TY  - JOUR
AU  - Nikolić, Jasmina B.
AU  - Prlainović, Nevena Ž.
AU  - Šekularac, Gavrilo M.
AU  - Matović, Luka R.
AU  - Lazić, Anita M.
AU  - Drmanić, Saša Ž.
PY  - 2024
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7387
AB  - The esters of substituted 1,4-dihydropyirdines (1,4-DHP) are formed in the reaction of an appropriate aldehyde and ethyl acetoacetate in the presence of concentrated water solution of ammonia. The esters form the amides by the reaction with primary amines. The series of the amides has been synthesized with the aim to analyze their chemical characteristics, antioxidant and antimicrobial activity. The amine used in this research is 2-aminothiazole. The antioxidant activity is analysed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-Azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) methods and the antimicrobial activity screening was performed by broth microdilution method, using different microbial strains. The characterization of the obtained amides was done by melting points, FTIR, NMR and elemental analysis. The possibilities for further research was suggested, which could lead to the application of selected compounds.
AB  - Естри супституисаних 1,4-дихидропиридина се формирају у реакцији одговарајућег алдехида и етил-ацетоацетата у присуству амонијум-хидроксида. Наведени естри
прелазе у амиде реакцијом са примарним аминима. Серија оваквих амида је синтетисана са циљем да се испита њихова антиоксидативна и антимиркобна активност, као и
хемијске карактеристике. Амин употребљен за синтезу је 2-аминотиазол. Антиоксидативна активност је анализирана DPPH и ABTS методама, а антимикробна бујон микродилуционом методом. Карактеризација добијених једињења урађена је помоћу тачака
топљења, FTIR, NMR и елементалном анализом. Предложене су могућности за наставак
истраживања, који бу водио њиховој примени одређених испитиваних једињења.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - The synthesis, characterization, antioxidant and antimicrobial activity of some novel amides of the esters of substituted 1,4-dihydropyridines
T1  - Синтеза, карактеризација, антиоксидативна и антимикробна активност некиx нових амида естара 1,4-дихидропиридина
EP  - 150
IS  - 2
SP  - 141
VL  - 89
DO  - 10.2298/JSC231023098N
ER  - 

@article{
author = "Nikolić, Jasmina B. and Prlainović, Nevena Ž. and Šekularac, Gavrilo M. and Matović, Luka R. and Lazić, Anita M. and Drmanić, Saša Ž.",
year = "2024",
abstract = "The esters of substituted 1,4-dihydropyirdines (1,4-DHP) are formed in the reaction of an appropriate aldehyde and ethyl acetoacetate in the presence of concentrated water solution of ammonia. The esters form the amides by the reaction with primary amines. The series of the amides has been synthesized with the aim to analyze their chemical characteristics, antioxidant and antimicrobial activity. The amine used in this research is 2-aminothiazole. The antioxidant activity is analysed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-Azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) methods and the antimicrobial activity screening was performed by broth microdilution method, using different microbial strains. The characterization of the obtained amides was done by melting points, FTIR, NMR and elemental analysis. The possibilities for further research was suggested, which could lead to the application of selected compounds., Естри супституисаних 1,4-дихидропиридина се формирају у реакцији одговарајућег алдехида и етил-ацетоацетата у присуству амонијум-хидроксида. Наведени естри
прелазе у амиде реакцијом са примарним аминима. Серија оваквих амида је синтетисана са циљем да се испита њихова антиоксидативна и антимиркобна активност, као и
хемијске карактеристике. Амин употребљен за синтезу је 2-аминотиазол. Антиоксидативна активност је анализирана DPPH и ABTS методама, а антимикробна бујон микродилуционом методом. Карактеризација добијених једињења урађена је помоћу тачака
топљења, FTIR, NMR и елементалном анализом. Предложене су могућности за наставак
истраживања, који бу водио њиховој примени одређених испитиваних једињења.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "The synthesis, characterization, antioxidant and antimicrobial activity of some novel amides of the esters of substituted 1,4-dihydropyridines, Синтеза, карактеризација, антиоксидативна и антимикробна активност некиx нових амида естара 1,4-дихидропиридина",
pages = "150-141",
number = "2",
volume = "89",
doi = "10.2298/JSC231023098N"
}

Nikolić, J. B., Prlainović, N. Ž., Šekularac, G. M., Matović, L. R., Lazić, A. M.,& Drmanić, S. Ž.. (2024). The synthesis, characterization, antioxidant and antimicrobial activity of some novel amides of the esters of substituted 1,4-dihydropyridines. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 89(2), 141-150.
https://doi.org/10.2298/JSC231023098N

Nikolić JB, Prlainović NŽ, Šekularac GM, Matović LR, Lazić AM, Drmanić SŽ. The synthesis, characterization, antioxidant and antimicrobial activity of some novel amides of the esters of substituted 1,4-dihydropyridines. in Journal of the Serbian Chemical Society. 2024;89(2):141-150.
doi:10.2298/JSC231023098N .

Nikolić, Jasmina B., Prlainović, Nevena Ž., Šekularac, Gavrilo M., Matović, Luka R., Lazić, Anita M., Drmanić, Saša Ž., "The synthesis, characterization, antioxidant and antimicrobial activity of some novel amides of the esters of substituted 1,4-dihydropyridines" in Journal of the Serbian Chemical Society, 89, no. 2 (2024):141-150,
https://doi.org/10.2298/JSC231023098N . .

TY  - JOUR
AU  - Vučković, Nemanja
AU  - Prlainović, Nevena
AU  - Glođović, Nikola
AU  - Čalija, Bojan
AU  - Milosavljević, Nedeljko
AU  - Kalagasidis Krušić, Melina
AU  - Milašinović, Nikola
PY  - 2024
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7149
AB  - Novel polymer network microformulations have been widely used for pharmaceutical applications. Especially challenging is to design and develop an ideal oral drug formulation due to many hostile factors in gastrointestinal (GI) tract microenvironment. Hydrogels attained striking attention for the use in controlled drug delivery systems, and for that purpose temperature- and pH-sensitive hydrogels have been extensively employed. This paper reports synthesis and characterization of innovative polymers-crosslinked hydrogel system consisted of N-isopropylacrylamide-graft-dextran (NiPAAm-g-Dex) and chitosan (Ch). Composition of the system was optimized to demonstrate distinguished encapsulation efficiency (EE) and release properties of diclofenac sodium (DS). The microspheres structure and morphology were confirmed by attenuated total reflectance Fourier transform infrared spectroscopy (ATR FT-IR) and scanning electron microscopy (SEM), respectively. Prepared microparticles have successfully passed through the simulated gastric and small intestine and reached the intestine, where the release of DS was carried out. In vitro release studies showed smooth release profile in a controllable manner with up to 40% release of the model drug after 4 h at pH 7.20 ± 0.01. Based on the results, novel polymer microformulations show excellent potential as controlled release drug delivery system and represent a superb candidate for additional in vivo testing.
PB  - Springer Science and Business Media Deutschland GmbH
T2  - Journal of the Iranian Chemical Society
T1  - Novel chitosan and N-isopropylacrylamide-grafted-dextran-based microformulations as effective oral drug delivery system
DO  - 10.1007/s13738-023-02960-1
ER  - 

@article{
author = "Vučković, Nemanja and Prlainović, Nevena and Glođović, Nikola and Čalija, Bojan and Milosavljević, Nedeljko and Kalagasidis Krušić, Melina and Milašinović, Nikola",
year = "2024",
abstract = "Novel polymer network microformulations have been widely used for pharmaceutical applications. Especially challenging is to design and develop an ideal oral drug formulation due to many hostile factors in gastrointestinal (GI) tract microenvironment. Hydrogels attained striking attention for the use in controlled drug delivery systems, and for that purpose temperature- and pH-sensitive hydrogels have been extensively employed. This paper reports synthesis and characterization of innovative polymers-crosslinked hydrogel system consisted of N-isopropylacrylamide-graft-dextran (NiPAAm-g-Dex) and chitosan (Ch). Composition of the system was optimized to demonstrate distinguished encapsulation efficiency (EE) and release properties of diclofenac sodium (DS). The microspheres structure and morphology were confirmed by attenuated total reflectance Fourier transform infrared spectroscopy (ATR FT-IR) and scanning electron microscopy (SEM), respectively. Prepared microparticles have successfully passed through the simulated gastric and small intestine and reached the intestine, where the release of DS was carried out. In vitro release studies showed smooth release profile in a controllable manner with up to 40% release of the model drug after 4 h at pH 7.20 ± 0.01. Based on the results, novel polymer microformulations show excellent potential as controlled release drug delivery system and represent a superb candidate for additional in vivo testing.",
publisher = "Springer Science and Business Media Deutschland GmbH",
journal = "Journal of the Iranian Chemical Society",
title = "Novel chitosan and N-isopropylacrylamide-grafted-dextran-based microformulations as effective oral drug delivery system",
doi = "10.1007/s13738-023-02960-1"
}

Vučković, N., Prlainović, N., Glođović, N., Čalija, B., Milosavljević, N., Kalagasidis Krušić, M.,& Milašinović, N.. (2024). Novel chitosan and N-isopropylacrylamide-grafted-dextran-based microformulations as effective oral drug delivery system. in Journal of the Iranian Chemical Society
Springer Science and Business Media Deutschland GmbH..
https://doi.org/10.1007/s13738-023-02960-1

Vučković N, Prlainović N, Glođović N, Čalija B, Milosavljević N, Kalagasidis Krušić M, Milašinović N. Novel chitosan and N-isopropylacrylamide-grafted-dextran-based microformulations as effective oral drug delivery system. in Journal of the Iranian Chemical Society. 2024;.
doi:10.1007/s13738-023-02960-1 .

