Приказ основних података о документу
Soft polymeric networks based on poly(methacrylic acid), itaconic acid, casein and liposomes for targeted delivery and controlled release of poorly water soluble active substance
dc.creator | Marković, Maja | |
dc.creator | Panić, Vesna | |
dc.creator | Šešlija, Sanja | |
dc.creator | Spasojević, Pavle | |
dc.creator | Ugrinović, Vukašin | |
dc.creator | Bošković-Vragolović, Nevenka | |
dc.creator | Pjanović, Rada | |
dc.date.accessioned | 2022-04-20T18:27:05Z | |
dc.date.available | 2022-04-20T18:27:05Z | |
dc.date.issued | 2019 | |
dc.identifier.isbn | 978-86-7466-785-9 | |
dc.identifier.uri | http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5075 | |
dc.description.abstract | Soft polymeric networks based on poly(methacrylic acid) (PMAA) are attractive candidates for targeted and controlled drug release due to their non-toxicity, biocompatibility and pH-sensitivity. The highly hydrophilic nature of PMAA networks enables transport of hydrophilic drugs only. This limitation has been overcome in present work by a PMAA modification with casein and liposomes. Casein is a natural amphiphilic protein which enabled the encapsulation and targeted and controlled release of the model drug- caffeine. The FTIR spectra showed that the hydrophobic interactions and hydrogen bonds were established between the casein and caffeine. The caffeine in vitro release was monitored in two media at 37C: phosphate buffer pH=6.8, which simulated the pH environment in the human intestines and 0.1M HCl pH=1.2, which simulated the pH environment in the human stomach. The presence of liposomes with the encapsulated caffeine in the carriers caused the decrease in the speed of caffeine release. Introduction of itaconic acid (IA) as a hydrophilic and pHsensitive substance with two carboxylic groups resulted in a nonregular structure of the carriers with large voids which caused an increase in swelling rate of the carriers and an increase in speed of caffeine release. All obtained results showed that the targeted and controlled release of a poorly water-soluble substance was achieved. | sr |
dc.language.iso | en | sr |
dc.publisher | ETRAN Society, Belgrade, Academic Mind, Belgrade | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172062/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/146010/RS// | sr |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | 6th International Conference on Electrical, Electronic and Computing Engineering, IcETRAN 2019 | sr |
dc.subject | Poly(methacrylic acid) | sr |
dc.subject | itaconic acid | sr |
dc.subject | casein | sr |
dc.subject | liposomes | sr |
dc.subject | controlled release | sr |
dc.subject | poorly water-soluble drug | sr |
dc.subject | release kinetic | sr |
dc.title | Soft polymeric networks based on poly(methacrylic acid), itaconic acid, casein and liposomes for targeted delivery and controlled release of poorly water soluble active substance | sr |
dc.type | conferenceObject | sr |
dc.rights.license | BY | sr |
dc.citation.epage | 670 | |
dc.citation.spage | 665 | |
dc.identifier.fulltext | http://TechnoRep.tmf.bg.ac.rs/bitstream/id/8229/bitstream_8229.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_technorep_5075 | |
dc.type.version | publishedVersion | sr |