Avramov-Ivić, M., Gavrovska, A., Vuković, D., Mijin, D., Petrović, S., Reljin, B., Reljin, I., Milivojević, M., Stevanović, S.,& Lović, J.. (2023). Sistem i postupak automatske klasifikacije UV/VIS signala radi dijagnostike bilijarne ciroze i njihova primena. in Katalog / 37. Međunarodna izložba Pronalazaka, novih tehnologija i industrijskog dizajna „Pronalazaštvo-Beograd 2023.”, Beograd, 13-16.06.2023
Beograd : Savez pronalazača Beograda., 95-96.
https://hdl.handle.net/21.15107/rcub_technorep_6971

Avramov-Ivić M, Gavrovska A, Vuković D, Mijin D, Petrović S, Reljin B, Reljin I, Milivojević M, Stevanović S, Lović J. Sistem i postupak automatske klasifikacije UV/VIS signala radi dijagnostike bilijarne ciroze i njihova primena. in Katalog / 37. Međunarodna izložba Pronalazaka, novih tehnologija i industrijskog dizajna „Pronalazaštvo-Beograd 2023.”, Beograd, 13-16.06.2023. 2023;:95-96.
https://hdl.handle.net/21.15107/rcub_technorep_6971 .

Avramov-Ivić, Milka, Gavrovska, Ana, Vuković, Dragan, Mijin, Dušan, Petrović, Slobodan, Reljin, Branimir, Reljin, Irini, Milivojević, Milan, Stevanović, Sanja, Lović, Jelena, "Sistem i postupak automatske klasifikacije UV/VIS signala radi dijagnostike bilijarne ciroze i njihova primena" in Katalog / 37. Međunarodna izložba Pronalazaka, novih tehnologija i industrijskog dizajna „Pronalazaštvo-Beograd 2023.”, Beograd, 13-16.06.2023 (2023):95-96,
https://hdl.handle.net/21.15107/rcub_technorep_6971 .

TY  - JOUR
AU  - Lović, Jelena
AU  - Bogdanović, Aleksandra
AU  - Tadić, Vanja
AU  - Mijin, Dušan
AU  - Vuković, Dragan
AU  - Petrović, Slobodan D.
AU  - Avramov-Ivić, Milka
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5191
AB  - Duloxetine hydrochloride (DUL) is effective in treating depression, and was examined for electroanalytical purposes. The DULstandard was investigated by cyclic voltammetry (CV) and determined using differential pulse voltammetry (DPV) via its electrooxidationat the Au electrode in 0.05 M NaHCO3. DPV showed a linear dependency of the anodic peak currents vs DUL standardconcentrations in the range from 0.1 to 3.33 μg ml−1 with the values of the limit of detection (LOD) and the limit of quantification(LOQ): 0.133 and 0.667 μg ml−1, respectively. Using the constructed and validated calibration curve, the values of unknown DULconcentrations in both Taita® tablets and in human serum spiked with the standard were determined. The number of protons andelectrons transferred was calculated and possible reaction mechanisms taking place on the surface of both electrodes wereproposed. The Au electrode exhibited a better sensitivity and a wider range of current vs concentration linear dependency for DULquantitative determination than the GC electrode. The study of DUL degradation showed that at the Au and GC electrodes, after4.5 h of potential cycling, degradation occurs, giving formaldehyde as a product, which was confirmed by high performance liquidchromatography (HPLC)
PB  - The Electrochemical Society
T2  - Journal of The Electrochemical Society
T1  - Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation
IS  - 7
SP  - 076507
VL  - 169
DO  - 10.1149/1945-7111/ac7e74
ER  - 

@article{
author = "Lović, Jelena and Bogdanović, Aleksandra and Tadić, Vanja and Mijin, Dušan and Vuković, Dragan and Petrović, Slobodan D. and Avramov-Ivić, Milka",
year = "2022",
abstract = "Duloxetine hydrochloride (DUL) is effective in treating depression, and was examined for electroanalytical purposes. The DULstandard was investigated by cyclic voltammetry (CV) and determined using differential pulse voltammetry (DPV) via its electrooxidationat the Au electrode in 0.05 M NaHCO3. DPV showed a linear dependency of the anodic peak currents vs DUL standardconcentrations in the range from 0.1 to 3.33 μg ml−1 with the values of the limit of detection (LOD) and the limit of quantification(LOQ): 0.133 and 0.667 μg ml−1, respectively. Using the constructed and validated calibration curve, the values of unknown DULconcentrations in both Taita® tablets and in human serum spiked with the standard were determined. The number of protons andelectrons transferred was calculated and possible reaction mechanisms taking place on the surface of both electrodes wereproposed. The Au electrode exhibited a better sensitivity and a wider range of current vs concentration linear dependency for DULquantitative determination than the GC electrode. The study of DUL degradation showed that at the Au and GC electrodes, after4.5 h of potential cycling, degradation occurs, giving formaldehyde as a product, which was confirmed by high performance liquidchromatography (HPLC)",
publisher = "The Electrochemical Society",
journal = "Journal of The Electrochemical Society",
title = "Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation",
number = "7",
pages = "076507",
volume = "169",
doi = "10.1149/1945-7111/ac7e74"
}

Lović, J., Bogdanović, A., Tadić, V., Mijin, D., Vuković, D., Petrović, S. D.,& Avramov-Ivić, M.. (2022). Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation. in Journal of The Electrochemical Society
The Electrochemical Society., 169(7), 076507.
https://doi.org/10.1149/1945-7111/ac7e74

Lović J, Bogdanović A, Tadić V, Mijin D, Vuković D, Petrović SD, Avramov-Ivić M. Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation. in Journal of The Electrochemical Society. 2022;169(7):076507.
doi:10.1149/1945-7111/ac7e74 .

Lović, Jelena, Bogdanović, Aleksandra, Tadić, Vanja, Mijin, Dušan, Vuković, Dragan, Petrović, Slobodan D., Avramov-Ivić, Milka, "Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation" in Journal of The Electrochemical Society, 169, no. 7 (2022):076507,
https://doi.org/10.1149/1945-7111/ac7e74 . .

