The Modeling of Insulin Controlled Release Process From Fibrous Artificial Store

Abstract

In the past, insulin was frequently administered by hypodermic injection, as liquids forms. To avoid problems incurred through the utilization of the injectable route of insulin administration, new dosage forms containing the insulin were introduced. Therefore, insulin delivery systems were developed to optimize the therapeutic properties of drug products and render them safer, more effective, and more reliable. The aim of this article is to present the modeling of the controlled releasing process of insulin from a fibrous artificial store. The release of insulin has been evaluated in both a physiological solution and blood serum in vitro and on experimental animals (mice) in vivo. On the basis of experimental results a mathematical model of diffusion-mediated release of insulin from cation-exchange fiber has been developed and presented in this paper.