Vučković, Nemanja, Prlainović, Nevena, Glođović, Nikola, Čalija, Bojan, Milosavljević, Nedeljko, Kalagasidis Krušić, Melina, Milašinović, Nikola, "Novel chitosan and N-isopropylacrylamide-grafted-dextran-based microformulations as effective oral drug delivery system" in Journal of the Iranian Chemical Society (2024),
https://doi.org/10.1007/s13738-023-02960-1 . .

TY  - JOUR
AU  - Prlainović, Nevena Ž.
AU  - Milovanović, Jelena S.
AU  - Milašinović, Nikola Z.
AU  - Bezbradica, Dejan I.
AU  - Mijin, Dušan Ž.
PY  - 2024
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7363
AB  - Lipase-catalyzed organic reactions have been widely practiced in the past three decades. Especially interesting are insoluble/immobilized forms due to providing a possibility of facile use and recyclability, thus reducing process costs, and making the procedure more environmentally friendly. Carbon-based supports have been extensively exploited for this purpose, because of neutral and biodegradable nature and thermal and chemical stability. Their high specific surface area, characteristic surface morphology and lower mass transfer resistances play a vital role in the performance of the attached enzyme. This review paper presents an overview of the main aspects of lipase immobilized on multi-walled carbon nanotubes (MWCNTs). Moreover, different immobilization strategies to achieve a biocatalyst with improved performances are discussed. Furthermore, as lipases are considered to have high commercial worth for synthesis of valuable organic molecules, the second part of the paper is dedicated to the overview of the most important industrial sectors in which these nanobiocatalysts have been used. In specific, applications in biodiesel production, flavour ester synthesis and racemization are summarized.
AB  - Lipaze su poslednjih decenija široko rasprostanjeni katalizatoriu raznovrsnim organskim reakcijama. Posebno su interesantne u imobilisanom/nerastvornom obliku jer je na ovaj način olakšana njihova upotreba uz mogućnost recikliranja i ponovne upotrebe čime se smanjuju troškovi samog procesa i postupak je ekološki prihvatljiviji. Kao nosači za vezivanje nanomaterijali na bazi ugljenika, posebno ugljenične nanocevi, su našli primenu zbog svojih izuzetnih fizičkih, mehaničkih i hemijskih svojstava. Njihova velika specifična površina, karakteristična površinska morfologija i smanjen otpor prenosu mase igraju vitalnu ulogu u performansama vezanog enzima. Ovaj pregledni rad predstavlja prikaz glavnih aspekata lipaze imobilisane na višeslojne ugljenične nanocevi i različitih strategija imobilizacije za dobijanje biokatalizatora sa poboljšanim svojstvima. Takođe, kako su lipaze enzimi od velikog komercijalnog značaja za organsku sintezu i primenu u biotehnologiji, drugi deo rada posvećen je pregledu najvažnijih industrijskih sektora u kojima su ovi nanobiokatalizatori našli primenu. Shodno tome, dat je pregled proizvodnje biodizela, mirisnih estara i racemizacije
PB  - Savez hemijskih inženjera Srbije
T2  - Hemijska industrija
T1  - Multi-walled carbon nanotubes as lipase carriers for organic synthesis: current trends and recent update
T1  - Višeslojne ugljenične nanocevi kao nosač lipaze za organsku sintezu: pregled najnovijih trendova
EP  - 16
IS  - 1
SP  - 1
VL  - 78
DO  - 10.2298/HEMIND230614003P
ER  - 

@article{
author = "Prlainović, Nevena Ž. and Milovanović, Jelena S. and Milašinović, Nikola Z. and Bezbradica, Dejan I. and Mijin, Dušan Ž.",
year = "2024",
abstract = "Lipase-catalyzed organic reactions have been widely practiced in the past three decades. Especially interesting are insoluble/immobilized forms due to providing a possibility of facile use and recyclability, thus reducing process costs, and making the procedure more environmentally friendly. Carbon-based supports have been extensively exploited for this purpose, because of neutral and biodegradable nature and thermal and chemical stability. Their high specific surface area, characteristic surface morphology and lower mass transfer resistances play a vital role in the performance of the attached enzyme. This review paper presents an overview of the main aspects of lipase immobilized on multi-walled carbon nanotubes (MWCNTs). Moreover, different immobilization strategies to achieve a biocatalyst with improved performances are discussed. Furthermore, as lipases are considered to have high commercial worth for synthesis of valuable organic molecules, the second part of the paper is dedicated to the overview of the most important industrial sectors in which these nanobiocatalysts have been used. In specific, applications in biodiesel production, flavour ester synthesis and racemization are summarized., Lipaze su poslednjih decenija široko rasprostanjeni katalizatoriu raznovrsnim organskim reakcijama. Posebno su interesantne u imobilisanom/nerastvornom obliku jer je na ovaj način olakšana njihova upotreba uz mogućnost recikliranja i ponovne upotrebe čime se smanjuju troškovi samog procesa i postupak je ekološki prihvatljiviji. Kao nosači za vezivanje nanomaterijali na bazi ugljenika, posebno ugljenične nanocevi, su našli primenu zbog svojih izuzetnih fizičkih, mehaničkih i hemijskih svojstava. Njihova velika specifična površina, karakteristična površinska morfologija i smanjen otpor prenosu mase igraju vitalnu ulogu u performansama vezanog enzima. Ovaj pregledni rad predstavlja prikaz glavnih aspekata lipaze imobilisane na višeslojne ugljenične nanocevi i različitih strategija imobilizacije za dobijanje biokatalizatora sa poboljšanim svojstvima. Takođe, kako su lipaze enzimi od velikog komercijalnog značaja za organsku sintezu i primenu u biotehnologiji, drugi deo rada posvećen je pregledu najvažnijih industrijskih sektora u kojima su ovi nanobiokatalizatori našli primenu. Shodno tome, dat je pregled proizvodnje biodizela, mirisnih estara i racemizacije",
publisher = "Savez hemijskih inženjera Srbije",
journal = "Hemijska industrija",
title = "Multi-walled carbon nanotubes as lipase carriers for organic synthesis: current trends and recent update, Višeslojne ugljenične nanocevi kao nosač lipaze za organsku sintezu: pregled najnovijih trendova",
pages = "16-1",
number = "1",
volume = "78",
doi = "10.2298/HEMIND230614003P"
}

Prlainović, N. Ž., Milovanović, J. S., Milašinović, N. Z., Bezbradica, D. I.,& Mijin, D. Ž.. (2024). Multi-walled carbon nanotubes as lipase carriers for organic synthesis: current trends and recent update. in Hemijska industrija
Savez hemijskih inženjera Srbije., 78(1), 1-16.
https://doi.org/10.2298/HEMIND230614003P

Prlainović NŽ, Milovanović JS, Milašinović NZ, Bezbradica DI, Mijin DŽ. Multi-walled carbon nanotubes as lipase carriers for organic synthesis: current trends and recent update. in Hemijska industrija. 2024;78(1):1-16.
doi:10.2298/HEMIND230614003P .

Prlainović, Nevena Ž., Milovanović, Jelena S., Milašinović, Nikola Z., Bezbradica, Dejan I., Mijin, Dušan Ž., "Multi-walled carbon nanotubes as lipase carriers for organic synthesis: current trends and recent update" in Hemijska industrija, 78, no. 1 (2024):1-16,
https://doi.org/10.2298/HEMIND230614003P . .

TY  - CONF
AU  - Mašulović, Aleksandra
AU  - Lađarević, Jelena
AU  - Ivanovska, Aleksandra
AU  - Kostić, Mirjana
AU  - Prlainović, Nevena
AU  - Bigović, Miljan
AU  - Mijin, Dušan
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6935
AB  - The reduction of water pollution represents one of the priority topics of the EU’s goal to achieve climate neutrality by 2050. Herby textile industry is focused on developments in numerous environmental and social issues, including high emissions, high water and/or energy consumption and heavy pollution [1]. Coloured effluents from this industry disposed into natural ecosystems are responsible for about 20% of global clean water pollution [2]. The European Union aims to reduce textile waste and increase the life cycle and recycling of textiles as part of the plan to achieve a circular economy by 2050 by sustainable products and empowering consumers to participate in the green transition [2]. One of the main research topics connecting textile industry and waste water reduction is found in synthesis of eco-friendly dyes which are superior to their natural analogues due to the excellent dyeing capabilities and colour fastness properties. Among these, azo pyridine dyes gained attention for the simplicity of their preparation, good colour fastness, high tinctorial strength, thermal and optical stability [3]. Traditionally, applied as disperse dyes, they have low water solubility and are used for colouring mostly synthetic fibres. Recent findings showed that the introduction of the pyridinium ring into pyridone molecule resulted in enhanced water solubility of the dyes and improved affinity towards various natural and synthetic fibres, especially wool and cellulose diacetate fibres [4].
For the purpose of addressing environmental issues in the textile industry, in this work, two pyridinium-based azo pyridone dyes with improved solubility and affinity towards different fibres, are used for dyeing wool fabric. The results show that the same dyebath can be efficiently used multiple times, therefore reducing waste in the water while securing the optimizing dying. The obtained fabrics from different cycles are further characterized by K/S values while the residue of the dye in the wastewater was recorded using UV-Vis spectra.
PB  - Podgorica : Chemical Society of Montenegro
C3  - Book of Abstracts / 23rd European Meeting on Environmental Chemistry, 3-6 December, 2023, Budva, Montenegro
T1  - Reducing Wastewater in Textile Industry: Innovative Dying Approach
SP  - 64
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6935
ER  - 

