Development of cornstarch aerogels with high porosity and their impregnation with natural bioactive compounds
Abstract
Aerogels are materials with high specific surface area and high porosity, which can be produced from
polysaccharides such as starch [1,2]. Starch is an abundant and low-cost polymer with versatility in processing. Aerogel
properties are influenced by the process parameters including starch-to-water ratio, gelatinization temperature (T),
selection of non-solvent for water replacement in hydrogels, selection of drying method, drying pressure (P) and T,
etc. [1,2]. Supercritical drying, which employs supercritical carbon dioxide (scCO2), is an environmentally friendly
process that allows relatively fast production of aerogels. Despite the superior properties of starch aerogels, they do
not express biological activity. This can be overcome by the incorporation of bioactive compounds (BCs) into aerogels
using the supercritical impregnation (SCI) process [3,4]. SCI implies the dissolution of BCs in scCO2, diffusion of BC-scCO2
solution into a polymer matrix, possible chemical or phys...ical interaction of BC with polymer, and complete removal of
scCO2 from the BC-polymer after a decrease of P and T to atmospheric. This process allows one-step production of
solvent-free added value materials at relatively low T and the incorporation of high amounts of BC with various biological
activities. Aerogels can be impregnated with pharmaceutical drugs but also with natural BCs (single or mixture) such as
plant extracts [3,4]. To produce aerogels, 10 g of cornstarch (amylose content 20−30%, HeMoss, Serbia) was mixed with
100 mL of distilled water, gelatinization T was changed from 70 to 100 °C, water contained in hydrogels was replaced
with acetone or ethanol during 1 or 5 days, drying P was varied from 8 to 20 MPa while drying T was 35 or 40 °C. Drying
of gels was performed in a 25 mL high-pressure view cell while impregnation of aerogels with BCs was performed in a
280 mL high-pressure unit (Eurotechnica GmbH, Germany). Developed aerogels were tested as possible carriers of hemp
and bilberry extracts as well as carriers of neat components such as carvacrol and citronellol. Produced cornstarch
aerogels showed high liquid absorption capacity (ca. 400%). Due to high specific surface area, low density, high porosity,
and biocompatibility, obtained aerogels present promising candidates for the development of biomaterials that will
release BCs in a controlled manner and enable antimicrobial activity. The SCI processes enabled the impregnation of a
high amount of tested natural BCs achieving loadings up to 33%. By controlling preparation process parameters, which
leads to tuning of pore size and pore size distribution, tailoring of aerogel properties for special purposes is possible.
Keywords:
Biomaterials / supercritical carbon dioxide / supercritical drying / supercritical impregnationSource:
Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts, 2024, 78, 1S, 30-Publisher:
- Beograd : Savez hemijskih inženjera Srbije
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200135 (University of Belgrade, Faculty of Technology and Metallurgy) (RS-MESTD-inst-2020-200135)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200287 (Innovation Center of the Faculty of Technology and Metallurgy) (RS-MESTD-inst-2020-200287)
Note:
- ExcellMater Conference 2024: Innovative Biomaterials for Novel Medical Devices, Belgrade, Serbia, April 10-12, 2024
Collections
Institution/Community
Tehnološko-metalurški fakultetTY - CONF AU - Milovanović, Stoja AU - Pajnik, Jelena AU - Marković, Darka AU - Janković-Častvan, Ivona AU - Lukić, Ivana PY - 2024 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7525 AB - Aerogels are materials with high specific surface area and high porosity, which can be produced from polysaccharides such as starch [1,2]. Starch is an abundant and low-cost polymer with versatility in processing. Aerogel properties are influenced by the process parameters including starch-to-water ratio, gelatinization temperature (T), selection of non-solvent for water replacement in hydrogels, selection of drying method, drying pressure (P) and T, etc. [1,2]. Supercritical drying, which employs supercritical carbon dioxide (scCO2), is an environmentally friendly process that allows relatively fast production of aerogels. Despite the superior properties of starch aerogels, they do not express biological activity. This can be overcome by the incorporation of bioactive compounds (BCs) into aerogels using the supercritical impregnation (SCI) process [3,4]. SCI implies the dissolution of BCs in scCO2, diffusion of BC-scCO2 solution into a polymer matrix, possible chemical or physical interaction of BC with polymer, and complete removal of scCO2 from the BC-polymer after a decrease of P and T to atmospheric. This process allows one-step production of solvent-free added value materials at relatively low T and the incorporation of high amounts of BC with various biological activities. Aerogels can be impregnated with pharmaceutical drugs but also with natural BCs (single or mixture) such as plant extracts [3,4]. To produce aerogels, 10 g of cornstarch (amylose content 20−30%, HeMoss, Serbia) was mixed with 100 mL of distilled water, gelatinization T was changed from 70 to 100 °C, water contained in hydrogels was replaced with acetone or ethanol during 1 or 5 days, drying P was varied from 8 to 20 MPa while drying T was 