TY  - CONF
AU  - Gruden-Movsesijan, Alisa
AU  - Tomić, Sergej
AU  - Ilić, Nataša
AU  - Đokić, Jelena
AU  - Glamočlija, Sofija
AU  - Vasilev, Saša
AU  - Sabljić, Ljiljana
AU  - Stojanović, Dušica
AU  - Miljković, Đorđe
AU  - Dinić, Miroslav
AU  - Radojević, Dušan
AU  - Jevtić, Bojan
AU  - Golić, Nataša
AU  - Uskoković, Petar
AU  - Sofronić-Milosavljević, Ljiljana
AU  - Čolić, Miodrag
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6671
AB  - Trichinella spiralis possess the potential to induce tolerance and restrain excessive immune responses, thus
exerting beneficial effect on the outcome of experimental autoimmune encephalomyelitis (EAE), the animal
model of human disease multiple sclerosis. Trichinella achieves this by continuous release of its excretoysecretory (ES L1) products in the form of a complex mixture of individual components and extracellular vesicles
(TsEVs), preferentially exsosomes. Our previous results suggested that the complex modulation of the host
immune response is achieved by ES L1 products or its individula components, which induce the maturation
of dendritic cells towards tolerogenic status. A new delivery system, based on nanomaterials as carriers of ES
L1, was designed to resemble what happens in nature, ie. spontaneous release of Trichinella products over
an extended period of time using a less invasive route of administration than all previously described for the
treatment of autoimmune diseases. PLGA biodegradable nanofibers loaded with ES L1 (PLGA-ES L1), were
used as subcutaneous implants. The tretment proved to be safe with no side effects, successful in delivering
parasite products and mitigating the course of relapsing/remitting EAE in Dark Agouti rats. The mechanisms
we examined included events at the systemic level and target tissue, spinal cord, that explain the shift from the
pro- to anti-inflammatory responses and success of treatment. PLGA-ES L1 treatment also prevents the EAEinduced disruption of intestinal epithelial barrier. It diminished the inflammation by lowering the expression
of TNF-α in gastrointestinal tract (GIT) and succesfully maintain the expression of mRNA for claudin, the most
important tight junction protein in GIT. Obseved protective effect was acompained with the re-establishment of gut microbiota diversity that was disturbed in EAE-induced animals.
PB  - Belgrade : Serbian Society for Parasitology
C3  - Programme & Abstract Book / 13th European Multicolloquium of Parasitology Belgrade, October 12-16
T1  - New delivery system for Trichinella spiralis antigens - accelerated approach to autoimmunity treatment
SP  - 92
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6671
ER  - 

@conference{
author = "Gruden-Movsesijan, Alisa and Tomić, Sergej and Ilić, Nataša and Đokić, Jelena and Glamočlija, Sofija and Vasilev, Saša and Sabljić, Ljiljana and Stojanović, Dušica and Miljković, Đorđe and Dinić, Miroslav and Radojević, Dušan and Jevtić, Bojan and Golić, Nataša and Uskoković, Petar and Sofronić-Milosavljević, Ljiljana and Čolić, Miodrag",
year = "2021",
abstract = "Trichinella spiralis possess the potential to induce tolerance and restrain excessive immune responses, thus
exerting beneficial effect on the outcome of experimental autoimmune encephalomyelitis (EAE), the animal
model of human disease multiple sclerosis. Trichinella achieves this by continuous release of its excretoysecretory (ES L1) products in the form of a complex mixture of individual components and extracellular vesicles
(TsEVs), preferentially exsosomes. Our previous results suggested that the complex modulation of the host
immune response is achieved by ES L1 products or its individula components, which induce the maturation
of dendritic cells towards tolerogenic status. A new delivery system, based on nanomaterials as carriers of ES
L1, was designed to resemble what happens in nature, ie. spontaneous release of Trichinella products over
an extended period of time using a less invasive route of administration than all previously described for the
treatment of autoimmune diseases. PLGA biodegradable nanofibers loaded with ES L1 (PLGA-ES L1), were
used as subcutaneous implants. The tretment proved to be safe with no side effects, successful in delivering
parasite products and mitigating the course of relapsing/remitting EAE in Dark Agouti rats. The mechanisms
we examined included events at the systemic level and target tissue, spinal cord, that explain the shift from the
pro- to anti-inflammatory responses and success of treatment. PLGA-ES L1 treatment also prevents the EAEinduced disruption of intestinal epithelial barrier. It diminished the inflammation by lowering the expression
of TNF-α in gastrointestinal tract (GIT) and succesfully maintain the expression of mRNA for claudin, the most
important tight junction protein in GIT. Obseved protective effect was acompained with the re-establishment of gut microbiota diversity that was disturbed in EAE-induced animals.",
publisher = "Belgrade : Serbian Society for Parasitology",
journal = "Programme & Abstract Book / 13th European Multicolloquium of Parasitology Belgrade, October 12-16",
title = "New delivery system for Trichinella spiralis antigens - accelerated approach to autoimmunity treatment",
pages = "92",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6671"
}