@conference{
author = "Mašulović, Aleksandra and Lađarević, Jelena and Ivanovska, Aleksandra and Kostić, Mirjana and Prlainović, Nevena and Bigović, Miljan and Mijin, Dušan",
year = "2023",
abstract = "The reduction of water pollution represents one of the priority topics of the EU’s goal to achieve climate neutrality by 2050. Herby textile industry is focused on developments in numerous environmental and social issues, including high emissions, high water and/or energy consumption and heavy pollution [1]. Coloured effluents from this industry disposed into natural ecosystems are responsible for about 20% of global clean water pollution [2]. The European Union aims to reduce textile waste and increase the life cycle and recycling of textiles as part of the plan to achieve a circular economy by 2050 by sustainable products and empowering consumers to participate in the green transition [2]. One of the main research topics connecting textile industry and waste water reduction is found in synthesis of eco-friendly dyes which are superior to their natural analogues due to the excellent dyeing capabilities and colour fastness properties. Among these, azo pyridine dyes gained attention for the simplicity of their preparation, good colour fastness, high tinctorial strength, thermal and optical stability [3]. Traditionally, applied as disperse dyes, they have low water solubility and are used for colouring mostly synthetic fibres. Recent findings showed that the introduction of the pyridinium ring into pyridone molecule resulted in enhanced water solubility of the dyes and improved affinity towards various natural and synthetic fibres, especially wool and cellulose diacetate fibres [4].
For the purpose of addressing environmental issues in the textile industry, in this work, two pyridinium-based azo pyridone dyes with improved solubility and affinity towards different fibres, are used for dyeing wool fabric. The results show that the same dyebath can be efficiently used multiple times, therefore reducing waste in the water while securing the optimizing dying. The obtained fabrics from different cycles are further characterized by K/S values while the residue of the dye in the wastewater was recorded using UV-Vis spectra.",
publisher = "Podgorica : Chemical Society of Montenegro",
journal = "Book of Abstracts / 23rd European Meeting on Environmental Chemistry, 3-6 December, 2023, Budva, Montenegro",
title = "Reducing Wastewater in Textile Industry: Innovative Dying Approach",
pages = "64",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6935"
}

Mašulović, A., Lađarević, J., Ivanovska, A., Kostić, M., Prlainović, N., Bigović, M.,& Mijin, D.. (2023). Reducing Wastewater in Textile Industry: Innovative Dying Approach. in Book of Abstracts / 23rd European Meeting on Environmental Chemistry, 3-6 December, 2023, Budva, Montenegro
Podgorica : Chemical Society of Montenegro., 64.
https://hdl.handle.net/21.15107/rcub_technorep_6935

Mašulović A, Lađarević J, Ivanovska A, Kostić M, Prlainović N, Bigović M, Mijin D. Reducing Wastewater in Textile Industry: Innovative Dying Approach. in Book of Abstracts / 23rd European Meeting on Environmental Chemistry, 3-6 December, 2023, Budva, Montenegro. 2023;:64.
https://hdl.handle.net/21.15107/rcub_technorep_6935 .

Mašulović, Aleksandra, Lađarević, Jelena, Ivanovska, Aleksandra, Kostić, Mirjana, Prlainović, Nevena, Bigović, Miljan, Mijin, Dušan, "Reducing Wastewater in Textile Industry: Innovative Dying Approach" in Book of Abstracts / 23rd European Meeting on Environmental Chemistry, 3-6 December, 2023, Budva, Montenegro (2023):64,
https://hdl.handle.net/21.15107/rcub_technorep_6935 .

TY  - JOUR
AU  - Ponjavić, Marijana
AU  - Malagurski, Ivana
AU  - Lazić, Jelena
AU  - Jeremić, Sanja
AU  - Pavlović, Vladimir
AU  - Prlainović, Nevena
AU  - Maksimović, Vesna
AU  - Ćosović, Vladan
AU  - Atanase, Leonard Ionut
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5866
AB  - The quest for sustainable biomaterials with excellent biocompatibility and tailorableproperties has put polyhydroxyalkanoates (PHAs) into the research spotlight. However, high productioncosts and the lack of bioactivity limit their market penetration. To address this, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) was combined with a bacterial pigment with stronganticancer activity, prodigiosin (PG), to obtain functionally enhanced PHBV-based biomaterials. Thesamples were produced in the form of films 115.6–118.8  m in thickness using the solvent castingmethod. The effects of PG incorporation on the physical properties (morphology, biopolymer crystallinityand thermal stability) and functionality of the obtained biomaterials were investigated. PGhas acted as a nucleating agent, in turn affecting the degree of crystallinity, thermal stability andmorphology of the films. All samples with PG had a more organized internal structure and highermelting and degradation temperatures. The calculated degree of crystallinity of the PHBV copolymerwas 53%, while the PG1, PG3 and PG3 films had values of 64.0%, 63.9% and 69.2%, respectively.Cytotoxicity studies have shown the excellent anticancer activity of films against HCT116 (coloncancer) cells, thus advancing PHBV biomedical application potential.
PB  - Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)
T2  - International Journal of Molecular Sciences
T1  - Advancing PHBV Biomedical Potential with the Incorporation of Bacterial Biopigment Prodigiosin
SP  - 1906
VL  - 24
DO  - 10.3390/ijms24031906
ER  - 

@article{
author = "Ponjavić, Marijana and Malagurski, Ivana and Lazić, Jelena and Jeremić, Sanja and Pavlović, Vladimir and Prlainović, Nevena and Maksimović, Vesna and Ćosović, Vladan and Atanase, Leonard Ionut",
year = "2023",
abstract = "The quest for sustainable biomaterials with excellent biocompatibility and tailorableproperties has put polyhydroxyalkanoates (PHAs) into the research spotlight. However, high productioncosts and the lack of bioactivity limit their market penetration. To address this, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) was combined with a bacterial pigment with stronganticancer activity, prodigiosin (PG), to obtain functionally enhanced PHBV-based biomaterials. Thesamples were produced in the form of films 115.6–118.8  m in thickness using the solvent castingmethod. The effects of PG incorporation on the physical properties (morphology, biopolymer crystallinityand thermal stability) and functionality of the obtained biomaterials were investigated. PGhas acted as a nucleating agent, in turn affecting the degree of crystallinity, thermal stability andmorphology of the films. All samples with PG had a more organized internal structure and highermelting and degradation temperatures. The calculated degree of crystallinity of the PHBV copolymerwas 53%, while the PG1, PG3 and PG3 films had values of 64.0%, 63.9% and 69.2%, respectively.Cytotoxicity studies have shown the excellent anticancer activity of films against HCT116 (coloncancer) cells, thus advancing PHBV biomedical application potential.",
publisher = "Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "International Journal of Molecular Sciences",
title = "Advancing PHBV Biomedical Potential with the Incorporation of Bacterial Biopigment Prodigiosin",
pages = "1906",
volume = "24",
doi = "10.3390/ijms24031906"
}

Ponjavić, M., Malagurski, I., Lazić, J., Jeremić, S., Pavlović, V., Prlainović, N., Maksimović, V., Ćosović, V.,& Atanase, L. I.. (2023). Advancing PHBV Biomedical Potential with the Incorporation of Bacterial Biopigment Prodigiosin. in International Journal of Molecular Sciences
Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)., 24, 1906.
https://doi.org/10.3390/ijms24031906

Ponjavić M, Malagurski I, Lazić J, Jeremić S, Pavlović V, Prlainović N, Maksimović V, Ćosović V, Atanase LI. Advancing PHBV Biomedical Potential with the Incorporation of Bacterial Biopigment Prodigiosin. in International Journal of Molecular Sciences. 2023;24:1906.
doi:10.3390/ijms24031906 .

Ponjavić, Marijana, Malagurski, Ivana, Lazić, Jelena, Jeremić, Sanja, Pavlović, Vladimir, Prlainović, Nevena, Maksimović, Vesna, Ćosović, Vladan, Atanase, Leonard Ionut, "Advancing PHBV Biomedical Potential with the Incorporation of Bacterial Biopigment Prodigiosin" in International Journal of Molecular Sciences, 24 (2023):1906,
https://doi.org/10.3390/ijms24031906 . .

TY  - CONF
AU  - Jovanović, Aleksandar
AU  - Knežević, Nataša
AU  - Čutović, Natalija
AU  - Đolić, Maja
AU  - Prlainović, Nevena
AU  - Veličković, Zlate
AU  - Vuksanović, Marija M.
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6029
AB  - Management of waste polymers (polyethylene - PE and polypropylene - PP) represents one of the major obstacles in the field of environmental protection, which demands a most efficient and eco-friendly technological solution. Due to the high use of various plastic materials, the amount of landfilled or dissipated plastic waste is continuously growing. Therefore, this paper examines the possibilities of recycling these polymers, alongside obtaining granules of similar or advanced physico-mechanical characteristics to the commercially available ones. The applied technology consists of several consecutive processes (collecting, grinding, washing and extruding) where the obtained materials can later be incorporated into widely applicable products, such as foils, bin liners, bags, among others. In this way, high-quality products with great market potential are obtained, which will consequently contribute to lower extraction and less depletion of natural resources. Thus major problems may be solved optimally, consolidating the efficiency of improved eco-friendly technologies which is in line with environmental protection and sustainable waste management.
PB  - University of Belgrade, Technical Faculty in Bor
C3  - 29th International Conference Ecological Truth and Environmental Research – EcoTER’22" Sokobanja, June 21-24, 2022
T1  - Improved technology for production of PE and PP regranulates
EP  - 189
SP  - 186
UR  - https://hdl.handle.net/21.15107/rcub_vinar_10673
ER  - 

@conference{
author = "Jovanović, Aleksandar and Knežević, Nataša and Čutović, Natalija and Đolić, Maja and Prlainović, Nevena and Veličković, Zlate and Vuksanović, Marija M.",
year = "2022",
abstract = "Management of waste polymers (polyethylene - PE and polypropylene - PP) represents one of the major obstacles in the field of environmental protection, which demands a most efficient and eco-friendly technological solution. Due to the high use of various plastic materials, the amount of landfilled or dissipated plastic waste is continuously growing. Therefore, this paper examines the possibilities of recycling these polymers, alongside obtaining granules of similar or advanced physico-mechanical characteristics to the commercially available ones. The applied technology consists of several consecutive processes (collecting, grinding, washing and extruding) where the obtained materials can later be incorporated into widely applicable products, such as foils, bin liners, bags, among others. In this way, high-quality products with great market potential are obtained, which will consequently contribute to lower extraction and less depletion of natural resources. Thus major problems may be solved optimally, consolidating the efficiency of improved eco-friendly technologies which is in line with environmental protection and sustainable waste management.",
publisher = "University of Belgrade, Technical Faculty in Bor",
journal = "29th International Conference Ecological Truth and Environmental Research – EcoTER’22" Sokobanja, June 21-24, 2022",
title = "Improved technology for production of PE and PP regranulates",
pages = "189-186",
url = "https://hdl.handle.net/21.15107/rcub_vinar_10673"
}

Jovanović, A., Knežević, N., Čutović, N., Đolić, M., Prlainović, N., Veličković, Z.,& Vuksanović, M. M.. (2022). Improved technology for production of PE and PP regranulates. in 29th International Conference Ecological Truth and Environmental Research – EcoTER’22" Sokobanja, June 21-24, 2022
University of Belgrade, Technical Faculty in Bor., 186-189.
https://hdl.handle.net/21.15107/rcub_vinar_10673

Jovanović A, Knežević N, Čutović N, Đolić M, Prlainović N, Veličković Z, Vuksanović MM. Improved technology for production of PE and PP regranulates. in 29th International Conference Ecological Truth and Environmental Research – EcoTER’22" Sokobanja, June 21-24, 2022. 2022;:186-189.
https://hdl.handle.net/21.15107/rcub_vinar_10673 .

