TY  - CONF
AU  - Gruden-Movsesijan, Alisa
AU  - Tomić, Sergej
AU  - Ilić, Nataša
AU  - Đokić, Jelena
AU  - Glamočlija, Sofija
AU  - Vasilev, Saša
AU  - Sabljić, Ljiljana
AU  - Stojanović, Dušica
AU  - Miljković, Đorđe
AU  - Dinić, Miroslav
AU  - Radojević, Dušan
AU  - Jevtić, Bojan
AU  - Golić, Nataša
AU  - Uskoković, Petar
AU  - Sofronić-Milosavljević, Ljiljana
AU  - Čolić, Miodrag
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6671
AB  - Trichinella spiralis possess the potential to induce tolerance and restrain excessive immune responses, thus
exerting beneficial effect on the outcome of experimental autoimmune encephalomyelitis (EAE), the animal
model of human disease multiple sclerosis. Trichinella achieves this by continuous release of its excretoysecretory (ES L1) products in the form of a complex mixture of individual components and extracellular vesicles
(TsEVs), preferentially exsosomes. Our previous results suggested that the complex modulation of the host
immune response is achieved by ES L1 products or its individula components, which induce the maturation
of dendritic cells towards tolerogenic status. A new delivery system, based on nanomaterials as carriers of ES
L1, was designed to resemble what happens in nature, ie. spontaneous release of Trichinella products over
an extended period of time using a less invasive route of administration than all previously described for the
treatment of autoimmune diseases. PLGA biodegradable nanofibers loaded with ES L1 (PLGA-ES L1), were
used as subcutaneous implants. The tretment proved to be safe with no side effects, successful in delivering
parasite products and mitigating the course of relapsing/remitting EAE in Dark Agouti rats. The mechanisms
we examined included events at the systemic level and target tissue, spinal cord, that explain the shift from the
pro- to anti-inflammatory responses and success of treatment. PLGA-ES L1 treatment also prevents the EAEinduced disruption of intestinal epithelial barrier. It diminished the inflammation by lowering the expression
of TNF-α in gastrointestinal tract (GIT) and succesfully maintain the expression of mRNA for claudin, the most
important tight junction protein in GIT. Obseved protective effect was acompained with the re-establishment of gut microbiota diversity that was disturbed in EAE-induced animals.
PB  - Belgrade : Serbian Society for Parasitology
C3  - Programme & Abstract Book / 13th European Multicolloquium of Parasitology Belgrade, October 12-16
T1  - New delivery system for Trichinella spiralis antigens - accelerated approach to autoimmunity treatment
SP  - 92
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6671
ER  - 

@conference{
author = "Gruden-Movsesijan, Alisa and Tomić, Sergej and Ilić, Nataša and Đokić, Jelena and Glamočlija, Sofija and Vasilev, Saša and Sabljić, Ljiljana and Stojanović, Dušica and Miljković, Đorđe and Dinić, Miroslav and Radojević, Dušan and Jevtić, Bojan and Golić, Nataša and Uskoković, Petar and Sofronić-Milosavljević, Ljiljana and Čolić, Miodrag",
year = "2021",
abstract = "Trichinella spiralis possess the potential to induce tolerance and restrain excessive immune responses, thus
exerting beneficial effect on the outcome of experimental autoimmune encephalomyelitis (EAE), the animal
model of human disease multiple sclerosis. Trichinella achieves this by continuous release of its excretoysecretory (ES L1) products in the form of a complex mixture of individual components and extracellular vesicles
(TsEVs), preferentially exsosomes. Our previous results suggested that the complex modulation of the host
immune response is achieved by ES L1 products or its individula components, which induce the maturation
of dendritic cells towards tolerogenic status. A new delivery system, based on nanomaterials as carriers of ES
L1, was designed to resemble what happens in nature, ie. spontaneous release of Trichinella products over
an extended period of time using a less invasive route of administration than all previously described for the
treatment of autoimmune diseases. PLGA biodegradable nanofibers loaded with ES L1 (PLGA-ES L1), were
used as subcutaneous implants. The tretment proved to be safe with no side effects, successful in delivering
parasite products and mitigating the course of relapsing/remitting EAE in Dark Agouti rats. The mechanisms
we examined included events at the systemic level and target tissue, spinal cord, that explain the shift from the
pro- to anti-inflammatory responses and success of treatment. PLGA-ES L1 treatment also prevents the EAEinduced disruption of intestinal epithelial barrier. It diminished the inflammation by lowering the expression
of TNF-α in gastrointestinal tract (GIT) and succesfully maintain the expression of mRNA for claudin, the most
important tight junction protein in GIT. Obseved protective effect was acompained with the re-establishment of gut microbiota diversity that was disturbed in EAE-induced animals.",
publisher = "Belgrade : Serbian Society for Parasitology",
journal = "Programme & Abstract Book / 13th European Multicolloquium of Parasitology Belgrade, October 12-16",
title = "New delivery system for Trichinella spiralis antigens - accelerated approach to autoimmunity treatment",
pages = "92",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6671"
}

