Encapsulation of vitamin E and folic acid into liposomes - carrier stability and controlled release
Abstract
In this study liposomes were investigated regarding the ability to encapsulate vitamins, vitamin E and folic acid. Liposomes were prepared using commercial mixture based on the soybean lecithin (Phospholipon 90 G) by the proliposome technique. High entrapment efficiency (85-90%) was achieved for both types of vitamins, while the size was dependent on the vitamin type (350 and 630 nm for vitamin E- and folic acid-containing liposomes). Physical stability expressed via changes of the size, polydispersity and zeta potential during storage was confirmed for the period of one month in case liposomes with folic acid and two months for the liposomes with vitamin E. The release study, done using Franc diffusion cell, under skin conditions (pH=5.5), showed that the release rate was determined by solubility of the vitamins.
Keywords:
liposomes / entrapment efficiency / vitamin E / folic acid / carrier stability / controlled releaseSource:
Proceedings / VII International Congress "Engineering, Environment and Materials in Process Industry" EEM2021, Jahorina, March 17-19, 2021, 2021, 227-234Publisher:
- Zvornik : Faculty of Technology
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200287 (Innovation Center of the Faculty of Technology and Metallurgy) (RS-MESTD-inst-2020-200287)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200135 (University of Belgrade, Faculty of Technology and Metallurgy) (RS-MESTD-inst-2020-200135)
Collections
Institution/Community
Inovacioni centarTY - CONF AU - Batinić, Petar AU - Đorđević, Verica AU - Balanč, Bojana AU - Bošković, Stefan AU - Bugarski, Branko PY - 2021 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7368 AB - In this study liposomes were investigated regarding the ability to encapsulate vitamins, vitamin E and folic acid. Liposomes were prepared using commercial mixture based on the soybean lecithin (Phospholipon 90 G) by the proliposome technique. High entrapment efficiency (85-90%) was achieved for both types of vitamins, while the size was dependent on the vitamin type (350 and 630 nm for vitamin E- and folic acid-containing liposomes). Physical stability expressed via changes of the size, polydispersity and zeta potential during storage was confirmed for the period of one month in case liposomes with folic acid and two months for the liposomes with vitamin E. The release study, done using Franc diffusion cell, under skin conditions (pH=5.5), showed that the release rate was determined by solubility of the vitamins. PB - Zvornik : Faculty of Technology C3 - Proceedings / VII International Congress "Engineering, Environment and Materials in Process Industry" EEM2021, Jahorina, March 17-19, 2021 T1 - Encapsulation of vitamin E and folic acid into liposomes - carrier stability and controlled release EP - 234 SP - 227 DO - 10.7251/EEMEN2101227B ER -
@conference{ author = "Batinić, Petar and Đorđević, Verica and Balanč, Bojana and Bošković, Stefan and Bugarski, Branko", year = "2021", abstract = "In this study liposomes were investigated regarding the ability to encapsulate vitamins, vitamin E and folic acid. Liposomes were prepared using commercial mixture based on the soybean lecithin (Phospholipon 90 G) by the proliposome technique. High entrapment efficiency (85-90%) was achieved for both types of vitamins, while the size was dependent on the vitamin type (350 and 630 nm for vitamin E- and folic acid-containing liposomes). Physical stability expressed via changes of the size, polydispersity and zeta potential during storage was confirmed for the period of one month in case liposomes with folic acid and two months for the liposomes with vitamin E. The release study, done using Franc diffusion cell, under skin conditions (pH=5.5), showed that the release rate was determined by solubility of the vitamins.", publisher = "Zvornik : Faculty of Technology", journal = "Proceedings / VII International Congress "Engineering, Environment and Materials in Process Industry" EEM2021, Jahorina, March 17-19, 2021", title = "Encapsulation of vitamin E and folic acid into liposomes - carrier stability and controlled release", pages = "234-227", doi = "10.7251/EEMEN2101227B" }
Batinić, P., Đorđević, V., Balanč, B., Bošković, S.,& Bugarski, B.. (2021). Encapsulation of vitamin E and folic acid into liposomes - carrier stability and controlled release. in Proceedings / VII International Congress "Engineering, Environment and Materials in Process Industry" EEM2021, Jahorina, March 17-19, 2021 Zvornik : Faculty of Technology., 227-234. https://doi.org/10.7251/EEMEN2101227B
Batinić P, Đorđević V, Balanč B, Bošković S, Bugarski B. Encapsulation of vitamin E and folic acid into liposomes - carrier stability and controlled release. in Proceedings / VII International Congress "Engineering, Environment and Materials in Process Industry" EEM2021, Jahorina, March 17-19, 2021. 2021;:227-234. doi:10.7251/EEMEN2101227B .
Batinić, Petar, Đorđević, Verica, Balanč, Bojana, Bošković, Stefan, Bugarski, Branko, "Encapsulation of vitamin E and folic acid into liposomes - carrier stability and controlled release" in Proceedings / VII International Congress "Engineering, Environment and Materials in Process Industry" EEM2021, Jahorina, March 17-19, 2021 (2021):227-234, https://doi.org/10.7251/EEMEN2101227B . .