Jovanović, Aleksandar, Knežević, Nataša, Čutović, Natalija, Đolić, Maja, Prlainović, Nevena, Veličković, Zlate, Vuksanović, Marija M., "Improved technology for production of PE and PP regranulates" in 29th International Conference Ecological Truth and Environmental Research – EcoTER’22" Sokobanja, June 21-24, 2022 (2022):186-189,
https://hdl.handle.net/21.15107/rcub_vinar_10673 .

TY  - JOUR
AU  - Omran, Kaled Mohamed Ben
AU  - Shwika, Salem Ibrahim
AU  - Vuksanović, Marija M.
AU  - Marinković, Aleksandar D.
AU  - Jovanović, Aleksandar
AU  - Prlainović, Nevena
AU  - Vasilski, Dragana
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5177
AB  - During a fire, passive fire protection systems are designed to prevent the spread of flames, smoke, and toxic gases. The new fire-retardant (FR) material, used for passive fire protection, is created by combining copolymers (VC–co–VAc) (Slovinyl KV 173) and PVC K70 with expanded graphite and plasticizers/modifiers such as diisononyl phthalate-DINP, diisononyl terephthalate-DINTP, dioctyl adipate-DOA, as well as plasticizers that are synthesized based on tertiary recycling of waste poly(ethylene terephthalate) (PET), 1-hexadecene, azodicarbonamide (ADC), tri(p-cresyl phosphate), epoxidized soybean oil (ESO) and acrylate emulsion (DH50, Ecrylic, or Flexryl, etc.). The obtained material's morphology was examined using an emission scanning electron microscope (FESEM) field. Tensile testing was used to determine the mechanical properties of the obtained samples, as well as Shore A hardness and toughness using the Charpy impact test. All samples obtained were tested according to non-flammability standards. To conform to the new trend of "green economy," the development of novel eco-friendly FRs with improved thermal and mechanical properties will include careful consideration of environmental protection and sustainable development.
PB  - Association of Metallurgical Engineers of Serbia
T2  - Metallurgical and Materials Engineering
T1  - CIRCULAR ECONOMY IMPLEMENTATION IN THE DEVELOPMENT OF FIRE-RETARDANT MATERIALS USED IN CONSTRUCTION, INDUSTRY, AND GENERAL-PURPOSE PRODUCTS
EP  - 379
IS  - 2
SP  - 369
VL  - 28
DO  - 10.30544/768
ER  - 

@article{
author = "Omran, Kaled Mohamed Ben and Shwika, Salem Ibrahim and Vuksanović, Marija M. and Marinković, Aleksandar D. and Jovanović, Aleksandar and Prlainović, Nevena and Vasilski, Dragana",
year = "2022",
abstract = "During a fire, passive fire protection systems are designed to prevent the spread of flames, smoke, and toxic gases. The new fire-retardant (FR) material, used for passive fire protection, is created by combining copolymers (VC–co–VAc) (Slovinyl KV 173) and PVC K70 with expanded graphite and plasticizers/modifiers such as diisononyl phthalate-DINP, diisononyl terephthalate-DINTP, dioctyl adipate-DOA, as well as plasticizers that are synthesized based on tertiary recycling of waste poly(ethylene terephthalate) (PET), 1-hexadecene, azodicarbonamide (ADC), tri(p-cresyl phosphate), epoxidized soybean oil (ESO) and acrylate emulsion (DH50, Ecrylic, or Flexryl, etc.). The obtained material's morphology was examined using an emission scanning electron microscope (FESEM) field. Tensile testing was used to determine the mechanical properties of the obtained samples, as well as Shore A hardness and toughness using the Charpy impact test. All samples obtained were tested according to non-flammability standards. To conform to the new trend of "green economy," the development of novel eco-friendly FRs with improved thermal and mechanical properties will include careful consideration of environmental protection and sustainable development.",
publisher = "Association of Metallurgical Engineers of Serbia",
journal = "Metallurgical and Materials Engineering",
title = "CIRCULAR ECONOMY IMPLEMENTATION IN THE DEVELOPMENT OF FIRE-RETARDANT MATERIALS USED IN CONSTRUCTION, INDUSTRY, AND GENERAL-PURPOSE PRODUCTS",
pages = "379-369",
number = "2",
volume = "28",
doi = "10.30544/768"
}

Omran, K. M. B., Shwika, S. I., Vuksanović, M. M., Marinković, A. D., Jovanović, A., Prlainović, N.,& Vasilski, D.. (2022). CIRCULAR ECONOMY IMPLEMENTATION IN THE DEVELOPMENT OF FIRE-RETARDANT MATERIALS USED IN CONSTRUCTION, INDUSTRY, AND GENERAL-PURPOSE PRODUCTS. in Metallurgical and Materials Engineering
Association of Metallurgical Engineers of Serbia., 28(2), 369-379.
https://doi.org/10.30544/768

Omran KMB, Shwika SI, Vuksanović MM, Marinković AD, Jovanović A, Prlainović N, Vasilski D. CIRCULAR ECONOMY IMPLEMENTATION IN THE DEVELOPMENT OF FIRE-RETARDANT MATERIALS USED IN CONSTRUCTION, INDUSTRY, AND GENERAL-PURPOSE PRODUCTS. in Metallurgical and Materials Engineering. 2022;28(2):369-379.
doi:10.30544/768 .

Omran, Kaled Mohamed Ben, Shwika, Salem Ibrahim, Vuksanović, Marija M., Marinković, Aleksandar D., Jovanović, Aleksandar, Prlainović, Nevena, Vasilski, Dragana, "CIRCULAR ECONOMY IMPLEMENTATION IN THE DEVELOPMENT OF FIRE-RETARDANT MATERIALS USED IN CONSTRUCTION, INDUSTRY, AND GENERAL-PURPOSE PRODUCTS" in Metallurgical and Materials Engineering, 28, no. 2 (2022):369-379,
https://doi.org/10.30544/768 . .

TY  - JOUR
AU  - Assaleh, Mohamed H.
AU  - Jeremić, Sanja
AU  - Cvijetić, Ilija
AU  - Marinković, Aleksandar
AU  - Prlainović, Nevena
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5111
AB  - Antimicrobial-resistance (AMR) has become the greatest concern and highly challenging issue when treating nosocomial infections. The exigency to develop new potent compounds continues to increase worldwide, whereby derivatives of natural products are becoming more attractive. In the present paper, the microbiological assessment of a series of 12 cinnamide hydrazides, four of them completely novel, against clinically relevant pathogens has discovered several derivatives with promising in vitro activities against Acinetobacter baumannii, one of the most dreaded opportunistic pathogens in hospitals. The compounds were synthesized by combining one of three different natural acids (cinnamic, 4-chloro or 4-methoxy) with four monothiocarbohydrazones (MTCHs) - an important class of synthetic organic molecules. Their structure was confirmed by elemental microanalysis, as well as ATR-FTIR, 1H and 13C NMR spectra, with the addition of 2D NMR spectra for novel compounds. The hybrids of cinnamic acids and pyridine derivatives are particularly active compounds with the lowest MIC50 value of 10.4 µM for p-chloro cinnamic acid and acetyl pyridine derivatives. An alignment-independent 3D QSAR model identified pharmacophoric hotspots and suggested several structural modifications that might improve the potency of this class of compounds against A. baumannii. The compounds are strong iron-chelating agents forming complexes with a stability constant between 107 and 109. The synthesized derivatives represent a promising class of antibacterial compounds with activities comparable to the commonly used antibiotics.
PB  - Elsevier B.V.
T2  - Journal of Molecular Structure
T1  - In vitro activity of novel cinnamic acids hydrazides against clinically important pathogens
SP  - 133016
VL  - 1262
DO  - 10.1016/j.molstruc.2022.133016
ER  - 