Gruden-Movsesijan, A., Tomić, S., Ilić, N., Đokić, J., Glamočlija, S., Vasilev, S., Sabljić, L., Stojanović, D., Miljković, Đ., Dinić, M., Radojević, D., Jevtić, B., Golić, N., Uskoković, P., Sofronić-Milosavljević, L.,& Čolić, M.. (2021). New delivery system for Trichinella spiralis antigens - accelerated approach to autoimmunity treatment. in Programme & Abstract Book / 13th European Multicolloquium of Parasitology Belgrade, October 12-16
Belgrade : Serbian Society for Parasitology., 92.
https://hdl.handle.net/21.15107/rcub_technorep_6671

Gruden-Movsesijan A, Tomić S, Ilić N, Đokić J, Glamočlija S, Vasilev S, Sabljić L, Stojanović D, Miljković Đ, Dinić M, Radojević D, Jevtić B, Golić N, Uskoković P, Sofronić-Milosavljević L, Čolić M. New delivery system for Trichinella spiralis antigens - accelerated approach to autoimmunity treatment. in Programme & Abstract Book / 13th European Multicolloquium of Parasitology Belgrade, October 12-16. 2021;:92.
https://hdl.handle.net/21.15107/rcub_technorep_6671 .

Gruden-Movsesijan, Alisa, Tomić, Sergej, Ilić, Nataša, Đokić, Jelena, Glamočlija, Sofija, Vasilev, Saša, Sabljić, Ljiljana, Stojanović, Dušica, Miljković, Đorđe, Dinić, Miroslav, Radojević, Dušan, Jevtić, Bojan, Golić, Nataša, Uskoković, Petar, Sofronić-Milosavljević, Ljiljana, Čolić, Miodrag, "New delivery system for Trichinella spiralis antigens - accelerated approach to autoimmunity treatment" in Programme & Abstract Book / 13th European Multicolloquium of Parasitology Belgrade, October 12-16 (2021):92,
https://hdl.handle.net/21.15107/rcub_technorep_6671 .

