Soft polymeric networks based on poly(methacrylic acid), itaconic acid, casein and liposomes for targeted delivery and controlled release of poorly water soluble active substance
Аутори
Marković, MajaPanić, Vesna
Šešlija, Sanja
Spasojević, Pavle
Ugrinović, Vukašin
Bošković-Vragolović, Nevenka
Pjanović, Rada
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Soft polymeric networks based on poly(methacrylic
acid) (PMAA) are attractive candidates for targeted and
controlled drug release due to their non-toxicity,
biocompatibility and pH-sensitivity. The highly hydrophilic
nature of PMAA networks enables transport of hydrophilic
drugs only. This limitation has been overcome in present work
by a PMAA modification with casein and liposomes. Casein is a
natural amphiphilic protein which enabled the encapsulation
and targeted and controlled release of the model drug- caffeine.
The FTIR spectra showed that the hydrophobic interactions and
hydrogen bonds were established between the casein and
caffeine. The caffeine in vitro release was monitored in two media
at 37C: phosphate buffer pH=6.8, which simulated the pH
environment in the human intestines and 0.1M HCl pH=1.2,
which simulated the pH environment in the human stomach. The
presence of liposomes with the encapsulated caffeine in the
carriers caused the decrease in the speed ...of caffeine release.
Introduction of itaconic acid (IA) as a hydrophilic and pHsensitive substance with two carboxylic groups resulted in a nonregular structure of the carriers with large voids which caused
an increase in swelling rate of the carriers and an increase in
speed of caffeine release. All obtained results showed that the
targeted and controlled release of a poorly water-soluble
substance was achieved.
Кључне речи:
Poly(methacrylic acid) / itaconic acid / casein / liposomes / controlled release / poorly water-soluble drug / release kineticИзвор:
6th International Conference on Electrical, Electronic and Computing Engineering, IcETRAN 2019, 2019, 665-670Издавач:
- ETRAN Society, Belgrade, Academic Mind, Belgrade
Финансирање / пројекти:
- Синтеза и карактеризација нових функционалних полимера и полимерних нанокомпозита (RS-MESTD-Basic Research (BR or ON)-172062)
- Геосистемске основе просторно-функционалне организације Републике Србије (RS-MESTD-MPN2006-2010-146010)
Колекције
Институција/група
Inovacioni centarTY - CONF AU - Marković, Maja AU - Panić, Vesna AU - Šešlija, Sanja AU - Spasojević, Pavle AU - Ugrinović, Vukašin AU - Bošković-Vragolović, Nevenka AU - Pjanović, Rada PY - 2019 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5075 AB - Soft polymeric networks based on poly(methacrylic acid) (PMAA) are attractive candidates for targeted and controlled drug release due to their non-toxicity, biocompatibility and pH-sensitivity. The highly hydrophilic nature of PMAA networks enables transport of hydrophilic drugs only. This limitation has been overcome in present work by a PMAA modification with casein and liposomes. Casein is a natural amphiphilic protein which enabled the encapsulation and targeted and controlled release of the model drug- caffeine. The FTIR spectra showed that the hydrophobic interactions and hydrogen bonds were established between the casein and caffeine. The caffeine in vitro release was monitored in two media at 37C: phosphate buffer pH=6.8, which simulated the pH environment in the human intestines and 0.1M HCl pH=1.2, which simulated the pH environment in the human stomach. The presence of liposomes with the encapsulated caffeine in the carriers caused the decrease in the speed of caffeine release. Introduction of itaconic acid (IA) as a hydrophilic and pHsensitive substance with two carboxylic groups resulted in a nonregular structure of the carriers with large voids which caused an increase in swelling rate of the carriers and an increase in speed of caffeine release. All obtained results showed that the targeted and controlled release of a poorly water-soluble substance was achieved. PB - ETRAN Society, Belgrade, Academic Mind, Belgrade C3 - 6th International Conference on Electrical, Electronic and Computing Engineering, IcETRAN 2019 T1 - Soft polymeric networks based on poly(methacrylic acid), itaconic acid, casein and liposomes for targeted delivery and controlled release of poorly water soluble active substance EP - 670 SP - 665 UR - https://hdl.handle.net/21.15107/rcub_technorep_5075 ER -
@conference{ author = "Marković, Maja and Panić, Vesna and Šešlija, Sanja and Spasojević, Pavle and Ugrinović, Vukašin and Bošković-Vragolović, Nevenka and Pjanović, Rada", year = "2019", abstract = "Soft polymeric networks based on poly(methacrylic acid) (PMAA) are attractive candidates for targeted and controlled drug release due to their non-toxicity, biocompatibility and pH-sensitivity. The highly hydrophilic nature of PMAA networks enables transport of hydrophilic drugs only. This limitation has been overcome in present work by a PMAA modification with casein and liposomes. Casein is a natural amphiphilic protein which enabled the encapsulation and targeted and controlled release of the model drug- caffeine. The FTIR spectra showed that the hydrophobic interactions and hydrogen bonds were established between the casein and caffeine. The caffeine in vitro release was monitored in two media at 37C: phosphate buffer pH=6.8, which simulated the pH environment in the human intestines and 0.1M HCl pH=1.2, which simulated the pH environment in the human stomach. The presence of liposomes with the encapsulated caffeine in the carriers caused the decrease in the speed of caffeine release. Introduction of itaconic acid (IA) as a hydrophilic and pHsensitive substance with two carboxylic groups resulted in a nonregular structure of the carriers with large voids which caused an increase in swelling rate of the carriers and an increase in speed of caffeine release. All obtained results showed that the targeted and controlled release of a poorly water-soluble substance was achieved.", publisher = "ETRAN Society, Belgrade, Academic Mind, Belgrade", journal = "6th International Conference on Electrical, Electronic and Computing Engineering, IcETRAN 2019", title = "Soft polymeric networks based on poly(methacrylic acid), itaconic acid, casein and liposomes for targeted delivery and controlled release of poorly water soluble active substance", pages = "670-665", url = "https://hdl.handle.net/21.15107/rcub_technorep_5075" }
Marković, M., Panić, V., Šešlija, S., Spasojević, P., Ugrinović, V., Bošković-Vragolović, N.,& Pjanović, R.. (2019). Soft polymeric networks based on poly(methacrylic acid), itaconic acid, casein and liposomes for targeted delivery and controlled release of poorly water soluble active substance. in 6th International Conference on Electrical, Electronic and Computing Engineering, IcETRAN 2019 ETRAN Society, Belgrade, Academic Mind, Belgrade., 665-670. https://hdl.handle.net/21.15107/rcub_technorep_5075
Marković M, Panić V, Šešlija S, Spasojević P, Ugrinović V, Bošković-Vragolović N, Pjanović R. Soft polymeric networks based on poly(methacrylic acid), itaconic acid, casein and liposomes for targeted delivery and controlled release of poorly water soluble active substance. in 6th International Conference on Electrical, Electronic and Computing Engineering, IcETRAN 2019. 2019;:665-670. https://hdl.handle.net/21.15107/rcub_technorep_5075 .
Marković, Maja, Panić, Vesna, Šešlija, Sanja, Spasojević, Pavle, Ugrinović, Vukašin, Bošković-Vragolović, Nevenka, Pjanović, Rada, "Soft polymeric networks based on poly(methacrylic acid), itaconic acid, casein and liposomes for targeted delivery and controlled release of poorly water soluble active substance" in 6th International Conference on Electrical, Electronic and Computing Engineering, IcETRAN 2019 (2019):665-670, https://hdl.handle.net/21.15107/rcub_technorep_5075 .