Drug delivery system is an amazing tool which is widely used for drug
protection and its controlled release in order to enhance drug bioavailability,
reduce side effects and therefore to improve overall therapy. Hydrogels have
been attracted great attention as drug carriers due to their great physicochemical
properties, similarity to the living tissues and biocompatibility. One group of
pH sensitive hydrogels are based on poly(methacrylic acid) (PMAA). These
non-toxic hydrogels are used as drug delivery system because they swell as
a response to the change in pH of external environment and drug is being
released during the process. In present study, in order to improve the control of
drug release rate, caffeine was encapsulated in liposomes which were further
embedded into PMC hydrogel (PMCL). It was investigated how the change in
neutralization degree of methacrylic acid affect the swelling degree of PMCL
hydrogels and caffeine release in two environments at 37 °C for 24 h...: 0.1 M
hydrochloride acid (pH 1) and phosphate buffer with pH value of 6.8 (pH 6.8), as
a simulation of pH environment in human stomach and intestines, respectively.
Obtained results show that PMCL hydrogels have great potential for controlled
release of poorly water-soluble drugs in human intestines.
TY - JOUR
AU - Pantic, Olga J.
AU - Pjanovic, Rada V.
AU - Panić, Vesna V.
AU - Savic, Sanja I.
AU - Spasojevic, Pavle M.
AU - Marković, Maja D.
PY - 2022
UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5479
AB - Drug delivery system is an amazing tool which is widely used for drug
protection and its controlled release in order to enhance drug bioavailability,
reduce side effects and therefore to improve overall therapy. Hydrogels have
been attracted great attention as drug carriers due to their great physicochemical
properties, similarity to the living tissues and biocompatibility. One group of
pH sensitive hydrogels are based on poly(methacrylic acid) (PMAA). These
non-toxic hydrogels are used as drug delivery system because they swell as
a response to the change in pH of external environment and drug is being
released during the process. In present study, in order to improve the control of
drug release rate, caffeine was encapsulated in liposomes which were further
embedded into PMC hydrogel (PMCL). It was investigated how the change in
neutralization degree of methacrylic acid affect the swelling degree of PMCL
hydrogels and caffeine release in two environments at 37 °C for 24 h: 0.1 M
hydrochloride acid (pH 1) and phosphate buffer with pH value of 6.8 (pH 6.8), as
a simulation of pH environment in human stomach and intestines, respectively.
Obtained results show that PMCL hydrogels have great potential for controlled
release of poorly water-soluble drugs in human intestines.
PB - the Faculty of Technology, University of Banja Luka
T2 - Journal of Chemists, Technologists and Environmentalists
T1 - Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release
EP - 5
IS - 1
SP - 1
VL - 3
DO - 10.7251/JCTE2203001P
ER -
@article{
author = "Pantic, Olga J. and Pjanovic, Rada V. and Panić, Vesna V. and Savic, Sanja I. and Spasojevic, Pavle M. and Marković, Maja D.",
year = "2022",
abstract = "Drug delivery system is an amazing tool which is widely used for drug
protection and its controlled release in order to enhance drug bioavailability,
reduce side effects and therefore to improve overall therapy. Hydrogels have
been attracted great attention as drug carriers due to their great physicochemical
properties, similarity to the living tissues and biocompatibility. One group of
pH sensitive hydrogels are based on poly(methacrylic acid) (PMAA). These
non-toxic hydrogels are used as drug delivery system because they swell as
a response to the change in pH of external environment and drug is being
released during the process. In present study, in order to improve the control of
drug release rate, caffeine was encapsulated in liposomes which were further
embedded into PMC hydrogel (PMCL). It was investigated how the change in
neutralization degree of methacrylic acid affect the swelling degree of PMCL
hydrogels and caffeine release in two environments at 37 °C for 24 h: 0.1 M
hydrochloride acid (pH 1) and phosphate buffer with pH value of 6.8 (pH 6.8), as
a simulation of pH environment in human stomach and intestines, respectively.
Obtained results show that PMCL hydrogels have great potential for controlled
release of poorly water-soluble drugs in human intestines.",
publisher = "the Faculty of Technology, University of Banja Luka",
journal = "Journal of Chemists, Technologists and Environmentalists",
title = "Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release",
pages = "5-1",
number = "1",
volume = "3",
doi = "10.7251/JCTE2203001P"
}
Pantic, O. J., Pjanovic, R. V., Panić, V. V., Savic, S. I., Spasojevic, P. M.,& Marković, M. D.. (2022). Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release. in Journal of Chemists, Technologists and Environmentalists
the Faculty of Technology, University of Banja Luka., 3(1), 1-5.
https://doi.org/10.7251/JCTE2203001P
Pantic OJ, Pjanovic RV, Panić VV, Savic SI, Spasojevic PM, Marković MD. Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release. in Journal of Chemists, Technologists and Environmentalists. 2022;3(1):1-5.
doi:10.7251/JCTE2203001P .
Pantic, Olga J., Pjanovic, Rada V., Panić, Vesna V., Savic, Sanja I., Spasojevic, Pavle M., Marković, Maja D., "Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release" in Journal of Chemists, Technologists and Environmentalists, 3, no. 1 (2022):1-5,
https://doi.org/10.7251/JCTE2203001P . .