TY  - JOUR
AU  - Marinković, Aleksandar
AU  - Nedeljković, Jelena
AU  - Mijin, Dušan
AU  - Ilić, Nataša
AU  - Petrović, Slobodan
PY  - 2011
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1847
AB  - Linear free energy relationships (LFER) were applied to the IR, 1H- and 13C- -NMR spectral data in N-alkyl and N-cycloalkyl cyanoacetamides. N-alkyl and N-cycloalkyl cyanocetamides were synthesized from corresponding amine and ethyl cyanoacetate. A number of substituents were employed for alkyl substitution, and fairly good correlations were obtained, using simple Hammett equation. In N-alkyl and N-cycloalkyl cyanoacetamides substituent cause SCS of N-H hydrogen primarily by steric interaction, polar subtituent effect influences SCS shift of C=O carbon, while steric effect of N-alkyl substituent causes IR stretching frequencies of N-H, C=O and CN group. The conformations of investigated compounds have been studied by the use of semiempirical PM6 method, and together with LFER analysis, give a better insight into the influence of such a structure on the transmission of electronic substituent effects. Negative ρ values for several correlations (reverse substituent effect) were found.
AB  - Principi linearnih korelacija slobodnih energija (LFER) su primenjeni na IR, 1H- i 13C-NMR spektralne podatke N-alkil i N-cikloalkilcijanoacetamida. Širok opseg alkil i cikloalkil suptituenata je korišćen pri sintezi N-alkil i N-cikloalkilcijanoacetamida sa ciljem ispitivanja uticaja njihovih elektronskih i sternih efekata na IR, 1H i 13C NMR spektralne podatke. Zadovoljavajuće korelacije su dobijene primenom proste Hammett-ove jednačine. Na osnovu korelacionih rezultata uočen je primaran uticaj sternih efekata supstituenata na SCS (supstituent indukovana hemijska pomeranja) vrednosti N-H vodonika ispitivanih jedinjenja, što je posledica blizine i različitih konformacija N-alkil i N-cikloalkil supstituenata. Takođe se uočava reversni efekat supstituenata na SCS pomeranja karbonilnog C=O ugljenika, kao posledica π-polarizacije. Indukovani dipol na N-alkil ili N-cikloalkil supstituentu izaziva povećanje elektronske gustine karbonilnog ugljenika iako elektron-akceptorski efekat supstituenta raste. Može se zaključiti da se efekat π-polarizacije odražava na veličinu rezonancionog efekta amidne grupe. Polarni efekat N-alkil ili N-cikloalkil supstituenata se primarno prenosi efektom polja kroz prostor. Uticaj efekata N-alkil ili N-cikloalkil supstituenata na IR vibracije istezanja N-H (simetrične i antisimetrične), C=O i CN veze je prevashodno određen konformacionim (sternim) efektom supstituenata koji utiče na jačinu veze, a time i na položaj trake u odgovarajućem spektru.
PB  - Association of the Chemical Engineers of Serbia
T2  - Chemical Industry & Chemical Engineering Quarterly
T1  - Correlation analysis of IR, 1H- and 13C-NMR spectral data of N-alkyl and N-cycloalkyl cyanoacetamides
T1  - Korelaciona analiza IR, 1H- i 13C-NMR spektalnih podataka N-alkil- i N-cikloalkilcijanoacetamida
EP  - 314
IS  - 3
SP  - 307
VL  - 17
DO  - 10.2298/CICEQ110302016M
ER  - 

