Electrospun polycaprolactone nanofibers functionalized with Achillea millefolium extract yield biomaterial with antibacterial, antioxidant and improved mechanical properties
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2023
Authors
Radisavljević, AnđelaStojanović, Dušica B.
Petrović, Miloš
Radojević, Vesna
Uskoković, Petar
Rajilić-Stojanović, Mirjana
Article (Published version)
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In this study, polycaprolactone (PCL), as a biocompatible polymer was functionalized by addition of medicinal plant extract- Achillea millefolium L. (yarrow). Nanofiber mats were fabricated from PCL solutions containing dry yarrow extract in four concentrations (5%, 10%, 15%, and 20% relative to the weight of the polymer) by using blend electrospinning method. The nanofibers were characterized for their biological, mechanical and drug release behavior. In vitro release of yarrow polyphenols from the electrospun PCL nanofibers over a period of 5 days showed the release of up to 98% of the total loaded polyphenols. The released polyphenols retained its antioxidant activity, which was determined by DPPH assay. Electrospun PCL/yarrow nanofiber mats exhibited the antibacterial effect against Staphylococcus aureus, but had no effect on the growth of Pseudomonas aeruginosa. All PCL/yarrow nanofiber mats had improved mechanical properties compared to the neat PCL nanofibers, as evident by an i...ncrease in Young's modulus of elasticity (up to 5.7 times), the tensile strength (up to 5.5 times), and the strain at break (up to 1.45 times). Based on our results, yarrow-loaded PCL nanofiber mats appeared to be multi-functional biomaterials suitable for the production of catheter-coating materials, patches, or gauzes with antibacterial and antioxidant properties.
Keywords:
Achillea millefolium / antibacterial activity / antioxidant activity / electrospinning / mechanical properties / polycaprolactoneSource:
Journal of Biomedical Materials Research - Part A, 2023, 111, 7, 962-974Publisher:
- John Wiley and Sons Inc.
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200135 (University of Belgrade, Faculty of Technology and Metallurgy) (RS-MESTD-inst-2020-200135)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200287 (Innovation Center of the Faculty of Technology and Metallurgy) (RS-MESTD-inst-2020-200287)
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Inovacioni centarTY - JOUR AU - Radisavljević, Anđela AU - Stojanović, Dušica B. AU - Petrović, Miloš AU - Radojević, Vesna AU - Uskoković, Petar AU - Rajilić-Stojanović, Mirjana PY - 2023 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5295 AB - In this study, polycaprolactone (PCL), as a biocompatible polymer was functionalized by addition of medicinal plant extract- Achillea millefolium L. (yarrow). Nanofiber mats were fabricated from PCL solutions containing dry yarrow extract in four concentrations (5%, 10%, 15%, and 20% relative to the weight of the polymer) by using blend electrospinning method. The nanofibers were characterized for their biological, mechanical and drug release behavior. In vitro release of yarrow polyphenols from the electrospun PCL nanofibers over a period of 5 days showed the release of up to 98% of the total loaded polyphenols. The released polyphenols retained its antioxidant activity, which was determined by DPPH assay. Electrospun PCL/yarrow nanofiber mats exhibited the antibacterial effect against Staphylococcus aureus, but had no effect on the growth of Pseudomonas aeruginosa. All PCL/yarrow nanofiber mats had improved mechanical properties compared to the neat PCL nanofibers, as evident by an increase in Young's modulus of elasticity (up to 5.7 times), the tensile strength (up to 5.5 times), and the strain at break (up to 1.45 times). Based on our results, yarrow-loaded PCL nanofiber mats appeared to be multi-functional biomaterials suitable for the production of catheter-coating materials, patches, or gauzes with antibacterial and antioxidant properties. PB - John Wiley and Sons Inc. T2 - Journal of Biomedical Materials Research - Part A T1 - Electrospun polycaprolactone nanofibers functionalized with Achillea millefolium extract yield biomaterial with antibacterial, antioxidant and improved mechanical properties EP - 974 IS - 7 SP - 962 VL - 111 DO - 10.1002/jbm.a.37481 ER -
@article{ author = "Radisavljević, Anđela and Stojanović, Dušica B. and Petrović, Miloš and Radojević, Vesna and Uskoković, Petar and Rajilić-Stojanović, Mirjana", year = "2023", abstract = "In this study, polycaprolactone (PCL), as a biocompatible polymer was functionalized by addition of medicinal plant extract- Achillea millefolium L. (yarrow). Nanofiber mats were fabricated from PCL solutions containing dry yarrow extract in four concentrations (5%, 10%, 15%, and 20% relative to the weight of the polymer) by using blend electrospinning method. The nanofibers were characterized for their biological, mechanical and drug release behavior. In vitro release of yarrow polyphenols from the electrospun PCL nanofibers over a period of 5 days showed the release of up to 98% of the total loaded polyphenols. The released polyphenols retained its antioxidant activity, which was determined by DPPH assay. Electrospun PCL/yarrow nanofiber mats exhibited the antibacterial effect against Staphylococcus aureus, but had no effect on the growth of Pseudomonas aeruginosa. All PCL/yarrow nanofiber mats had improved mechanical properties compared to the neat PCL nanofibers, as evident by an increase in Young's modulus of elasticity (up to 5.7 times), the tensile strength (up to 5.5 times), and the strain at break (up to 1.45 times). Based on our results, yarrow-loaded PCL nanofiber mats appeared to be multi-functional biomaterials suitable for the production of catheter-coating materials, patches, or gauzes with antibacterial and antioxidant properties.", publisher = "John Wiley and Sons Inc.", journal = "Journal of Biomedical Materials Research - Part A", title = "Electrospun polycaprolactone nanofibers functionalized with Achillea millefolium extract yield biomaterial with antibacterial, antioxidant and improved mechanical properties", pages = "974-962", number = "7", volume = "111", doi = "10.1002/jbm.a.37481" }
Radisavljević, A., Stojanović, D. B., Petrović, M., Radojević, V., Uskoković, P.,& Rajilić-Stojanović, M.. (2023). Electrospun polycaprolactone nanofibers functionalized with Achillea millefolium extract yield biomaterial with antibacterial, antioxidant and improved mechanical properties. in Journal of Biomedical Materials Research - Part A John Wiley and Sons Inc.., 111(7), 962-974. https://doi.org/10.1002/jbm.a.37481
Radisavljević A, Stojanović DB, Petrović M, Radojević V, Uskoković P, Rajilić-Stojanović M. Electrospun polycaprolactone nanofibers functionalized with Achillea millefolium extract yield biomaterial with antibacterial, antioxidant and improved mechanical properties. in Journal of Biomedical Materials Research - Part A. 2023;111(7):962-974. doi:10.1002/jbm.a.37481 .
Radisavljević, Anđela, Stojanović, Dušica B., Petrović, Miloš, Radojević, Vesna, Uskoković, Petar, Rajilić-Stojanović, Mirjana, "Electrospun polycaprolactone nanofibers functionalized with Achillea millefolium extract yield biomaterial with antibacterial, antioxidant and improved mechanical properties" in Journal of Biomedical Materials Research - Part A, 111, no. 7 (2023):962-974, https://doi.org/10.1002/jbm.a.37481 . .