@article{
author = "Assaleh, Mohamed H. and Jeremić, Sanja and Cvijetić, Ilija and Marinković, Aleksandar and Prlainović, Nevena",
year = "2022",
abstract = "Antimicrobial-resistance (AMR) has become the greatest concern and highly challenging issue when treating nosocomial infections. The exigency to develop new potent compounds continues to increase worldwide, whereby derivatives of natural products are becoming more attractive. In the present paper, the microbiological assessment of a series of 12 cinnamide hydrazides, four of them completely novel, against clinically relevant pathogens has discovered several derivatives with promising in vitro activities against Acinetobacter baumannii, one of the most dreaded opportunistic pathogens in hospitals. The compounds were synthesized by combining one of three different natural acids (cinnamic, 4-chloro or 4-methoxy) with four monothiocarbohydrazones (MTCHs) - an important class of synthetic organic molecules. Their structure was confirmed by elemental microanalysis, as well as ATR-FTIR, 1H and 13C NMR spectra, with the addition of 2D NMR spectra for novel compounds. The hybrids of cinnamic acids and pyridine derivatives are particularly active compounds with the lowest MIC50 value of 10.4 µM for p-chloro cinnamic acid and acetyl pyridine derivatives. An alignment-independent 3D QSAR model identified pharmacophoric hotspots and suggested several structural modifications that might improve the potency of this class of compounds against A. baumannii. The compounds are strong iron-chelating agents forming complexes with a stability constant between 107 and 109. The synthesized derivatives represent a promising class of antibacterial compounds with activities comparable to the commonly used antibiotics.",
publisher = "Elsevier B.V.",
journal = "Journal of Molecular Structure",
title = "In vitro activity of novel cinnamic acids hydrazides against clinically important pathogens",
pages = "133016",
volume = "1262",
doi = "10.1016/j.molstruc.2022.133016"
}

Assaleh, M. H., Jeremić, S., Cvijetić, I., Marinković, A.,& Prlainović, N.. (2022). In vitro activity of novel cinnamic acids hydrazides against clinically important pathogens. in Journal of Molecular Structure
Elsevier B.V.., 1262, 133016.
https://doi.org/10.1016/j.molstruc.2022.133016

Assaleh MH, Jeremić S, Cvijetić I, Marinković A, Prlainović N. In vitro activity of novel cinnamic acids hydrazides against clinically important pathogens. in Journal of Molecular Structure. 2022;1262:133016.
doi:10.1016/j.molstruc.2022.133016 .

Assaleh, Mohamed H., Jeremić, Sanja, Cvijetić, Ilija, Marinković, Aleksandar, Prlainović, Nevena, "In vitro activity of novel cinnamic acids hydrazides against clinically important pathogens" in Journal of Molecular Structure, 1262 (2022):133016,
https://doi.org/10.1016/j.molstruc.2022.133016 . .

TY  - JOUR
AU  - Assaleh, Mohamed H.
AU  - Bjelogrlic, Snezana K.
AU  - Prlainović, Nevena
AU  - Cvijetić, Ilija
AU  - Bozic, Aleksandra
AU  - Aranđelović, Irena
AU  - Vukovic, Dragana
AU  - Marinković, Aleksandar
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4986
AB  - A series of twelve novel hybrids of cinnamic acid and thiocarbohydrazones were designed, synthesized in high yield using a simple coupling strategy via acid chlorides, and evaluated for their impact against Mycobacterium tuberculosis (Mtb) and cancer cells survival. Among them, compound 3 demonstrated strong anti-Mtb activity by reducing bacilli survival for>90 % in all three treated Mtb isolates, whereas isoniazid and rifampicin did not. Moreover, compound 3 didn't affect vitality of HepG-2 cells, implying on advantageous hepatotoxicity profile compared to current therapeutic options for tuberculosis. Compounds 2a and 3b displayed as strong inducers of apoptosis in A549 cells, both activating intrinsic caspase pathway and cell cycle arrest at the G0/ G1 phase. Subsequent analyses disclosed differences in their activities, where 3b has ability to induce production of mitochondrial superoxide anions, while 2a significantly inhibited cellular mobility. More importantly, 3b considerably affected viability of HepG-2 and HaCaT cells, whereas 2a had moderate impact only on the later. Molecular modeling studies indicated high permeability and good absorption through the human intestine, and moderate aqueous solubility with poor blood-brain barrier permeability. In summary, our results reveal that novel compounds 3 and 2a represent promising agents for tuberculosis and cancer treatment, respectively, indicating that fur-ther investigation needs to be performed to clarify the mechanisms of their anti-Mtb and anticancer activity. (c) 2021 The Authors. Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
T2  - Arabian Journal of Chemistry
T1  - Antimycobacterial and anticancer activity of newly designed cinnamic acid hydrazides with favorable toxicity profile: Antimycobacterial and anticancer activity of newly designed cinnamic acid
IS  - 1
SP  - 103532
VL  - 15
DO  - 10.1016/j.arabjc.2021.103532
ER  - 

@article{
author = "Assaleh, Mohamed H. and Bjelogrlic, Snezana K. and Prlainović, Nevena and Cvijetić, Ilija and Bozic, Aleksandra and Aranđelović, Irena and Vukovic, Dragana and Marinković, Aleksandar",
year = "2022",
abstract = "A series of twelve novel hybrids of cinnamic acid and thiocarbohydrazones were designed, synthesized in high yield using a simple coupling strategy via acid chlorides, and evaluated for their impact against Mycobacterium tuberculosis (Mtb) and cancer cells survival. Among them, compound 3 demonstrated strong anti-Mtb activity by reducing bacilli survival for>90 % in all three treated Mtb isolates, whereas isoniazid and rifampicin did not. Moreover, compound 3 didn't affect vitality of HepG-2 cells, implying on advantageous hepatotoxicity profile compared to current therapeutic options for tuberculosis. Compounds 2a and 3b displayed as strong inducers of apoptosis in A549 cells, both activating intrinsic caspase pathway and cell cycle arrest at the G0/ G1 phase. Subsequent analyses disclosed differences in their activities, where 3b has ability to induce production of mitochondrial superoxide anions, while 2a significantly inhibited cellular mobility. More importantly, 3b considerably affected viability of HepG-2 and HaCaT cells, whereas 2a had moderate impact only on the later. Molecular modeling studies indicated high permeability and good absorption through the human intestine, and moderate aqueous solubility with poor blood-brain barrier permeability. In summary, our results reveal that novel compounds 3 and 2a represent promising agents for tuberculosis and cancer treatment, respectively, indicating that fur-ther investigation needs to be performed to clarify the mechanisms of their anti-Mtb and anticancer activity. (c) 2021 The Authors. Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).",
journal = "Arabian Journal of Chemistry",
title = "Antimycobacterial and anticancer activity of newly designed cinnamic acid hydrazides with favorable toxicity profile: Antimycobacterial and anticancer activity of newly designed cinnamic acid",
number = "1",
pages = "103532",
volume = "15",
doi = "10.1016/j.arabjc.2021.103532"
}

Assaleh, M. H., Bjelogrlic, S. K., Prlainović, N., Cvijetić, I., Bozic, A., Aranđelović, I., Vukovic, D.,& Marinković, A.. (2022). Antimycobacterial and anticancer activity of newly designed cinnamic acid hydrazides with favorable toxicity profile: Antimycobacterial and anticancer activity of newly designed cinnamic acid. in Arabian Journal of Chemistry, 15(1), 103532.
https://doi.org/10.1016/j.arabjc.2021.103532

Assaleh MH, Bjelogrlic SK, Prlainović N, Cvijetić I, Bozic A, Aranđelović I, Vukovic D, Marinković A. Antimycobacterial and anticancer activity of newly designed cinnamic acid hydrazides with favorable toxicity profile: Antimycobacterial and anticancer activity of newly designed cinnamic acid. in Arabian Journal of Chemistry. 2022;15(1):103532.
doi:10.1016/j.arabjc.2021.103532 .

Assaleh, Mohamed H., Bjelogrlic, Snezana K., Prlainović, Nevena, Cvijetić, Ilija, Bozic, Aleksandra, Aranđelović, Irena, Vukovic, Dragana, Marinković, Aleksandar, "Antimycobacterial and anticancer activity of newly designed cinnamic acid hydrazides with favorable toxicity profile: Antimycobacterial and anticancer activity of newly designed cinnamic acid" in Arabian Journal of Chemistry, 15, no. 1 (2022):103532,
https://doi.org/10.1016/j.arabjc.2021.103532 . .

TY  - JOUR
AU  - Milentijevic, Goran
AU  - Marinković, Aleksandar
AU  - Rancic, Milica
AU  - Bogdanović, Aleksandra
AU  - Prlainović, Nevena
AU  - Markovic, Smiljana
AU  - Milosavljevic, Milutin
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4779
AB  - The specific objectives of the presented study were related to the optimization of the production process of N-alkyl-, N,N-dialkyl-, and N-cycloalkyl-O-isobutyl thiocarbamate; trial industrial production of N-ethyl-O-isobutyl thiocarbamate; and the evaluation of flotation efficiency of N-ethyl-O-isobutyl thiocarbamate using a real ore sample. The optimization of thiocarbamate syntheses were performed by varying the molar ratio of isobutyl alcohol, carbon disulfide, potassium hydroxide, reaction time, and reaction temperature. In the first step, one-pot reaction took place to produce alkyl xanthate and was followed with chlorination to give alkyl chloroformate (O-alkyl carbonochloridothioate); finally, thiocarbamates were obtained by the reaction with corresponding amines. N-alkyl-O-ethyl thiocarbamate was synthesized as a comparative flotation agent. The structure of the synthesized compounds was confirmed by IR, H-1 and C-13 NMR, and MS instrumental methods, and the purity was determined by gas chromatographic method and elemental analysis. The optimized methods gave high-purity products in a significant yield that was also confirmed by semi-industrial production of N-ethyl-O-isobutyl thiocarbamate. The optimized thiocarbamate synthesis, without isolation of intermediates, is of great importance from the aspect of green technologies. Flotation efficiency test results, using real copper and zinc ores, showed the highest activity of N-ethyl-O-isobutyl thiocarbamate. The optimal one-pot thiocarbamate synthesis provides a simple procedure with a high conversion degree, and, thus, offers valuable technology applicable at the industrial scale.
T2  - Minerals
T1  - New Facile One-Pot Synthesis of Isobutyl Thiocarbamate in Recycling Solvent Mixture
IS  - 12
VL  - 11
DO  - 10.3390/min11121346
ER  - 