TY  - JOUR
AU  - Lović, Jelena
AU  - Bogdanović, Aleksandra
AU  - Mijin, Dušan
AU  - Vuković, Dragan
AU  - Petrović, Slobodan
AU  - Avramov-Ivić, Milka
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5197
AB  - Ticagrelor hydrochloride (TCG) is effective in platelet inhibition and useful for preventing cardiovascular death, myocardial infarction, or ischaemic stroke. The drug standard was investigated by cyclic voltammetry (CV) and quantitatively determined using differential pulse voltammetry (DPV) via its electrooxidation at Au electrode in 0.05 M NaHCO3. DPV showed a linear dependency of the anodic peak currents vs. TCG standard concentrations in the range from 3 x 10-7 mol l-1 to 10-5 mol l-1 with the values of the limit of detection (LOD) and the limit of quantification: 0.288 μmol l-1 and 0.96 μmol l-1, respectively. Using the constructed and validated calibration curve, the values of unknown ticagrelor concentrations in Ticagrex® tablets and in human serum spiked with the standard were determined. Mechanistic study suggests that the oxidation proceeds at sulfur atom by removal of one electron as the rate determining step. In the next, fast step, formed radical cation loose another electron and sulfoxide is formed (with water molecule as nucleophile). The study of TCG degradation showed that at the Au, after 4.5 h of potential cycling, degradation occurs, which was confirmed by UV spectroscopy.
PB  - ESG
T2  - International Journal of Electrochemical Science
T1  - Ticagrelor Determination via Its Electrooxidation as the Standard, in Tablets and the Spiked Human Serum at Au Solid Electrode
SP  - 220928
VL  - 17
DO  - 10.20964/2022.09.36
ER  - 

@article{
author = "Lović, Jelena and Bogdanović, Aleksandra and Mijin, Dušan and Vuković, Dragan and Petrović, Slobodan and Avramov-Ivić, Milka",
year = "2022",
abstract = "Ticagrelor hydrochloride (TCG) is effective in platelet inhibition and useful for preventing cardiovascular death, myocardial infarction, or ischaemic stroke. The drug standard was investigated by cyclic voltammetry (CV) and quantitatively determined using differential pulse voltammetry (DPV) via its electrooxidation at Au electrode in 0.05 M NaHCO3. DPV showed a linear dependency of the anodic peak currents vs. TCG standard concentrations in the range from 3 x 10-7 mol l-1 to 10-5 mol l-1 with the values of the limit of detection (LOD) and the limit of quantification: 0.288 μmol l-1 and 0.96 μmol l-1, respectively. Using the constructed and validated calibration curve, the values of unknown ticagrelor concentrations in Ticagrex® tablets and in human serum spiked with the standard were determined. Mechanistic study suggests that the oxidation proceeds at sulfur atom by removal of one electron as the rate determining step. In the next, fast step, formed radical cation loose another electron and sulfoxide is formed (with water molecule as nucleophile). The study of TCG degradation showed that at the Au, after 4.5 h of potential cycling, degradation occurs, which was confirmed by UV spectroscopy.",
publisher = "ESG",
journal = "International Journal of Electrochemical Science",
title = "Ticagrelor Determination via Its Electrooxidation as the Standard, in Tablets and the Spiked Human Serum at Au Solid Electrode",
pages = "220928",
volume = "17",
doi = "10.20964/2022.09.36"
}

Lović, J., Bogdanović, A., Mijin, D., Vuković, D., Petrović, S.,& Avramov-Ivić, M.. (2022). Ticagrelor Determination via Its Electrooxidation as the Standard, in Tablets and the Spiked Human Serum at Au Solid Electrode. in International Journal of Electrochemical Science
ESG., 17, 220928.
https://doi.org/10.20964/2022.09.36

Lović J, Bogdanović A, Mijin D, Vuković D, Petrović S, Avramov-Ivić M. Ticagrelor Determination via Its Electrooxidation as the Standard, in Tablets and the Spiked Human Serum at Au Solid Electrode. in International Journal of Electrochemical Science. 2022;17:220928.
doi:10.20964/2022.09.36 .

Lović, Jelena, Bogdanović, Aleksandra, Mijin, Dušan, Vuković, Dragan, Petrović, Slobodan, Avramov-Ivić, Milka, "Ticagrelor Determination via Its Electrooxidation as the Standard, in Tablets and the Spiked Human Serum at Au Solid Electrode" in International Journal of Electrochemical Science, 17 (2022):220928,
https://doi.org/10.20964/2022.09.36 . .

TY  - CONF
AU  - Avramov Ivić, Milka
AU  - Petrović, Slobodan D.
AU  - Reljin, Branimir
AU  - Reljin, Irini
AU  - Mijin, Dušan
AU  - Stevanović, Sanja
AU  - Lović, Jelena
AU  - Vuković, Dragan
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7304
AB  - The constant need to find an increasing number of diagnostic more selective techniques by which we would be able to determine an altered substrate as characteristic of the disease suspected is everyday clinical problem. It is important to note that diagnostic failure is the main cause of unnecessary costs that account for about 35% funds intended for healing in funds. The greatest number of people will experience at least one diagnostic error during their lifetime. The already realized results concerning new invented UV-vis method and automatic classification of the obtained spectroscopic signals in diagnostics of different diseases led to the the invention and construction of Computer-Aided Decision-Assistant system for Diagnosis of Different Diseases. It was achieved by automatization of UV-vis signals of different body fluids without or with known official diagnosis. In the invention and construction of this system is included clinical work, the softwer and hardwer realization, design and logo. Results included into the realization of constructed prototype will be presented.
PB  - Beograd : Udruženje inženjera Srbije za koroziju i zaštitu materijala UISKOZAM
C3  - Stecište nauke i prakse u oblastima korozije, zaštite materijala i životne sredine Elektronski izvor : knjiga radova / XXI YuCorr Jugoslovenska korozija Međunarodna konferencija = Meeting point of the science and practice in the fields of corrosion, materials and environmental protection : proceedings / XXI YuCorr International Conference, September 17-20, 2019, Tara Mountain, Serbia
T1  - Computer–aided decision–assistant system for diagnosis of different diseases
T1  - Računarski zasnovan sistem za asistenciju pri dijagnostici različitih oboljenja
SP  - 2
UR  - https://hdl.handle.net/21.15107/rcub_technorep_7304
ER  - 

