Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation
Samo za registrovane korisnike
2022
Autori
Lović, JelenaBogdanović, Aleksandra
Tadić, Vanja
Mijin, Dušan
Vuković, Dragan
Petrović, Slobodan D.
Avramov-Ivić, Milka
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Duloxetine hydrochloride (DUL) is effective in treating depression, and was examined for electroanalytical purposes. The DULstandard was investigated by cyclic voltammetry (CV) and determined using differential pulse voltammetry (DPV) via its electrooxidationat the Au electrode in 0.05 M NaHCO3. DPV showed a linear dependency of the anodic peak currents vs DUL standardconcentrations in the range from 0.1 to 3.33 μg ml−1 with the values of the limit of detection (LOD) and the limit of quantification(LOQ): 0.133 and 0.667 μg ml−1, respectively. Using the constructed and validated calibration curve, the values of unknown DULconcentrations in both Taita® tablets and in human serum spiked with the standard were determined. The number of protons andelectrons transferred was calculated and possible reaction mechanisms taking place on the surface of both electrodes wereproposed. The Au electrode exhibited a better sensitivity and a wider range of current vs concentration linear dependency for ...DULquantitative determination than the GC electrode. The study of DUL degradation showed that at the Au and GC electrodes, after4.5 h of potential cycling, degradation occurs, giving formaldehyde as a product, which was confirmed by high performance liquidchromatography (HPLC)
Ključne reči:
Duloxetine hydrochloride determination; / Taita® tablet / human serum / kinetics and reaction mechanismIzvor:
Journal of The Electrochemical Society, 2022, 169, 7, 076507-Izdavač:
- The Electrochemical Society
Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200026 (Univerzitet u Beogradu, Institut za hemiju, tehnologiju i metalurgiju - IHTM) (RS-200026)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200135 (Univerzitet u Beogradu, Tehnološko-metalurški fakultet) (RS-200135)
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Lović, Jelena AU - Bogdanović, Aleksandra AU - Tadić, Vanja AU - Mijin, Dušan AU - Vuković, Dragan AU - Petrović, Slobodan D. AU - Avramov-Ivić, Milka PY - 2022 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5191 AB - Duloxetine hydrochloride (DUL) is effective in treating depression, and was examined for electroanalytical purposes. The DULstandard was investigated by cyclic voltammetry (CV) and determined using differential pulse voltammetry (DPV) via its electrooxidationat the Au electrode in 0.05 M NaHCO3. DPV showed a linear dependency of the anodic peak currents vs DUL standardconcentrations in the range from 0.1 to 3.33 μg ml−1 with the values of the limit of detection (LOD) and the limit of quantification(LOQ): 0.133 and 0.667 μg ml−1, respectively. Using the constructed and validated calibration curve, the values of unknown DULconcentrations in both Taita® tablets and in human serum spiked with the standard were determined. The number of protons andelectrons transferred was calculated and possible reaction mechanisms taking place on the surface of both electrodes wereproposed. The Au electrode exhibited a better sensitivity and a wider range of current vs concentration linear dependency for DULquantitative determination than the GC electrode. The study of DUL degradation showed that at the Au and GC electrodes, after4.5 h of potential cycling, degradation occurs, giving formaldehyde as a product, which was confirmed by high performance liquidchromatography (HPLC) PB - The Electrochemical Society T2 - Journal of The Electrochemical Society T1 - Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation IS - 7 SP - 076507 VL - 169 DO - 10.1149/1945-7111/ac7e74 ER -
@article{ author = "Lović, Jelena and Bogdanović, Aleksandra and Tadić, Vanja and Mijin, Dušan and Vuković, Dragan and Petrović, Slobodan D. and Avramov-Ivić, Milka", year = "2022", abstract = "Duloxetine hydrochloride (DUL) is effective in treating depression, and was examined for electroanalytical purposes. The DULstandard was investigated by cyclic voltammetry (CV) and determined using differential pulse voltammetry (DPV) via its electrooxidationat the Au electrode in 0.05 M NaHCO3. DPV showed a linear dependency of the anodic peak currents vs DUL standardconcentrations in the range from 0.1 to 3.33 μg ml−1 with the values of the limit of detection (LOD) and the limit of quantification(LOQ): 0.133 and 0.667 μg ml−1, respectively. Using the constructed and validated calibration curve, the values of unknown DULconcentrations in both Taita® tablets and in human serum spiked with the standard were determined. The number of protons andelectrons transferred was calculated and possible reaction mechanisms taking place on the surface of both electrodes wereproposed. The Au electrode exhibited a better sensitivity and a wider range of current vs concentration linear dependency for DULquantitative determination than the GC electrode. The study of DUL degradation showed that at the Au and GC electrodes, after4.5 h of potential cycling, degradation occurs, giving formaldehyde as a product, which was confirmed by high performance liquidchromatography (HPLC)", publisher = "The Electrochemical Society", journal = "Journal of The Electrochemical Society", title = "Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation", number = "7", pages = "076507", volume = "169", doi = "10.1149/1945-7111/ac7e74" }
Lović, J., Bogdanović, A., Tadić, V., Mijin, D., Vuković, D., Petrović, S. D.,& Avramov-Ivić, M.. (2022). Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation. in Journal of The Electrochemical Society The Electrochemical Society., 169(7), 076507. https://doi.org/10.1149/1945-7111/ac7e74
Lović J, Bogdanović A, Tadić V, Mijin D, Vuković D, Petrović SD, Avramov-Ivić M. Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation. in Journal of The Electrochemical Society. 2022;169(7):076507. doi:10.1149/1945-7111/ac7e74 .
Lović, Jelena, Bogdanović, Aleksandra, Tadić, Vanja, Mijin, Dušan, Vuković, Dragan, Petrović, Slobodan D., Avramov-Ivić, Milka, "Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation" in Journal of The Electrochemical Society, 169, no. 7 (2022):076507, https://doi.org/10.1149/1945-7111/ac7e74 . .