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Collective Cell Migration on Collagen-I Networks: The Impact of Matrix Viscoelasticity

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2022
bitstream_12768.pdf (1.437Mb)
Authors
Pajić-Lijaković, Ivana
Milivojević, Milan
Clark, Andrew G.
Review (Published version)
Metadata
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Abstract
Collective cell migration on extracellular matrix (ECM) networks is a key biological process involved in development, tissue homeostasis and diseases such as metastatic cancer. During invasion of epithelial cancers, cell clusters migrate through the surrounding stroma, which is comprised primarily of networks of collagen-I fibers. There is growing evidence that the rheological and topological properties of collagen networks can impact cell behavior and cell migration dynamics. During migration, cells exert mechanical forces on their substrate, resulting in an active remodeling of ECM networks that depends not only on the forces produced, but also on the molecular mechanisms that dictate network rheology. One aspect of collagen network rheology whose role is emerging as a crucial parameter in dictating cell behavior is network viscoelasticity. Dynamic reorganization of ECM networks can induce local changes in network organization and mechanics, which can further feed back on cell migrat...ion dynamics and cell-cell rearrangement. A number of studies, including many recent publications, have investigated the mechanisms underlying structural changes to collagen networks in response to mechanical force as well as the role of collagen rheology and topology in regulating cell behavior. In this mini-review, we explore the cause-consequence relationship between collagen network viscoelasticity and cell rearrangements at various spatiotemporal scales. We focus on structural alterations of collagen-I networks during collective cell migration and discuss the main rheological parameters, and in particular the role of viscoelasticity, which can contribute to local matrix stiffening during cell movement and can elicit changes in cell dynamics.

Keywords:
cell rearrangement / collagen / collective cell migration / extracellular matrix / matrix remodeling / residual stress accumulation / viscoelasticity
Source:
Frontiers in Cell and Developmental Biology, 2022, 10, -901026
Publisher:
  • Frontiers Media S.A.
Funding / projects:
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200135 (University of Belgrade, Faculty of Technology and Metallurgy) (RS-200135)

DOI: 10.3389/fcell.2022.901026

ISSN: 2296-634X

WoS: 00082832710000

Scopus: 2-s2.0-85134413231
[ Google Scholar ]
1
URI
http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5185
Collections
  • Radovi istraživača / Researchers’ publications (TMF)
Institution/Community
Tehnološko-metalurški fakultet
TY  - JOUR
AU  - Pajić-Lijaković, Ivana
AU  - Milivojević, Milan
AU  - Clark, Andrew G.
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5185
AB  - Collective cell migration on extracellular matrix (ECM) networks is a key biological process involved in development, tissue homeostasis and diseases such as metastatic cancer. During invasion of epithelial cancers, cell clusters migrate through the surrounding stroma, which is comprised primarily of networks of collagen-I fibers. There is growing evidence that the rheological and topological properties of collagen networks can impact cell behavior and cell migration dynamics. During migration, cells exert mechanical forces on their substrate, resulting in an active remodeling of ECM networks that depends not only on the forces produced, but also on the molecular mechanisms that dictate network rheology. One aspect of collagen network rheology whose role is emerging as a crucial parameter in dictating cell behavior is network viscoelasticity. Dynamic reorganization of ECM networks can induce local changes in network organization and mechanics, which can further feed back on cell migration dynamics and cell-cell rearrangement. A number of studies, including many recent publications, have investigated the mechanisms underlying structural changes to collagen networks in response to mechanical force as well as the role of collagen rheology and topology in regulating cell behavior. In this mini-review, we explore the cause-consequence relationship between collagen network viscoelasticity and cell rearrangements at various spatiotemporal scales. We focus on structural alterations of collagen-I networks during collective cell migration and discuss the main rheological parameters, and in particular the role of viscoelasticity, which can contribute to local matrix stiffening during cell movement and can elicit changes in cell dynamics.
PB  - Frontiers Media S.A.
T2  - Frontiers in Cell and Developmental Biology
T1  - Collective Cell Migration on Collagen-I Networks: The Impact of Matrix Viscoelasticity
EP  - 901026
VL  - 10
DO  - 10.3389/fcell.2022.901026
ER  - 
@article{
author = "Pajić-Lijaković, Ivana and Milivojević, Milan and Clark, Andrew G.",
year = "2022",
abstract = "Collective cell migration on extracellular matrix (ECM) networks is a key biological process involved in development, tissue homeostasis and diseases such as metastatic cancer. During invasion of epithelial cancers, cell clusters migrate through the surrounding stroma, which is comprised primarily of networks of collagen-I fibers. There is growing evidence that the rheological and topological properties of collagen networks can impact cell behavior and cell migration dynamics. During migration, cells exert mechanical forces on their substrate, resulting in an active remodeling of ECM networks that depends not only on the forces produced, but also on the molecular mechanisms that dictate network rheology. One aspect of collagen network rheology whose role is emerging as a crucial parameter in dictating cell behavior is network viscoelasticity. Dynamic reorganization of ECM networks can induce local changes in network organization and mechanics, which can further feed back on cell migration dynamics and cell-cell rearrangement. A number of studies, including many recent publications, have investigated the mechanisms underlying structural changes to collagen networks in response to mechanical force as well as the role of collagen rheology and topology in regulating cell behavior. In this mini-review, we explore the cause-consequence relationship between collagen network viscoelasticity and cell rearrangements at various spatiotemporal scales. We focus on structural alterations of collagen-I networks during collective cell migration and discuss the main rheological parameters, and in particular the role of viscoelasticity, which can contribute to local matrix stiffening during cell movement and can elicit changes in cell dynamics.",
publisher = "Frontiers Media S.A.",
journal = "Frontiers in Cell and Developmental Biology",
title = "Collective Cell Migration on Collagen-I Networks: The Impact of Matrix Viscoelasticity",
pages = "901026",
volume = "10",
doi = "10.3389/fcell.2022.901026"
}
Pajić-Lijaković, I., Milivojević, M.,& Clark, A. G.. (2022). Collective Cell Migration on Collagen-I Networks: The Impact of Matrix Viscoelasticity. in Frontiers in Cell and Developmental Biology
Frontiers Media S.A.., 10.
https://doi.org/10.3389/fcell.2022.901026
Pajić-Lijaković I, Milivojević M, Clark AG. Collective Cell Migration on Collagen-I Networks: The Impact of Matrix Viscoelasticity. in Frontiers in Cell and Developmental Biology. 2022;10:null-901026.
doi:10.3389/fcell.2022.901026 .
Pajić-Lijaković, Ivana, Milivojević, Milan, Clark, Andrew G., "Collective Cell Migration on Collagen-I Networks: The Impact of Matrix Viscoelasticity" in Frontiers in Cell and Developmental Biology, 10 (2022),
https://doi.org/10.3389/fcell.2022.901026 . .

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