@article{
author = "Milentijevic, Goran and Marinković, Aleksandar and Rancic, Milica and Bogdanović, Aleksandra and Prlainović, Nevena and Markovic, Smiljana and Milosavljevic, Milutin",
year = "2021",
abstract = "The specific objectives of the presented study were related to the optimization of the production process of N-alkyl-, N,N-dialkyl-, and N-cycloalkyl-O-isobutyl thiocarbamate; trial industrial production of N-ethyl-O-isobutyl thiocarbamate; and the evaluation of flotation efficiency of N-ethyl-O-isobutyl thiocarbamate using a real ore sample. The optimization of thiocarbamate syntheses were performed by varying the molar ratio of isobutyl alcohol, carbon disulfide, potassium hydroxide, reaction time, and reaction temperature. In the first step, one-pot reaction took place to produce alkyl xanthate and was followed with chlorination to give alkyl chloroformate (O-alkyl carbonochloridothioate); finally, thiocarbamates were obtained by the reaction with corresponding amines. N-alkyl-O-ethyl thiocarbamate was synthesized as a comparative flotation agent. The structure of the synthesized compounds was confirmed by IR, H-1 and C-13 NMR, and MS instrumental methods, and the purity was determined by gas chromatographic method and elemental analysis. The optimized methods gave high-purity products in a significant yield that was also confirmed by semi-industrial production of N-ethyl-O-isobutyl thiocarbamate. The optimized thiocarbamate synthesis, without isolation of intermediates, is of great importance from the aspect of green technologies. Flotation efficiency test results, using real copper and zinc ores, showed the highest activity of N-ethyl-O-isobutyl thiocarbamate. The optimal one-pot thiocarbamate synthesis provides a simple procedure with a high conversion degree, and, thus, offers valuable technology applicable at the industrial scale.",
journal = "Minerals",
title = "New Facile One-Pot Synthesis of Isobutyl Thiocarbamate in Recycling Solvent Mixture",
number = "12",
volume = "11",
doi = "10.3390/min11121346"
}

Milentijevic, G., Marinković, A., Rancic, M., Bogdanović, A., Prlainović, N., Markovic, S.,& Milosavljevic, M.. (2021). New Facile One-Pot Synthesis of Isobutyl Thiocarbamate in Recycling Solvent Mixture. in Minerals, 11(12).
https://doi.org/10.3390/min11121346

Milentijevic G, Marinković A, Rancic M, Bogdanović A, Prlainović N, Markovic S, Milosavljevic M. New Facile One-Pot Synthesis of Isobutyl Thiocarbamate in Recycling Solvent Mixture. in Minerals. 2021;11(12).
doi:10.3390/min11121346 .

Milentijevic, Goran, Marinković, Aleksandar, Rancic, Milica, Bogdanović, Aleksandra, Prlainović, Nevena, Markovic, Smiljana, Milosavljevic, Milutin, "New Facile One-Pot Synthesis of Isobutyl Thiocarbamate in Recycling Solvent Mixture" in Minerals, 11, no. 12 (2021),
https://doi.org/10.3390/min11121346 . .

TY  - JOUR
AU  - Milošević, Milena D.
AU  - Marinković, Aleksandar
AU  - Petrović, Predrag
AU  - Klaus, Anita
AU  - Nikolić, Milica G.
AU  - Prlainović, Nevena
AU  - Cvijetić, Ilija
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4393
AB  - In this study we synthesized a series of sixteen bis(imino)pyridines (BIPs) starting from 2,6-diaminopyridine and various aromatic aldehydes, and evaluated their antioxidant, antibacterial, antifungal and acetylcholinesterase (AChE) inhibitory activity. The chemical structures were elucidated by FTIR, elemental analysis, ESR and HRMS. H-1 and C-13 NMR spectra couldn't be acquired due to the formation of stable, carbon-centered radical cations in a solution, as confirmed by ESR spectroscopy and DFT calculations. The in vitro antioxidant potency was evaluated using four assays: free radical scavenging activity (DPPH and ABTS), reducing power and total antioxidant capacity assay. BIPs demonstrated excellent antioxidant properties, and two derivatives proved to be more potent than reference antioxidants (ascorbic acid and Trolox) in all assays. DFT calculations on.B97XD/6-311++g(d,p) level of theory provided valuable insights into the radical scavenging mechanism of BIPs. For hydroxyl-substituted BIPs, hydrogen atom transfer (HAT) is a predominant mechanism, while the single electron transfer coupled with proton transfer (SET-PT) governs the antioxidant activity of other derivatives. Intramolecular hydrogen bonding (IHB) plays an important role in the mechanism of antioxidant activity as revealed by noncovalent interaction analysis and rotational barrier calculations. The spin density of radical cations is localized on carbon atoms of a pyridine ring, which corroborates with g-factors and multiplicity obtained from ESR analysis. The most potent BIP exhibited moderate inhibitory activity toward AChE (IC50 = 20 +/- 4 mu M), while molecular docking suggested binding at the peripheral anionic site of AChE with the MMFF94 binding enthalpy of -43.4 kcal/mol. Moderate in vitro antimicrobial activity of BIPs have been determined against several pathogenic bacterial strains: Pseudomonas aeruginosa, Escherichia coli, Enterococcus faecalis, Staphylococcus aureus and clinical isolate of methicillin resistant S. aureus (MRSA). The antifungal activity of BIPs toward Candida albicans was also confirmed. The similarity ensemble approach combined with molecular docking suggested leucyl aminopeptidase as the probable antimicrobial target for the three most potent BIP derivatives.
PB  - Academic Press Inc Elsevier Science, San Diego
T2  - Bioorganic Chemistry
T1  - Synthesis, characterization and SAR studies of bis(imino)pyridines as antioxidants, acetylcholinesterase inhibitors and antimicrobial agents
VL  - 102
DO  - 10.1016/j.bioorg.2020.104073
ER  - 

@article{
author = "Milošević, Milena D. and Marinković, Aleksandar and Petrović, Predrag and Klaus, Anita and Nikolić, Milica G. and Prlainović, Nevena and Cvijetić, Ilija",
year = "2020",
abstract = "In this study we synthesized a series of sixteen bis(imino)pyridines (BIPs) starting from 2,6-diaminopyridine and various aromatic aldehydes, and evaluated their antioxidant, antibacterial, antifungal and acetylcholinesterase (AChE) inhibitory activity. The chemical structures were elucidated by FTIR, elemental analysis, ESR and HRMS. H-1 and C-13 NMR spectra couldn't be acquired due to the formation of stable, carbon-centered radical cations in a solution, as confirmed by ESR spectroscopy and DFT calculations. The in vitro antioxidant potency was evaluated using four assays: free radical scavenging activity (DPPH and ABTS), reducing power and total antioxidant capacity assay. BIPs demonstrated excellent antioxidant properties, and two derivatives proved to be more potent than reference antioxidants (ascorbic acid and Trolox) in all assays. DFT calculations on.B97XD/6-311++g(d,p) level of theory provided valuable insights into the radical scavenging mechanism of BIPs. For hydroxyl-substituted BIPs, hydrogen atom transfer (HAT) is a predominant mechanism, while the single electron transfer coupled with proton transfer (SET-PT) governs the antioxidant activity of other derivatives. Intramolecular hydrogen bonding (IHB) plays an important role in the mechanism of antioxidant activity as revealed by noncovalent interaction analysis and rotational barrier calculations. The spin density of radical cations is localized on carbon atoms of a pyridine ring, which corroborates with g-factors and multiplicity obtained from ESR analysis. The most potent BIP exhibited moderate inhibitory activity toward AChE (IC50 = 20 +/- 4 mu M), while molecular docking suggested binding at the peripheral anionic site of AChE with the MMFF94 binding enthalpy of -43.4 kcal/mol. Moderate in vitro antimicrobial activity of BIPs have been determined against several pathogenic bacterial strains: Pseudomonas aeruginosa, Escherichia coli, Enterococcus faecalis, Staphylococcus aureus and clinical isolate of methicillin resistant S. aureus (MRSA). The antifungal activity of BIPs toward Candida albicans was also confirmed. The similarity ensemble approach combined with molecular docking suggested leucyl aminopeptidase as the probable antimicrobial target for the three most potent BIP derivatives.",
publisher = "Academic Press Inc Elsevier Science, San Diego",
journal = "Bioorganic Chemistry",
title = "Synthesis, characterization and SAR studies of bis(imino)pyridines as antioxidants, acetylcholinesterase inhibitors and antimicrobial agents",
volume = "102",
doi = "10.1016/j.bioorg.2020.104073"
}

Milošević, M. D., Marinković, A., Petrović, P., Klaus, A., Nikolić, M. G., Prlainović, N.,& Cvijetić, I.. (2020). Synthesis, characterization and SAR studies of bis(imino)pyridines as antioxidants, acetylcholinesterase inhibitors and antimicrobial agents. in Bioorganic Chemistry
Academic Press Inc Elsevier Science, San Diego., 102.
https://doi.org/10.1016/j.bioorg.2020.104073

Milošević MD, Marinković A, Petrović P, Klaus A, Nikolić MG, Prlainović N, Cvijetić I. Synthesis, characterization and SAR studies of bis(imino)pyridines as antioxidants, acetylcholinesterase inhibitors and antimicrobial agents. in Bioorganic Chemistry. 2020;102.
doi:10.1016/j.bioorg.2020.104073 .

Milošević, Milena D., Marinković, Aleksandar, Petrović, Predrag, Klaus, Anita, Nikolić, Milica G., Prlainović, Nevena, Cvijetić, Ilija, "Synthesis, characterization and SAR studies of bis(imino)pyridines as antioxidants, acetylcholinesterase inhibitors and antimicrobial agents" in Bioorganic Chemistry, 102 (2020),
https://doi.org/10.1016/j.bioorg.2020.104073 . .

