Приказ основних података о документу

dc.creatorRadunović, Milena
dc.creatorPavić, Aleksandar
dc.creatorIvanović, Vera
dc.creatorMilivojević, Marija
dc.creatorRadović, Igor
dc.creatorDi Carlo, Roberta
dc.creatorPilato, Serena
dc.creatorFontana, Antonella
dc.creatorPiattelli, Adriano
dc.creatorPetrović, Sanja
dc.date.accessioned2022-06-06T08:13:42Z
dc.date.available2022-06-06T08:13:42Z
dc.date.issued2022
dc.identifier.issn0109-5641
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/5144
dc.description.abstractThe aims of the study were: 1) to evaluate the effect on biofilm formation of barrier membranes and titanium surfaces coated with graphene-oxide (GO); 2) to analyze the connection between the superficial topography of the tested materials and the amount of bacterial accumulation on them and 3) to analyze the biocompatibility of GO functionalized discs using the zebrafish model. Methods: Single species bacterial biofilms (Streptococcus oralis, Veilonella parvula, Fusobacterium nucleatum, Porphyomonas gingivalis) were grown on GO-free membranes, membranes coated with 2 and 10 μg/ml of GO, GO-free and GO-coated titanium discs. The biofilms were analyzed by determining the CFU count and by Scanning Electron Microscopy (SEM) and the materials’ topography by Atomic Force Microscopy (AFM). Zebrafish model was used to determine the materials’ toxicity and inflammatory effects. Results: AFM showed similar roughness of control and GO-coated materials. CFU counts on GO-coated discs were significantly lower than on control discs for all species. CFU counts of S. oralis, V. parvula and P. gingivalis were lower on biofilms grown on both types of GO-coated membranes than on GO-free membrane. SEM analysis showed different formation of single species biofilm of S. oralis on control and GO-coated materials. GO-functionalized titanium discs do not induce toxic or inflammatory effects. Significance: Titanium implant surfaces functionalized with GO have shown to be biocompatible and less susceptible to biofilm formation. These results encourage further in vivo investigation of the tested materials on infection prevention, specifically in prevention and reduction of peri-implant mucositis and periimplantitis incidence.sr
dc.language.isoensr
dc.publisherElsevier Inc.sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200129/RS//sr
dc.rightsrestrictedAccesssr
dc.sourceDental Materialssr
dc.subjectAtomic Force Microscopysr
dc.subjectBiocompatible Materials Testingsr
dc.subjectBiofilmsr
dc.subjectDental Materialsr
dc.subjectGraphene oxidesr
dc.subjectZebrafishsr
dc.subjectPeri-Implantitissr
dc.subjectScanning Electron Microscopysr
dc.titleBiocompatibility and antibiofilm activity of graphene-oxide functionalized titanium discs and collagen membranessr
dc.typearticlesr
dc.rights.licenseARRsr
dc.citation.epage1127
dc.citation.issue7
dc.citation.rankaM21~
dc.citation.spage1117
dc.citation.volume38
dc.identifier.doi10.1016/j.dental.2022.04.024
dc.identifier.scopus2-s2.0-85130358735
dc.type.versionpublishedVersionsr


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Приказ основних података о документу