Effect of crosslinker amount on hybrid hydrogels swelling and drug release
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Targeted drug delivery is powerful tool which researchers use to achieve safer and more efficient
therapy of many diseases, including various types of cancer. Many chemotherapeutics are poorly watersoluble, so their encapsulation and targeted delivery remain quite challenge. Hydrogels based on
poly(methacrylic acid) (PMAA) are widely investigated for targeted drug delivery due to their pH
sensitivity, non-toxicity and biocompatibility. Still, due to the PMAA highly hydrophilic nature, PMAA
can only be used for encapsulation and targeted delivery of water-soluble drugs. Our previous research
was directed towards overcoming this limitation: PMAA was modified with amphiphilic protein –
casein and poorly-water soluble model drug – caffeine – was encapsulated (PMAC). Present study is
focused on investigation how variation of amount of one of the most important hydrogels network
parameter such as crosslinker affect PMAC swelling properties and caffeine release. The group of
hybrid h...ydrogels – PMAC – was synthesized with various amount of crosslinker: 0.4mol%, 0.8mol%,
1.6mol% and 3.2mol% with respect to methacrylic acid. Swelling behavior of hybrid hydrogels and
caffeine release was investigated in two environments which simulated human stomach and intestines.
Obtained results showed that targeted delivery of poorly water-soluble model drug was achieved and
that its release can be prolonged up to 24h. Also, kinetic of poorly water-soluble drug release can be
easily modified only by changing crosslinker amount. PMAC hybrid hydrogels have huge potential for
targeted delivery of poorly water-soluble active substances.
Кључне речи:
poly(methacrylic acid) / casein / crosslinking / hydrogels swelling / drug releaseИзвор:
1 st International Conference on Chemo and BioInformatics ICCBIKG 2021, 2021, 125-128Издавач:
- Institute for Information Technologies, University of Kragujevac, Serbia, Jovana Cvijića bb, 2021
Финансирање / пројекти:
- Министарство просвете, науке и технолошког развоја Републике Србије, Уговор бр. 200287 (Иновациони центар Технолошко-металуршког факултета у Београду доо) (RS-200287)
- Министарство просвете, науке и технолошког развоја Републике Србије, Уговор бр. 200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (RS-200017)
Колекције
Институција/група
Inovacioni centarTY - CONF AU - Marković, Maja D. AU - Panić, Vesna V. AU - Tadic, Julijana D. AU - Pjanović, Rada V. PY - 2021 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5069 AB - Targeted drug delivery is powerful tool which researchers use to achieve safer and more efficient therapy of many diseases, including various types of cancer. Many chemotherapeutics are poorly watersoluble, so their encapsulation and targeted delivery remain quite challenge. Hydrogels based on poly(methacrylic acid) (PMAA) are widely investigated for targeted drug delivery due to their pH sensitivity, non-toxicity and biocompatibility. Still, due to the PMAA highly hydrophilic nature, PMAA can only be used for encapsulation and targeted delivery of water-soluble drugs. Our previous research was directed towards overcoming this limitation: PMAA was modified with amphiphilic protein – casein and poorly-water soluble model drug – caffeine – was encapsulated (PMAC). Present study is focused on investigation how variation of amount of one of the most important hydrogels network parameter such as crosslinker affect PMAC swelling properties and caffeine release. The group of hybrid hydrogels – PMAC – was synthesized with various amount of crosslinker: 0.4mol%, 0.8mol%, 1.6mol% and 3.2mol% with respect to methacrylic acid. Swelling behavior of hybrid hydrogels and caffeine release was investigated in two environments which simulated human stomach and intestines. Obtained results showed that targeted delivery of poorly water-soluble model drug was achieved and that its release can be prolonged up to 24h. Also, kinetic of poorly water-soluble drug release can be easily modified only by changing crosslinker amount. PMAC hybrid hydrogels have huge potential for targeted delivery of poorly water-soluble active substances. PB - Institute for Information Technologies, University of Kragujevac, Serbia, Jovana Cvijića bb, 2021 C3 - 1 st International Conference on Chemo and BioInformatics ICCBIKG 2021 T1 - Effect of crosslinker amount on hybrid hydrogels swelling and drug release EP - 128 SP - 125 DO - 10.46793/ICCBI21.125M ER -
@conference{ author = "Marković, Maja D. and Panić, Vesna V. and Tadic, Julijana D. and Pjanović, Rada V.", year = "2021", abstract = "Targeted drug delivery is powerful tool which researchers use to achieve safer and more efficient therapy of many diseases, including various types of cancer. Many chemotherapeutics are poorly watersoluble, so their encapsulation and targeted delivery remain quite challenge. Hydrogels based on poly(methacrylic acid) (PMAA) are widely investigated for targeted drug delivery due to their pH sensitivity, non-toxicity and biocompatibility. Still, due to the PMAA highly hydrophilic nature, PMAA can only be used for encapsulation and targeted delivery of water-soluble drugs. Our previous research was directed towards overcoming this limitation: PMAA was modified with amphiphilic protein – casein and poorly-water soluble model drug – caffeine – was encapsulated (PMAC). Present study is focused on investigation how variation of amount of one of the most important hydrogels network parameter such as crosslinker affect PMAC swelling properties and caffeine release. The group of hybrid hydrogels – PMAC – was synthesized with various amount of crosslinker: 0.4mol%, 0.8mol%, 1.6mol% and 3.2mol% with respect to methacrylic acid. Swelling behavior of hybrid hydrogels and caffeine release was investigated in two environments which simulated human stomach and intestines. Obtained results showed that targeted delivery of poorly water-soluble model drug was achieved and that its release can be prolonged up to 24h. Also, kinetic of poorly water-soluble drug release can be easily modified only by changing crosslinker amount. PMAC hybrid hydrogels have huge potential for targeted delivery of poorly water-soluble active substances.", publisher = "Institute for Information Technologies, University of Kragujevac, Serbia, Jovana Cvijića bb, 2021", journal = "1 st International Conference on Chemo and BioInformatics ICCBIKG 2021", title = "Effect of crosslinker amount on hybrid hydrogels swelling and drug release", pages = "128-125", doi = "10.46793/ICCBI21.125M" }
Marković, M. D., Panić, V. V., Tadic, J. D.,& Pjanović, R. V.. (2021). Effect of crosslinker amount on hybrid hydrogels swelling and drug release. in 1 st International Conference on Chemo and BioInformatics ICCBIKG 2021 Institute for Information Technologies, University of Kragujevac, Serbia, Jovana Cvijića bb, 2021., 125-128. https://doi.org/10.46793/ICCBI21.125M
Marković MD, Panić VV, Tadic JD, Pjanović RV. Effect of crosslinker amount on hybrid hydrogels swelling and drug release. in 1 st International Conference on Chemo and BioInformatics ICCBIKG 2021. 2021;:125-128. doi:10.46793/ICCBI21.125M .
Marković, Maja D., Panić, Vesna V., Tadic, Julijana D., Pjanović, Rada V., "Effect of crosslinker amount on hybrid hydrogels swelling and drug release" in 1 st International Conference on Chemo and BioInformatics ICCBIKG 2021 (2021):125-128, https://doi.org/10.46793/ICCBI21.125M . .