@conference{
author = "Avramov Ivić, Milka and Petrović, Slobodan D. and Reljin, Branimir and Reljin, Irini and Mijin, Dušan and Stevanović, Sanja and Lović, Jelena and Vuković, Dragan",
year = "2019",
abstract = "The constant need to find an increasing number of diagnostic more selective techniques by which we would be able to determine an altered substrate as characteristic of the disease suspected is everyday clinical problem. It is important to note that diagnostic failure is the main cause of unnecessary costs that account for about 35% funds intended for healing in funds. The greatest number of people will experience at least one diagnostic error during their lifetime. The already realized results concerning new invented UV-vis method and automatic classification of the obtained spectroscopic signals in diagnostics of different diseases led to the the invention and construction of Computer-Aided Decision-Assistant system for Diagnosis of Different Diseases. It was achieved by automatization of UV-vis signals of different body fluids without or with known official diagnosis. In the invention and construction of this system is included clinical work, the softwer and hardwer realization, design and logo. Results included into the realization of constructed prototype will be presented.",
publisher = "Beograd : Udruženje inženjera Srbije za koroziju i zaštitu materijala UISKOZAM",
journal = "Stecište nauke i prakse u oblastima korozije, zaštite materijala i životne sredine Elektronski izvor : knjiga radova / XXI YuCorr Jugoslovenska korozija Međunarodna konferencija = Meeting point of the science and practice in the fields of corrosion, materials and environmental protection : proceedings / XXI YuCorr International Conference, September 17-20, 2019, Tara Mountain, Serbia",
title = "Computer–aided decision–assistant system for diagnosis of different diseases, Računarski zasnovan sistem za asistenciju pri dijagnostici različitih oboljenja",
pages = "2",
url = "https://hdl.handle.net/21.15107/rcub_technorep_7304"
}

Avramov Ivić, M., Petrović, S. D., Reljin, B., Reljin, I., Mijin, D., Stevanović, S., Lović, J.,& Vuković, D.. (2019). Computer–aided decision–assistant system for diagnosis of different diseases. in Stecište nauke i prakse u oblastima korozije, zaštite materijala i životne sredine Elektronski izvor : knjiga radova / XXI YuCorr Jugoslovenska korozija Međunarodna konferencija = Meeting point of the science and practice in the fields of corrosion, materials and environmental protection : proceedings / XXI YuCorr International Conference, September 17-20, 2019, Tara Mountain, Serbia
Beograd : Udruženje inženjera Srbije za koroziju i zaštitu materijala UISKOZAM., 2.
https://hdl.handle.net/21.15107/rcub_technorep_7304

Avramov Ivić M, Petrović SD, Reljin B, Reljin I, Mijin D, Stevanović S, Lović J, Vuković D. Computer–aided decision–assistant system for diagnosis of different diseases. in Stecište nauke i prakse u oblastima korozije, zaštite materijala i životne sredine Elektronski izvor : knjiga radova / XXI YuCorr Jugoslovenska korozija Međunarodna konferencija = Meeting point of the science and practice in the fields of corrosion, materials and environmental protection : proceedings / XXI YuCorr International Conference, September 17-20, 2019, Tara Mountain, Serbia. 2019;:2.
https://hdl.handle.net/21.15107/rcub_technorep_7304 .

Avramov Ivić, Milka, Petrović, Slobodan D., Reljin, Branimir, Reljin, Irini, Mijin, Dušan, Stevanović, Sanja, Lović, Jelena, Vuković, Dragan, "Computer–aided decision–assistant system for diagnosis of different diseases" in Stecište nauke i prakse u oblastima korozije, zaštite materijala i životne sredine Elektronski izvor : knjiga radova / XXI YuCorr Jugoslovenska korozija Međunarodna konferencija = Meeting point of the science and practice in the fields of corrosion, materials and environmental protection : proceedings / XXI YuCorr International Conference, September 17-20, 2019, Tara Mountain, Serbia (2019):2,
https://hdl.handle.net/21.15107/rcub_technorep_7304 .

TY  - JOUR
AU  - Avramov-Ivić, Milka
AU  - Lović, Jelena
AU  - Stevanović, Sanja
AU  - Nikolić, Nebojša
AU  - Trišović, Nemanja
AU  - Lađarević, Jelena
AU  - Vuković, Dragan
AU  - Drmanić, Saša
AU  - Mladenović, Aleksandar R.
AU  - Jadranin, Milka
AU  - Petrović, Slobodan
AU  - Mijin, Dušan
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4306
AB  - Esomeprazole is the most effective of the proton-pump inhibitors for the acid-related diseases and at first was examined for the electroanalytical purposes. The drug standard and as a content of injection powder was investigated by cyclic voltammetry (CV) and quantitatively determined using square wave voltammetry (SWV) via its electrooxidation at Au electrode in 0.05 M NaHCO3. SWV showed a linear dependency of the anodic peak currents vs. esomeprazole standard concentrations in the range from 3.0 to 500 mu g mL(-1) with the values of limit of detection (LOD) and limit of quantification (LOQ): 1.4 and 4.6 mu g mL(-1), respectively. Using the constructed and validated calibration curve, the values of unknown esomeprazole concentrations in injection powder and in human serum spiked with standard were determined. Before the electrochemical oxidation, it was shown by atomic force microscopy (AFM) that the small esomeprazole islands formed inside holes were visible and their diameter was about 200 nm attributed to physico-chemical characteristics of esomeprazole. After the electrochemical oxidation, the morphology of esomeprazole standard on Au surface was completely changed and composed of spherical particles in a diameter between 200 and 600 nm. With esomeprazole suspended in human serum, the process of crystallization partly occurred in the form of spherical grains with the average size of these grains was about 4 gm. The analysis at the macro level done by the optical microscopy (OM) confirmed this opinion. The study of esomeprazole degradation showed that at Au electrode, after 3 h of cycling, a neglectable amount of the esomeprazole was changed. Using IrOx electrode under directed stress conditions, its almost complete degradation was realized after 3 h confirmed by high performance liquid chromatography (HPLC). Total organic carbon (TOC) analysis showed that 95% of esomeprazole was mineralized. The HPLC and Liquid chromatography-mass spectrometry (LC-MS) study revealed the formation of 4-hydroxy omeprazole sulphide, 4-hydroxy omeprazole sulphone, esomeprazole sulphone and methylated esomeprazole.
PB  - Elsevier Science Sa, Lausanne
T2  - Journal of Electroanalytical Chemistry
T1  - Electrochemical behavior of esomeprazole: Its determination at Au electrode as standard and in injection powder combined with the study of its degradation
VL  - 848
DO  - 10.1016/j.jelechem.2019.113303
ER  - 

