Alkylation of N-substituted-2-phenylacetamides
Alkilovanje n-supstituisanih 2-fenilacetamida
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Various N-substituted phenylacetamides were alkylated using different alkylating agents under neutral and basic conditions. Reactions were performed at different reaction temperatures and in various solvents. Also, a number of various catalysts were used including phase-transfer catalysts. Reactions were followed using GC or GC-MS technique and the presence as well as the yields of the alkylation products were established. Generally, the best yield and high selectivity in the studied reactions were achieved under basic conditions where in the certain cases some products, mostly N-product were obtained solely in quantitative yields.
Različiti N-supstituisani 2-fenilacetamidi su alkilovani koristeći različite agense za alkilovanje u neutralnoj i baznoj sredini. Reakcije su izvođene u različitim rastvaračima i na različitim temperaturama. Korišćeni su i različiti katalizatori, uključujući međufazne katalizatore. Reakcije su praćene upotrebom GC i GC-MS tehnika. Najbolji prinosi kao i selektivnost ostvareni su pri alkilovanju N-supstituisanih 2-fenilacetamida u baznoj sredini pri čemu je N-proizvod nastao u skoro kvantitativnom prinosu.
Ključne reči:
alkylation / amides / phenylacetamides / alkylation under neutral conditions / alkylation under basic conditions / phase-transfer conditionsIzvor:
Journal of the Serbian Chemical Society, 2004, 69, 10, 711-736Izdavač:
- Serbian Chemical Society, Belgrade
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Mijin, Dušan AU - Misić-Vuković, Milica AU - Petrović, Slobodan PY - 2004 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/606 AB - Various N-substituted phenylacetamides were alkylated using different alkylating agents under neutral and basic conditions. Reactions were performed at different reaction temperatures and in various solvents. Also, a number of various catalysts were used including phase-transfer catalysts. Reactions were followed using GC or GC-MS technique and the presence as well as the yields of the alkylation products were established. Generally, the best yield and high selectivity in the studied reactions were achieved under basic conditions where in the certain cases some products, mostly N-product were obtained solely in quantitative yields. AB - Različiti N-supstituisani 2-fenilacetamidi su alkilovani koristeći različite agense za alkilovanje u neutralnoj i baznoj sredini. Reakcije su izvođene u različitim rastvaračima i na različitim temperaturama. Korišćeni su i različiti katalizatori, uključujući međufazne katalizatore. Reakcije su praćene upotrebom GC i GC-MS tehnika. Najbolji prinosi kao i selektivnost ostvareni su pri alkilovanju N-supstituisanih 2-fenilacetamida u baznoj sredini pri čemu je N-proizvod nastao u skoro kvantitativnom prinosu. PB - Serbian Chemical Society, Belgrade T2 - Journal of the Serbian Chemical Society T1 - Alkylation of N-substituted-2-phenylacetamides T1 - Alkilovanje n-supstituisanih 2-fenilacetamida EP - 736 IS - 10 SP - 711 VL - 69 UR - https://hdl.handle.net/21.15107/rcub_technorep_606 ER -
@article{ author = "Mijin, Dušan and Misić-Vuković, Milica and Petrović, Slobodan", year = "2004", abstract = "Various N-substituted phenylacetamides were alkylated using different alkylating agents under neutral and basic conditions. Reactions were performed at different reaction temperatures and in various solvents. Also, a number of various catalysts were used including phase-transfer catalysts. Reactions were followed using GC or GC-MS technique and the presence as well as the yields of the alkylation products were established. Generally, the best yield and high selectivity in the studied reactions were achieved under basic conditions where in the certain cases some products, mostly N-product were obtained solely in quantitative yields., Različiti N-supstituisani 2-fenilacetamidi su alkilovani koristeći različite agense za alkilovanje u neutralnoj i baznoj sredini. Reakcije su izvođene u različitim rastvaračima i na različitim temperaturama. Korišćeni su i različiti katalizatori, uključujući međufazne katalizatore. Reakcije su praćene upotrebom GC i GC-MS tehnika. Najbolji prinosi kao i selektivnost ostvareni su pri alkilovanju N-supstituisanih 2-fenilacetamida u baznoj sredini pri čemu je N-proizvod nastao u skoro kvantitativnom prinosu.", publisher = "Serbian Chemical Society, Belgrade", journal = "Journal of the Serbian Chemical Society", title = "Alkylation of N-substituted-2-phenylacetamides, Alkilovanje n-supstituisanih 2-fenilacetamida", pages = "736-711", number = "10", volume = "69", url = "https://hdl.handle.net/21.15107/rcub_technorep_606" }
Mijin, D., Misić-Vuković, M.,& Petrović, S.. (2004). Alkylation of N-substituted-2-phenylacetamides. in Journal of the Serbian Chemical Society Serbian Chemical Society, Belgrade., 69(10), 711-736. https://hdl.handle.net/21.15107/rcub_technorep_606
Mijin D, Misić-Vuković M, Petrović S. Alkylation of N-substituted-2-phenylacetamides. in Journal of the Serbian Chemical Society. 2004;69(10):711-736. https://hdl.handle.net/21.15107/rcub_technorep_606 .
Mijin, Dušan, Misić-Vuković, Milica, Petrović, Slobodan, "Alkylation of N-substituted-2-phenylacetamides" in Journal of the Serbian Chemical Society, 69, no. 10 (2004):711-736, https://hdl.handle.net/21.15107/rcub_technorep_606 .