@article{
author = "Marinković, Aleksandar and Nedeljković, Jelena and Mijin, Dušan and Ilić, Nataša and Petrović, Slobodan",
year = "2011",
abstract = "Linear free energy relationships (LFER) were applied to the IR, 1H- and 13C- -NMR spectral data in N-alkyl and N-cycloalkyl cyanoacetamides. N-alkyl and N-cycloalkyl cyanocetamides were synthesized from corresponding amine and ethyl cyanoacetate. A number of substituents were employed for alkyl substitution, and fairly good correlations were obtained, using simple Hammett equation. In N-alkyl and N-cycloalkyl cyanoacetamides substituent cause SCS of N-H hydrogen primarily by steric interaction, polar subtituent effect influences SCS shift of C=O carbon, while steric effect of N-alkyl substituent causes IR stretching frequencies of N-H, C=O and CN group. The conformations of investigated compounds have been studied by the use of semiempirical PM6 method, and together with LFER analysis, give a better insight into the influence of such a structure on the transmission of electronic substituent effects. Negative ρ values for several correlations (reverse substituent effect) were found., Principi linearnih korelacija slobodnih energija (LFER) su primenjeni na IR, 1H- i 13C-NMR spektralne podatke N-alkil i N-cikloalkilcijanoacetamida. Širok opseg alkil i cikloalkil suptituenata je korišćen pri sintezi N-alkil i N-cikloalkilcijanoacetamida sa ciljem ispitivanja uticaja njihovih elektronskih i sternih efekata na IR, 1H i 13C NMR spektralne podatke. Zadovoljavajuće korelacije su dobijene primenom proste Hammett-ove jednačine. Na osnovu korelacionih rezultata uočen je primaran uticaj sternih efekata supstituenata na SCS (supstituent indukovana hemijska pomeranja) vrednosti N-H vodonika ispitivanih jedinjenja, što je posledica blizine i različitih konformacija N-alkil i N-cikloalkil supstituenata. Takođe se uočava reversni efekat supstituenata na SCS pomeranja karbonilnog C=O ugljenika, kao posledica π-polarizacije. Indukovani dipol na N-alkil ili N-cikloalkil supstituentu izaziva povećanje elektronske gustine karbonilnog ugljenika iako elektron-akceptorski efekat supstituenta raste. Može se zaključiti da se efekat π-polarizacije odražava na veličinu rezonancionog efekta amidne grupe. Polarni efekat N-alkil ili N-cikloalkil supstituenata se primarno prenosi efektom polja kroz prostor. Uticaj efekata N-alkil ili N-cikloalkil supstituenata na IR vibracije istezanja N-H (simetrične i antisimetrične), C=O i CN veze je prevashodno određen konformacionim (sternim) efektom supstituenata koji utiče na jačinu veze, a time i na položaj trake u odgovarajućem spektru.",
publisher = "Association of the Chemical Engineers of Serbia",
journal = "Chemical Industry & Chemical Engineering Quarterly",
title = "Correlation analysis of IR, 1H- and 13C-NMR spectral data of N-alkyl and N-cycloalkyl cyanoacetamides, Korelaciona analiza IR, 1H- i 13C-NMR spektalnih podataka N-alkil- i N-cikloalkilcijanoacetamida",
pages = "314-307",
number = "3",
volume = "17",
doi = "10.2298/CICEQ110302016M"
}

Marinković, A., Nedeljković, J., Mijin, D., Ilić, N.,& Petrović, S.. (2011). Correlation analysis of IR, 1H- and 13C-NMR spectral data of N-alkyl and N-cycloalkyl cyanoacetamides. in Chemical Industry & Chemical Engineering Quarterly
Association of the Chemical Engineers of Serbia., 17(3), 307-314.
https://doi.org/10.2298/CICEQ110302016M

Marinković A, Nedeljković J, Mijin D, Ilić N, Petrović S. Correlation analysis of IR, 1H- and 13C-NMR spectral data of N-alkyl and N-cycloalkyl cyanoacetamides. in Chemical Industry & Chemical Engineering Quarterly. 2011;17(3):307-314.
doi:10.2298/CICEQ110302016M .

Marinković, Aleksandar, Nedeljković, Jelena, Mijin, Dušan, Ilić, Nataša, Petrović, Slobodan, "Correlation analysis of IR, 1H- and 13C-NMR spectral data of N-alkyl and N-cycloalkyl cyanoacetamides" in Chemical Industry & Chemical Engineering Quarterly, 17, no. 3 (2011):307-314,
https://doi.org/10.2298/CICEQ110302016M . .