@article{
author = "Avramov-Ivić, Milka and Lović, Jelena and Stevanović, Sanja and Nikolić, Nebojša and Trišović, Nemanja and Lađarević, Jelena and Vuković, Dragan and Drmanić, Saša and Mladenović, Aleksandar R. and Jadranin, Milka and Petrović, Slobodan and Mijin, Dušan",
year = "2019",
abstract = "Esomeprazole is the most effective of the proton-pump inhibitors for the acid-related diseases and at first was examined for the electroanalytical purposes. The drug standard and as a content of injection powder was investigated by cyclic voltammetry (CV) and quantitatively determined using square wave voltammetry (SWV) via its electrooxidation at Au electrode in 0.05 M NaHCO3. SWV showed a linear dependency of the anodic peak currents vs. esomeprazole standard concentrations in the range from 3.0 to 500 mu g mL(-1) with the values of limit of detection (LOD) and limit of quantification (LOQ): 1.4 and 4.6 mu g mL(-1), respectively. Using the constructed and validated calibration curve, the values of unknown esomeprazole concentrations in injection powder and in human serum spiked with standard were determined. Before the electrochemical oxidation, it was shown by atomic force microscopy (AFM) that the small esomeprazole islands formed inside holes were visible and their diameter was about 200 nm attributed to physico-chemical characteristics of esomeprazole. After the electrochemical oxidation, the morphology of esomeprazole standard on Au surface was completely changed and composed of spherical particles in a diameter between 200 and 600 nm. With esomeprazole suspended in human serum, the process of crystallization partly occurred in the form of spherical grains with the average size of these grains was about 4 gm. The analysis at the macro level done by the optical microscopy (OM) confirmed this opinion. The study of esomeprazole degradation showed that at Au electrode, after 3 h of cycling, a neglectable amount of the esomeprazole was changed. Using IrOx electrode under directed stress conditions, its almost complete degradation was realized after 3 h confirmed by high performance liquid chromatography (HPLC). Total organic carbon (TOC) analysis showed that 95% of esomeprazole was mineralized. The HPLC and Liquid chromatography-mass spectrometry (LC-MS) study revealed the formation of 4-hydroxy omeprazole sulphide, 4-hydroxy omeprazole sulphone, esomeprazole sulphone and methylated esomeprazole.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Journal of Electroanalytical Chemistry",
title = "Electrochemical behavior of esomeprazole: Its determination at Au electrode as standard and in injection powder combined with the study of its degradation",
volume = "848",
doi = "10.1016/j.jelechem.2019.113303"
}

Avramov-Ivić, M., Lović, J., Stevanović, S., Nikolić, N., Trišović, N., Lađarević, J., Vuković, D., Drmanić, S., Mladenović, A. R., Jadranin, M., Petrović, S.,& Mijin, D.. (2019). Electrochemical behavior of esomeprazole: Its determination at Au electrode as standard and in injection powder combined with the study of its degradation. in Journal of Electroanalytical Chemistry
Elsevier Science Sa, Lausanne., 848.
https://doi.org/10.1016/j.jelechem.2019.113303

Avramov-Ivić M, Lović J, Stevanović S, Nikolić N, Trišović N, Lađarević J, Vuković D, Drmanić S, Mladenović AR, Jadranin M, Petrović S, Mijin D. Electrochemical behavior of esomeprazole: Its determination at Au electrode as standard and in injection powder combined with the study of its degradation. in Journal of Electroanalytical Chemistry. 2019;848.
doi:10.1016/j.jelechem.2019.113303 .

Avramov-Ivić, Milka, Lović, Jelena, Stevanović, Sanja, Nikolić, Nebojša, Trišović, Nemanja, Lađarević, Jelena, Vuković, Dragan, Drmanić, Saša, Mladenović, Aleksandar R., Jadranin, Milka, Petrović, Slobodan, Mijin, Dušan, "Electrochemical behavior of esomeprazole: Its determination at Au electrode as standard and in injection powder combined with the study of its degradation" in Journal of Electroanalytical Chemistry, 848 (2019),
https://doi.org/10.1016/j.jelechem.2019.113303 . .

TY  - CONF
AU  - Avramov Ivić, Milka
AU  - Lović, Jelena
AU  - Lađarević, Jelena
AU  - Mijin, Dušan
AU  - Stevanović, Sanja
AU  - Nikolić, Nebojša
AU  - Vuković, Dragan
AU  - Petrović, Slobodan
PY  - 2018
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6746
AB  - Esomeprazole has been shown to be the most effective oral PPI for controlling intragastric pH. The persistence of esomeprasole in environmental systems could be solved by different types of its degradation. In this work electrocatalytic degradation of esomeprasole has been investigated in the presence of sodium sulfate and sodium chloride using IrOx electrode and was monitored using UV-Vis spectrophotometer at 303 nm. Also the electro degradation process was examined and on Au electrode. NanoScope III A (Veeco, USA) microscope was used to study the morphology of Esomeprazole on the gold surface by atomic force microscopy. By optical microscopy the
morphology of Esomeprazole dissolved in human serum on the gold surface was studied as well.
AB  - Ezomeprazol je poznat kao najefikasniji lek , tj. inhibitor protonske pumpe u
kontroli intragastricne vrednosti pH. Njegovo prisustvo u vodenim tokovima i
zemljištu se resava osmišljavanjem novih postupaka degradacije. U ovom radu
elektrokatalitiþka degradacija ezomeprazola je prouþavana u natrijum sulfatu i
natrijum hloridu na IrOx elektrodi. Reakcija je praüena korišüenjem UV-Vis
spektrofotometra na 303 nm. Takoÿe je prouþavana degradacija ezomeprazola
na elektrodi od zlata. NanoScope III A (Veeco, USA) mikroskop je korišüen u
prouþavanju morfologije ezomeprazola na površini eelektrode od zlata
mikroskopijom mneÿuatomskih sila. Optiþkom mikroskopijom je ispitivana
morfologija ezomeprazola na površini eelektrode od zlata u prisustvu humanog
seruma.
PB  - Podgorica : Crnogorsko društvo za koroziju, zaštitu materijala i zaštitu životne sredine
C3  - Knjiga radova / Četvrti Međunarodni simpozijum o koroziji i zaštiti materijala, životnoj sredini i zaštiti od požara = Proceedings / Fourth International symposium on corrosion and materials protection, environmental protection and protection against fire, Bar, 18-21. septembar 2018. godine
T1  - Electrochemical degradation of esomeprasole on different electrodes in a sense of environment protection
T1  - Elektrohemijska degradacija esomeprazola na različitim elektrodama u cilju zaštite životne sredine
EP  - 65
SP  - 61
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6746
ER  - 

