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Temperature-Sensitive Hydrogels as Carriers for Modulated Delivery of Acetaminophen
dc.creator | Ilić-Stojanović, Snežana | |
dc.creator | Nikolić, Ljubiša | |
dc.creator | Nikolić, Vesna | |
dc.creator | Ristić, Ivan | |
dc.creator | Cakić, Suzana | |
dc.creator | Petrović, Slobodan D. | |
dc.date.accessioned | 2023-10-10T11:16:43Z | |
dc.date.available | 2023-10-10T11:16:43Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 2310-2861 | |
dc.identifier.uri | http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6664 | |
dc.description.abstract | The purposes of this study are the polymerization of temperature-sensitive copolymers based on N-isopropyl acrylamide and 10 mol % of 2-hydroxypropylmethacrylate, characterisations of their thermal, morphological and swelling properties, as well as the analysis of potential application in drug-delivery systems. Acetaminophen, the representative of non-steroidal anti-inflammatory drugs, was used as a model drug in this study. It is a common pain relief drug, which is also used for fever treatment. However, oral administration comes with certain health risks, mainly the overdose and frequent administration of up to four times a day. The goal of applying temperature-sensitive hydrogel is to enable extended administration once a day, depending on the body temperature. The swelling behavior of the obtained poly(N-isopropyl acrylamide-co-2-hydroxypropylmethacrylate) (p(NIPA/HPMA)) hydrogels and their temperature-sensitivity, kinetics and order of swelling processes at 18 and 38 °C were analyzed. The thermal properties of these hydrogels were observed by the DSC method, and the obtained thermograms showed both melting and glass transitions. The drug delivery system of p(NIPA/HPMA) hydrogels with loaded acetaminophen was analyzed using scanning electron microscopy and Fourier transform infrared spectroscopy methods. Structural analysis of FTIR spectra indicates that non-covalent intermolecular interactions of the type of hydrogen bonds were formed among functional groups of acetaminophen and side-chains of p(NIPA/HPMA) hydrogels. The surface structure of p(NIPA/HPMA) hydrogels after drug loading indicates the acetaminophen presence into the pores of the hydrogel network, and their loading efficiency was higher than 92%. Qualitative and quantitative analysis of acetaminophen, determined by the high-pressure liquid chromatography method, showed that about 90–99% of the loaded amount was released from p(NIPA/HPMA) hydrogels within 24 h. Kinetic parameters of the acetaminophen release under simulated gastrointestinal conditions were determined. Based on obtained results, the drug delivery system of temperature-sensitive p(NIPA/HPMA) hydrogels with loaded acetaminophen could be suitable for additional investigation for modulated drug administration, e.g., for extended drug administration. | sr |
dc.language.iso | en | sr |
dc.publisher | MDPI | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200133/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200134/RS// | sr |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Gels | sr |
dc.subject | 2-hydroxypropylmethacrylate | sr |
dc.subject | acetaminophen | sr |
dc.subject | drug carrier | sr |
dc.subject | DSC | sr |
dc.subject | hydrogels | sr |
dc.subject | modulated drug release | sr |
dc.subject | N-isopropyl acrylamide | sr |
dc.title | Temperature-Sensitive Hydrogels as Carriers for Modulated Delivery of Acetaminophen | sr |
dc.type | article | sr |
dc.rights.license | BY | sr |
dc.citation.issue | 9 | |
dc.citation.rank | M21~ | |
dc.citation.spage | 684 | |
dc.citation.volume | 9 | |
dc.identifier.doi | 10.3390/gels9090684 | |
dc.identifier.fulltext | http://TechnoRep.tmf.bg.ac.rs/bitstream/id/18003/Temperature_Sensitive_Hydrogels_pub_2023.pdf | |
dc.identifier.scopus | 2-s2.0-85172233842 | |
dc.type.version | publishedVersion | sr |