Gruden-Movsesijan, A., Tomić, S., Ilić, N., Đokić, J., Glamočlija, S., Vasilev, S., Sabljić, L., Stojanović, D., Miljković, Đ., Dinić, M., Radojević, D., Jevtić, B., Golić, N., Uskoković, P., Sofronić-Milosavljević, L.,& Čolić, M.. (2021). New delivery system for Trichinella spiralis antigens - accelerated approach to autoimmunity treatment. in Programme & Abstract Book / 13th European Multicolloquium of Parasitology Belgrade, October 12-16
Belgrade : Serbian Society for Parasitology., 92.
https://hdl.handle.net/21.15107/rcub_technorep_6671

Gruden-Movsesijan A, Tomić S, Ilić N, Đokić J, Glamočlija S, Vasilev S, Sabljić L, Stojanović D, Miljković Đ, Dinić M, Radojević D, Jevtić B, Golić N, Uskoković P, Sofronić-Milosavljević L, Čolić M. New delivery system for Trichinella spiralis antigens - accelerated approach to autoimmunity treatment. in Programme & Abstract Book / 13th European Multicolloquium of Parasitology Belgrade, October 12-16. 2021;:92.
https://hdl.handle.net/21.15107/rcub_technorep_6671 .

Gruden-Movsesijan, Alisa, Tomić, Sergej, Ilić, Nataša, Đokić, Jelena, Glamočlija, Sofija, Vasilev, Saša, Sabljić, Ljiljana, Stojanović, Dušica, Miljković, Đorđe, Dinić, Miroslav, Radojević, Dušan, Jevtić, Bojan, Golić, Nataša, Uskoković, Petar, Sofronić-Milosavljević, Ljiljana, Čolić, Miodrag, "New delivery system for Trichinella spiralis antigens - accelerated approach to autoimmunity treatment" in Programme & Abstract Book / 13th European Multicolloquium of Parasitology Belgrade, October 12-16 (2021):92,
https://hdl.handle.net/21.15107/rcub_technorep_6671 .

TY  - JOUR
AU  - Jevtić, Sanja
AU  - Jevtić, Bojan
AU  - Rajić, Nevenka
PY  - 2016
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5084
AB  - U radu su ispitana adsorpciona svojstva letećeg pepela sa deponije termoelektrane „Moravaˮ, u 
odnosu na fosfat-jone prisutne u vodenoj sredini. Pepeo iz ove termoelektrane pokazuje dobra 
adsorpciona svojstva i mogao bi da se primeni za uklanjanje fosfata. Efikasnost adsorpcije raste sa povećanjem početne koncentracije fosfata, temperature i vremena kontakta. Adsorpcija se odigrava po principu hemisorpcije pri čemu dolazi do obrazovanja kalcijum-hidrogenfosfata-dihidrata za koji je rendgenskom difrakcijom praha utvrđeno da odgovara brušitu. Kinetika adsorpcije prati Lagergrenov model pseudo-drugog reda. Kiselo-bazna obrada pepela dovodi do promene fizičko-hemijskih svojstava što ima za posledicu smanjenje adsorpcionog kapaciteta pepela.
AB  - The paper studied the adsorption properties of the fly ash from the landfill of thermal power plant 
“Morava” towards phosphate ions present in aqueous medium. The ash shows good adsorption properties and could be used for removal of phosphate ions. Adsorption efficiency increases with increasing initial phosphate concentration, temperature and contact time. Adsorption takes place by chemisorption and formation of calcium hydrogen phosphate dihydrate for which a powder X-ray diffraction analysis shows that it belongs to brushite. Adsorption kinetics follows the Lagergren's pseudo-second order kinetic model. An acid-base treatment of the ash leads to changes of physical-chemical properties resulting in a decrease of the adsorption capacity of the ash.
PB  - Naučno-stručno društvo za zaštitu životne sredine Srbije
T2  - Ecologica
T1  - Ispitivanje adsorpcionih svojstava elektrofilterskog pepela sa deponije termoelektrane „Moravaˮ u odnosu na fosfat-jone prisutne u vodenom rastvoru
EP  - 559
SP  - 555
VL  - 83
UR  - https://hdl.handle.net/21.15107/rcub_technorep_5084
ER  - 