@conference{
author = "Avramov Ivić, Milka and Lović, Jelena and Lađarević, Jelena and Mijin, Dušan and Stevanović, Sanja and Nikolić, Nebojša and Vuković, Dragan and Petrović, Slobodan",
year = "2018",
abstract = "Esomeprazole has been shown to be the most effective oral PPI for controlling intragastric pH. The persistence of esomeprasole in environmental systems could be solved by different types of its degradation. In this work electrocatalytic degradation of esomeprasole has been investigated in the presence of sodium sulfate and sodium chloride using IrOx electrode and was monitored using UV-Vis spectrophotometer at 303 nm. Also the electro degradation process was examined and on Au electrode. NanoScope III A (Veeco, USA) microscope was used to study the morphology of Esomeprazole on the gold surface by atomic force microscopy. By optical microscopy the
morphology of Esomeprazole dissolved in human serum on the gold surface was studied as well., Ezomeprazol je poznat kao najefikasniji lek , tj. inhibitor protonske pumpe u
kontroli intragastricne vrednosti pH. Njegovo prisustvo u vodenim tokovima i
zemljištu se resava osmišljavanjem novih postupaka degradacije. U ovom radu
elektrokatalitiþka degradacija ezomeprazola je prouþavana u natrijum sulfatu i
natrijum hloridu na IrOx elektrodi. Reakcija je praüena korišüenjem UV-Vis
spektrofotometra na 303 nm. Takoÿe je prouþavana degradacija ezomeprazola
na elektrodi od zlata. NanoScope III A (Veeco, USA) mikroskop je korišüen u
prouþavanju morfologije ezomeprazola na površini eelektrode od zlata
mikroskopijom mneÿuatomskih sila. Optiþkom mikroskopijom je ispitivana
morfologija ezomeprazola na površini eelektrode od zlata u prisustvu humanog
seruma.",
publisher = "Podgorica : Crnogorsko društvo za koroziju, zaštitu materijala i zaštitu životne sredine",
journal = "Knjiga radova / Četvrti Međunarodni simpozijum o koroziji i zaštiti materijala, životnoj sredini i zaštiti od požara = Proceedings / Fourth International symposium on corrosion and materials protection, environmental protection and protection against fire, Bar, 18-21. septembar 2018. godine",
title = "Electrochemical degradation of esomeprasole on different electrodes in a sense of environment protection, Elektrohemijska degradacija esomeprazola na različitim elektrodama u cilju zaštite životne sredine",
pages = "65-61",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6746"
}

Avramov Ivić, M., Lović, J., Lađarević, J., Mijin, D., Stevanović, S., Nikolić, N., Vuković, D.,& Petrović, S.. (2018). Electrochemical degradation of esomeprasole on different electrodes in a sense of environment protection. in Knjiga radova / Četvrti Međunarodni simpozijum o koroziji i zaštiti materijala, životnoj sredini i zaštiti od požara = Proceedings / Fourth International symposium on corrosion and materials protection, environmental protection and protection against fire, Bar, 18-21. septembar 2018. godine
Podgorica : Crnogorsko društvo za koroziju, zaštitu materijala i zaštitu životne sredine., 61-65.
https://hdl.handle.net/21.15107/rcub_technorep_6746

Avramov Ivić M, Lović J, Lađarević J, Mijin D, Stevanović S, Nikolić N, Vuković D, Petrović S. Electrochemical degradation of esomeprasole on different electrodes in a sense of environment protection. in Knjiga radova / Četvrti Međunarodni simpozijum o koroziji i zaštiti materijala, životnoj sredini i zaštiti od požara = Proceedings / Fourth International symposium on corrosion and materials protection, environmental protection and protection against fire, Bar, 18-21. septembar 2018. godine. 2018;:61-65.
https://hdl.handle.net/21.15107/rcub_technorep_6746 .

Avramov Ivić, Milka, Lović, Jelena, Lađarević, Jelena, Mijin, Dušan, Stevanović, Sanja, Nikolić, Nebojša, Vuković, Dragan, Petrović, Slobodan, "Electrochemical degradation of esomeprasole on different electrodes in a sense of environment protection" in Knjiga radova / Četvrti Međunarodni simpozijum o koroziji i zaštiti materijala, životnoj sredini i zaštiti od požara = Proceedings / Fourth International symposium on corrosion and materials protection, environmental protection and protection against fire, Bar, 18-21. septembar 2018. godine (2018):61-65,
https://hdl.handle.net/21.15107/rcub_technorep_6746 .

TY  - JOUR
AU  - Lović, Jelena
AU  - Stevanović, Sanja
AU  - Anđelković, Boban D.
AU  - Petrović, Slobodan
AU  - Vuković, Dragan
AU  - Prlainović, Nevena
AU  - Mijin, Dušan
AU  - Nikolić, Nebojša
AU  - Avramov-Ivić, Milka
PY  - 2018
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3907
AB  - Glucose biosensor containing cysteine (Cys), glutaraldehyde (GA) and glucose oxidase (GOx) onto gold electrode is constructed and already electrochemically tested. Now, the electrochemical behavior of biosensor in human serum is further investigated and supported by morphological characterization of layers for the first time. The morphology and microstructure of layers was examined by Fourier transformed infra red spectroscopy (FTIR), atomic force (AFM) and optical microscopy (OM). The electrochemical indication that the Cys-GA-GOx film on Au surface is not compact and that there were some bare regions which remain catalytically active is supported by AFM and OM results. The construction and the nature of bonding of Au-Cys-GA-GOx biosensor layers is confirmed by the FTIR study.
PB  - Electrochemical Science Group, Beograd
T2  - International Journal of Electrochemical Science
T1  - Electrochemical glucose biosensor with the characterization of surface morphology and content of glucose oxidase-glutaraldehyde-cysteine layers on gold electrode
EP  - 12348
IS  - 12
SP  - 12340
VL  - 13
DO  - 10.20964/2018.12.59
ER  - 

