Lukić, Miodrag J.

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orcid::0000-0002-4981-9776
  • Lukić, Miodrag J. (3)
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Author's Bibliography

Mg/Cu co-substituted hydroxyapatite - Biocompatibility, mechanical properties and antimicrobial activity

Veljović, Đorđe; Matić, Tamara; Stamenić, Tanja; Kojić, Vesna; Dimitrijević-Branković, Suzana; Lukić, Miodrag J.; Jevtić, Sanja; Radovanović, Željko; Petrović, Rada; Janaćković, Đorđe

(Elsevier Sci Ltd, Oxford, 2019)

TY  - JOUR
AU  - Veljović, Đorđe
AU  - Matić, Tamara
AU  - Stamenić, Tanja
AU  - Kojić, Vesna
AU  - Dimitrijević-Branković, Suzana
AU  - Lukić, Miodrag J.
AU  - Jevtić, Sanja
AU  - Radovanović, Željko
AU  - Petrović, Rada
AU  - Janaćković, Đorđe
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4126
AB  - The aim of this study was to improve the mechanical properties and to optimize antimicrobial activity of hydroxyapatite (HAP) by simultaneous doping with Mg and Cu ions in order to obtain material that would be able to assist in the bone/tooth healing process, prevent post-implementation infections and provide satisfying values of hardness and fracture toughness for biomedical application. Ion doping was done during the hydrothermal synthesis of HAP powders, whereby the content of Mg ions in the starting solution was varied between 1-20 mol. % with regard to Ca ions, while the amount of Cu ions was kept constant at 0.4 mol. %. The green compacts were sintered for 2 h at temperatures ranging 750-1200 degrees C depending on the Mg content, chosen in agreement with dilatometry results. Presence of Mg ions was found to favour transition from HAP to beta-tricalcium phosphate phase (beta-TCP), which enabled formation of biphasic HAP/beta-TCP and pure beta-TCP phase at 160 degrees C during hydrothermal synthesis. In vitro investigation of antimicrobial activity against Escherichia coli, Staphylococcus aureus and Enterococcus faecalis showed satisfactory antimicrobial activity. MTT assay performed on MRC-5 and L929 cell lines showed excellent cytocompatibility and cell proliferation. Maximum hardness by Vickers and fracture toughness values, 4.96 GPa and 1.75 MPa m(1/2) respectively, were obtained upon addition of 5 mol. % Mg, as a consequence of the lowest grain size and porosity, as well as the highest densification rate. This is, to the best of our knowledge, the highest fracture toughness for HAP or beta-TCP ceramics reported thus far.
PB  - Elsevier Sci Ltd, Oxford
T2  - Ceramics International
T1  - Mg/Cu co-substituted hydroxyapatite - Biocompatibility, mechanical properties and antimicrobial activity
EP  - 22039
IS  - 17
SP  - 22029
VL  - 45
DO  - 10.1016/j.ceramint.2019.07.219
ER  - 
@article{
author = "Veljović, Đorđe and Matić, Tamara and Stamenić, Tanja and Kojić, Vesna and Dimitrijević-Branković, Suzana and Lukić, Miodrag J. and Jevtić, Sanja and Radovanović, Željko and Petrović, Rada and Janaćković, Đorđe",
year = "2019",