@article{
author = "Jevtić, Sanja and Jevtić, Bojan and Rajić, Nevenka",
year = "2016",
abstract = "U radu su ispitana adsorpciona svojstva letećeg pepela sa deponije termoelektrane „Moravaˮ, u 
odnosu na fosfat-jone prisutne u vodenoj sredini. Pepeo iz ove termoelektrane pokazuje dobra 
adsorpciona svojstva i mogao bi da se primeni za uklanjanje fosfata. Efikasnost adsorpcije raste sa povećanjem početne koncentracije fosfata, temperature i vremena kontakta. Adsorpcija se odigrava po principu hemisorpcije pri čemu dolazi do obrazovanja kalcijum-hidrogenfosfata-dihidrata za koji je rendgenskom difrakcijom praha utvrđeno da odgovara brušitu. Kinetika adsorpcije prati Lagergrenov model pseudo-drugog reda. Kiselo-bazna obrada pepela dovodi do promene fizičko-hemijskih svojstava što ima za posledicu smanjenje adsorpcionog kapaciteta pepela., The paper studied the adsorption properties of the fly ash from the landfill of thermal power plant 
“Morava” towards phosphate ions present in aqueous medium. The ash shows good adsorption properties and could be used for removal of phosphate ions. Adsorption efficiency increases with increasing initial phosphate concentration, temperature and contact time. Adsorption takes place by chemisorption and formation of calcium hydrogen phosphate dihydrate for which a powder X-ray diffraction analysis shows that it belongs to brushite. Adsorption kinetics follows the Lagergren's pseudo-second order kinetic model. An acid-base treatment of the ash leads to changes of physical-chemical properties resulting in a decrease of the adsorption capacity of the ash.",
publisher = "Naučno-stručno društvo za zaštitu životne sredine Srbije",
journal = "Ecologica",
title = "Ispitivanje adsorpcionih svojstava elektrofilterskog pepela sa deponije termoelektrane „Moravaˮ u odnosu na fosfat-jone prisutne u vodenom rastvoru",
pages = "559-555",
volume = "83",
url = "https://hdl.handle.net/21.15107/rcub_technorep_5084"
}

Jevtić, S., Jevtić, B.,& Rajić, N.. (2016). Ispitivanje adsorpcionih svojstava elektrofilterskog pepela sa deponije termoelektrane „Moravaˮ u odnosu na fosfat-jone prisutne u vodenom rastvoru. in Ecologica
Naučno-stručno društvo za zaštitu životne sredine Srbije., 83, 555-559.
https://hdl.handle.net/21.15107/rcub_technorep_5084

Jevtić S, Jevtić B, Rajić N. Ispitivanje adsorpcionih svojstava elektrofilterskog pepela sa deponije termoelektrane „Moravaˮ u odnosu na fosfat-jone prisutne u vodenom rastvoru. in Ecologica. 2016;83:555-559.
https://hdl.handle.net/21.15107/rcub_technorep_5084 .

Jevtić, Sanja, Jevtić, Bojan, Rajić, Nevenka, "Ispitivanje adsorpcionih svojstava elektrofilterskog pepela sa deponije termoelektrane „Moravaˮ u odnosu na fosfat-jone prisutne u vodenom rastvoru" in Ecologica, 83 (2016):555-559,
https://hdl.handle.net/21.15107/rcub_technorep_5084 .