The aim of the present study was to examine the oxidative properties and an assay of azithromycin and Hemomycin (R) at a gold electrode in neutral electrolyte using cyclic linear sweep voltammetry. The maximum value of the current of the oxidation peak of pure azithromycin and azithromycin from Hemomycin (R) at 0.6 V versus SCE in 0.05 M NaHCO3 and in a mixture methanol -0.05 M NaHCO3 (1:1) at a scan rate of 50 mV s(-1) is a linear function of the concentration in the range of 0.235-0.588 mg/cm(3). HPLC analysis of the bulk of electrolyte confirmed the data obtained by analysis of the values of the current peak concerning the concentration of antibiotic in the investigated concentration range. The role of methanol, when present, is discussed. In the case of azithromycin, the presence of methanol leads to higher current peak values. However, in the case of Hemonlycin (R), methanol should be avoided because of its inhibiting influence on the qualitative and quantitative determination of ...azithromycin and on the azithromycin/lactose, separation.
TY - JOUR
AU - Avramov-Ivić, Milka
AU - Petrović, Slobodan
AU - Mijin, Dušan
AU - Živković, Predrag M.
AU - Kosović, IM
AU - Drljević, Katica
AU - Jovanović, Mica B.
PY - 2006
UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/863
AB - The aim of the present study was to examine the oxidative properties and an assay of azithromycin and Hemomycin (R) at a gold electrode in neutral electrolyte using cyclic linear sweep voltammetry. The maximum value of the current of the oxidation peak of pure azithromycin and azithromycin from Hemomycin (R) at 0.6 V versus SCE in 0.05 M NaHCO3 and in a mixture methanol -0.05 M NaHCO3 (1:1) at a scan rate of 50 mV s(-1) is a linear function of the concentration in the range of 0.235-0.588 mg/cm(3). HPLC analysis of the bulk of electrolyte confirmed the data obtained by analysis of the values of the current peak concerning the concentration of antibiotic in the investigated concentration range. The role of methanol, when present, is discussed. In the case of azithromycin, the presence of methanol leads to higher current peak values. However, in the case of Hemonlycin (R), methanol should be avoided because of its inhibiting influence on the qualitative and quantitative determination of azithromycin and on the azithromycin/lactose, separation.
PB - Pergamon-Elsevier Science Ltd, Oxford
T2 - Electrochimica Acta
T1 - Studies on electrochemical oxidation of azithromycin and Hemomycin (R) at gold electrode in neutral electrolyte
EP - 2416
IS - 12
SP - 2407
VL - 51
DO - 10.1016/j.electacta.2005.07.032
ER -
@article{
author = "Avramov-Ivić, Milka and Petrović, Slobodan and Mijin, Dušan and Živković, Predrag M. and Kosović, IM and Drljević, Katica and Jovanović, Mica B.",
year = "2006",
abstract = "The aim of the present study was to examine the oxidative properties and an assay of azithromycin and Hemomycin (R) at a gold electrode in neutral electrolyte using cyclic linear sweep voltammetry. The maximum value of the current of the oxidation peak of pure azithromycin and azithromycin from Hemomycin (R) at 0.6 V versus SCE in 0.05 M NaHCO3 and in a mixture methanol -0.05 M NaHCO3 (1:1) at a scan rate of 50 mV s(-1) is a linear function of the concentration in the range of 0.235-0.588 mg/cm(3). HPLC analysis of the bulk of electrolyte confirmed the data obtained by analysis of the values of the current peak concerning the concentration of antibiotic in the investigated concentration range. The role of methanol, when present, is discussed. In the case of azithromycin, the presence of methanol leads to higher current peak values. However, in the case of Hemonlycin (R), methanol should be avoided because of its inhibiting influence on the qualitative and quantitative determination of azithromycin and on the azithromycin/lactose, separation.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Electrochimica Acta",
title = "Studies on electrochemical oxidation of azithromycin and Hemomycin (R) at gold electrode in neutral electrolyte",
pages = "2416-2407",
number = "12",
volume = "51",
doi = "10.1016/j.electacta.2005.07.032"
}
Avramov-Ivić, M., Petrović, S., Mijin, D., Živković, P. M., Kosović, I., Drljević, K.,& Jovanović, M. B.. (2006). Studies on electrochemical oxidation of azithromycin and Hemomycin (R) at gold electrode in neutral electrolyte. in Electrochimica Acta
Pergamon-Elsevier Science Ltd, Oxford., 51(12), 2407-2416.
https://doi.org/10.1016/j.electacta.2005.07.032
Avramov-Ivić M, Petrović S, Mijin D, Živković PM, Kosović I, Drljević K, Jovanović MB. Studies on electrochemical oxidation of azithromycin and Hemomycin (R) at gold electrode in neutral electrolyte. in Electrochimica Acta. 2006;51(12):2407-2416.
doi:10.1016/j.electacta.2005.07.032 .
Avramov-Ivić, Milka, Petrović, Slobodan, Mijin, Dušan, Živković, Predrag M., Kosović, IM, Drljević, Katica, Jovanović, Mica B., "Studies on electrochemical oxidation of azithromycin and Hemomycin (R) at gold electrode in neutral electrolyte" in Electrochimica Acta, 51, no. 12 (2006):2407-2416,
https://doi.org/10.1016/j.electacta.2005.07.032 . .