abstract = "The aim of this study was to improve the mechanical properties and to optimize antimicrobial activity of hydroxyapatite (HAP) by simultaneous doping with Mg and Cu ions in order to obtain material that would be able to assist in the bone/tooth healing process, prevent post-implementation infections and provide satisfying values of hardness and fracture toughness for biomedical application. Ion doping was done during the hydrothermal synthesis of HAP powders, whereby the content of Mg ions in the starting solution was varied between 1-20 mol. % with regard to Ca ions, while the amount of Cu ions was kept constant at 0.4 mol. %. The green compacts were sintered for 2 h at temperatures ranging 750-1200 degrees C depending on the Mg content, chosen in agreement with dilatometry results. Presence of Mg ions was found to favour transition from HAP to beta-tricalcium phosphate phase (beta-TCP), which enabled formation of biphasic HAP/beta-TCP and pure beta-TCP phase at 160 degrees C during hydrothermal synthesis. In vitro investigation of antimicrobial activity against Escherichia coli, Staphylococcus aureus and Enterococcus faecalis showed satisfactory antimicrobial activity. MTT assay performed on MRC-5 and L929 cell lines showed excellent cytocompatibility and cell proliferation. Maximum hardness by Vickers and fracture toughness values, 4.96 GPa and 1.75 MPa m(1/2) respectively, were obtained upon addition of 5 mol. % Mg, as a consequence of the lowest grain size and porosity, as well as the highest densification rate. This is, to the best of our knowledge, the highest fracture toughness for HAP or beta-TCP ceramics reported thus far.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Ceramics International",
title = "Mg/Cu co-substituted hydroxyapatite - Biocompatibility, mechanical properties and antimicrobial activity",
pages = "22039-22029",
number = "17",
volume = "45",
doi = "10.1016/j.ceramint.2019.07.219"
}
Veljović, Đ., Matić, T., Stamenić, T., Kojić, V., Dimitrijević-Branković, S., Lukić, M. J., Jevtić, S., Radovanović, Ž., Petrović, R.,& Janaćković, Đ.. (2019). Mg/Cu co-substituted hydroxyapatite - Biocompatibility, mechanical properties and antimicrobial activity. in Ceramics International
Elsevier Sci Ltd, Oxford., 45(17), 22029-22039.
https://doi.org/10.1016/j.ceramint.2019.07.219
Veljović Đ, Matić T, Stamenić T, Kojić V, Dimitrijević-Branković S, Lukić MJ, Jevtić S, Radovanović Ž, Petrović R, Janaćković Đ. Mg/Cu co-substituted hydroxyapatite - Biocompatibility, mechanical properties and antimicrobial activity. in Ceramics International. 2019;45(17):22029-22039.
doi:10.1016/j.ceramint.2019.07.219 .
Veljović, Đorđe, Matić, Tamara, Stamenić, Tanja, Kojić, Vesna, Dimitrijević-Branković, Suzana, Lukić, Miodrag J., Jevtić, Sanja, Radovanović, Željko, Petrović, Rada, Janaćković, Đorđe, "Mg/Cu co-substituted hydroxyapatite - Biocompatibility, mechanical properties and antimicrobial activity" in Ceramics International, 45, no. 17 (2019):22029-22039,
https://doi.org/10.1016/j.ceramint.2019.07.219 . .
48
15
43

