The mathematical model of insulin desorption from the bioactive, fibrous artificial store
Abstract
The aim of this study was to study insulin desorption from fibrous insulin artificial store in vitro as well as in vivo, with the intention to define a mathematical model that would describe this process. Release profile of cylindrical fibrous matrixes for various insulin concentrations, desorption temperatures, time periods, and pH were presented. Change of insulin concentration in the fibers and the effect of insulin release were discussed. This model was also used to predict the optimal conditions of the release process. Possibility of predicting the effect of the fibrous store design parameters (fibre radius, amount of bonded insulin, fiber type) on the resulting insulin release rate was the major advantage of this mathematical model. Also, taking all the relevant conditions regarding these experiments into consideration, by the application of mathematical model, the diffusion coefficient during insulin release was determined.
Keywords:
mathematical modeling / desorption / release / polymer / insulin / cation-exchange fibers / in vitroSource:
Journal of Biomedical Materials Research Part A, 2006, 79A, 3, 635-642Publisher:
- Wiley-Liss, Hoboken
DOI: 10.1002/jbm.a.30838
ISSN: 1549-3296
PubMed: 16826597
WoS: 000242134700022
Scopus: 2-s2.0-33751581061
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Medović, Adela AU - Škundrić, Petar AU - Kostić, Mirjana AU - Pajić-Lijaković, Ivana PY - 2006 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/973 AB - The aim of this study was to study insulin desorption from fibrous insulin artificial store in vitro as well as in vivo, with the intention to define a mathematical model that would describe this process. Release profile of cylindrical fibrous matrixes for various insulin concentrations, desorption temperatures, time periods, and pH were presented. Change of insulin concentration in the fibers and the effect of insulin release were discussed. This model was also used to predict the optimal conditions of the release process. Possibility of predicting the effect of the fibrous store design parameters (fibre radius, amount of bonded insulin, fiber type) on the resulting insulin release rate was the major advantage of this mathematical model. Also, taking all the relevant conditions regarding these experiments into consideration, by the application of mathematical model, the diffusion coefficient during insulin release was determined. PB - Wiley-Liss, Hoboken T2 - Journal of Biomedical Materials Research Part A T1 - The mathematical model of insulin desorption from the bioactive, fibrous artificial store EP - 642 IS - 3 SP - 635 VL - 79A DO - 10.1002/jbm.a.30838 ER -
@article{ author = "Medović, Adela and Škundrić, Petar and Kostić, Mirjana and Pajić-Lijaković, Ivana", year = "2006", abstract = "The aim of this study was to study insulin desorption from fibrous insulin artificial store in vitro as well as in vivo, with the intention to define a mathematical model that would describe this process. Release profile of cylindrical fibrous matrixes for various insulin concentrations, desorption temperatures, time periods, and pH were presented. Change of insulin concentration in the fibers and the effect of insulin release were discussed. This model was also used to predict the optimal conditions of the release process. Possibility of predicting the effect of the fibrous store design parameters (fibre radius, amount of bonded insulin, fiber type) on the resulting insulin release rate was the major advantage of this mathematical model. Also, taking all the relevant conditions regarding these experiments into consideration, by the application of mathematical model, the diffusion coefficient during insulin release was determined.", publisher = "Wiley-Liss, Hoboken", journal = "Journal of Biomedical Materials Research Part A", title = "The mathematical model of insulin desorption from the bioactive, fibrous artificial store", pages = "642-635", number = "3", volume = "79A", doi = "10.1002/jbm.a.30838" }
Medović, A., Škundrić, P., Kostić, M.,& Pajić-Lijaković, I.. (2006). The mathematical model of insulin desorption from the bioactive, fibrous artificial store. in Journal of Biomedical Materials Research Part A Wiley-Liss, Hoboken., 79A(3), 635-642. https://doi.org/10.1002/jbm.a.30838
Medović A, Škundrić P, Kostić M, Pajić-Lijaković I. The mathematical model of insulin desorption from the bioactive, fibrous artificial store. in Journal of Biomedical Materials Research Part A. 2006;79A(3):635-642. doi:10.1002/jbm.a.30838 .
Medović, Adela, Škundrić, Petar, Kostić, Mirjana, Pajić-Lijaković, Ivana, "The mathematical model of insulin desorption from the bioactive, fibrous artificial store" in Journal of Biomedical Materials Research Part A, 79A, no. 3 (2006):635-642, https://doi.org/10.1002/jbm.a.30838 . .