TY  - JOUR
AU  - Ilić, Nataša
AU  - Marinković, Aleksandar
AU  - Brković, Danijela V.
AU  - Petrović, Slobodan
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1659
AB  - Phencyclidine (PCP) or 1-phenyl-cyclohexylpiperidine is the best-known representative drug from the compound class of arylcyclohexylamines. On a pharmacological activities basis, it belongs to the family of drugs known as dissociative anesthetics. In recent years, great attention has been paid to the investigation of substances that have been abused, including PCP. PCP is a synthetic drug with stimulating and hallucinogenic effects (street name 'angel dust'), and it is included in the Schedule Substances List in Serbia and worldwide. In the beginning, PCP has been sold in pharmacies as a local anesthetic, but very quickly it was withdrawn from sale because of unwanted effects on consumer health causing psychoactive addiction. Taking into account that great attention is being given nowadays to substances that are subject of abuse, biological and pharmacological effects of PCP and its derivative, which depend on their structure and methods for synthesis, is described in this paper. It is shown that PCP is antagonist of N-methyl-D-aspartate (NMDA) and that it causes antiglutamatergic hallucinations, unlike BTCP whose agonist is an NMDA receptor and is obtained by modifying the structure of PCP. This paper presents a PCP metabolism and provides an overview of the methods for their identification and quantification in biological samples. Immunological tests of PCP in biological samples can provide a quick but wrong result because of the possible interference with the other substances of abuse as opposed to instrumental methods. Based on the presented method and the results it was concluded that the method of choice for the examinations of biological samples for the presence of PCP is gas chromatography in combination with mass spectroscopy.
AB  - Fenciklidin (PCP) ili 1-fenil-cikloheksilpiperidin spada u klasu arilcikloheksilaminskih derivata i po svojoj farmakološkoj aktivnosti pripada familiji disocijativnih anestetika. PCP je sintetička droga sa stimulativnim i halucinogenim dejstvom, koja se prvobitno pojavila u apotekama kao lokalni anestetik, ali je vrlo brzo povučena iz prodaje zbog neželjenih efekata po zdravlje njenih konzumenata i postala je predmet zloupotrebe. S obzirom da se danas velika pažnja poklanja supstancama koja su predmet zloupotrebe, u ovom radu je opisano biološko i farmakološko dejstvo PCP i njegovih derivata u zavisnosti od njihove strukture, kao i metode za dobijanje istog. Pokazano je da je PCP antagonist N-metil-D-aspartat (NMDA) receptora, koji blokira aktivnost NMDA receptora te dovodi do antiglutamatergičnih halucinacija. U radu je prikazan metabolizam PCP kao i pregled metoda za njegovo dokazivanje i kvantifikaciju u biološkim uzorcima jer se nalazi na tzv. Listi supstanci pod kontrolom. Na osnovu rezultata koja su dobijena kvalitativnim i kvantitativnim ispitivanjem PCP u biološkim uzorcima može se zaključiti da su hromatografske i spektrografske metoda najosetljivije za razdvajanje i detekciju PCP.
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - Synthesis and characterization of phencyclidine and its derivatives
T1  - Sinteza i karakterizacija fenciklidina i njegovih derivata
EP  - 400
IS  - 5
SP  - 389
VL  - 64
DO  - 10.2298/HEMIND100523050I
ER  - 

