Приказ основних података о документу

dc.creatorMarković, Maja D.
dc.creatorPanić, Vesna V.
dc.creatorTadic, Julijana D.
dc.creatorPjanović, Rada V.
dc.date.accessioned2022-04-20T12:52:30Z
dc.date.available2022-04-20T12:52:30Z
dc.date.issued2021
dc.identifier.isbn978-86-82172-01-7
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/5069
dc.description.abstractTargeted drug delivery is powerful tool which researchers use to achieve safer and more efficient therapy of many diseases, including various types of cancer. Many chemotherapeutics are poorly watersoluble, so their encapsulation and targeted delivery remain quite challenge. Hydrogels based on poly(methacrylic acid) (PMAA) are widely investigated for targeted drug delivery due to their pH sensitivity, non-toxicity and biocompatibility. Still, due to the PMAA highly hydrophilic nature, PMAA can only be used for encapsulation and targeted delivery of water-soluble drugs. Our previous research was directed towards overcoming this limitation: PMAA was modified with amphiphilic protein – casein and poorly-water soluble model drug – caffeine – was encapsulated (PMAC). Present study is focused on investigation how variation of amount of one of the most important hydrogels network parameter such as crosslinker affect PMAC swelling properties and caffeine release. The group of hybrid hydrogels – PMAC – was synthesized with various amount of crosslinker: 0.4mol%, 0.8mol%, 1.6mol% and 3.2mol% with respect to methacrylic acid. Swelling behavior of hybrid hydrogels and caffeine release was investigated in two environments which simulated human stomach and intestines. Obtained results showed that targeted delivery of poorly water-soluble model drug was achieved and that its release can be prolonged up to 24h. Also, kinetic of poorly water-soluble drug release can be easily modified only by changing crosslinker amount. PMAC hybrid hydrogels have huge potential for targeted delivery of poorly water-soluble active substances.sr
dc.language.isoensr
dc.publisherInstitute for Information Technologies, University of Kragujevac, Serbia, Jovana Cvijića bb, 2021sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200287/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200017/RS//sr
dc.rightsopenAccesssr
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.source1 st International Conference on Chemo and BioInformatics ICCBIKG 2021sr
dc.subjectpoly(methacrylic acid)sr
dc.subjectcaseinsr
dc.subjectcrosslinkingsr
dc.subjecthydrogels swellingsr
dc.subjectdrug releasesr
dc.titleEffect of crosslinker amount on hybrid hydrogels swelling and drug releasesr
dc.typeconferenceObjectsr
dc.rights.licenseBYsr
dc.citation.epage128
dc.citation.spage125
dc.identifier.doi10.46793/ICCBI21.125M
dc.identifier.fulltexthttp://TechnoRep.tmf.bg.ac.rs/bitstream/id/8220/bitstream_8220.pdf
dc.type.versionpublishedVersionsr


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Приказ основних података о документу