@article{
author = "Lović, Jelena and Stevanović, Sanja and Anđelković, Boban D. and Petrović, Slobodan and Vuković, Dragan and Prlainović, Nevena and Mijin, Dušan and Nikolić, Nebojša and Avramov-Ivić, Milka",
year = "2018",
abstract = "Glucose biosensor containing cysteine (Cys), glutaraldehyde (GA) and glucose oxidase (GOx) onto gold electrode is constructed and already electrochemically tested. Now, the electrochemical behavior of biosensor in human serum is further investigated and supported by morphological characterization of layers for the first time. The morphology and microstructure of layers was examined by Fourier transformed infra red spectroscopy (FTIR), atomic force (AFM) and optical microscopy (OM). The electrochemical indication that the Cys-GA-GOx film on Au surface is not compact and that there were some bare regions which remain catalytically active is supported by AFM and OM results. The construction and the nature of bonding of Au-Cys-GA-GOx biosensor layers is confirmed by the FTIR study.",
publisher = "Electrochemical Science Group, Beograd",
journal = "International Journal of Electrochemical Science",
title = "Electrochemical glucose biosensor with the characterization of surface morphology and content of glucose oxidase-glutaraldehyde-cysteine layers on gold electrode",
pages = "12348-12340",
number = "12",
volume = "13",
doi = "10.20964/2018.12.59"
}

Lović, J., Stevanović, S., Anđelković, B. D., Petrović, S., Vuković, D., Prlainović, N., Mijin, D., Nikolić, N.,& Avramov-Ivić, M.. (2018). Electrochemical glucose biosensor with the characterization of surface morphology and content of glucose oxidase-glutaraldehyde-cysteine layers on gold electrode. in International Journal of Electrochemical Science
Electrochemical Science Group, Beograd., 13(12), 12340-12348.
https://doi.org/10.20964/2018.12.59

Lović J, Stevanović S, Anđelković BD, Petrović S, Vuković D, Prlainović N, Mijin D, Nikolić N, Avramov-Ivić M. Electrochemical glucose biosensor with the characterization of surface morphology and content of glucose oxidase-glutaraldehyde-cysteine layers on gold electrode. in International Journal of Electrochemical Science. 2018;13(12):12340-12348.
doi:10.20964/2018.12.59 .

Lović, Jelena, Stevanović, Sanja, Anđelković, Boban D., Petrović, Slobodan, Vuković, Dragan, Prlainović, Nevena, Mijin, Dušan, Nikolić, Nebojša, Avramov-Ivić, Milka, "Electrochemical glucose biosensor with the characterization of surface morphology and content of glucose oxidase-glutaraldehyde-cysteine layers on gold electrode" in International Journal of Electrochemical Science, 13, no. 12 (2018):12340-12348,
https://doi.org/10.20964/2018.12.59 . .

TY  - JOUR
AU  - Lović, Jelena
AU  - Stevanović, Sanja
AU  - Nikolić, Nebojša
AU  - Petrović, Slobodan
AU  - Vuković, Dragan
AU  - Prlainović, Nevena
AU  - Mijin, Dušan
AU  - Avramov-Ivić, Milka
PY  - 2017
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3570
AB  - The method to develop a stable glucose biosensor with successive attachment of cysteine (Cys), glutaraldehyde (GA) and glucose oxidase (GOx) onto gold electrode is presented. The cyclic voltammetry (CV) suggests the diffusion control of the glucose oxidation. The obtained biosensor shows a fast electron transfer of k(0) = 20.4 s(-1), high affinity for glucose with the apparent MichaelisMenten constant K-M(app) = 1.15 mM, a low detection limit of 0.94 mM in a linear range 1.5-7 mM. This biosensor exhibits good stability and reproducibility. Good biocompatibility of modified electrode surface, which enhances the covalent bonded enzyme and consequently glucose oxidation, resulted in biosensor with excellent performances. Biosensor was tested in samples containing human serum.
PB  - Electrochemical Science Group, Beograd
T2  - International Journal of Electrochemical Science
T1  - Glucose Sensing Using Glucose Oxidase-GlutaraldehydeCysteine Modified Gold Electrode
EP  - 5817
IS  - 7
SP  - 5806
VL  - 12
DO  - 10.20964/2017.07.65
ER  - 

@article{
author = "Lović, Jelena and Stevanović, Sanja and Nikolić, Nebojša and Petrović, Slobodan and Vuković, Dragan and Prlainović, Nevena and Mijin, Dušan and Avramov-Ivić, Milka",
year = "2017",
abstract = "The method to develop a stable glucose biosensor with successive attachment of cysteine (Cys), glutaraldehyde (GA) and glucose oxidase (GOx) onto gold electrode is presented. The cyclic voltammetry (CV) suggests the diffusion control of the glucose oxidation. The obtained biosensor shows a fast electron transfer of k(0) = 20.4 s(-1), high affinity for glucose with the apparent MichaelisMenten constant K-M(app) = 1.15 mM, a low detection limit of 0.94 mM in a linear range 1.5-7 mM. This biosensor exhibits good stability and reproducibility. Good biocompatibility of modified electrode surface, which enhances the covalent bonded enzyme and consequently glucose oxidation, resulted in biosensor with excellent performances. Biosensor was tested in samples containing human serum.",
publisher = "Electrochemical Science Group, Beograd",
journal = "International Journal of Electrochemical Science",
title = "Glucose Sensing Using Glucose Oxidase-GlutaraldehydeCysteine Modified Gold Electrode",
pages = "5817-5806",
number = "7",
volume = "12",
doi = "10.20964/2017.07.65"
}

Lović, J., Stevanović, S., Nikolić, N., Petrović, S., Vuković, D., Prlainović, N., Mijin, D.,& Avramov-Ivić, M.. (2017). Glucose Sensing Using Glucose Oxidase-GlutaraldehydeCysteine Modified Gold Electrode. in International Journal of Electrochemical Science
Electrochemical Science Group, Beograd., 12(7), 5806-5817.
https://doi.org/10.20964/2017.07.65

Lović J, Stevanović S, Nikolić N, Petrović S, Vuković D, Prlainović N, Mijin D, Avramov-Ivić M. Glucose Sensing Using Glucose Oxidase-GlutaraldehydeCysteine Modified Gold Electrode. in International Journal of Electrochemical Science. 2017;12(7):5806-5817.
doi:10.20964/2017.07.65 .

Lović, Jelena, Stevanović, Sanja, Nikolić, Nebojša, Petrović, Slobodan, Vuković, Dragan, Prlainović, Nevena, Mijin, Dušan, Avramov-Ivić, Milka, "Glucose Sensing Using Glucose Oxidase-GlutaraldehydeCysteine Modified Gold Electrode" in International Journal of Electrochemical Science, 12, no. 7 (2017):5806-5817,
https://doi.org/10.20964/2017.07.65 . .

