Ibuprofen: Synthesis, production and properties

Abstract

Since its introduction in 1969, ibuprofen has become one of the most common painkillers in the world. Ibuprofen in an NSAID (non-steroidal anti-inflammatory drug) and like other drugs of its class it possesses analgetic, antipyretic and anti-inflammatory properties. While ibuprofen is a relatively simple molecule, there is still sufficient structural complexity to ensure that a large number of different synthetic approaches are possible. Since the introduction of pharmaceutical products containing ibuprofen, industrial and academic scientists have developed many potential production processes. This paper describes the history, synthesis and production, as well as the properties and stability of ibuprofen.

Ibuprofen predstavlja nesteroidni antiinflamantorni lek (NSAID) koji je komerci jalizovan krajem šesdesetih i početkom sedamdesetih godina dvadesetog veka. lako je ibuprofen po svojoj strukturi relativno jednostavan molekul, postoji dovoljna strukturna složenost koja omogućava veći broj različitih načina dobijanja. U ovom radu prikazani su postupci za dobijanje ibuprofena (racemskog i S-oblika) i to kako oni komercijalni tako i oni koji su samo od naučne važnosti Takođe su razmatrana svojstva i stabilnost ibuprofena kao i nečistoće koje ga prate.