α-Tricalcium phosphate/fluorapatite-based cement – Promising dental root canal filling material
Authors
Kazuz, AbdulRadovanović, Željko
Veljović, Đorđe
Kojić, Vesna
Jakimov, Dimitar
Vlajić-Tovilović, Tamara
Miletić, Vesna
Petrović, Rada
Janaćković, Đorđe
Article (Published version)
Metadata
Show full item recordAbstract
α-Tricalcium phosphate/fluorapatite (α-TCP/FAp) mixed powders were prepared in order to obtain dental root canal filling cements. Different liquids for cement pastes have been investigated and the most suitable one for obtaining rheologically optimal pastes was chosen for further analysis. Morphological changes in the cement materials as a consequence of the formation of hydroxyapatite (HAp) after the immersion in a simulated body fluid (SBF), an influence on the cell viability, and final success of the filling were investigated by field emission scanning electron microscopy. Treatment of the α-TCP/FAp mixtures in SBF at 37 °C resulted in a complete transformation of α-TCP into HAp after 10 days, while the exposure of MRC-5 human and L929 animal fibroblast cells to the cement showed complete absence of cytotoxicity. The root canal of an extracted tooth was filled with the α-TCP/FAp cement containing 5 wt.% of FAp and relatively strong adhesion between the cement and dentine was observe...d after 48 h. The same cement material was immersed during 10 days in SBF and after that both human and animal fibroblast cells during in vitro MTT tests showed higher cell viability compared to the control sample. These findings lead to a conclusion that the α-TCP/FAp based cement demonstrates potential for further development towards dental cement application.
Keywords:
apatite / bioactivity / biocompatibility / dental cement / dental materialsSource:
Processing and Application of Ceramics, 2022, 16, 1, 22-29Publisher:
- University of Novi Sad, Faculty of Technology
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200135 (University of Belgrade, Faculty of Technology and Metallurgy) (RS-MESTD-inst-2020-200135)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200287 (Innovation Center of the Faculty of Technology and Metallurgy) (RS-MESTD-inst-2020-200287)
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Kazuz, Abdul AU - Radovanović, Željko AU - Veljović, Đorđe AU - Kojić, Vesna AU - Jakimov, Dimitar AU - Vlajić-Tovilović, Tamara AU - Miletić, Vesna AU - Petrović, Rada AU - Janaćković, Đorđe PY - 2022 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5143 AB - α-Tricalcium phosphate/fluorapatite (α-TCP/FAp) mixed powders were prepared in order to obtain dental root canal filling cements. Different liquids for cement pastes have been investigated and the most suitable one for obtaining rheologically optimal pastes was chosen for further analysis. Morphological changes in the cement materials as a consequence of the formation of hydroxyapatite (HAp) after the immersion in a simulated body fluid (SBF), an influence on the cell viability, and final success of the filling were investigated by field emission scanning electron microscopy. Treatment of the α-TCP/FAp mixtures in SBF at 37 °C resulted in a complete transformation of α-TCP into HAp after 10 days, while the exposure of MRC-5 human and L929 animal fibroblast cells to the cement showed complete absence of cytotoxicity. The root canal of an extracted tooth was filled with the α-TCP/FAp cement containing 5 wt.% of FAp and relatively strong adhesion between the cement and dentine was observed after 48 h. The same cement material was immersed during 10 days in SBF and after that both human and animal fibroblast cells during in vitro MTT tests showed higher cell viability compared to the control sample. These findings lead to a conclusion that the α-TCP/FAp based cement demonstrates potential for further development towards dental cement application. PB - University of Novi Sad, Faculty of Technology T2 - Processing and Application of Ceramics T1 - α-Tricalcium phosphate/fluorapatite-based cement – Promising dental root canal filling material EP - 29 IS - 1 SP - 22 VL - 16 DO - 10.2298/PAC2201022K ER -
@article{ author = "Kazuz, Abdul and Radovanović, Željko and Veljović, Đorđe and Kojić, Vesna and Jakimov, Dimitar and Vlajić-Tovilović, Tamara and Miletić, Vesna and Petrović, Rada and Janaćković, Đorđe", year = "2022", abstract = "α-Tricalcium phosphate/fluorapatite (α-TCP/FAp) mixed powders were prepared in order to obtain dental root canal filling cements. Different liquids for cement pastes have been investigated and the most suitable one for obtaining rheologically optimal pastes was chosen for further analysis. Morphological changes in the cement materials as a consequence of the formation of hydroxyapatite (HAp) after the immersion in a simulated body fluid (SBF), an influence on the cell viability, and final success of the filling were investigated by field emission scanning electron microscopy. Treatment of the α-TCP/FAp mixtures in SBF at 37 °C resulted in a complete transformation of α-TCP into HAp after 10 days, while the exposure of MRC-5 human and L929 animal fibroblast cells to the cement showed complete absence of cytotoxicity. The root canal of an extracted tooth was filled with the α-TCP/FAp cement containing 5 wt.% of FAp and relatively strong adhesion between the cement and dentine was observed after 48 h. The same cement material was immersed during 10 days in SBF and after that both human and animal fibroblast cells during in vitro MTT tests showed higher cell viability compared to the control sample. These findings lead to a conclusion that the α-TCP/FAp based cement demonstrates potential for further development towards dental cement application.", publisher = "University of Novi Sad, Faculty of Technology", journal = "Processing and Application of Ceramics", title = "α-Tricalcium phosphate/fluorapatite-based cement – Promising dental root canal filling material", pages = "29-22", number = "1", volume = "16", doi = "10.2298/PAC2201022K" }
Kazuz, A., Radovanović, Ž., Veljović, Đ., Kojić, V., Jakimov, D., Vlajić-Tovilović, T., Miletić, V., Petrović, R.,& Janaćković, Đ.. (2022). α-Tricalcium phosphate/fluorapatite-based cement – Promising dental root canal filling material. in Processing and Application of Ceramics University of Novi Sad, Faculty of Technology., 16(1), 22-29. https://doi.org/10.2298/PAC2201022K
Kazuz A, Radovanović Ž, Veljović Đ, Kojić V, Jakimov D, Vlajić-Tovilović T, Miletić V, Petrović R, Janaćković Đ. α-Tricalcium phosphate/fluorapatite-based cement – Promising dental root canal filling material. in Processing and Application of Ceramics. 2022;16(1):22-29. doi:10.2298/PAC2201022K .
Kazuz, Abdul, Radovanović, Željko, Veljović, Đorđe, Kojić, Vesna, Jakimov, Dimitar, Vlajić-Tovilović, Tamara, Miletić, Vesna, Petrović, Rada, Janaćković, Đorđe, "α-Tricalcium phosphate/fluorapatite-based cement – Promising dental root canal filling material" in Processing and Application of Ceramics, 16, no. 1 (2022):22-29, https://doi.org/10.2298/PAC2201022K . .