Mg/Cu co-substituted hydroxyapatite – Biocompatibility, mechanical properties and antimicrobial activity

Veljović, Đorđe; Matić, Tamara; Stamenić, Tanja; Kojić, Vesna; Dimitrijević-Branković, Suzana; Lukić, Miodrag J.; Jevtić, Sanja; Radovanović, Željko; Petrović, Rada; Janaćković, Đorđe

(Elsevier Ltd, 2019)

TY  - JOUR
AU  - Veljović, Đorđe
AU  - Matić, Tamara
AU  - Stamenić, Tanja
AU  - Kojić, Vesna
AU  - Dimitrijević-Branković, Suzana
AU  - Lukić, Miodrag J.
AU  - Jevtić, Sanja
AU  - Radovanović, Željko
AU  - Petrović, Rada
AU  - Janaćković, Đorđe
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5045
AB  - The aim of this study was to improve the mechanical properties and to optimize antimicrobial activity of hydroxyapatite (HAP) by simultaneous doping with Mg and Cu ions in order to obtain material that would be able to assist in the bone/tooth healing process, prevent post-implementation infections and provide satisfying values of hardness and fracture toughness for biomedical application. Ion doping was done during the hydrothermal synthesis of HAP powders, whereby the content of Mg ions in the starting solution was varied between 1-20 mol. % with regard to Ca ions, while the amount of Cu ions was kept constant at 0.4 mol. %. The green compacts were sintered for 2 h at temperatures ranging 750–1200 °C depending on the Mg content, chosen in agreement with dilatometry results. Presence of Mg ions was found to favour transition from HAP to β−tricalcium phosphate phase (β−TCP), which enabled formation of biphasic HAP/β−TCP and pure β−TCP phase at 160 °C during hydrothermal synthesis. In vitro investigation of antimicrobial activity against Escherichia coli, Staphylococcus aureus and Enterococcus faecalis showed satisfactory antimicrobial activity. MTT assay performed on MRC-5 and L929 cell lines showed excellent cytocompatibility and cell proliferation. Maximum hardness by Vickers and fracture toughness values, 4.96 GPa and 1.75 MPa m1/2 respectively, were obtained upon addition of 5 mol. % Mg, as a consequence of the lowest grain size and porosity, as well as the highest densification rate. This is, to the best of our knowledge, the highest fracture toughness for HAP or β-TCP ceramics reported thus far.
PB  - Elsevier Ltd
T2  - Ceramics International
T1  - Mg/Cu co-substituted hydroxyapatite – Biocompatibility, mechanical properties and antimicrobial activity
EP  - 22039
IS  - 17
SP  - 22029
VL  - 45
DO  - 10.1016/j.ceramint.2019.07.219
ER  - 
@article{
author = "Veljović, Đorđe and Matić, Tamara and Stamenić, Tanja and Kojić, Vesna and Dimitrijević-Branković, Suzana and Lukić, Miodrag J. and Jevtić, Sanja and Radovanović, Željko and Petrović, Rada and Janaćković, Đorđe",
year = "2019",
abstract = "The aim of this study was to improve the mechanical properties and to optimize antimicrobial activity of hydroxyapatite (HAP) by simultaneous doping with Mg and Cu ions in order to obtain material that would be able to assist in the bone/tooth healing process, prevent post-implementation infections and provide satisfying values of hardness and fracture toughness for biomedical application. Ion doping was done during the hydrothermal synthesis of HAP powders, whereby the content of Mg ions in the starting solution was varied between 1-20 mol. % with regard to Ca ions, while the amount of Cu ions was kept constant at 0.4 mol. %. The green compacts were sintered for 2 h at temperatures ranging 750–1200 °C depending on the Mg content, chosen in agreement with dilatometry results. Presence of Mg ions was found to favour transition from HAP to β−tricalcium phosphate phase (β−TCP), which enabled formation of biphasic HAP/β−TCP and pure β−TCP phase at 160 °C during hydrothermal synthesis. In vitro investigation of antimicrobial activity against Escherichia coli, Staphylococcus aureus and Enterococcus faecalis showed satisfactory antimicrobial activity. MTT assay performed on MRC-5 and L929 cell lines showed excellent cytocompatibility and cell proliferation. Maximum hardness by Vickers and fracture toughness values, 4.96 GPa and 1.75 MPa m1/2 respectively, were obtained upon addition of 5 mol. % Mg, as a consequence of the lowest grain size and porosity, as well as the highest densification rate. This is, to the best of our knowledge, the highest fracture toughness for HAP or β-TCP ceramics reported thus far.",
publisher = "Elsevier Ltd",
journal = "Ceramics International",
title = "Mg/Cu co-substituted hydroxyapatite – Biocompatibility, mechanical properties and antimicrobial activity",
pages = "22039-22029",
number = "17",
volume = "45",
doi = "10.1016/j.ceramint.2019.07.219"
}
Veljović, Đ., Matić, T., Stamenić, T., Kojić, V., Dimitrijević-Branković, S., Lukić, M. J., Jevtić, S., Radovanović, Ž., Petrović, R.,& Janaćković, Đ.. (2019). Mg/Cu co-substituted hydroxyapatite – Biocompatibility, mechanical properties and antimicrobial activity. in Ceramics International
Elsevier Ltd., 45(17), 22029-22039.
https://doi.org/10.1016/j.ceramint.2019.07.219
Veljović Đ, Matić T, Stamenić T, Kojić V, Dimitrijević-Branković S, Lukić MJ, Jevtić S, Radovanović Ž, Petrović R, Janaćković Đ. Mg/Cu co-substituted hydroxyapatite – Biocompatibility, mechanical properties and antimicrobial activity. in Ceramics International. 2019;45(17):22029-22039.
doi:10.1016/j.ceramint.2019.07.219 .
Veljović, Đorđe, Matić, Tamara, Stamenić, Tanja, Kojić, Vesna, Dimitrijević-Branković, Suzana, Lukić, Miodrag J., Jevtić, Sanja, Radovanović, Željko, Petrović, Rada, Janaćković, Đorđe, "Mg/Cu co-substituted hydroxyapatite – Biocompatibility, mechanical properties and antimicrobial activity" in Ceramics International, 45, no. 17 (2019):22029-22039,
https://doi.org/10.1016/j.ceramint.2019.07.219 . .
48
15
42

