Приказ основних података о документу

dc.creatorBabić Radić, Marija M.
dc.creatorFilipović, Vuk V.
dc.creatorVuković, Jovana S.
dc.creatorVukomanović, Marija
dc.creatorIlić-Tomić, Tatjana
dc.creatorNikodinović-Runić, Jasmina
dc.creatorTomić, Simonida Lj.
dc.date.accessioned2023-05-11T13:49:10Z
dc.date.available2023-05-11T13:49:10Z
dc.date.issued2023
dc.identifier.issn2073-4360
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/6360
dc.description.abstractThe idea of this study was to create a new scaffolding system based on 2-hydroxyethyl methacrylate, gelatin, and alginate that contains titanium(IV) oxide nanoparticles as a platform for the controlled release of the bioactive agent curcumin. The innovative strategy to develop hybrid scaffolds was the modified porogenation method. The effect of the scaffold composition on the chemical, morphology, porosity, mechanical, hydrophilicity, swelling, degradation, biocompatibility, loading, and release features of hybrid scaffolds was evaluated. A porous structure with interconnected pores in the range of 52.33–65.76%, favorable swelling capacity, fully hydrophilic surfaces, degradability to 45% for 6 months, curcumin loading efficiency above 96%, and favorable controlled release profiles were obtained. By applying four kinetic models of release, valuable parameters were obtained for the curcumin/PHEMA/gelatin/alginate/TiO2 release platform. Cytotoxicity test results depend on the composition of the scaffolds and showed satisfactory cell growth with visible cell accumulation on the hybrid surfaces. The constructed hybrid scaffolds have suitable high-performance properties, suggesting potential for further in vivo and clinical studies.sr
dc.language.isoensr
dc.publisherMDPIsr
dc.relationSCOPES program of the Swiss National Science Foundation (SNSF) and the Swiss Agency for Development and Cooperation (SDC) (Grant No IZ73ZO_152327).sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200135/RS//sr
dc.rightsopenAccesssr
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcePolymerssr
dc.subject2-hydroxyethyl methacrylatesr
dc.subjectalginatesr
dc.subjectcurcumin release platformsr
dc.subjectgelatinsr
dc.subjecthybrid scaffoldssr
dc.subjectnanoTiO2sr
dc.title2-Hydroxyethyl Methacrylate/Gelatin/Alginate Scaffolds Reinforced with Nano TiO2 as a Promising Curcumin Release Platformsr
dc.typearticlesr
dc.rights.licenseBYsr
dc.citation.issue7
dc.citation.rankM21~
dc.citation.spage1643
dc.citation.volume15
dc.identifier.doi10.3390/polym15071643
dc.identifier.fulltexthttp://TechnoRep.tmf.bg.ac.rs/bitstream/id/17022/2_Hydroxyethyl_Methacrylate_pub_2023.pdf
dc.identifier.scopus2-s2.0-85152860308
dc.type.versionpublishedVersionsr


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Приказ основних података о документу