TY  - JOUR
AU  - Lović, Jelena
AU  - Trišović, Nemanja
AU  - Antanasijević, Jelena
AU  - Nikolić, Nebojša
AU  - Stevanović, Sanja
AU  - Mijin, Dušan
AU  - Vuković, Dragan
AU  - Mladenović, Aleksandar R.
AU  - Petrović, Slobodan
AU  - Avramov-Ivić, Milka
PY  - 2016
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3312
AB  - Nonmedical use of sildenafil citrate (SC) requires new methods for drug determination in human serum and in tablets. SC as standard and in Sildena (R) tablets is determined by square wave voltammetry (SWV) in 0.1 M H2SO4 (harmful for human serum) at gold electrode in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.5,1) mu M and on cysteine (Cys) modified gold electrode (Au/Cys) in a range: (1 x 10(-3),1 x 10(-2), 0.05, 0.1) mu M. The presence of Cys causes two times larger peak currents and shifting of the incipient potential of the SC oxidation to 0.1 V in negative direction. A safe procedure for SC determination as standard and in Sildena (R) tablets spiked with human serum is developed by SWV at gold electrode in 0.05 M NaHCO3 (suitable for human liquids) in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.2, 03) mu M. Microscopic characterization of the surfaces morphology was also performed. The SC concentrations were checked by high performance liquid chromatography-ultraviolet spectroscopy (HPLC-UV) showing that electrochemical method is more sensitive and can be used for the measurements of very low concentrations of the analyte.
PB  - Elsevier Science Sa, Lausanne
T2  - Journal of Electroanalytical Chemistry
T1  - Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode
EP  - 107
SP  - 103
VL  - 782
DO  - 10.1016/j.jelechem.2016.10.022
ER  - 

@article{
author = "Lović, Jelena and Trišović, Nemanja and Antanasijević, Jelena and Nikolić, Nebojša and Stevanović, Sanja and Mijin, Dušan and Vuković, Dragan and Mladenović, Aleksandar R. and Petrović, Slobodan and Avramov-Ivić, Milka",
year = "2016",
abstract = "Nonmedical use of sildenafil citrate (SC) requires new methods for drug determination in human serum and in tablets. SC as standard and in Sildena (R) tablets is determined by square wave voltammetry (SWV) in 0.1 M H2SO4 (harmful for human serum) at gold electrode in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.5,1) mu M and on cysteine (Cys) modified gold electrode (Au/Cys) in a range: (1 x 10(-3),1 x 10(-2), 0.05, 0.1) mu M. The presence of Cys causes two times larger peak currents and shifting of the incipient potential of the SC oxidation to 0.1 V in negative direction. A safe procedure for SC determination as standard and in Sildena (R) tablets spiked with human serum is developed by SWV at gold electrode in 0.05 M NaHCO3 (suitable for human liquids) in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.2, 03) mu M. Microscopic characterization of the surfaces morphology was also performed. The SC concentrations were checked by high performance liquid chromatography-ultraviolet spectroscopy (HPLC-UV) showing that electrochemical method is more sensitive and can be used for the measurements of very low concentrations of the analyte.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Journal of Electroanalytical Chemistry",
title = "Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode",
pages = "107-103",
volume = "782",
doi = "10.1016/j.jelechem.2016.10.022"
}

Lović, J., Trišović, N., Antanasijević, J., Nikolić, N., Stevanović, S., Mijin, D., Vuković, D., Mladenović, A. R., Petrović, S.,& Avramov-Ivić, M.. (2016). Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode. in Journal of Electroanalytical Chemistry
Elsevier Science Sa, Lausanne., 782, 103-107.
https://doi.org/10.1016/j.jelechem.2016.10.022

Lović J, Trišović N, Antanasijević J, Nikolić N, Stevanović S, Mijin D, Vuković D, Mladenović AR, Petrović S, Avramov-Ivić M. Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode. in Journal of Electroanalytical Chemistry. 2016;782:103-107.
doi:10.1016/j.jelechem.2016.10.022 .

Lović, Jelena, Trišović, Nemanja, Antanasijević, Jelena, Nikolić, Nebojša, Stevanović, Sanja, Mijin, Dušan, Vuković, Dragan, Mladenović, Aleksandar R., Petrović, Slobodan, Avramov-Ivić, Milka, "Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode" in Journal of Electroanalytical Chemistry, 782 (2016):103-107,
https://doi.org/10.1016/j.jelechem.2016.10.022 . .

TY  - JOUR
AU  - Sajc, L.
AU  - Vunjak-Novaković, Gordana
AU  - Grubisić, D.
AU  - Kovačević, N.
AU  - Vuković, Dragan
AU  - Bugarski, Branko
PY  - 1995
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/60
AB  - The production of anthraquinones by Frangula alnus Mill. plant cells was used as a model system to evaluate the performance of a liquid-liquid extractive product-recovery process. The shake flask experiments have shown higher production of anthraquinones in cell suspension and flask cultures of calcium-alginate-immobilized cells when silicone oil was incorporated into the medium, compared to a control without silicone oil. An external-loop air-lift bioreactor, developed and designed for the production and simultaneous extraction of extracellular plant cell products, was regarded as a four-phase system, with dispersed gas, non-aqueous solvent and calcium-alginate-immobilized plant cells in Murashige and Skoog medium. Continuous extraction of anthraquinones by silicone oil and n-hexadecane inside the bioreactor resulted in 10–30 times higher cell productivity, compared to that of immobilized cells in a flask. Based on the mixing pattern, immobilized biocatalyst extraparticle and intraparticle diffusional constraints and the kinetics of growth, substrate consumption and product formation, a mathematical model was developed to describe the time course of a batch plant cell culture.
PB  - Springer, New York
T2  - Applied Microbiology and Biotechnology
T1  - Production of anthraquinones by immobilized Frangula alnus Mill. plant cells in a four-phase air-lift bioreactor
EP  - 423
IS  - 3
SP  - 416
VL  - 43
DO  - 10.1007/BF00218443
ER  - 