A facile route for hydroxyapatite densification with an increased heating rate

Lukić, Miodrag J.; Sezen, Meltem; Veljović, Đorđe; Mraković, Ana

(Elsevier Science Bv, Amsterdam, 2017)

TY  - JOUR
AU  - Lukić, Miodrag J.
AU  - Sezen, Meltem
AU  - Veljović, Đorđe
AU  - Mraković, Ana
PY  - 2017
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3590
AB  - The densification behavior of hydroxyapatite nanorods prepared by chemical precipitation method in open reactor conditions was investigated by application of different heating rates. The non-isothermal processing was performed with 2, 10, and 50 degrees C/min up to 1200 degrees C and yielded fully dense ceramics. The implementation of the higher heating rate provided grain size refinement from micrometer level for the slowest ramp, down to 250 nm in the case of processing with 50 degrees C/min, without any drawbacks regarding final density. The relative amount of retained structural hydroxyl groups in sintered ceramics was gradually increased with the heating rate. Furthermore, the qualitative level of optical translucency was increased with a higher heating rate which can be explained by the beneficial alignment of HAp nanorods during the fast heating rate processing, achieved microstructural refinement, and higher amount of structural hydroxyl groups.
PB  - Elsevier Science Bv, Amsterdam
T2  - Materials Letters
T1  - A facile route for hydroxyapatite densification with an increased heating rate
EP  - 15
SP  - 12
VL  - 207
DO  - 10.1016/j.matlet.2017.07.020
ER  - 
@article{
author = "Lukić, Miodrag J. and Sezen, Meltem and Veljović, Đorđe and Mraković, Ana",
year = "2017",
abstract = "The densification behavior of hydroxyapatite nanorods prepared by chemical precipitation method in open reactor conditions was investigated by application of different heating rates. The non-isothermal processing was performed with 2, 10, and 50 degrees C/min up to 1200 degrees C and yielded fully dense ceramics. The implementation of the higher heating rate provided grain size refinement from micrometer level for the slowest ramp, down to 250 nm in the case of processing with 50 degrees C/min, without any drawbacks regarding final density. The relative amount of retained structural hydroxyl groups in sintered ceramics was gradually increased with the heating rate. Furthermore, the qualitative level of optical translucency was increased with a higher heating rate which can be explained by the beneficial alignment of HAp nanorods during the fast heating rate processing, achieved microstructural refinement, and higher amount of structural hydroxyl groups.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Materials Letters",
title = "A facile route for hydroxyapatite densification with an increased heating rate",
pages = "15-12",
volume = "207",
doi = "10.1016/j.matlet.2017.07.020"
}
Lukić, M. J., Sezen, M., Veljović, Đ.,& Mraković, A.. (2017). A facile route for hydroxyapatite densification with an increased heating rate. in Materials Letters
Elsevier Science Bv, Amsterdam., 207, 12-15.
https://doi.org/10.1016/j.matlet.2017.07.020
Lukić MJ, Sezen M, Veljović Đ, Mraković A. A facile route for hydroxyapatite densification with an increased heating rate. in Materials Letters. 2017;207:12-15.
doi:10.1016/j.matlet.2017.07.020 .
Lukić, Miodrag J., Sezen, Meltem, Veljović, Đorđe, Mraković, Ana, "A facile route for hydroxyapatite densification with an increased heating rate" in Materials Letters, 207 (2017):12-15,
https://doi.org/10.1016/j.matlet.2017.07.020 . .
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