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dc.creatorTomić, Simonida
dc.creatorSuljovrujić, Edin H.
dc.creatorFilipović, Jovanka M.
dc.date.accessioned2021-03-10T10:34:57Z
dc.date.available2021-03-10T10:34:57Z
dc.date.issued2006
dc.identifier.issn0170-0839
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/961
dc.description.abstractNovel poly(Bisomer/HEMA/IA) hydrogels were prepared by radical copolymerization of poly(alkylene glycol) (meth)acrylates, i.e. short chains Bisomers, 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) in a mixture of water/ethanol as solvent. These hydrogels were characterized in terms of swelling in conditions similar to the biological fluids (pH range 2.20-7.40 buffer solutions), compression-strain measurements, thermal properties and morphology. The influence of the type of Bisomer and of the itaconic acid on swelling and mechanical properties, as well as on morphology and thermal behavior of the resulting hydrogels, were investigated. The in vitro study of biocompatibility, carried out with the hydrogels containing different types of Bisomers, showed no evidence of cell toxicity nor any considerable hemolytic activity. All hydrogels showed satisfactory bioadhesive properties, so these materials have potential as drug carriers or biological glue and sealants.en
dc.publisherSpringer, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/141013/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145072/RS//
dc.rightsrestrictedAccess
dc.sourcePolymer Bulletin
dc.subject2-hydroxyethyl methacrylateen
dc.subjectitaconic aciden
dc.subjectpoly(alkylene glycol) (meth)acrylatesen
dc.subjecthydrogelsen
dc.subjectphysicochemical propertiesen
dc.subjectbiological evaluationen
dc.titleBiocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic aciden
dc.typearticle
dc.rights.licenseARR
dc.citation.epage702
dc.citation.issue5
dc.citation.other57(5): 691-702
dc.citation.rankM22
dc.citation.spage691
dc.citation.volume57
dc.identifier.doi10.1007/s00289-006-0606-3
dc.identifier.rcubconv_2728
dc.identifier.scopus2-s2.0-33747641583
dc.identifier.wos000240019500009
dc.type.versionpublishedVersion


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