Cell jamming-to-unjamming transitions and vice versa in development: Physical aspects
Abstract
Collective cell migration is essential for a wide range of biological processes such as: morphogenesis, wound healing, and cancer spreading. However, it is well known that migrating epithelial collectives frequently undergo jamming, stay trapped some period of time, and then start migration again. Consequently, only a part of epithelial cells actively contributes to the tissue development. In contrast to epithelial cells, migrating mesenchymal collectives successfully avoid the jamming. It has been confirmed that the epithelial unjamming cannot be treated as the epithelial-to-mesenchymal transition. Some other mechanism is responsible for the epithelial jamming/unjamming. Despite extensive research devoted to study the cell jamming/unjamming, we still do not understand the origin of this phenomenon. The origin is connected to physical factors such as: the cell compressive residual stress accumulation and surface characteristics of migrating (unjamming) and resting (jamming) epithelial ...clusters which depend primarily on the strength of cell-cell adhesion contacts and cell contractility. The main goal of this theoretical consideration is to clarify these cause-consequence relations.
Keywords:
Collective cell migration / Interfacial tension between adjust tissues / Remodelling of cell-cell adhesion contacts / Tissue cohesiveness / Tissue surface tension / ViscoelasticitySource:
BioSystems, 2023, 234, 105045-Publisher:
- Elsevier Ltd.
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200135 (University of Belgrade, Faculty of Technology and Metallurgy) (RS-MESTD-inst-2020-200135)
DOI: 10.1016/j.biosystems.2023.105045
ISSN: 0303-2647
PubMed: 37813238
Scopus: 2-s2.0-85173497800
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Pajić-Lijaković, Ivana AU - Milivojević, Milan PY - 2023 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6711 AB - Collective cell migration is essential for a wide range of biological processes such as: morphogenesis, wound healing, and cancer spreading. However, it is well known that migrating epithelial collectives frequently undergo jamming, stay trapped some period of time, and then start migration again. Consequently, only a part of epithelial cells actively contributes to the tissue development. In contrast to epithelial cells, migrating mesenchymal collectives successfully avoid the jamming. It has been confirmed that the epithelial unjamming cannot be treated as the epithelial-to-mesenchymal transition. Some other mechanism is responsible for the epithelial jamming/unjamming. Despite extensive research devoted to study the cell jamming/unjamming, we still do not understand the origin of this phenomenon. The origin is connected to physical factors such as: the cell compressive residual stress accumulation and surface characteristics of migrating (unjamming) and resting (jamming) epithelial clusters which depend primarily on the strength of cell-cell adhesion contacts and cell contractility. The main goal of this theoretical consideration is to clarify these cause-consequence relations. PB - Elsevier Ltd. T2 - BioSystems T1 - Cell jamming-to-unjamming transitions and vice versa in development: Physical aspects SP - 105045 VL - 234 DO - 10.1016/j.biosystems.2023.105045 ER -
@article{ author = "Pajić-Lijaković, Ivana and Milivojević, Milan", year = "2023", abstract = "Collective cell migration is essential for a wide range of biological processes such as: morphogenesis, wound healing, and cancer spreading. However, it is well known that migrating epithelial collectives frequently undergo jamming, stay trapped some period of time, and then start migration again. Consequently, only a part of epithelial cells actively contributes to the tissue development. In contrast to epithelial cells, migrating mesenchymal collectives successfully avoid the jamming. It has been confirmed that the epithelial unjamming cannot be treated as the epithelial-to-mesenchymal transition. Some other mechanism is responsible for the epithelial jamming/unjamming. Despite extensive research devoted to study the cell jamming/unjamming, we still do not understand the origin of this phenomenon. The origin is connected to physical factors such as: the cell compressive residual stress accumulation and surface characteristics of migrating (unjamming) and resting (jamming) epithelial clusters which depend primarily on the strength of cell-cell adhesion contacts and cell contractility. The main goal of this theoretical consideration is to clarify these cause-consequence relations.", publisher = "Elsevier Ltd.", journal = "BioSystems", title = "Cell jamming-to-unjamming transitions and vice versa in development: Physical aspects", pages = "105045", volume = "234", doi = "10.1016/j.biosystems.2023.105045" }
Pajić-Lijaković, I.,& Milivojević, M.. (2023). Cell jamming-to-unjamming transitions and vice versa in development: Physical aspects. in BioSystems Elsevier Ltd.., 234, 105045. https://doi.org/10.1016/j.biosystems.2023.105045
Pajić-Lijaković I, Milivojević M. Cell jamming-to-unjamming transitions and vice versa in development: Physical aspects. in BioSystems. 2023;234:105045. doi:10.1016/j.biosystems.2023.105045 .
Pajić-Lijaković, Ivana, Milivojević, Milan, "Cell jamming-to-unjamming transitions and vice versa in development: Physical aspects" in BioSystems, 234 (2023):105045, https://doi.org/10.1016/j.biosystems.2023.105045 . .