@article{
author = "Ilić, Nataša and Marinković, Aleksandar and Brković, Danijela V. and Petrović, Slobodan",
year = "2010",
abstract = "Phencyclidine (PCP) or 1-phenyl-cyclohexylpiperidine is the best-known representative drug from the compound class of arylcyclohexylamines. On a pharmacological activities basis, it belongs to the family of drugs known as dissociative anesthetics. In recent years, great attention has been paid to the investigation of substances that have been abused, including PCP. PCP is a synthetic drug with stimulating and hallucinogenic effects (street name 'angel dust'), and it is included in the Schedule Substances List in Serbia and worldwide. In the beginning, PCP has been sold in pharmacies as a local anesthetic, but very quickly it was withdrawn from sale because of unwanted effects on consumer health causing psychoactive addiction. Taking into account that great attention is being given nowadays to substances that are subject of abuse, biological and pharmacological effects of PCP and its derivative, which depend on their structure and methods for synthesis, is described in this paper. It is shown that PCP is antagonist of N-methyl-D-aspartate (NMDA) and that it causes antiglutamatergic hallucinations, unlike BTCP whose agonist is an NMDA receptor and is obtained by modifying the structure of PCP. This paper presents a PCP metabolism and provides an overview of the methods for their identification and quantification in biological samples. Immunological tests of PCP in biological samples can provide a quick but wrong result because of the possible interference with the other substances of abuse as opposed to instrumental methods. Based on the presented method and the results it was concluded that the method of choice for the examinations of biological samples for the presence of PCP is gas chromatography in combination with mass spectroscopy., Fenciklidin (PCP) ili 1-fenil-cikloheksilpiperidin spada u klasu arilcikloheksilaminskih derivata i po svojoj farmakološkoj aktivnosti pripada familiji disocijativnih anestetika. PCP je sintetička droga sa stimulativnim i halucinogenim dejstvom, koja se prvobitno pojavila u apotekama kao lokalni anestetik, ali je vrlo brzo povučena iz prodaje zbog neželjenih efekata po zdravlje njenih konzumenata i postala je predmet zloupotrebe. S obzirom da se danas velika pažnja poklanja supstancama koja su predmet zloupotrebe, u ovom radu je opisano biološko i farmakološko dejstvo PCP i njegovih derivata u zavisnosti od njihove strukture, kao i metode za dobijanje istog. Pokazano je da je PCP antagonist N-metil-D-aspartat (NMDA) receptora, koji blokira aktivnost NMDA receptora te dovodi do antiglutamatergičnih halucinacija. U radu je prikazan metabolizam PCP kao i pregled metoda za njegovo dokazivanje i kvantifikaciju u biološkim uzorcima jer se nalazi na tzv. Listi supstanci pod kontrolom. Na osnovu rezultata koja su dobijena kvalitativnim i kvantitativnim ispitivanjem PCP u biološkim uzorcima može se zaključiti da su hromatografske i spektrografske metoda najosetljivije za razdvajanje i detekciju PCP.",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Synthesis and characterization of phencyclidine and its derivatives, Sinteza i karakterizacija fenciklidina i njegovih derivata",
pages = "400-389",
number = "5",
volume = "64",
doi = "10.2298/HEMIND100523050I"
}

Ilić, N., Marinković, A., Brković, D. V.,& Petrović, S.. (2010). Synthesis and characterization of phencyclidine and its derivatives. in Hemijska industrija
Association of Chemical Engineers of Serbia., 64(5), 389-400.
https://doi.org/10.2298/HEMIND100523050I

Ilić N, Marinković A, Brković DV, Petrović S. Synthesis and characterization of phencyclidine and its derivatives. in Hemijska industrija. 2010;64(5):389-400.
doi:10.2298/HEMIND100523050I .

Ilić, Nataša, Marinković, Aleksandar, Brković, Danijela V., Petrović, Slobodan, "Synthesis and characterization of phencyclidine and its derivatives" in Hemijska industrija, 64, no. 5 (2010):389-400,
https://doi.org/10.2298/HEMIND100523050I . .

