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Active wetting of epithelial tissues: modeling considerations

Authorized Users Only
2023
Authors
Pajić-Lijaković, Ivana
Milivojević, Milan
Article (Published version)
Metadata
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Abstract
Morphogenesis, tissue regeneration, and cancer invasion involve transitions in tissue morphology. These transitions, caused by collective cell migration (CCM), have been interpreted as active wetting/de-wetting transitions. This phenomenon is considered based on a model system as wetting of a cell aggregate on a rigid substrate, which includes cell aggregate movement and isotropic/anisotropic spreading of a cell monolayer around the aggregate depending on the substrate rigidity and aggregate size. This model system accounts for the transition between 3D epithelial aggregate and 2D cell monolayer as a product of: (1) tissue surface tension, (2) surface tension of substrate matrix, (3) cell–matrix interfacial tension, (4) interfacial tension gradient, (5) viscoelasticity caused by CCM, and (6) viscoelasticity of substrate matrix. These physical parameters depend on the cell contractility and state of cell–cell and cell–matrix adhesion contacts, as well as the stretching/compression of ce...llular systems caused by CCM. Despite extensive research devoted to study cell wetting, we still do not understand the interplay among these physical parameters which induces an oscillatory trend of cell rearrangement. This review focuses on these physical parameters in governing the cell rearrangement in the context of epithelial aggregate wetting/de-wetting, and on modeling approaches aimed at reproducing and understanding these biological systems. In this context, we not only review previously published biophysical models for cell rearrangement caused by CCM, but also propose new extensions of those models to point out the interrelation between cell–matrix interfacial tension and epithelial viscoelasticity and the role of the interfacial tension gradient in cell spreading.

Keywords:
Cell residual stress accumulation / Collective cell migration / Marangoni effect / Tissue surface tension / Viscoelasticity
Source:
European Biophysics Journal, 2023
Publisher:
  • Springer Science and Business Media Deutschland GmbH
Funding / projects:
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200135 (University of Belgrade, Faculty of Technology and Metallurgy) (RS-200135)

DOI: 10.1007/s00249-022-01625-w

ISSN: 0175-7571

Scopus: 2-s2.0-85145501538
[ Google Scholar ]
URI
http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5300
Collections
  • Radovi istraživača / Researchers’ publications (TMF)
Institution/Community
Tehnološko-metalurški fakultet
TY  - JOUR
AU  - Pajić-Lijaković, Ivana
AU  - Milivojević, Milan
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5300
AB  - Morphogenesis, tissue regeneration, and cancer invasion involve transitions in tissue morphology. These transitions, caused by collective cell migration (CCM), have been interpreted as active wetting/de-wetting transitions. This phenomenon is considered based on a model system as wetting of a cell aggregate on a rigid substrate, which includes cell aggregate movement and isotropic/anisotropic spreading of a cell monolayer around the aggregate depending on the substrate rigidity and aggregate size. This model system accounts for the transition between 3D epithelial aggregate and 2D cell monolayer as a product of: (1) tissue surface tension, (2) surface tension of substrate matrix, (3) cell–matrix interfacial tension, (4) interfacial tension gradient, (5) viscoelasticity caused by CCM, and (6) viscoelasticity of substrate matrix. These physical parameters depend on the cell contractility and state of cell–cell and cell–matrix adhesion contacts, as well as the stretching/compression of cellular systems caused by CCM. Despite extensive research devoted to study cell wetting, we still do not understand the interplay among these physical parameters which induces an oscillatory trend of cell rearrangement. This review focuses on these physical parameters in governing the cell rearrangement in the context of epithelial aggregate wetting/de-wetting, and on modeling approaches aimed at reproducing and understanding these biological systems. In this context, we not only review previously published biophysical models for cell rearrangement caused by CCM, but also propose new extensions of those models to point out the interrelation between cell–matrix interfacial tension and epithelial viscoelasticity and the role of the interfacial tension gradient in cell spreading.
PB  - Springer Science and Business Media Deutschland GmbH
T2  - European Biophysics Journal
T1  - Active wetting of epithelial tissues: modeling considerations
DO  - 10.1007/s00249-022-01625-w
ER  - 
@article{
author = "Pajić-Lijaković, Ivana and Milivojević, Milan",
year = "2023",
abstract = "Morphogenesis, tissue regeneration, and cancer invasion involve transitions in tissue morphology. These transitions, caused by collective cell migration (CCM), have been interpreted as active wetting/de-wetting transitions. This phenomenon is considered based on a model system as wetting of a cell aggregate on a rigid substrate, which includes cell aggregate movement and isotropic/anisotropic spreading of a cell monolayer around the aggregate depending on the substrate rigidity and aggregate size. This model system accounts for the transition between 3D epithelial aggregate and 2D cell monolayer as a product of: (1) tissue surface tension, (2) surface tension of substrate matrix, (3) cell–matrix interfacial tension, (4) interfacial tension gradient, (5) viscoelasticity caused by CCM, and (6) viscoelasticity of substrate matrix. These physical parameters depend on the cell contractility and state of cell–cell and cell–matrix adhesion contacts, as well as the stretching/compression of cellular systems caused by CCM. Despite extensive research devoted to study cell wetting, we still do not understand the interplay among these physical parameters which induces an oscillatory trend of cell rearrangement. This review focuses on these physical parameters in governing the cell rearrangement in the context of epithelial aggregate wetting/de-wetting, and on modeling approaches aimed at reproducing and understanding these biological systems. In this context, we not only review previously published biophysical models for cell rearrangement caused by CCM, but also propose new extensions of those models to point out the interrelation between cell–matrix interfacial tension and epithelial viscoelasticity and the role of the interfacial tension gradient in cell spreading.",
publisher = "Springer Science and Business Media Deutschland GmbH",
journal = "European Biophysics Journal",
title = "Active wetting of epithelial tissues: modeling considerations",
doi = "10.1007/s00249-022-01625-w"
}
Pajić-Lijaković, I.,& Milivojević, M.. (2023). Active wetting of epithelial tissues: modeling considerations. in European Biophysics Journal
Springer Science and Business Media Deutschland GmbH..
https://doi.org/10.1007/s00249-022-01625-w
Pajić-Lijaković I, Milivojević M. Active wetting of epithelial tissues: modeling considerations. in European Biophysics Journal. 2023;.
doi:10.1007/s00249-022-01625-w .
Pajić-Lijaković, Ivana, Milivojević, Milan, "Active wetting of epithelial tissues: modeling considerations" in European Biophysics Journal (2023),
https://doi.org/10.1007/s00249-022-01625-w . .

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