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Surface activity of cancer cells: The fusion of two cell aggregates

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2023
bitstream_13777.pdf (1.005Mb)
Authors
Pajić-Lijaković, Ivana
Milivojević, Milan
Article (Published version)
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Abstract
A key feature that distinguishes cancer cells from all other cells is their capability to spread throughout the body. Although how cancer cells collectively migrate by following molecular rules which influence the state of cell-cell adhesion contacts has been comprehensively formulated, the impact of physical interactions on cell spreading remains less understood. Cumulative effects of physical interactions exist as the interplay between various physical parameters such as (1) tissue surface tension, (2) viscoelasticity caused by collective cell migration, and (3) solid stress accumulated in the cell aggregate core region. This review aims to point out the role of these physical parameters in cancer cell spreading by considering and comparing the rearrangement of various mono-cultured cancer and epithelial model systems such as the fusion of two cell aggregates. While epithelial cells undergo volumetric cell rearrangement driven by the tissue surface tension, which directs cell movemen...t from the surface to the core region of two-aggregate systems, cancer cells rather perform surface cell rearrangement. Cancer cells migrate toward the surface of the two-aggregate system driven by the solid stress while the surface tension is significantly reduced. The solid stress, accumulated in the core region of the two-aggregate system, is capable of suppressing the movement of epithelial cells that can undergo the jamming state transition; however, this stress enhances the movement of cancer cells. We have focused here on the multi-scale rheological modeling approaches that aimed at reproducing and understanding these biological systems.

Keywords:
Collective cell migration / Solid stress / Surface activity of cancer cells / The state of cell-cell adhesion contacts / Tissue surface tension / Viscoelasticity
Source:
Biocell, 2023, 47, 1, 15-25
Publisher:
  • Tech Science Press
Funding / projects:
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200135 (University of Belgrade, Faculty of Technology and Metallurgy) (RS-200135)

DOI: 10.32604/biocell.2023.023469

ISSN: 0327-9545

Scopus: 2-s2.0-85137244908
[ Google Scholar ]
3
URI
http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5287
Collections
  • Radovi istraživača / Researchers’ publications (TMF)
Institution/Community
Tehnološko-metalurški fakultet
TY  - JOUR
AU  - Pajić-Lijaković, Ivana
AU  - Milivojević, Milan
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5287
AB  - A key feature that distinguishes cancer cells from all other cells is their capability to spread throughout the body. Although how cancer cells collectively migrate by following molecular rules which influence the state of cell-cell adhesion contacts has been comprehensively formulated, the impact of physical interactions on cell spreading remains less understood. Cumulative effects of physical interactions exist as the interplay between various physical parameters such as (1) tissue surface tension, (2) viscoelasticity caused by collective cell migration, and (3) solid stress accumulated in the cell aggregate core region. This review aims to point out the role of these physical parameters in cancer cell spreading by considering and comparing the rearrangement of various mono-cultured cancer and epithelial model systems such as the fusion of two cell aggregates. While epithelial cells undergo volumetric cell rearrangement driven by the tissue surface tension, which directs cell movement from the surface to the core region of two-aggregate systems, cancer cells rather perform surface cell rearrangement. Cancer cells migrate toward the surface of the two-aggregate system driven by the solid stress while the surface tension is significantly reduced. The solid stress, accumulated in the core region of the two-aggregate system, is capable of suppressing the movement of epithelial cells that can undergo the jamming state transition; however, this stress enhances the movement of cancer cells. We have focused here on the multi-scale rheological modeling approaches that aimed at reproducing and understanding these biological systems.
PB  - Tech Science Press
T2  - Biocell
T1  - Surface activity of cancer cells: The fusion of two cell aggregates
EP  - 25
IS  - 1
SP  - 15
VL  - 47
DO  - 10.32604/biocell.2023.023469
ER  - 
@article{
author = "Pajić-Lijaković, Ivana and Milivojević, Milan",
year = "2023",
abstract = "A key feature that distinguishes cancer cells from all other cells is their capability to spread throughout the body. Although how cancer cells collectively migrate by following molecular rules which influence the state of cell-cell adhesion contacts has been comprehensively formulated, the impact of physical interactions on cell spreading remains less understood. Cumulative effects of physical interactions exist as the interplay between various physical parameters such as (1) tissue surface tension, (2) viscoelasticity caused by collective cell migration, and (3) solid stress accumulated in the cell aggregate core region. This review aims to point out the role of these physical parameters in cancer cell spreading by considering and comparing the rearrangement of various mono-cultured cancer and epithelial model systems such as the fusion of two cell aggregates. While epithelial cells undergo volumetric cell rearrangement driven by the tissue surface tension, which directs cell movement from the surface to the core region of two-aggregate systems, cancer cells rather perform surface cell rearrangement. Cancer cells migrate toward the surface of the two-aggregate system driven by the solid stress while the surface tension is significantly reduced. The solid stress, accumulated in the core region of the two-aggregate system, is capable of suppressing the movement of epithelial cells that can undergo the jamming state transition; however, this stress enhances the movement of cancer cells. We have focused here on the multi-scale rheological modeling approaches that aimed at reproducing and understanding these biological systems.",
publisher = "Tech Science Press",
journal = "Biocell",
title = "Surface activity of cancer cells: The fusion of two cell aggregates",
pages = "25-15",
number = "1",
volume = "47",
doi = "10.32604/biocell.2023.023469"
}
Pajić-Lijaković, I.,& Milivojević, M.. (2023). Surface activity of cancer cells: The fusion of two cell aggregates. in Biocell
Tech Science Press., 47(1), 15-25.
https://doi.org/10.32604/biocell.2023.023469
Pajić-Lijaković I, Milivojević M. Surface activity of cancer cells: The fusion of two cell aggregates. in Biocell. 2023;47(1):15-25.
doi:10.32604/biocell.2023.023469 .
Pajić-Lijaković, Ivana, Milivojević, Milan, "Surface activity of cancer cells: The fusion of two cell aggregates" in Biocell, 47, no. 1 (2023):15-25,
https://doi.org/10.32604/biocell.2023.023469 . .

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