@article{
author = "Sajc, L. and Vunjak-Novaković, Gordana and Grubisić, D. and Kovačević, N. and Vuković, Dragan and Bugarski, Branko",
year = "1995",
abstract = "The production of anthraquinones by Frangula alnus Mill. plant cells was used as a model system to evaluate the performance of a liquid-liquid extractive product-recovery process. The shake flask experiments have shown higher production of anthraquinones in cell suspension and flask cultures of calcium-alginate-immobilized cells when silicone oil was incorporated into the medium, compared to a control without silicone oil. An external-loop air-lift bioreactor, developed and designed for the production and simultaneous extraction of extracellular plant cell products, was regarded as a four-phase system, with dispersed gas, non-aqueous solvent and calcium-alginate-immobilized plant cells in Murashige and Skoog medium. Continuous extraction of anthraquinones by silicone oil and n-hexadecane inside the bioreactor resulted in 10–30 times higher cell productivity, compared to that of immobilized cells in a flask. Based on the mixing pattern, immobilized biocatalyst extraparticle and intraparticle diffusional constraints and the kinetics of growth, substrate consumption and product formation, a mathematical model was developed to describe the time course of a batch plant cell culture.",
publisher = "Springer, New York",
journal = "Applied Microbiology and Biotechnology",
title = "Production of anthraquinones by immobilized Frangula alnus Mill. plant cells in a four-phase air-lift bioreactor",
pages = "423-416",
number = "3",
volume = "43",
doi = "10.1007/BF00218443"
}

Sajc, L., Vunjak-Novaković, G., Grubisić, D., Kovačević, N., Vuković, D.,& Bugarski, B.. (1995). Production of anthraquinones by immobilized Frangula alnus Mill. plant cells in a four-phase air-lift bioreactor. in Applied Microbiology and Biotechnology
Springer, New York., 43(3), 416-423.
https://doi.org/10.1007/BF00218443

Sajc L, Vunjak-Novaković G, Grubisić D, Kovačević N, Vuković D, Bugarski B. Production of anthraquinones by immobilized Frangula alnus Mill. plant cells in a four-phase air-lift bioreactor. in Applied Microbiology and Biotechnology. 1995;43(3):416-423.
doi:10.1007/BF00218443 .

Sajc, L., Vunjak-Novaković, Gordana, Grubisić, D., Kovačević, N., Vuković, Dragan, Bugarski, Branko, "Production of anthraquinones by immobilized Frangula alnus Mill. plant cells in a four-phase air-lift bioreactor" in Applied Microbiology and Biotechnology, 43, no. 3 (1995):416-423,
https://doi.org/10.1007/BF00218443 . .

TY  - JOUR
AU  - Sajc, L.
AU  - Obradović, Bojana
AU  - Vuković, Dragan
AU  - Bugarski, Branko
AU  - Grubisić, D.
AU  - Vunjak-Novaković, Gordana
PY  - 1995
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/59
AB  - An external loop air lift reactor (ELALR) was developed and designed for continuous production and extraction of extracellular secondary metabolites by immobilized Frangula alnus Mill. plant cells. This system was considered as a four‐phase system, with dispersed gas, nonaqueous liquid solvent, and calcium alginate particles in water or Murashige and Skoog medium. Analysis of the four‐phase ELALR revealed the influence of gas, solvent, calcium alginate particles and MS medium composition on gas and solvent holdup, liquid circulation velocity, mixing in aqueous liquid phase, and mass transfer coefficients of oxygen and plant cell product. It was shown that the gas holdup appears to be the principal variable determining the properties of the four‐phase system. An unified correlation for the gas holdup, based on drift flux flow in a three‐phase system, has been extended to the four‐phase system. Bubble size and bubble size distribution observed in the bubbly flow regime were the same in water as in the MS medium system (Sauter mean diameter 2.5 mm). Consequently, gas holdup and all related parameters, such as liquid circulation velocity, oxygen mass transfer coefficient, and axial liquid dispersion in MS medium, were similar to those in water for the four‐phase system.
PB  - Wiley, Hoboken
T2  - Biotechnology Progress
T1  - Hydrodynamics and Mass Transfer in a Four‐Phase External Loop Air Lift Bioreactor
EP  - 428
IS  - 4
SP  - 420
VL  - 11
DO  - 10.1021/bp00034a009
ER  - 

@article{
author = "Sajc, L. and Obradović, Bojana and Vuković, Dragan and Bugarski, Branko and Grubisić, D. and Vunjak-Novaković, Gordana",
year = "1995",
abstract = "An external loop air lift reactor (ELALR) was developed and designed for continuous production and extraction of extracellular secondary metabolites by immobilized Frangula alnus Mill. plant cells. This system was considered as a four‐phase system, with dispersed gas, nonaqueous liquid solvent, and calcium alginate particles in water or Murashige and Skoog medium. Analysis of the four‐phase ELALR revealed the influence of gas, solvent, calcium alginate particles and MS medium composition on gas and solvent holdup, liquid circulation velocity, mixing in aqueous liquid phase, and mass transfer coefficients of oxygen and plant cell product. It was shown that the gas holdup appears to be the principal variable determining the properties of the four‐phase system. An unified correlation for the gas holdup, based on drift flux flow in a three‐phase system, has been extended to the four‐phase system. Bubble size and bubble size distribution observed in the bubbly flow regime were the same in water as in the MS medium system (Sauter mean diameter 2.5 mm). Consequently, gas holdup and all related parameters, such as liquid circulation velocity, oxygen mass transfer coefficient, and axial liquid dispersion in MS medium, were similar to those in water for the four‐phase system.",
publisher = "Wiley, Hoboken",
journal = "Biotechnology Progress",
title = "Hydrodynamics and Mass Transfer in a Four‐Phase External Loop Air Lift Bioreactor",
pages = "428-420",
number = "4",
volume = "11",
doi = "10.1021/bp00034a009"
}

Sajc, L., Obradović, B., Vuković, D., Bugarski, B., Grubisić, D.,& Vunjak-Novaković, G.. (1995). Hydrodynamics and Mass Transfer in a Four‐Phase External Loop Air Lift Bioreactor. in Biotechnology Progress
Wiley, Hoboken., 11(4), 420-428.
https://doi.org/10.1021/bp00034a009

Sajc L, Obradović B, Vuković D, Bugarski B, Grubisić D, Vunjak-Novaković G. Hydrodynamics and Mass Transfer in a Four‐Phase External Loop Air Lift Bioreactor. in Biotechnology Progress. 1995;11(4):420-428.
doi:10.1021/bp00034a009 .

Sajc, L., Obradović, Bojana, Vuković, Dragan, Bugarski, Branko, Grubisić, D., Vunjak-Novaković, Gordana, "Hydrodynamics and Mass Transfer in a Four‐Phase External Loop Air Lift Bioreactor" in Biotechnology Progress, 11, no. 4 (1995):420-428,
https://doi.org/10.1021/bp00034a009 . .