Enalapril was originally synthesized by Merck Sharp and Dohme and is an angiotensin converting enzyme inhibitor. Thus, enalapril is used in the treatment of mild to severe hypertension. Enalapril is chemically (S)-1-[N-[1-(et-hoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-prolin and although the first synthesis was published in 1980, it can be obtained using different synthetic pathways. This paper describes the synthesis as well as the properties and stability of enalapril.
Enalapril spada u Inhibitors angiotenzin-konvertujućeg-enzima (ACE) i predstavlja drugu generaciju takvih lekova. Prva sinteza enalaprila je razvijena u istraživačkim laboratorijama Merck Sharp & Dohme. U radu su prikazani načini dobijanja enalaprila, odnosno enalapril maleata koji se mogu naći u literaturi. Takođe je razmatrana i stabilnost enalaprila kao i način njegove degradacije.
TY - JOUR
AU - Mijin, Dušan
AU - Stanković, Milena
AU - Petrović, Slobodan
PY - 2004
UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/624
AB - Enalapril was originally synthesized by Merck Sharp and Dohme and is an angiotensin converting enzyme inhibitor. Thus, enalapril is used in the treatment of mild to severe hypertension. Enalapril is chemically (S)-1-[N-[1-(et-hoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-prolin and although the first synthesis was published in 1980, it can be obtained using different synthetic pathways. This paper describes the synthesis as well as the properties and stability of enalapril.
AB - Enalapril spada u Inhibitors angiotenzin-konvertujućeg-enzima (ACE) i predstavlja drugu generaciju takvih lekova. Prva sinteza enalaprila je razvijena u istraživačkim laboratorijama Merck Sharp & Dohme. U radu su prikazani načini dobijanja enalaprila, odnosno enalapril maleata koji se mogu naći u literaturi. Takođe je razmatrana i stabilnost enalaprila kao i način njegove degradacije.
PB - Association of Chemical Engineers of Serbia
T2 - Hemijska industrija
T1 - Enalapril: Synthesis and properties
T1 - Enalapril - dobijanje i svojstva
EP - 366
IS - 7-8
SP - 355
VL - 58
DO - 10.2298/HEMIND0408355M
ER -
@article{
author = "Mijin, Dušan and Stanković, Milena and Petrović, Slobodan",
year = "2004",
abstract = "Enalapril was originally synthesized by Merck Sharp and Dohme and is an angiotensin converting enzyme inhibitor. Thus, enalapril is used in the treatment of mild to severe hypertension. Enalapril is chemically (S)-1-[N-[1-(et-hoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-prolin and although the first synthesis was published in 1980, it can be obtained using different synthetic pathways. This paper describes the synthesis as well as the properties and stability of enalapril., Enalapril spada u Inhibitors angiotenzin-konvertujućeg-enzima (ACE) i predstavlja drugu generaciju takvih lekova. Prva sinteza enalaprila je razvijena u istraživačkim laboratorijama Merck Sharp & Dohme. U radu su prikazani načini dobijanja enalaprila, odnosno enalapril maleata koji se mogu naći u literaturi. Takođe je razmatrana i stabilnost enalaprila kao i način njegove degradacije.",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Enalapril: Synthesis and properties, Enalapril - dobijanje i svojstva",
pages = "366-355",
number = "7-8",
volume = "58",
doi = "10.2298/HEMIND0408355M"
}
Mijin, D., Stanković, M.,& Petrović, S.. (2004). Enalapril: Synthesis and properties. in Hemijska industrija
Association of Chemical Engineers of Serbia., 58(7-8), 355-366.
https://doi.org/10.2298/HEMIND0408355M
Mijin D, Stanković M, Petrović S. Enalapril: Synthesis and properties. in Hemijska industrija. 2004;58(7-8):355-366.
doi:10.2298/HEMIND0408355M .
Mijin, Dušan, Stanković, Milena, Petrović, Slobodan, "Enalapril: Synthesis and properties" in Hemijska industrija, 58, no. 7-8 (2004):355-366,
https://doi.org/10.2298/HEMIND0408355M . .
