Supercritical carbon dioxide (scCO2) application in the pharmaceutical industry is still undeveloped regardless of significant research interests in this processing medium shown in the last decades. ScCO2 technologies can improve drug solubility, bioavailability, and therapeutic effect. These technologies can lead to the development of new formulations that will contribute to a decrease in drug dose, medication frequency, and increase patients’ well-being. Considering the significant decrease in the price of high-pressure equipment and society's growing need for cleaner production and safer products, it is expected that symbiosis between supercritical fluid and pharmaceutical technologies will happen soon. Therefore, this review was focused on the latest contributions of scCO2 technologies to the pharmaceutical field. The main aim was to bring these technologies closer to pharmaceutical specialists. For this purpose, the most commonly used technologies were explained and discussed: the... preparation of solid dispersions, polymer impregnation with drugs, and drug micro/nanoparticle production using scCO2.
TY - JOUR
AU - Milovanović, Stoja
AU - Lukić, Ivana
PY - 2022
UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5962
AB - Supercritical carbon dioxide (scCO2) application in the pharmaceutical industry is still undeveloped regardless of significant research interests in this processing medium shown in the last decades. ScCO2 technologies can improve drug solubility, bioavailability, and therapeutic effect. These technologies can lead to the development of new formulations that will contribute to a decrease in drug dose, medication frequency, and increase patients’ well-being. Considering the significant decrease in the price of high-pressure equipment and society's growing need for cleaner production and safer products, it is expected that symbiosis between supercritical fluid and pharmaceutical technologies will happen soon. Therefore, this review was focused on the latest contributions of scCO2 technologies to the pharmaceutical field. The main aim was to bring these technologies closer to pharmaceutical specialists. For this purpose, the most commonly used technologies were explained and discussed: the preparation of solid dispersions, polymer impregnation with drugs, and drug micro/nanoparticle production using scCO2.
PB - Pharmaceutical Association of Serbia
T2 - Arhiv za Farmaciju
T1 - An overview on the application of supercritical carbon dioxide for the processing of pharmaceuticals
T1 - Pregled mogućnosti primene natkritičnog ugljenik(IV)-oksida u proizvodnji lekova
EP - 590
IS - 6
SP - 566
VL - 72
DO - 10.5937/ARHFARM72-39999
ER -
@article{
author = "Milovanović, Stoja and Lukić, Ivana",
year = "2022",
abstract = "Supercritical carbon dioxide (scCO2) application in the pharmaceutical industry is still undeveloped regardless of significant research interests in this processing medium shown in the last decades. ScCO2 technologies can improve drug solubility, bioavailability, and therapeutic effect. These technologies can lead to the development of new formulations that will contribute to a decrease in drug dose, medication frequency, and increase patients’ well-being. Considering the significant decrease in the price of high-pressure equipment and society's growing need for cleaner production and safer products, it is expected that symbiosis between supercritical fluid and pharmaceutical technologies will happen soon. Therefore, this review was focused on the latest contributions of scCO2 technologies to the pharmaceutical field. The main aim was to bring these technologies closer to pharmaceutical specialists. For this purpose, the most commonly used technologies were explained and discussed: the preparation of solid dispersions, polymer impregnation with drugs, and drug micro/nanoparticle production using scCO2.",
publisher = "Pharmaceutical Association of Serbia",
journal = "Arhiv za Farmaciju",
title = "An overview on the application of supercritical carbon dioxide for the processing of pharmaceuticals, Pregled mogućnosti primene natkritičnog ugljenik(IV)-oksida u proizvodnji lekova",
pages = "590-566",
number = "6",
volume = "72",
doi = "10.5937/ARHFARM72-39999"
}
Milovanović, S.,& Lukić, I.. (2022). An overview on the application of supercritical carbon dioxide for the processing of pharmaceuticals. in Arhiv za Farmaciju
Pharmaceutical Association of Serbia., 72(6), 566-590.
https://doi.org/10.5937/ARHFARM72-39999
Milovanović S, Lukić I. An overview on the application of supercritical carbon dioxide for the processing of pharmaceuticals. in Arhiv za Farmaciju. 2022;72(6):566-590.
doi:10.5937/ARHFARM72-39999 .
Milovanović, Stoja, Lukić, Ivana, "An overview on the application of supercritical carbon dioxide for the processing of pharmaceuticals" in Arhiv za Farmaciju, 72, no. 6 (2022):566-590,
https://doi.org/10.5937/ARHFARM72-39999 . .
