Synthesis and characterization of biodegradable aliphatic copolyesters with poly(ethylene oxide) soft segments
Samo za registrovane korisnike
2008
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
A series of multiblock poly(ether-ester)s based on poly(butylene succinate) (PBS) as the hard segments and hydrophilic poly(ethylene oxide) (PEO) as the soft segments was synthesized with the aim of developing degradable polymers which could combine the mechanical properties of high performance elastomers with those of flexible plastics. The aliphatic poly(ether-ester)s were synthesized by the catalyzed two-step transesterification reaction of dimethyl succinate, 1,4-butanediol and α,ω-hydroxyl terminated poly(ethylene oxide) (PEO, over(M, -)n = 1000 g/mol) in bulk. The content of soft PEO segments in the polymer chains was varied from about 10 to 50 mass%. The effect of the introduction of the soft PEO segments on the structure, thermal and physical properties, as well as on the biodegradation properties was investigated. The composition and structure of these aliphatic segmented copolyesters were determined by 1H NMR spectroscopy. The molecular weights of the polyesters were verified... by gel permeation chromatography (GPC), as well as by viscometry of dilute solutions and polymer melts. The thermal properties were investigated using differential scanning calorimetry (DSC). The degree of crystallinity was determined by means of DSC and wide-angle X-ray scattering. A depression of melting temperature and a reduction of crystallinity of the hard segments with increasing content of PEO segments were observed. Biodegradation of the synthesized copolyesters, estimated in enzymatic degradation tests in phosphate buffer solution with Candida rugosa lipase at 37 °C was compared with hydrolytic degradation in the buffer solution. The weight losses of the samples were in the range from 2 to 10 mass%. GPC analysis confirmed that there were significant changes in molecular weight of copolyesters with higher content of PEO segments, up to 40% of initial values. This leads to conclusion that degradation mechanism of the poly(ether-ester)s based on PEO segments occurs through bulk degradation in addition to surface erosion.
Ključne reči:
Enzymatic degradation / Hydrolytic degradation / Poly(butylene succinate) / Poly(ether-ester)s / Poly(ethylene oxide)Izvor:
European Polymer Journal, 2008, 44, 3, 904-917Izdavač:
- Elsevier Ltd
Finansiranje / projekti:
- Ministry of Science, Higher Education and Technology of Slovenia as part of a bilateral project.
- Sinteza i karakterizacija polimera i polimernih (nano)kompozita definisane molekulske i nadmolekulske strukture (RS-MESTD-MPN2006-2010-142023)
DOI: 10.1016/j.eurpolymj.2007.11.035
ISSN: 0014-3057
WoS: 000255604600035
Scopus: 2-s2.0-39849088549
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Pepić, Dragana AU - Žagar, Ema AU - Žigon, Majda AU - Kržan, Andrej AU - Kunaver, Matjaz AU - Đonlagić, Jasna PY - 2008 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5576 AB - A series of multiblock poly(ether-ester)s based on poly(butylene succinate) (PBS) as the hard segments and hydrophilic poly(ethylene oxide) (PEO) as the soft segments was synthesized with the aim of developing degradable polymers which could combine the mechanical properties of high performance elastomers with those of flexible plastics. The aliphatic poly(ether-ester)s were synthesized by the catalyzed two-step transesterification reaction of dimethyl succinate, 1,4-butanediol and α,ω-hydroxyl terminated poly(ethylene oxide) (PEO, over(M, -)n = 1000 g/mol) in bulk. The content of soft PEO segments in the polymer chains was varied from about 10 to 50 mass%. The effect of the introduction of the soft PEO segments on the structure, thermal and physical properties, as well as on the biodegradation properties was investigated. The composition and structure of these aliphatic segmented copolyesters were determined by 1H NMR spectroscopy. The molecular weights of the polyesters were verified by gel permeation chromatography (GPC), as well as by viscometry of dilute solutions and polymer melts. The thermal properties were investigated using differential scanning calorimetry (DSC). The degree of crystallinity was determined by means of DSC and wide-angle X-ray scattering. A