Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery
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2011
Authors
Vukomanović, Marija
Škapin, Srečo Davor

Jančar, Boštjan
Maksin, Tatjana
Ignjatović, Nenad

Uskoković, Vuk

Uskoković, Dragan

Article (Published version)

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Biodegradable poly(D,L-lactide-co-glycolide) (PLGA) and bioactive hydroxyapatite (HAP) are selected for the formation of a multifunctional system with the specific core-shell structure to be applied as a carrier of a drug. As a result, both components of PLGA/HAp core-shells are able to capture one part of the drug. Polymeric shells consisting of small nanospheres up to 20 nm in size act as a matrix in which one part of the drug is dispersed. In the same time, ceramic cores are formed of rod-like hydroxyapatite particles at the surface of which another part of the drug is adsorbed onto the interface between the polymer and the ceramics. The content of the loaded drug, as well as the selected solvent/non-solvent system, have a crucial influence on the resulting PLGA/HAp morphology and, finally, unimodal distribution of core-shells is obtained. The redistribution of the drug between the organic and inorganic parts of the material is expected to provide an interesting contribution to the ...kinetics of the drug release resulting in non-typical two-step drug release. (C) 2010 Elsevier B.V. All rights reserved.
Keywords:
Core-shells / Drug delivery / Multifunctional materials / poly(D,L-lactide-co-glycolide) / Ultrasonic processing / hydroxyapatiteSource:
Colloids and Surfaces B: Biointerfaces, 2011, 82, 2, 404-413Funding / projects:
- Sinteza funkcionalnih materijala sa kontrolisanom strukturom na molekularnom i nano nivou (RS-142006)
DOI: 10.1016/j.colsurfb.2010.09.011
ISSN: 0927-7765 (print); 1873-4367 (electronic)
PubMed: 20951005
WoS: 000285858200021
Scopus: 2-s2.0-78649442520
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Vukomanović, Marija AU - Škapin, Srečo Davor AU - Jančar, Boštjan AU - Maksin, Tatjana AU - Ignjatović, Nenad AU - Uskoković, Vuk AU - Uskoković, Dragan PY - 2011 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5650 AB - Biodegradable poly(D,L-lactide-co-glycolide) (PLGA) and bioactive hydroxyapatite (HAP) are selected for the formation of a multifunctional system with the specific core-shell structure to be applied as a carrier of a drug. As a result, both components of PLGA/HAp core-shells are able to capture one part of the drug. Polymeric shells consisting of small nanospheres up to 20 nm in size act as a matrix in which one part of the drug is dispersed. In the same time, ceramic cores are formed of rod-like hydroxyapatite particles at the surface of which another part of the drug is adsorbed onto the interface between the polymer and the ceramics. The content of the loaded drug, as well as the selected solvent/non-solvent system, have a crucial influence on the resulting PLGA/HAp morphology and, finally, unimodal distribution of core-shells is obtained. The redistribution of the drug between the organic and inorganic parts of the material is expected to provide an interesting contribution to the kinetics of the drug release resulting in non-typical two-step drug release. (C) 2010 Elsevier B.V. All rights reserved. T2 - Colloids and Surfaces B: Biointerfaces T1 - Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery EP - 413 IS - 2 SP - 404 VL - 82 DO - 10.1016/j.colsurfb.2010.09.011 UR - https://hdl.handle.net/21.15107/rcub_dais_2749 ER -
@article{ author = "Vukomanović, Marija and Škapin, Srečo Davor and Jančar, Boštjan and Maksin, Tatjana and Ignjatović, Nenad and Uskoković, Vuk and Uskoković, Dragan", year = "2011", abstract = "Biodegradable poly(D,L-lactide-co-glycolide) (PLGA) and bioactive hydroxyapatite (HAP) are selected for the formation of a multifunctional system with the specific core-shell structure to be applied as a carrier of a drug. As a result, both components of PLGA/HAp core-shells are able to capture one part of the drug. Polymeric shells consisting of small nanospheres up to 20 nm in size act as a matrix in which one part of the drug is dispersed. In the same time, ceramic cores are formed of rod-like hydroxyapatite particles at the surface of which another part of the drug is adsorbed onto the interface between the polymer and the ceramics. The content of the loaded drug, as well as the selected solvent/non-solvent system, have a crucial influence on the resulting PLGA/HAp morphology and, finally, unimodal distribution of core-shells is obtained. The redistribution of the drug between the organic and inorganic parts of the material is expected to provide an interesting contribution to the kinetics of the drug release resulting in non-typical two-step drug release. (C) 2010 Elsevier B.V. All rights reserved.", journal = "Colloids and Surfaces B: Biointerfaces", title = "Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery", pages = "413-404", number = "2", volume = "82", doi = "10.1016/j.colsurfb.2010.09.011", url = "https://hdl.handle.net/21.15107/rcub_dais_2749" }
Vukomanović, M., Škapin, S. D., Jančar, B., Maksin, T., Ignjatović, N., Uskoković, V.,& Uskoković, D.. (2011). Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery. in Colloids and Surfaces B: Biointerfaces, 82(2), 404-413. https://doi.org/10.1016/j.colsurfb.2010.09.011 https://hdl.handle.net/21.15107/rcub_dais_2749
Vukomanović M, Škapin SD, Jančar B, Maksin T, Ignjatović N, Uskoković V, Uskoković D. Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery. in Colloids and Surfaces B: Biointerfaces. 2011;82(2):404-413. doi:10.1016/j.colsurfb.2010.09.011 https://hdl.handle.net/21.15107/rcub_dais_2749 .
Vukomanović, Marija, Škapin, Srečo Davor, Jančar, Boštjan, Maksin, Tatjana, Ignjatović, Nenad, Uskoković, Vuk, Uskoković, Dragan, "Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery" in Colloids and Surfaces B: Biointerfaces, 82, no. 2 (2011):404-413, https://doi.org/10.1016/j.colsurfb.2010.09.011 ., https://hdl.handle.net/21.15107/rcub_dais_2749 .