Researchers are making everyday efforts to develop new drugs or improve present ones in order
to enhance therapies of various diseases, especially serious ones like cancer. Drug delivery
systems (DDS) are one of the solutions for safer and more efficient therapy. Hydrogels based
on poly(methacrylic acid) (PMAA) are extensively investigated as DDS due to their nontoxicity, biocompatibility and pH sensitivity. Many chemotherapeutics are poorly watersoluble, so it is quite challenging to encapsulate them into highly hydrophilic PMAA. In our
previous study we overcome this limitation by modifying PMAA with amphiphilic casein and
demonstrated that poorly water-soluble model drug – caffeine can be successfully encapsulated
and released in control manner from these samples (H hydrogels). In present study we go step
forward and investigated how the change in the amount of encapsulated caffeine affect the
mechanism of caffeine release from the H hydrogels in medium with pH of 6.8 (which... simulates
the environment in human intestines). Commonly used models for the analysis of kinetics of
drug release from hydrogels: Ritger-Peppas, Higuchi and Kopcha model are employed for the
analysis of the mechanism of caffeine release. Presented results indicate that it is possible to
adjust the manner and mechanism of drug release by changing the amount of encapsulated drug,
due to which the H hydrogels can adapt to the unique requirements of the therapy.
Source:
PROCEEDINGS OF THE 28th International Symposium on Analytical and Environmental Problems, 2022, 221-226
TY - CONF
AU - Marković, Maja D.
AU - Panić, Vesna V.
AU - Pjanović, Rada V.
PY - 2022
UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5477
AB - Researchers are making everyday efforts to develop new drugs or improve present ones in order
to enhance therapies of various diseases, especially serious ones like cancer. Drug delivery
systems (DDS) are one of the solutions for safer and more efficient therapy. Hydrogels based
on poly(methacrylic acid) (PMAA) are extensively investigated as DDS due to their nontoxicity, biocompatibility and pH sensitivity. Many chemotherapeutics are poorly watersoluble, so it is quite challenging to encapsulate them into highly hydrophilic PMAA. In our
previous study we overcome this limitation by modifying PMAA with amphiphilic casein and
demonstrated that poorly water-soluble model drug – caffeine can be successfully encapsulated
and released in control manner from these samples (H hydrogels). In present study we go step
forward and investigated how the change in the amount of encapsulated caffeine affect the
mechanism of caffeine release from the H hydrogels in medium with pH of 6.8 (which simulates
the environment in human intestines). Commonly used models for the analysis of kinetics of
drug release from hydrogels: Ritger-Peppas, Higuchi and Kopcha model are employed for the
analysis of the mechanism of caffeine release. Presented results indicate that it is possible to
adjust the manner and mechanism of drug release by changing the amount of encapsulated drug,
due to which the H hydrogels can adapt to the unique requirements of the therapy.
PB - University of Szeged
C3 - PROCEEDINGS OF THE 28th International Symposium on Analytical and Environmental Problems
T1 - THE EFFECT OF ENCAPSULATED AMOUNT OF CAFFEINE ON THE MECHANISM OF ITS RELEASE FROM HYDROGELS BASED ON POLY(METHACRYLIC ACID) AND CASEIN
EP - 226
SP - 221
UR - https://hdl.handle.net/21.15107/rcub_technorep_5477
ER -
@conference{
author = "Marković, Maja D. and Panić, Vesna V. and Pjanović, Rada V.",
year = "2022",
abstract = "Researchers are making everyday efforts to develop new drugs or improve present ones in order
to enhance therapies of various diseases, especially serious ones like cancer. Drug delivery
systems (DDS) are one of the solutions for safer and more efficient therapy. Hydrogels based
on poly(methacrylic acid) (PMAA) are extensively investigated as DDS due to their nontoxicity, biocompatibility and pH sensitivity. Many chemotherapeutics are poorly watersoluble, so it is quite challenging to encapsulate them into highly hydrophilic PMAA. In our
previous study we overcome this limitation by modifying PMAA with amphiphilic casein and
demonstrated that poorly water-soluble model drug – caffeine can be successfully encapsulated
and released in control manner from these samples (H hydrogels). In present study we go step
forward and investigated how the change in the amount of encapsulated caffeine affect the
mechanism of caffeine release from the H hydrogels in medium with pH of 6.8 (which simulates
the environment in human intestines). Commonly used models for the analysis of kinetics of
drug release from hydrogels: Ritger-Peppas, Higuchi and Kopcha model are employed for the
analysis of the mechanism of caffeine release. Presented results indicate that it is possible to
adjust the manner and mechanism of drug release by changing the amount of encapsulated drug,
due to which the H hydrogels can adapt to the unique requirements of the therapy.",
publisher = "University of Szeged",
journal = "PROCEEDINGS OF THE 28th International Symposium on Analytical and Environmental Problems",
title = "THE EFFECT OF ENCAPSULATED AMOUNT OF CAFFEINE ON THE MECHANISM OF ITS RELEASE FROM HYDROGELS BASED ON POLY(METHACRYLIC ACID) AND CASEIN",
pages = "226-221",
url = "https://hdl.handle.net/21.15107/rcub_technorep_5477"
}
Marković, M. D., Panić, V. V.,& Pjanović, R. V.. (2022). THE EFFECT OF ENCAPSULATED AMOUNT OF CAFFEINE ON THE MECHANISM OF ITS RELEASE FROM HYDROGELS BASED ON POLY(METHACRYLIC ACID) AND CASEIN. in PROCEEDINGS OF THE 28th International Symposium on Analytical and Environmental Problems
University of Szeged., 221-226.
https://hdl.handle.net/21.15107/rcub_technorep_5477
Marković MD, Panić VV, Pjanović RV. THE EFFECT OF ENCAPSULATED AMOUNT OF CAFFEINE ON THE MECHANISM OF ITS RELEASE FROM HYDROGELS BASED ON POLY(METHACRYLIC ACID) AND CASEIN. in PROCEEDINGS OF THE 28th International Symposium on Analytical and Environmental Problems. 2022;:221-226.
https://hdl.handle.net/21.15107/rcub_technorep_5477 .
Marković, Maja D., Panić, Vesna V., Pjanović, Rada V., "THE EFFECT OF ENCAPSULATED AMOUNT OF CAFFEINE ON THE MECHANISM OF ITS RELEASE FROM HYDROGELS BASED ON POLY(METHACRYLIC ACID) AND CASEIN" in PROCEEDINGS OF THE 28th International Symposium on Analytical and Environmental Problems (2022):221-226,
https://hdl.handle.net/21.15107/rcub_technorep_5477 .