TY  - JOUR
AU  - Ilić, Nataša
AU  - Marinković, Aleksandar
AU  - Mijin, Dušan
AU  - Nevešćanin, Marina
AU  - Petrović, Slobodan
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1662
AB  - The electron-ionization induced mass spectra of twenty six N-monosubstituted cyanoacetamides were recorded and their fragmentation patterns were studied. The effect of N-alkyl and N-aryl substituents to the fragmentation of the investigated compounds was discussed. Mechanistic generalization lead to a conclusion that fission of the carbon-carbon bonds next to carbonyl function or nitrogen were processes common for N-alkyl and N-(4-substituted phenyl) cyanoacetamides. In some amides, the elimination of the acyl group by a ketene fragment gave rise to the more stable ion. Cycloalkyl amides could not fragment by single carbon-carbon bond fission, but subsequent rearrangement resulted in formation of stable even electron ion. N-(4-substituted phenyl) cyanoacetamides were more stable showing also characteristic fragmentation depending on substituent present at phenyl ring.
AB  - U ovom radu su proučavani fragmentacioni putevi dvadeset šest N-monosupstituisanih cijanoacetamida dobijenih jonizacijom izazvanom bombardovanjem elektronima. Na osnovu definisanih fragmentacionih puteva diskutovan je uticaj prisutnih N-alkil i N-aril supstituenata. Sagledavanjem mehanizama fragmentacija ispitivanih N-monosupstituisanih cijanoacetamida uočava se da je cepanje veze ugljenik-ugljenik susedne karbonilnoj grupi ili azotu proces uočen i kod N-alkil i N-(4-supstituisanih fenil) cijanoacetamida. Kod nekih amida, eliminacija acil grupe u vidu fragmenta ketena dovodi do nastajanju stabilnijih jona. Cikloalkil amidi ne mogu da se fragmentišu samo cepanjem veze ugljenik-ugljenik, već u narednom koraku pregradnje daju stabilnije parne jone. N-(4-supstituisani fenil) cijanoacetamidi se stabilni u primenjenim jonizacionim uslovima i pokazuju karakteristične fragmentcije na koje utiče prisutni supstituent na fenilnom jezgru.
PB  - Association of the Chemical Engineers of Serbia
T2  - Chemical Industry & Chemical Engineering Quarterly
T1  - EI/MS/MS spectra of N-monosubstituted cyanoacetamides
T1  - EI/MS/MS spektri N-monosupstituisanih cijanoacetamida
EP  - 397
IS  - 4
SP  - 387
VL  - 16
DO  - 10.2298/CICEQ100421042I
ER  - 

@article{
author = "Ilić, Nataša and Marinković, Aleksandar and Mijin, Dušan and Nevešćanin, Marina and Petrović, Slobodan",
year = "2010",
abstract = "The electron-ionization induced mass spectra of twenty six N-monosubstituted cyanoacetamides were recorded and their fragmentation patterns were studied. The effect of N-alkyl and N-aryl substituents to the fragmentation of the investigated compounds was discussed. Mechanistic generalization lead to a conclusion that fission of the carbon-carbon bonds next to carbonyl function or nitrogen were processes common for N-alkyl and N-(4-substituted phenyl) cyanoacetamides. In some amides, the elimination of the acyl group by a ketene fragment gave rise to the more stable ion. Cycloalkyl amides could not fragment by single carbon-carbon bond fission, but subsequent rearrangement resulted in formation of stable even electron ion. N-(4-substituted phenyl) cyanoacetamides were more stable showing also characteristic fragmentation depending on substituent present at phenyl ring., U ovom radu su proučavani fragmentacioni putevi dvadeset šest N-monosupstituisanih cijanoacetamida dobijenih jonizacijom izazvanom bombardovanjem elektronima. Na osnovu definisanih fragmentacionih puteva diskutovan je uticaj prisutnih N-alkil i N-aril supstituenata. Sagledavanjem mehanizama fragmentacija ispitivanih N-monosupstituisanih cijanoacetamida uočava se da je cepanje veze ugljenik-ugljenik susedne karbonilnoj grupi ili azotu proces uočen i kod N-alkil i N-(4-supstituisanih fenil) cijanoacetamida. Kod nekih amida, eliminacija acil grupe u vidu fragmenta ketena dovodi do nastajanju stabilnijih jona. Cikloalkil amidi ne mogu da se fragmentišu samo cepanjem veze ugljenik-ugljenik, već u narednom koraku pregradnje daju stabilnije parne jone. N-(4-supstituisani fenil) cijanoacetamidi se stabilni u primenjenim jonizacionim uslovima i pokazuju karakteristične fragmentcije na koje utiče prisutni supstituent na fenilnom jezgru.",
publisher = "Association of the Chemical Engineers of Serbia",
journal = "Chemical Industry & Chemical Engineering Quarterly",
title = "EI/MS/MS spectra of N-monosubstituted cyanoacetamides, EI/MS/MS spektri N-monosupstituisanih cijanoacetamida",
pages = "397-387",
number = "4",
volume = "16",
doi = "10.2298/CICEQ100421042I"
}