depression of melting temperature and a reduction of crystallinity of the hard segments with increasing content of PEO segments were observed. Biodegradation of the synthesized copolyesters, estimated in enzymatic degradation tests in phosphate buffer solution with Candida rugosa lipase at 37 °C was compared with hydrolytic degradation in the buffer solution. The weight losses of the samples were in the range from 2 to 10 mass%. GPC analysis confirmed that there were significant changes in molecular weight of copolyesters with higher content of PEO segments, up to 40% of initial values. This leads to conclusion that degradation mechanism of the poly(ether-ester)s based on PEO segments occurs through bulk degradation in addition to surface erosion. PB - Elsevier Ltd T2 - European Polymer Journal T1 - Synthesis and characterization of biodegradable aliphatic copolyesters with poly(ethylene oxide) soft segments EP - 917 IS - 3 SP - 904 VL - 44 DO - 10.1016/j.eurpolymj.2007.11.035 ER -
@article{ author = "Pepić, Dragana and Žagar, Ema and Žigon, Majda and Kržan, Andrej and Kunaver, Matjaz and Đonlagić, Jasna", year = "2008", abstract = "A series of multiblock poly(ether-ester)s based on poly(butylene succinate) (PBS) as the hard segments and hydrophilic poly(ethylene oxide) (PEO) as the soft segments was synthesized with the aim of developing degradable polymers which could combine the mechanical properties of high performance elastomers with those of flexible plastics. The aliphatic poly(ether-ester)s were synthesized by the catalyzed two-step transesterification reaction of dimethyl succinate, 1,4-butanediol and α,ω-hydroxyl terminated poly(ethylene oxide) (PEO, over(M, -)n = 1000 g/mol) in bulk. The content of soft PEO segments in the polymer chains was varied from about 10 to 50 mass%. The effect of the introduction of the soft PEO segments on the structure, thermal and physical properties, as well as on the biodegradation properties was investigated. The composition and structure of these aliphatic segmented copolyesters were determined by 1H NMR spectroscopy. The molecular weights of the polyesters were verified by gel permeation chromatography (GPC), as well as by viscometry of dilute solutions and polymer melts. The thermal properties were investigated using differential scanning calorimetry (DSC). The degree of crystallinity was determined by means of DSC and wide-angle X-ray scattering. A depression of melting temperature and a reduction of crystallinity of the hard segments with increasing content of PEO segments were observed. Biodegradation of the synthesized copolyesters, estimated in enzymatic degradation tests in phosphate buffer solution with Candida rugosa lipase at 37 °C was compared with hydrolytic degradation in the buffer solution. The weight losses of the samples were in the range from 2 to 10 mass%. GPC analysis confirmed that there were significant changes in molecular weight of copolyesters with higher content of PEO segments, up to 40% of initial values. This leads to conclusion that degradation mechanism of the poly(ether-ester)s based on PEO segments occurs through bulk degradation in addition to surface erosion.", publisher = "Elsevier Ltd", journal = "European Polymer Journal", title = "Synthesis and characterization of biodegradable aliphatic copolyesters with poly(ethylene oxide) soft segments", pages = "917-904", number = "3", volume = "44", doi = "10.1016/j.eurpolymj.2007.11.035" }
Pepić, D., Žagar, E., Žigon, M., Kržan, A., Kunaver, M.,& Đonlagić, J.. (2008). Synthesis and characterization of biodegradable aliphatic copolyesters with poly(ethylene oxide) soft segments. in European Polymer Journal Elsevier Ltd., 44(3), 904-917. https://doi.org/10.1016/j.eurpolymj.2007.11.035
Pepić D, Žagar E, Žigon M, Kržan A, Kunaver M, Đonlagić J. Synthesis and characterization of biodegradable aliphatic copolyesters with poly(ethylene oxide) soft segments. in European Polymer Journal. 2008;44(3):904-917. doi:10.1016/j.eurpolymj.2007.11.035 .
Pepić, Dragana, Žagar, Ema, Žigon, Majda, Kržan, Andrej, Kunaver, Matjaz, Đonlagić, Jasna, "Synthesis and characterization of biodegradable aliphatic copolyesters with poly(ethylene oxide) soft segments" in European Polymer Journal, 44, no. 3 (2008):904-917, https://doi.org/10.1016/j.eurpolymj.2007.11.035 . .