Benzylation of N-(4-chlorophenyl)-2-phenylacetamidewith benzyl chloride in the presence of powdered potassium hydroxide under various reaction conditions was performed in order to establish the possible reaction products. Different temperatures and ratios of reactants and solvents were used. The reactions were also carried out in the presence of different phase-transfer catalysts in toluene as a solvent. The formation of the reaction products was followed using gas chromatography. On the basis of the obtained results, the reactivity and the orientation in the alkylation reaction of the investigated amide is discussed.
N-(4-hlorfenil)-2-fenilacetamid je alkilovan benzil-hloridom u različitim rastvarač ima u prisustvu sprašenog kalijum-hidroksida na različitim temperaturama. Reakcije su izvođene u prisustvu različitih međufaznih katalizatora kao i bez katalizatora u cilju ispitivanja uticaja reakcionih uslova na reaktivnost i orijentaciju reakcije alkilovanja ispitivanog jedinjenja.
TY - JOUR
AU - Mijin, Dušan
AU - Janković, Vida D.
AU - Petrović, Slobodan
PY - 2004
UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/615
AB - Benzylation of N-(4-chlorophenyl)-2-phenylacetamidewith benzyl chloride in the presence of powdered potassium hydroxide under various reaction conditions was performed in order to establish the possible reaction products. Different temperatures and ratios of reactants and solvents were used. The reactions were also carried out in the presence of different phase-transfer catalysts in toluene as a solvent. The formation of the reaction products was followed using gas chromatography. On the basis of the obtained results, the reactivity and the orientation in the alkylation reaction of the investigated amide is discussed.
AB - N-(4-hlorfenil)-2-fenilacetamid je alkilovan benzil-hloridom u različitim rastvarač ima u prisustvu sprašenog kalijum-hidroksida na različitim temperaturama. Reakcije su izvođene u prisustvu različitih međufaznih katalizatora kao i bez katalizatora u cilju ispitivanja uticaja reakcionih uslova na reaktivnost i orijentaciju reakcije alkilovanja ispitivanog jedinjenja.
PB - Serbian Chemical Society, Belgrade
T2 - Journal of the Serbian Chemical Society
T1 - Alkylation of N-substituted 2-phenylacetamides: Benzylation of N-(4-chlorophenyl)-2-phenylacetamide
T1 - Alkilovanje n-supstituisanih 2-fenilacetamida: Benzilovanje n-(4-hlorfenil)-2-fenilacetamida
EP - 92
IS - 2
SP - 85
VL - 69
UR - https://hdl.handle.net/21.15107/rcub_technorep_615
ER -
@article{
author = "Mijin, Dušan and Janković, Vida D. and Petrović, Slobodan",
year = "2004",
abstract = "Benzylation of N-(4-chlorophenyl)-2-phenylacetamidewith benzyl chloride in the presence of powdered potassium hydroxide under various reaction conditions was performed in order to establish the possible reaction products. Different temperatures and ratios of reactants and solvents were used. The reactions were also carried out in the presence of different phase-transfer catalysts in toluene as a solvent. The formation of the reaction products was followed using gas chromatography. On the basis of the obtained results, the reactivity and the orientation in the alkylation reaction of the investigated amide is discussed., N-(4-hlorfenil)-2-fenilacetamid je alkilovan benzil-hloridom u različitim rastvarač ima u prisustvu sprašenog kalijum-hidroksida na različitim temperaturama. Reakcije su izvođene u prisustvu različitih međufaznih katalizatora kao i bez katalizatora u cilju ispitivanja uticaja reakcionih uslova na reaktivnost i orijentaciju reakcije alkilovanja ispitivanog jedinjenja.",
publisher = "Serbian Chemical Society, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Alkylation of N-substituted 2-phenylacetamides: Benzylation of N-(4-chlorophenyl)-2-phenylacetamide, Alkilovanje n-supstituisanih 2-fenilacetamida: Benzilovanje n-(4-hlorfenil)-2-fenilacetamida",
pages = "92-85",
number = "2",
volume = "69",
url = "https://hdl.handle.net/21.15107/rcub_technorep_615"
}
Mijin, D., Janković, V. D.,& Petrović, S.. (2004). Alkylation of N-substituted 2-phenylacetamides: Benzylation of N-(4-chlorophenyl)-2-phenylacetamide. in Journal of the Serbian Chemical Society
Serbian Chemical Society, Belgrade., 69(2), 85-92.
https://hdl.handle.net/21.15107/rcub_technorep_615
Mijin D, Janković VD, Petrović S. Alkylation of N-substituted 2-phenylacetamides: Benzylation of N-(4-chlorophenyl)-2-phenylacetamide. in Journal of the Serbian Chemical Society. 2004;69(2):85-92.
https://hdl.handle.net/21.15107/rcub_technorep_615 .
Mijin, Dušan, Janković, Vida D., Petrović, Slobodan, "Alkylation of N-substituted 2-phenylacetamides: Benzylation of N-(4-chlorophenyl)-2-phenylacetamide" in Journal of the Serbian Chemical Society, 69, no. 2 (2004):85-92,
https://hdl.handle.net/21.15107/rcub_technorep_615 .
