Alkylation of N-substituted-2-phenylacetamides

Abstract

Various N-substituted phenylacetamides were alkylated using different alkylating agents under neutral and basic conditions. Reactions were performed at different reaction temperatures and in various solvents. Also, a number of various catalysts were used including phase-transfer catalysts. Reactions were followed using GC or GC-MS technique and the presence as well as the yields of the alkylation products were established. Generally, the best yield and high selectivity in the studied reactions were achieved under basic conditions where in the certain cases some products, mostly N-product were obtained solely in quantitative yields.

Različiti N-supstituisani 2-fenilacetamidi su alkilovani koristeći različite agense za alkilovanje u neutralnoj i baznoj sredini. Reakcije su izvođene u različitim rastvaračima i na različitim temperaturama. Korišćeni su i različiti katalizatori, uključujući međufazne katalizatore. Reakcije su praćene upotrebom GC i GC-MS tehnika. Najbolji prinosi kao i selektivnost ostvareni su pri alkilovanju N-supstituisanih 2-fenilacetamida u baznoj sredini pri čemu je N-proizvod nastao u skoro kvantitativnom prinosu.