TY  - JOUR
AU  - Tomašević, Anđelka
AU  - Marinković, Aleksandar
AU  - Mijin, Dušan
AU  - Radišić, Marina
AU  - Porobić, Slavica
AU  - Prlainović, Nevena
AU  - Gašić, Slavica
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4375
AB  - Photocatalytic degradation of the carbamate insecticide methomyl and its commercial product Lannate-90 in aqueous suspension of TiO2 and ZnO using an Osram ultra-vitalux lamp (315-400 nm) was investigated. The objective of the investigation was to study and compare the rates of photochemical degradation of the pure active compound and its formulated product in order to find out the impact of inert ingredients on degradation processes. The photo-chemical degradation of pure methomyl was found to be slower than the degradation of its commercial product Lannate-90. Photodegradation was investigated by UV-Vis spectrometry and HPLC, while mineralization was monitored using IC and TOC analyses. Light absorption capabilities of catalysts were characterized by ultraviolet-visible diffuse reflectance spectroscopy method, while the stability of catalysts was studied by infrared analyses. Degradation products of methomyl and its formulated product were identified by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) results and tentative photodegradation pathways were proposed.
PB  - Savez hemijskih inženjera, Beograd
T2  - Chemical Industry & Chemical Engineering Quarterly
T1  - A study of photocatalytic degradation of methomyl and its commercial product lannate-90
EP  - 247
IS  - 3
SP  - 237
VL  - 26
DO  - 10.2298/CICEQ190424002T
ER  - 

@article{
author = "Tomašević, Anđelka and Marinković, Aleksandar and Mijin, Dušan and Radišić, Marina and Porobić, Slavica and Prlainović, Nevena and Gašić, Slavica",
year = "2020",
abstract = "Photocatalytic degradation of the carbamate insecticide methomyl and its commercial product Lannate-90 in aqueous suspension of TiO2 and ZnO using an Osram ultra-vitalux lamp (315-400 nm) was investigated. The objective of the investigation was to study and compare the rates of photochemical degradation of the pure active compound and its formulated product in order to find out the impact of inert ingredients on degradation processes. The photo-chemical degradation of pure methomyl was found to be slower than the degradation of its commercial product Lannate-90. Photodegradation was investigated by UV-Vis spectrometry and HPLC, while mineralization was monitored using IC and TOC analyses. Light absorption capabilities of catalysts were characterized by ultraviolet-visible diffuse reflectance spectroscopy method, while the stability of catalysts was studied by infrared analyses. Degradation products of methomyl and its formulated product were identified by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) results and tentative photodegradation pathways were proposed.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Chemical Industry & Chemical Engineering Quarterly",
title = "A study of photocatalytic degradation of methomyl and its commercial product lannate-90",
pages = "247-237",
number = "3",
volume = "26",
doi = "10.2298/CICEQ190424002T"
}

Tomašević, A., Marinković, A., Mijin, D., Radišić, M., Porobić, S., Prlainović, N.,& Gašić, S.. (2020). A study of photocatalytic degradation of methomyl and its commercial product lannate-90. in Chemical Industry & Chemical Engineering Quarterly
Savez hemijskih inženjera, Beograd., 26(3), 237-247.
https://doi.org/10.2298/CICEQ190424002T

Tomašević A, Marinković A, Mijin D, Radišić M, Porobić S, Prlainović N, Gašić S. A study of photocatalytic degradation of methomyl and its commercial product lannate-90. in Chemical Industry & Chemical Engineering Quarterly. 2020;26(3):237-247.
doi:10.2298/CICEQ190424002T .

Tomašević, Anđelka, Marinković, Aleksandar, Mijin, Dušan, Radišić, Marina, Porobić, Slavica, Prlainović, Nevena, Gašić, Slavica, "A study of photocatalytic degradation of methomyl and its commercial product lannate-90" in Chemical Industry & Chemical Engineering Quarterly, 26, no. 3 (2020):237-247,
https://doi.org/10.2298/CICEQ190424002T . .

TY  - JOUR
AU  - Velicić, Zorica
AU  - Rusmirović, Jelena
AU  - Prlainović, Nevena
AU  - Tomić, Nataša
AU  - Veličković, Zlate
AU  - Taleb, Khaled
AU  - Marinković, Aleksandar
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4461
AB  - In this work, the optimization of synthesis of terpolymer monolith based on glycidyl methacrylate (GMA), ethylene glycol dimethacrylate (EGDMA) and additional cross-linkers: trimethylolpropanetriacrylate (TMPTA) or triethylene glycol dimethacrylate (TEGDMA) was performed. Moreover, novel vinyl functionalized cross-linkable polymers: ethanolamine (EA)/methacryloyl (MAC) modified poly (methyl methacrylate) (PMMA), and hydrolyzed poly (ethylene-co-vinyl acetate) copolymer (EVOH) modified with MAC either directly or via ethyl malonyl chloride/EA bridging group (m-EVA) were used as cross-linkable polymer to improve mechanical/elastic properties of the obtained monoliths. Optimization procedure, performed applying response surface methodology (RSM), was focused on the production of materials with improved dimensional stability/integrity and porosity with abundance of epoxide groups capable for immobilization of lipase from Candida rugosa (CRL). Structural characterization of the synthesized monoliths was determined using FTIR, Raman and H-1 NMR spectroscopies, while morphology/porosity was determined by SEM technique and image analysis; and mechanical properties by diametral compression testing. The most potential monolith containing m-EVA polymeric cross-linker, i.e. GMA/EGDMA/TEGDMA/m-EVA monolith, was used as CRL carrier in a two-step immobilization process. Enzyme loading and the activity of obtained preparations for various initial enzyme concentrations were monitored after 4 and 48 h of immobilization. The resulting catalysts show high potency in biocatalytic reactions with the highest percentage of retained initial lipase activity of 64.5%.
PB  - Springer, Dordrecht
T2  - Journal of Polymer Research
T1  - The optimization of glycidyl methacrylate based terpolymer monolith synthesis: an effective Candida rugosa lipase immobilization support
IS  - 5
VL  - 27
DO  - 10.1007/s10965-020-02127-z
ER  - 

@article{
author = "Velicić, Zorica and Rusmirović, Jelena and Prlainović, Nevena and Tomić, Nataša and Veličković, Zlate and Taleb, Khaled and Marinković, Aleksandar",
year = "2020",
abstract = "In this work, the optimization of synthesis of terpolymer monolith based on glycidyl methacrylate (GMA), ethylene glycol dimethacrylate (EGDMA) and additional cross-linkers: trimethylolpropanetriacrylate (TMPTA) or triethylene glycol dimethacrylate (TEGDMA) was performed. Moreover, novel vinyl functionalized cross-linkable polymers: ethanolamine (EA)/methacryloyl (MAC) modified poly (methyl methacrylate) (PMMA), and hydrolyzed poly (ethylene-co-vinyl acetate) copolymer (EVOH) modified with MAC either directly or via ethyl malonyl chloride/EA bridging group (m-EVA) were used as cross-linkable polymer to improve mechanical/elastic properties of the obtained monoliths. Optimization procedure, performed applying response surface methodology (RSM), was focused on the production of materials with improved dimensional stability/integrity and porosity with abundance of epoxide groups capable for immobilization of lipase from Candida rugosa (CRL). Structural characterization of the synthesized monoliths was determined using FTIR, Raman and H-1 NMR spectroscopies, while morphology/porosity was determined by SEM technique and image analysis; and mechanical properties by diametral compression testing. The most potential monolith containing m-EVA polymeric cross-linker, i.e. GMA/EGDMA/TEGDMA/m-EVA monolith, was used as CRL carrier in a two-step immobilization process. Enzyme loading and the activity of obtained preparations for various initial enzyme concentrations were monitored after 4 and 48 h of immobilization. The resulting catalysts show high potency in biocatalytic reactions with the highest percentage of retained initial lipase activity of 64.5%.",
publisher = "Springer, Dordrecht",
journal = "Journal of Polymer Research",
title = "The optimization of glycidyl methacrylate based terpolymer monolith synthesis: an effective Candida rugosa lipase immobilization support",
number = "5",
volume = "27",
doi = "10.1007/s10965-020-02127-z"
}

Velicić, Z., Rusmirović, J., Prlainović, N., Tomić, N., Veličković, Z., Taleb, K.,& Marinković, A.. (2020). The optimization of glycidyl methacrylate based terpolymer monolith synthesis: an effective Candida rugosa lipase immobilization support. in Journal of Polymer Research
Springer, Dordrecht., 27(5).
https://doi.org/10.1007/s10965-020-02127-z

Velicić Z, Rusmirović J, Prlainović N, Tomić N, Veličković Z, Taleb K, Marinković A. The optimization of glycidyl methacrylate based terpolymer monolith synthesis: an effective Candida rugosa lipase immobilization support. in Journal of Polymer Research. 2020;27(5).
doi:10.1007/s10965-020-02127-z .

Velicić, Zorica, Rusmirović, Jelena, Prlainović, Nevena, Tomić, Nataša, Veličković, Zlate, Taleb, Khaled, Marinković, Aleksandar, "The optimization of glycidyl methacrylate based terpolymer monolith synthesis: an effective Candida rugosa lipase immobilization support" in Journal of Polymer Research, 27, no. 5 (2020),
https://doi.org/10.1007/s10965-020-02127-z . .

