doi:10.1016/j.ijpharm.2018.11.015 .
Djuris, Jelena, Milovanovic, Stoja, Medarevic, Djordje, Dobricic, Vladimir, Dapčević, Aleksandra, Ibric, Svetlana, "Selection of the suitable polymer for supercritical fluid assisted preparation of carvedilol solid dispersions" in International Journal of Pharmaceutics, 554 (2019):190-200, https://doi.org/10.1016/j.ijpharm.2018.11.015 . .