Show simple item record

dc.creatorMarković, Maja
dc.creatorPanić, Vesna
dc.creatorŠešlija, Sanja
dc.creatorSpasojević, Pavle
dc.creatorUgrinović, Vukašin
dc.creatorBošković-Vragolović, Nevenka
dc.creatorPjanović, Rada
dc.date.accessioned2022-04-20T18:27:05Z
dc.date.available2022-04-20T18:27:05Z
dc.date.issued2019
dc.identifier.isbn978-86-7466-785-9
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/5075
dc.description.abstractSoft polymeric networks based on poly(methacrylic acid) (PMAA) are attractive candidates for targeted and controlled drug release due to their non-toxicity, biocompatibility and pH-sensitivity. The highly hydrophilic nature of PMAA networks enables transport of hydrophilic drugs only. This limitation has been overcome in present work by a PMAA modification with casein and liposomes. Casein is a natural amphiphilic protein which enabled the encapsulation and targeted and controlled release of the model drug- caffeine. The FTIR spectra showed that the hydrophobic interactions and hydrogen bonds were established between the casein and caffeine. The caffeine in vitro release was monitored in two media at 37C: phosphate buffer pH=6.8, which simulated the pH environment in the human intestines and 0.1M HCl pH=1.2, which simulated the pH environment in the human stomach. The presence of liposomes with the encapsulated caffeine in the carriers caused the decrease in the speed of caffeine release. Introduction of itaconic acid (IA) as a hydrophilic and pHsensitive substance with two carboxylic groups resulted in a nonregular structure of the carriers with large voids which caused an increase in swelling rate of the carriers and an increase in speed of caffeine release. All obtained results showed that the targeted and controlled release of a poorly water-soluble substance was achieved.sr
dc.language.isoensr
dc.publisherETRAN Society, Belgrade, Academic Mind, Belgradesr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172062/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/146010/RS//sr
dc.rightsopenAccesssr
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.source6th International Conference on Electrical, Electronic and Computing Engineering, IcETRAN 2019sr
dc.subjectPoly(methacrylic acid)sr
dc.subjectitaconic acidsr
dc.subjectcaseinsr
dc.subjectliposomessr
dc.subjectcontrolled releasesr
dc.subjectpoorly water-soluble drugsr
dc.subjectrelease kineticsr
dc.titleSoft polymeric networks based on poly(methacrylic acid), itaconic acid, casein and liposomes for targeted delivery and controlled release of poorly water soluble active substancesr
dc.typeconferenceObjectsr
dc.rights.licenseBYsr
dc.citation.epage670
dc.citation.spage665
dc.identifier.fulltexthttp://TechnoRep.tmf.bg.ac.rs/bitstream/id/8229/bitstream_8229.pdf
dc.type.versionpublishedVersionsr


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record