Приказ основних података о документу

dc.creatorRadisavljević, Anđela
dc.creatorStojanović, Dušica B.
dc.creatorPetrović, Miloš
dc.creatorRadojević, Vesna
dc.creatorUskoković, Petar
dc.creatorRajilić-Stojanović, Mirjana
dc.date.accessioned2023-01-10T11:14:54Z
dc.date.available2023-01-10T11:14:54Z
dc.date.issued2023
dc.identifier.issn1549-3296
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/5295
dc.description.abstractIn this study, polycaprolactone (PCL), as a biocompatible polymer was functionalized by addition of medicinal plant extract- Achillea millefolium L. (yarrow). Nanofiber mats were fabricated from PCL solutions containing dry yarrow extract in four concentrations (5%, 10%, 15%, and 20% relative to the weight of the polymer) by using blend electrospinning method. The nanofibers were characterized for their biological, mechanical and drug release behavior. In vitro release of yarrow polyphenols from the electrospun PCL nanofibers over a period of 5 days showed the release of up to 98% of the total loaded polyphenols. The released polyphenols retained its antioxidant activity, which was determined by DPPH assay. Electrospun PCL/yarrow nanofiber mats exhibited the antibacterial effect against Staphylococcus aureus, but had no effect on the growth of Pseudomonas aeruginosa. All PCL/yarrow nanofiber mats had improved mechanical properties compared to the neat PCL nanofibers, as evident by an increase in Young's modulus of elasticity (up to 5.7 times), the tensile strength (up to 5.5 times), and the strain at break (up to 1.45 times). Based on our results, yarrow-loaded PCL nanofiber mats appeared to be multi-functional biomaterials suitable for the production of catheter-coating materials, patches, or gauzes with antibacterial and antioxidant properties.sr
dc.language.isoensr
dc.publisherJohn Wiley and Sons Inc.sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200135/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200287/RS//sr
dc.rightsrestrictedAccesssr
dc.sourceJournal of Biomedical Materials Research - Part Asr
dc.subjectAchillea millefoliumsr
dc.subjectantibacterial activitysr
dc.subjectantioxidant activitysr
dc.subjectelectrospinningsr
dc.subjectmechanical propertiessr
dc.subjectpolycaprolactonesr
dc.titleElectrospun polycaprolactone nanofibers functionalized with Achillea millefolium extract yield biomaterial with antibacterial, antioxidant and improved mechanical propertiessr
dc.typearticlesr
dc.rights.licenseARRsr
dc.citation.epage974
dc.citation.issue7
dc.citation.rankM21~
dc.citation.spage962
dc.citation.volume111
dc.identifier.doi10.1002/jbm.a.37481
dc.identifier.scopus2-s2.0-85145192979
dc.type.versionpublishedVersionsr


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу