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Biomedical Applications of Thermosensitive Hydrogels for Controlled/Modulated Piroxicam Delivery

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2023
Biomedical_Applications_pub_2023.pdf (2.355Mb)
Authors
Ilić-Stojanović, Snežana
Nikolić, Ljubiša
Nikolić, Vesna
Ristić, Ivan
Cakić, Suzana
Petrović, Slobodan D.
Article (Published version)
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Abstract
The objectives of this study are the synthesis of thermosensitive poly(N-isopropylacrylamide-co-2-hydroxypropyl methacrylate), p(NiPAm-HPMet), hydrogels and the analysis of a drug-delivery system based on piroxicam, as a model drug, and synthesized hydrogels. A high pressure liquid chromatography method has been used in order to determine both qualitative and quantitative amounts of unreacted monomers and crosslinkers from polymerized hydrogels. Swelling kinetics and the order of a swelling process of the hydrogels have been analyzed at 10 and 40 °C. The copolymers’ thermal properties have been monitored by the differential scanning calorimetry (DSC) method. DSC termograms have shown that melting occurs in two temperature intervals (142.36–150.72 °C and 153.14–156.49 °C). A matrix system with incorporated piroxicam has been analyzed by using FTIR and SEM methods. Structural analysis has demonstrated that intermolecular non-covalent interactions have been built between side-groups of co...polymer and loaded piroxicam. Morphology of p(NiPAm-HPMet) after drug incorporation indicates the piroxicam presence into the copolymer pores. Kinetic parameters of the piroxicam release from hydrogels at 37 °C and pH 7.4 indicate that the fluid transport mechanism corresponds to Fickian diffusion. As a result, formulation of thermosensitive p(NiPAm-HPMet) hydrogels with incorporated piroxicam could be of interest for further testing as a drug carrier for modulated and prolonged release, especially for topical administration.

Keywords:
2-hydroxypropyl methacrylate / drug carrier / DSC / hydrogels / modulated drug release / N-isopropylacrylamide / piroxicam
Source:
Gels, 2023, 9, 1, 70-
Publisher:
  • MDPI
Funding / projects:
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200133 (Univeristy of Niš, Faculty of Technology, Leskovac) (RS-200133)
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200134 (University of Novi Sad, Faculty of Technology) (RS-200134)

DOI: 10.3390/gels9010070

ISSN: 2310-2861

Scopus: 2-s2.0-85146791632
[ Google Scholar ]
URI
http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5805
Collections
  • Radovi istraživača / Researchers’ publications (TMF)
Institution/Community
Tehnološko-metalurški fakultet
TY  - JOUR
AU  - Ilić-Stojanović, Snežana
AU  - Nikolić, Ljubiša
AU  - Nikolić, Vesna
AU  - Ristić, Ivan
AU  - Cakić, Suzana
AU  - Petrović, Slobodan D.
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5805
AB  - The objectives of this study are the synthesis of thermosensitive poly(N-isopropylacrylamide-co-2-hydroxypropyl methacrylate), p(NiPAm-HPMet), hydrogels and the analysis of a drug-delivery system based on piroxicam, as a model drug, and synthesized hydrogels. A high pressure liquid chromatography method has been used in order to determine both qualitative and quantitative amounts of unreacted monomers and crosslinkers from polymerized hydrogels. Swelling kinetics and the order of a swelling process of the hydrogels have been analyzed at 10 and 40 °C. The copolymers’ thermal properties have been monitored by the differential scanning calorimetry (DSC) method. DSC termograms have shown that melting occurs in two temperature intervals (142.36–150.72 °C and 153.14–156.49 °C). A matrix system with incorporated piroxicam has been analyzed by using FTIR and SEM methods. Structural analysis has demonstrated that intermolecular non-covalent interactions have been built between side-groups of copolymer and loaded piroxicam. Morphology of p(NiPAm-HPMet) after drug incorporation indicates the piroxicam presence into the copolymer pores. Kinetic parameters of the piroxicam release from hydrogels at 37 °C and pH 7.4 indicate that the fluid transport mechanism corresponds to Fickian diffusion. As a result, formulation of thermosensitive p(NiPAm-HPMet) hydrogels with incorporated piroxicam could be of interest for further testing as a drug carrier for modulated and prolonged release, especially for topical administration.
PB  - MDPI
T2  - Gels
T1  - Biomedical Applications of Thermosensitive Hydrogels for Controlled/Modulated Piroxicam Delivery
IS  - 1
SP  - 70
VL  - 9
DO  - 10.3390/gels9010070
ER  - 
@article{
author = "Ilić-Stojanović, Snežana and Nikolić, Ljubiša and Nikolić, Vesna and Ristić, Ivan and Cakić, Suzana and Petrović, Slobodan D.",
year = "2023",
abstract = "The objectives of this study are the synthesis of thermosensitive poly(N-isopropylacrylamide-co-2-hydroxypropyl methacrylate), p(NiPAm-HPMet), hydrogels and the analysis of a drug-delivery system based on piroxicam, as a model drug, and synthesized hydrogels. A high pressure liquid chromatography method has been used in order to determine both qualitative and quantitative amounts of unreacted monomers and crosslinkers from polymerized hydrogels. Swelling kinetics and the order of a swelling process of the hydrogels have been analyzed at 10 and 40 °C. The copolymers’ thermal properties have been monitored by the differential scanning calorimetry (DSC) method. DSC termograms have shown that melting occurs in two temperature intervals (142.36–150.72 °C and 153.14–156.49 °C). A matrix system with incorporated piroxicam has been analyzed by using FTIR and SEM methods. Structural analysis has demonstrated that intermolecular non-covalent interactions have been built between side-groups of copolymer and loaded piroxicam. Morphology of p(NiPAm-HPMet) after drug incorporation indicates the piroxicam presence into the copolymer pores. Kinetic parameters of the piroxicam release from hydrogels at 37 °C and pH 7.4 indicate that the fluid transport mechanism corresponds to Fickian diffusion. As a result, formulation of thermosensitive p(NiPAm-HPMet) hydrogels with incorporated piroxicam could be of interest for further testing as a drug carrier for modulated and prolonged release, especially for topical administration.",
publisher = "MDPI",
journal = "Gels",
title = "Biomedical Applications of Thermosensitive Hydrogels for Controlled/Modulated Piroxicam Delivery",
number = "1",
pages = "70",
volume = "9",
doi = "10.3390/gels9010070"
}
Ilić-Stojanović, S., Nikolić, L., Nikolić, V., Ristić, I., Cakić, S.,& Petrović, S. D.. (2023). Biomedical Applications of Thermosensitive Hydrogels for Controlled/Modulated Piroxicam Delivery. in Gels
MDPI., 9(1), 70.
https://doi.org/10.3390/gels9010070
Ilić-Stojanović S, Nikolić L, Nikolić V, Ristić I, Cakić S, Petrović SD. Biomedical Applications of Thermosensitive Hydrogels for Controlled/Modulated Piroxicam Delivery. in Gels. 2023;9(1):70.
doi:10.3390/gels9010070 .
Ilić-Stojanović, Snežana, Nikolić, Ljubiša, Nikolić, Vesna, Ristić, Ivan, Cakić, Suzana, Petrović, Slobodan D., "Biomedical Applications of Thermosensitive Hydrogels for Controlled/Modulated Piroxicam Delivery" in Gels, 9, no. 1 (2023):70,
https://doi.org/10.3390/gels9010070 . .

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