Prikaz osnovnih podataka o dokumentu
Biomechanical Aspects in Bone Tumor Engineering
dc.creator | Menshikh, Ksenia | |
dc.creator | Banićević, Ivana | |
dc.creator | Obradović, Bojana | |
dc.creator | Rimondini, Lia | |
dc.date.accessioned | 2023-12-25T11:08:34Z | |
dc.date.available | 2023-12-25T11:08:34Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 1937-3368 | |
dc.identifier.uri | http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7027 | |
dc.description.abstract | In the past decades, anticancer drug development brought the field of tumor engineering to a new level by the need of robust test systems. Simulating tumor microenvironment in vitro remains a challenge, and osteosarcoma—the most common primary bone cancer—is no exception. The growing evidence points to the inevitable connection between biomechanical stimuli and tumor chemosensitivity and aggressiveness, thus making this component of the microenvironment a mandatory requirement to the developed models. In this review, we addressed the question: is the “in vivo - in vitro” gap in osteosarcoma engineering bridged from the perspective of biomechanical stimuli? The most notable biomechanical cues in the tumor cell microenvironment are observed and compared in the contexts of in vivo conditions and engineered three-dimensional in vitro models. | sr |
dc.language.iso | en | sr |
dc.publisher | Mary Ann Liebert Inc. | sr |
dc.relation | European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no. 860462 and the grant agreement no. 952033 | sr |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Tissue Engineering - Part B: Reviews | sr |
dc.subject | 3D in vitro models | sr |
dc.subject | bone cancer | sr |
dc.subject | bone tumor microenvironment | sr |
dc.subject | osteosarcoma | sr |
dc.title | Biomechanical Aspects in Bone Tumor Engineering | sr |
dc.type | article | sr |
dc.rights.license | BY | sr |
dc.citation.rank | M21~ | |
dc.identifier.doi | 10.1089/ten.teb.2023.0106 | |
dc.identifier.fulltext | http://TechnoRep.tmf.bg.ac.rs/bitstream/id/19250/Biomechanical_Aspects_pub_2023.pdf | |
dc.identifier.pmid | 37830183 | |
dc.identifier.scopus | 2-s2.0-85179441743 | |
dc.type.version | publishedVersion | sr |