Synthesis and characterization of 1-(4-substitutedbenzyl)-3’,4’-dihydro-2’H-spiro[imidazolidine-4,1’-naphtalene]-2,5-dione derivatives as potential anticonvulsant agents
Sinteza i karakterizacija 1-(4-supstituisanih benzil)-3’,4’-dihidro-2’H-spiro[imidazolidin-4,1’-naftalen]-2,5-diona potencijalnih antikonvulzivnih agenasa
Conference object (Published version)
Metadata
Show full item recordAbstract
Among the diverse pharmacological activity reported for spirohydantoin and the closely related spirosuccinimides, their anticonvulsant and antiproliferative activities are commonly encountered. Of all cyclic ureide derivatives, Phenytoin (5,5-diphenylhydantoin) is one of the well-known commercially available anticonvulsants, which is also widely used as an antiarrhythmic agent. However, the clinical use of 5,5-diphenylhydantoin is limited by its central nervous adverse effects in addition to a wide variety of drug interactions [1]. With the aim of developing new analogs with a more efficient therapeutic effect, a series of 1-(4-substitutedbenzyl)-3’,4’-dihydro-2’H-spiro[imidazolidine-4,1’-naphtalene]-2,5-diones, have been synthesized, characterized by melting points, FT-IR, 1H and 13C NMR spectroscopic techniques, and evaluated for anticonvulsant activity. The objective of the present investigation is to identify the pharmacological impact of the spirocyclic attachment of a semi-rigid ...tetralin residue at C-5 of the imidazolidine-2,4-dione ring and to explore the effect of substitution at N-3 on anticonvulsant activity.
Source:
Book of Abstracts / Sixth Conference of Young Chemists of Serbia, Belgrade, 27th October 2018, 2018, 56-Publisher:
- Beograd : Serbian Chemical Society
Funding / projects:
- Study of the Synthesis, Structure and Activity of Natural and Synthetic Organic Compounds (RS-MESTD-Basic Research (BR or ON)-172013)
Collections
Institution/Community
Inovacioni centarTY - CONF AU - Lazić, Anita M. AU - Mandić, Željko AU - Trišović, Nemanja P. AU - Ušćumlić, Gordana S. PY - 2018 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6789 AB - Among the diverse pharmacological activity reported for spirohydantoin and the closely related spirosuccinimides, their anticonvulsant and antiproliferative activities are commonly encountered. Of all cyclic ureide derivatives, Phenytoin (5,5-diphenylhydantoin) is one of the well-known commercially available anticonvulsants, which is also widely used as an antiarrhythmic agent. However, the clinical use of 5,5-diphenylhydantoin is limited by its central nervous adverse effects in addition to a wide variety of drug interactions [1]. With the aim of developing new analogs with a more efficient therapeutic effect, a series of 1-(4-substitutedbenzyl)-3’,4’-dihydro-2’H-spiro[imidazolidine-4,1’-naphtalene]-2,5-diones, have been synthesized, characterized by melting points, FT-IR, 1H and 13C NMR spectroscopic techniques, and evaluated for anticonvulsant activity. The objective of the present investigation is to identify the pharmacological impact of the spirocyclic attachment of a semi-rigid tetralin residue at C-5 of the imidazolidine-2,4-dione ring and to explore the effect of substitution at N-3 on anticonvulsant activity. PB - Beograd : Serbian Chemical Society C3 - Book of Abstracts / Sixth Conference of Young Chemists of Serbia, Belgrade, 27th October 2018 T1 - Synthesis and characterization of 1-(4-substitutedbenzyl)-3’,4’-dihydro-2’H-spiro[imidazolidine-4,1’-naphtalene]-2,5-dione derivatives as potential anticonvulsant agents T1 - Sinteza i karakterizacija 1-(4-supstituisanih benzil)-3’,4’-dihidro-2’H-spiro[imidazolidin-4,1’-naftalen]-2,5-diona potencijalnih antikonvulzivnih agenasa SP - 56 UR - https://hdl.handle.net/21.15107/rcub_technorep_6789 ER -
@conference{ author = "Lazić, Anita M. and Mandić, Željko and Trišović, Nemanja P. and Ušćumlić, Gordana S.", year = "2018", abstract = "Among the diverse pharmacological activity reported for spirohydantoin and the closely related spirosuccinimides, their anticonvulsant and antiproliferative activities are commonly encountered. Of all cyclic ureide derivatives, Phenytoin (5,5-diphenylhydantoin) is one of the well-known commercially available anticonvulsants, which is also widely used as an antiarrhythmic agent. However, the clinical use of 5,5-diphenylhydantoin is limited by its central nervous adverse effects in addition to a wide variety of drug interactions [1]. With the aim of developing new analogs with a more efficient therapeutic effect, a series of 1-(4-substitutedbenzyl)-3’,4’-dihydro-2’H-spiro[imidazolidine-4,1’-naphtalene]-2,5-diones, have been synthesized, characterized by melting points, FT-IR, 1H and 13C NMR spectroscopic techniques, and evaluated for anticonvulsant activity. The objective of the present investigation is to identify the pharmacological impact of the spirocyclic attachment of a semi-rigid tetralin residue at C-5 of the imidazolidine-2,4-dione ring and to explore the effect of substitution at N-3 on anticonvulsant activity.", publisher = "Beograd : Serbian Chemical Society", journal = "Book of Abstracts / Sixth Conference of Young Chemists of Serbia, Belgrade, 27th October 2018", title = "Synthesis and characterization of 1-(4-substitutedbenzyl)-3’,4’-dihydro-2’H-spiro[imidazolidine-4,1’-naphtalene]-2,5-dione derivatives as potential anticonvulsant agents, Sinteza i karakterizacija 1-(4-supstituisanih benzil)-3’,4’-dihidro-2’H-spiro[imidazolidin-4,1’-naftalen]-2,5-diona potencijalnih antikonvulzivnih agenasa", pages = "56", url = "https://hdl.handle.net/21.15107/rcub_technorep_6789" }
Lazić, A. M., Mandić, Ž., Trišović, N. P.,& Ušćumlić, G. S.. (2018). Synthesis and characterization of 1-(4-substitutedbenzyl)-3’,4’-dihydro-2’H-spiro[imidazolidine-4,1’-naphtalene]-2,5-dione derivatives as potential anticonvulsant agents. in Book of Abstracts / Sixth Conference of Young Chemists of Serbia, Belgrade, 27th October 2018 Beograd : Serbian Chemical Society., 56. https://hdl.handle.net/21.15107/rcub_technorep_6789
Lazić AM, Mandić Ž, Trišović NP, Ušćumlić GS. Synthesis and characterization of 1-(4-substitutedbenzyl)-3’,4’-dihydro-2’H-spiro[imidazolidine-4,1’-naphtalene]-2,5-dione derivatives as potential anticonvulsant agents. in Book of Abstracts / Sixth Conference of Young Chemists of Serbia, Belgrade, 27th October 2018. 2018;:56. https://hdl.handle.net/21.15107/rcub_technorep_6789 .
Lazić, Anita M., Mandić, Željko, Trišović, Nemanja P., Ušćumlić, Gordana S., "Synthesis and characterization of 1-(4-substitutedbenzyl)-3’,4’-dihydro-2’H-spiro[imidazolidine-4,1’-naphtalene]-2,5-dione derivatives as potential anticonvulsant agents" in Book of Abstracts / Sixth Conference of Young Chemists of Serbia, Belgrade, 27th October 2018 (2018):56, https://hdl.handle.net/21.15107/rcub_technorep_6789 .