The oral mucoadhesive film is a novel and attractive formulation for local and/or systemic drug
delivery through the mucosal membrane of the oral cavity. Certain active pharmaceutical ingredients (API) in conventional formulations (tablets, capsules, syrups) are absorbed in the gastrointestinal tract and undergo first-pass metabolism through the liver, thereby reducing their bioavailability. This problem can be overcome by using intraoral formulations, such as mucoadhesive buccal films that disintegrate and dissolve in the oral cavity where the absorption of API occurs. In this work, the mucoadhesive films were prepared by 3D paste printing and the influence of processing parameters on film properties and the release rate of a drug was investigated. Gelatin (GA) and the blend of gelatin/polyvinylpyrrolidone (GA/PVP) were used because of their biocompatibility. Propranolol hydrochloride (PRH) was used as a model substance because it has high first-pass metabolism and is soluble in wate...r. Film morphology and drug distribution were followed by SEM analysis. Dissolution test in simulated saliva was done to see how PRH was released from films. Mucoadhesion test revealed that the GA/PVP films with PRH have the highest adhesion force. Obtained results introduce GA/PVP as a promising material with good adhesion and rate of drug release.
Извор:
Twenty-second Annual Conference YUCOMAT 2021, Herceg Novi, Montenegro, 2021, 122-
TY - CONF
AU - Jovanović, Marija N.
AU - Radisavljević, Anđela N.
AU - Petrović, Miloš M
AU - Stojanović, Dušica B.
AU - Ibrić, Svetlana R.
AU - Uskoković, Petar S.
PY - 2021
UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6078
AB - The oral mucoadhesive film is a novel and attractive formulation for local and/or systemic drug
delivery through the mucosal membrane of the oral cavity. Certain active pharmaceutical ingredients (API) in conventional formulations (tablets, capsules, syrups) are absorbed in the gastrointestinal tract and undergo first-pass metabolism through the liver, thereby reducing their bioavailability. This problem can be overcome by using intraoral formulations, such as mucoadhesive buccal films that disintegrate and dissolve in the oral cavity where the absorption of API occurs. In this work, the mucoadhesive films were prepared by 3D paste printing and the influence of processing parameters on film properties and the release rate of a drug was investigated. Gelatin (GA) and the blend of gelatin/polyvinylpyrrolidone (GA/PVP) were used because of their biocompatibility. Propranolol hydrochloride (PRH) was used as a model substance because it has high first-pass metabolism and is soluble in water. Film morphology and drug distribution were followed by SEM analysis. Dissolution test in simulated saliva was done to see how PRH was released from films. Mucoadhesion test revealed that the GA/PVP films with PRH have the highest adhesion force. Obtained results introduce GA/PVP as a promising material with good adhesion and rate of drug release.
PB - Belgrade : Materials Research Society of Serbia
C3 - Twenty-second Annual Conference YUCOMAT 2021, Herceg Novi, Montenegro
T1 - 3D printed mucoadhesive gelatin based buccal films
SP - 122
UR - https://hdl.handle.net/21.15107/rcub_technorep_6078
ER -
@conference{
author = "Jovanović, Marija N. and Radisavljević, Anđela N. and Petrović, Miloš M and Stojanović, Dušica B. and Ibrić, Svetlana R. and Uskoković, Petar S.",
year = "2021",
abstract = "The oral mucoadhesive film is a novel and attractive formulation for local and/or systemic drug
delivery through the mucosal membrane of the oral cavity. Certain active pharmaceutical ingredients (API) in conventional formulations (tablets, capsules, syrups) are absorbed in the gastrointestinal tract and undergo first-pass metabolism through the liver, thereby reducing their bioavailability. This problem can be overcome by using intraoral formulations, such as mucoadhesive buccal films that disintegrate and dissolve in the oral cavity where the absorption of API occurs. In this work, the mucoadhesive films were prepared by 3D paste printing and the influence of processing parameters on film properties and the release rate of a drug was investigated. Gelatin (GA) and the blend of gelatin/polyvinylpyrrolidone (GA/PVP) were used because of their biocompatibility. Propranolol hydrochloride (PRH) was used as a model substance because it has high first-pass metabolism and is soluble in water. Film morphology and drug distribution were followed by SEM analysis. Dissolution test in simulated saliva was done to see how PRH was released from films. Mucoadhesion test revealed that the GA/PVP films with PRH have the highest adhesion force. Obtained results introduce GA/PVP as a promising material with good adhesion and rate of drug release.",
publisher = "Belgrade : Materials Research Society of Serbia",
journal = "Twenty-second Annual Conference YUCOMAT 2021, Herceg Novi, Montenegro",
title = "3D printed mucoadhesive gelatin based buccal films",
pages = "122",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6078"
}
Jovanović, M. N., Radisavljević, A. N., Petrović, M. M., Stojanović, D. B., Ibrić, S. R.,& Uskoković, P. S.. (2021). 3D printed mucoadhesive gelatin based buccal films. in Twenty-second Annual Conference YUCOMAT 2021, Herceg Novi, Montenegro
Belgrade : Materials Research Society of Serbia., 122.
https://hdl.handle.net/21.15107/rcub_technorep_6078
Jovanović MN, Radisavljević AN, Petrović MM, Stojanović DB, Ibrić SR, Uskoković PS. 3D printed mucoadhesive gelatin based buccal films. in Twenty-second Annual Conference YUCOMAT 2021, Herceg Novi, Montenegro. 2021;:122.
https://hdl.handle.net/21.15107/rcub_technorep_6078 .
Jovanović, Marija N., Radisavljević, Anđela N., Petrović, Miloš M, Stojanović, Dušica B., Ibrić, Svetlana R., Uskoković, Petar S., "3D printed mucoadhesive gelatin based buccal films" in Twenty-second Annual Conference YUCOMAT 2021, Herceg Novi, Montenegro (2021):122,
https://hdl.handle.net/21.15107/rcub_technorep_6078 .