Ilić, N., Marinković, A., Mijin, D., Nevešćanin, M.,& Petrović, S.. (2010). EI/MS/MS spectra of N-monosubstituted cyanoacetamides. in Chemical Industry & Chemical Engineering Quarterly
Association of the Chemical Engineers of Serbia., 16(4), 387-397.
https://doi.org/10.2298/CICEQ100421042I

Ilić N, Marinković A, Mijin D, Nevešćanin M, Petrović S. EI/MS/MS spectra of N-monosubstituted cyanoacetamides. in Chemical Industry & Chemical Engineering Quarterly. 2010;16(4):387-397.
doi:10.2298/CICEQ100421042I .

Ilić, Nataša, Marinković, Aleksandar, Mijin, Dušan, Nevešćanin, Marina, Petrović, Slobodan, "EI/MS/MS spectra of N-monosubstituted cyanoacetamides" in Chemical Industry & Chemical Engineering Quarterly, 16, no. 4 (2010):387-397,
https://doi.org/10.2298/CICEQ100421042I . .

TY  - JOUR
AU  - Marinković, Aleksandar
AU  - Perić-Grujić, Aleksandra
AU  - Jovanović, Bratislav Ž.
AU  - Ilić, Nataša
AU  - Nevešćanin, Marina
PY  - 2006
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/960
PB  - John Wiley & Sons Ltd, Chichester
T2  - Rapid Communications in Mass Spectrometry
T1  - Electron ionization tandem mass spectra of some 3-cyano-4-substituted phenyl-6-phenyl-2(1H)-pyridones
EP  - 2633
IS  - 17
SP  - 2630
VL  - 20
DO  - 10.1002/rcm.2630
ER  - 

@article{
author = "Marinković, Aleksandar and Perić-Grujić, Aleksandra and Jovanović, Bratislav Ž. and Ilić, Nataša and Nevešćanin, Marina",
year = "2006",
publisher = "John Wiley & Sons Ltd, Chichester",
journal = "Rapid Communications in Mass Spectrometry",
title = "Electron ionization tandem mass spectra of some 3-cyano-4-substituted phenyl-6-phenyl-2(1H)-pyridones",
pages = "2633-2630",
number = "17",
volume = "20",
doi = "10.1002/rcm.2630"
}

Marinković, A., Perić-Grujić, A., Jovanović, B. Ž., Ilić, N.,& Nevešćanin, M.. (2006). Electron ionization tandem mass spectra of some 3-cyano-4-substituted phenyl-6-phenyl-2(1H)-pyridones. in Rapid Communications in Mass Spectrometry
John Wiley & Sons Ltd, Chichester., 20(17), 2630-2633.
https://doi.org/10.1002/rcm.2630

Marinković A, Perić-Grujić A, Jovanović BŽ, Ilić N, Nevešćanin M. Electron ionization tandem mass spectra of some 3-cyano-4-substituted phenyl-6-phenyl-2(1H)-pyridones. in Rapid Communications in Mass Spectrometry. 2006;20(17):2630-2633.
doi:10.1002/rcm.2630 .

Marinković, Aleksandar, Perić-Grujić, Aleksandra, Jovanović, Bratislav Ž., Ilić, Nataša, Nevešćanin, Marina, "Electron ionization tandem mass spectra of some 3-cyano-4-substituted phenyl-6-phenyl-2(1H)-pyridones" in Rapid Communications in Mass Spectrometry, 20, no. 17 (2006):2630-2633,
https://doi.org/10.1002/rcm.2630 . .