Show simple item record

Synthesis, structure and properties of 7,8-benzo-1,3-diazaspiro[4.5]decane-2,4-dione and its derivatives

dc.creatorMandić, Željko
dc.creatorLazić, Anita M.
dc.creatorBožić, Bojan Đ.
dc.creatorUšćumlić, Gordana S.
dc.date.accessioned2023-11-06T09:12:54Z
dc.date.available2023-11-06T09:12:54Z
dc.date.issued2016
dc.identifier.isbn978-86-7132-064-1
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/6762
dc.description.abstractDerivati tetrantoina (7,8-benzo-1,3-diazaspiro[4.5]dekan-2,4-diona) (Slika ) su jedinjenja širokog spektra biološke aktivnosti. Mnogi od njih su poznata antikonvulzivna, antivirusna i antikancerogena jedinjenja, a uspešno se koriste i u lečenju dijabetesa. U okviru ovog rada, sintetizovan je tetrantoin i njegovi derivati koji u položaju 3 hidantoinskog prstena sadrže supstituisanu benzil grupu (supstituent X: H, CH3, OCH3, Cl, Br, CN). Struktura navedenih jedinjenja potvrđena je temperaturama topljenja, 1 H i 13 C NMR, Ft-IR i UV spektroskopskim metodama. Na osnovu strukturnih i lipofilnih karakteristika diskutovana je potencijalna biološka aktivnost sintetizovanih jedinjenja.sr
dc.description.abstractDerivatives of tetrantoin (7,8-benzo-1,3-diazaspiro[4.5]decane-2,4-dione) (Figure) are the compounds of a wide range of biological activities. Many of them are known anticonvulsant, anticancer and antiviral compounds, and are successfully used in the treatment of diabetes. In this work, was synthesized tetrantoin and its derivatives which in the 3-position of the hydantoin ring containing a substituted benzyl group (the substituent X: H, CH3, OCH3, Cl, Br, CN). The structure of these compounds was confirmed by melting point, 1H and 13C NMR, FT-IR and UV spectroscopic methods. Based on structural lipophilic characteristics is discussed the potential biological activity of the synthesized compounds.sr
dc.language.isosrsr
dc.publisherBeograd : Srpsko hemijsko društvosr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172013/RS//sr
dc.rightsopenAccesssr
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceKratki izvodi radova / Četvrta konferencija mladih hemičara Srbije, Beograd, 5. novembar 2016sr
dc.titleSinteza, struktura i svojstva 7,8-benzo-1,3-diazaspiro[4.5]dekan-2,4-diona i njegovih derivatasr
dc.titleSynthesis, structure and properties of 7,8-benzo-1,3-diazaspiro[4.5]decane-2,4-dione and its derivativessr
dc.typeconferenceObjectsr
dc.rights.licenseBYsr
dc.citation.spage55
dc.identifier.fulltexthttp://TechnoRep.tmf.bg.ac.rs/bitstream/id/18370/Synthesis_structure_and_properties_pub_2016.pdf
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_technorep_6762
dc.type.versionpublishedVersionsr


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record