35 or 40 °C. Drying of gels was performed in a 25 mL high-pressure view cell while impregnation of aerogels with BCs was performed in a 280 mL high-pressure unit (Eurotechnica GmbH, Germany). Developed aerogels were tested as possible carriers of hemp and bilberry extracts as well as carriers of neat components such as carvacrol and citronellol. Produced cornstarch aerogels showed high liquid absorption capacity (ca. 400%). Due to high specific surface area, low density, high porosity, and biocompatibility, obtained aerogels present promising candidates for the development of biomaterials that will release BCs in a controlled manner and enable antimicrobial activity. The SCI processes enabled the impregnation of a high amount of tested natural BCs achieving loadings up to 33%. By controlling preparation process parameters, which leads to tuning of pore size and pore size distribution, tailoring of aerogel properties for special purposes is possible. PB - Beograd : Savez hemijskih inženjera Srbije C3 - Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts T1 - Development of cornstarch aerogels with high porosity and their impregnation with natural bioactive compounds IS - 1S SP - 30 VL - 78 UR - https://hdl.handle.net/21.15107/rcub_technorep_7525 ER -
@conference{ author = "Milovanović, Stoja and Pajnik, Jelena and Marković, Darka and Janković-Častvan, Ivona and Lukić, Ivana", year = "2024", abstract = "Aerogels are materials with high specific surface area and high porosity, which can be produced from polysaccharides such as starch [1,2]. Starch is an abundant and low-cost polymer with versatility in processing. Aerogel properties are influenced by the process parameters including starch-to-water ratio, gelatinization temperature (T), selection of non-solvent for water replacement in hydrogels, selection of drying method, drying pressure (P) and T, etc. [1,2]. Supercritical drying, which employs supercritical carbon dioxide (scCO2), is an environmentally friendly process that allows relatively fast production of aerogels. Despite the superior properties of starch aerogels, they do not express biological activity. This can be overcome by the incorporation of bioactive compounds (BCs) into aerogels using the supercritical impregnation (SCI) process [3,4]. SCI implies the dissolution of BCs in scCO2, diffusion of BC-scCO2 solution into a polymer matrix, possible chemical or physical interaction of BC with polymer, and complete removal of scCO2 from the BC-polymer after a decrease of P and T to atmospheric. This process allows one-step production of solvent-free added value materials at relatively low T and the incorporation of high amounts of BC with various biological activities. Aerogels can be impregnated with pharmaceutical drugs but also with natural BCs (single or mixture) such as plant extracts [3,4]. To produce aerogels, 10 g of cornstarch (amylose content 20−30%, HeMoss, Serbia) was mixed with 100 mL of distilled water, gelatinization T was changed from 70 to 100 °C, water contained in hydrogels was replaced with acetone or ethanol during 1 or 5 days, drying P was varied from 8 to 20 MPa while drying T was 35 or 40 °C. Drying of gels was performed in a 25 mL high-pressure view cell while impregnation of aerogels with BCs was performed in a 280 mL high-pressure unit (Eurotechnica GmbH, Germany). Developed aerogels were tested as possible carriers of hemp and bilberry extracts as well as carriers of neat components such as carvacrol and citronellol. Produced cornstarch aerogels showed high liquid absorption capacity (ca. 400%). Due to high specific surface area, low density, high porosity, and biocompatibility, obtained aerogels present promising candidates for the development of biomaterials that will release BCs in a controlled manner and enable antimicrobial activity. The SCI processes enabled the impregnation of a high amount of tested natural BCs achieving loadings up to 33%. By controlling preparation process parameters, which leads to tuning of pore size and pore size distribution, tailoring of aerogel properties for special purposes is possible.", publisher = "Beograd : Savez hemijskih inženjera Srbije", journal = "Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts", title = "Development of cornstarch aerogels with high porosity and their impregnation with natural bioactive compounds", number = "1S", pages = "30", volume = "78", url = "https://hdl.handle.net/21.15107/rcub_technorep_7525" }
Milovanović, S., Pajnik, J., Marković, D., Janković-Častvan, I.,& Lukić, I.. (2024). Development of cornstarch aerogels with high porosity and their impregnation with natural bioactive compounds. in Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts Beograd : Savez hemijskih inženjera Srbije., 78(1S), 30. https://hdl.handle.net/21.15107/rcub_technorep_7525
Milovanović S, Pajnik J, Marković D, Janković-Častvan I, Lukić I. Development of cornstarch aerogels with high porosity and their impregnation with natural bioactive compounds. in Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts. 2024;78(1S):30. https://hdl.handle.net/21.15107/rcub_technorep_7525 .
Milovanović, Stoja, Pajnik, Jelena, Marković, Darka, Janković-Častvan, Ivona, Lukić, Ivana, "Development of cornstarch aerogels with high porosity and their impregnation with natural bioactive compounds" in Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts, 78, no. 1S (2024):30, https://hdl.handle.net/21.15107/rcub_technorep_7525 .