TY  - JOUR
AU  - Tomašević, Anđelka
AU  - Mijin, Dušan
AU  - Radišić, Marina
AU  - Prlainović, Nevena
AU  - Cvijetić, Ilija
AU  - Kovačević, Danijela
AU  - Marinković, Aleksandar
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4480
AB  - This study describes photolysis of 1 x 10(-4) M methomyl solution in deionized water and in eleven organic solvents, both polar and nonpolar: methanol, ethanol, n-propanol, isopropanol, sec-butanol, tert-butanol, isobutanol, isopentanol, n-hexane, acetonitrile, and dichloromethane. Photolysis of methomyl at 254 nm was performed using Osram mercury lamp (6 x 8 W) by exposing to irradiation for five hours. All photolytic methomyl reactions were studied by UV/Vis spectroscopy within a wavelength range of 190 - 300 nm (Spectrum Mode), and at 233.4 nm (Quantitative Mode), while the rate of photodecomposition of methomyl was measured using UV spectroscopy and HPLC. In order to get better insight in the photolysis of methomyl, a liquid chromatography-mass spectrometry (LC-MSn) was used. The rate of methomyl photolysis was solvent-specific and the following reaction rate order was established: deionized water  gt  tert-butanol  gt  n-hexane  gt  sec-butanol  gt  ethanol  gt  isopentanol  gt  isobutanol  gt  isopropanol  gt  methanol  gt  acetonitrile  gt  dichloromethane  gt  n-propanol. Both nonspecific and specific solvent-solute interactions contribute mutually to the differences in the obtained quantum yields. Results of quantum chemical calculations, using CBS-QB3 method, provided insights into the solvent effects on both ground and excited state. The LC/MSn analysis showed the formation of several photolytic products.
PB  - Elsevier Science Sa, Lausanne
T2  - Journal of Photochemistry and Photobiology A-Chemistry
T1  - Photolysis of insecticide methomyl in various solvents: An experimental and theoretical study
VL  - 391
DO  - 10.1016/j.jphotochem.2020.112366
ER  - 

@article{
author = "Tomašević, Anđelka and Mijin, Dušan and Radišić, Marina and Prlainović, Nevena and Cvijetić, Ilija and Kovačević, Danijela and Marinković, Aleksandar",
year = "2020",
abstract = "This study describes photolysis of 1 x 10(-4) M methomyl solution in deionized water and in eleven organic solvents, both polar and nonpolar: methanol, ethanol, n-propanol, isopropanol, sec-butanol, tert-butanol, isobutanol, isopentanol, n-hexane, acetonitrile, and dichloromethane. Photolysis of methomyl at 254 nm was performed using Osram mercury lamp (6 x 8 W) by exposing to irradiation for five hours. All photolytic methomyl reactions were studied by UV/Vis spectroscopy within a wavelength range of 190 - 300 nm (Spectrum Mode), and at 233.4 nm (Quantitative Mode), while the rate of photodecomposition of methomyl was measured using UV spectroscopy and HPLC. In order to get better insight in the photolysis of methomyl, a liquid chromatography-mass spectrometry (LC-MSn) was used. The rate of methomyl photolysis was solvent-specific and the following reaction rate order was established: deionized water  gt  tert-butanol  gt  n-hexane  gt  sec-butanol  gt  ethanol  gt  isopentanol  gt  isobutanol  gt  isopropanol  gt  methanol  gt  acetonitrile  gt  dichloromethane  gt  n-propanol. Both nonspecific and specific solvent-solute interactions contribute mutually to the differences in the obtained quantum yields. Results of quantum chemical calculations, using CBS-QB3 method, provided insights into the solvent effects on both ground and excited state. The LC/MSn analysis showed the formation of several photolytic products.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Journal of Photochemistry and Photobiology A-Chemistry",
title = "Photolysis of insecticide methomyl in various solvents: An experimental and theoretical study",
volume = "391",
doi = "10.1016/j.jphotochem.2020.112366"
}

Tomašević, A., Mijin, D., Radišić, M., Prlainović, N., Cvijetić, I., Kovačević, D.,& Marinković, A.. (2020). Photolysis of insecticide methomyl in various solvents: An experimental and theoretical study. in Journal of Photochemistry and Photobiology A-Chemistry
Elsevier Science Sa, Lausanne., 391.
https://doi.org/10.1016/j.jphotochem.2020.112366

Tomašević A, Mijin D, Radišić M, Prlainović N, Cvijetić I, Kovačević D, Marinković A. Photolysis of insecticide methomyl in various solvents: An experimental and theoretical study. in Journal of Photochemistry and Photobiology A-Chemistry. 2020;391.
doi:10.1016/j.jphotochem.2020.112366 .

Tomašević, Anđelka, Mijin, Dušan, Radišić, Marina, Prlainović, Nevena, Cvijetić, Ilija, Kovačević, Danijela, Marinković, Aleksandar, "Photolysis of insecticide methomyl in various solvents: An experimental and theoretical study" in Journal of Photochemistry and Photobiology A-Chemistry, 391 (2020),
https://doi.org/10.1016/j.jphotochem.2020.112366 . .

TY  - CONF
AU  - Tomašević, Anđelka
AU  - Marinković, Aleksandar
AU  - Mijin, Dušan
AU  - Prlainović, Nevena
AU  - Gašić, Slavica
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7316
PB  - Ljubljana : Slovenian Chemical Society
C3  - EAAOP-6 : 6th European Conference on Environmental Applications of Advanced Oxidation Processes : 26-30 June 2019, Portorož - Portorose, Slovenia : book of abstracts
T1  - Photocatalytic degradation of methomyl and Lannate-90
EP  - 388
SP  - 387
UR  - https://hdl.handle.net/21.15107/rcub_technorep_7316
ER  - 

@conference{
author = "Tomašević, Anđelka and Marinković, Aleksandar and Mijin, Dušan and Prlainović, Nevena and Gašić, Slavica",
year = "2019",
publisher = "Ljubljana : Slovenian Chemical Society",
journal = "EAAOP-6 : 6th European Conference on Environmental Applications of Advanced Oxidation Processes : 26-30 June 2019, Portorož - Portorose, Slovenia : book of abstracts",
title = "Photocatalytic degradation of methomyl and Lannate-90",
pages = "388-387",
url = "https://hdl.handle.net/21.15107/rcub_technorep_7316"
}

Tomašević, A., Marinković, A., Mijin, D., Prlainović, N.,& Gašić, S.. (2019). Photocatalytic degradation of methomyl and Lannate-90. in EAAOP-6 : 6th European Conference on Environmental Applications of Advanced Oxidation Processes : 26-30 June 2019, Portorož - Portorose, Slovenia : book of abstracts
Ljubljana : Slovenian Chemical Society., 387-388.
https://hdl.handle.net/21.15107/rcub_technorep_7316

Tomašević A, Marinković A, Mijin D, Prlainović N, Gašić S. Photocatalytic degradation of methomyl and Lannate-90. in EAAOP-6 : 6th European Conference on Environmental Applications of Advanced Oxidation Processes : 26-30 June 2019, Portorož - Portorose, Slovenia : book of abstracts. 2019;:387-388.
https://hdl.handle.net/21.15107/rcub_technorep_7316 .

Tomašević, Anđelka, Marinković, Aleksandar, Mijin, Dušan, Prlainović, Nevena, Gašić, Slavica, "Photocatalytic degradation of methomyl and Lannate-90" in EAAOP-6 : 6th European Conference on Environmental Applications of Advanced Oxidation Processes : 26-30 June 2019, Portorož - Portorose, Slovenia : book of abstracts (2019):387-388,
https://hdl.handle.net/21.15107/rcub_technorep_7316 .

TY  - CONF
AU  - Tomašević, Anđelka
AU  - Mijin, Dušan
AU  - Gašić, Slavica
AU  - Prlainović, Nevena
AU  - Marinković, Aleksandar
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7317
PB  - Leskovac : Faculty of Technology
C3  - Book of abstracts / 13th Symposium with international participation "Novel Technologies and Economic Development" Leskovac, October, 18-19, 2019
T1  - Photocatalysis of carbofuran: comparison of ZnO and TiO2 efficiency
SP  - 92
UR  - https://hdl.handle.net/21.15107/rcub_technorep_7317
ER  - 

@conference{
author = "Tomašević, Anđelka and Mijin, Dušan and Gašić, Slavica and Prlainović, Nevena and Marinković, Aleksandar",
year = "2019",
publisher = "Leskovac : Faculty of Technology",
journal = "Book of abstracts / 13th Symposium with international participation "Novel Technologies and Economic Development" Leskovac, October, 18-19, 2019",
title = "Photocatalysis of carbofuran: comparison of ZnO and TiO2 efficiency",
pages = "92",
url = "https://hdl.handle.net/21.15107/rcub_technorep_7317"
}

Tomašević, A., Mijin, D., Gašić, S., Prlainović, N.,& Marinković, A.. (2019). Photocatalysis of carbofuran: comparison of ZnO and TiO2 efficiency. in Book of abstracts / 13th Symposium with international participation "Novel Technologies and Economic Development" Leskovac, October, 18-19, 2019
Leskovac : Faculty of Technology., 92.
https://hdl.handle.net/21.15107/rcub_technorep_7317

Tomašević A, Mijin D, Gašić S, Prlainović N, Marinković A. Photocatalysis of carbofuran: comparison of ZnO and TiO2 efficiency. in Book of abstracts / 13th Symposium with international participation "Novel Technologies and Economic Development" Leskovac, October, 18-19, 2019. 2019;:92.
https://hdl.handle.net/21.15107/rcub_technorep_7317 .

Tomašević, Anđelka, Mijin, Dušan, Gašić, Slavica, Prlainović, Nevena, Marinković, Aleksandar, "Photocatalysis of carbofuran: comparison of ZnO and TiO2 efficiency" in Book of abstracts / 13th Symposium with international participation "Novel Technologies and Economic Development" Leskovac, October, 18-19, 2019 (2019):92,
https://hdl.handle.net/21.15107/rcub_technorep_7317 .

TY  - CHAP
AU  - Šekuljica, Nataša
AU  - Prlainović, Nevena
AU  - Knežević-Jugović, Zorica
AU  - Mijin, Dušan
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6269
AB  - Horseradish peroxidase is a heme-containing plant enzyme (HRP; EC 1.11.1.7) with a wide range of biotechnological and medical applications. In combination with hydrogen peroxide (H2O2) as an oxidant HRP can be used in the oxidation of various substrates (e.g. considered as toxic, muthagenic, recalcitrant and carcinogenic compounds with harmful impact on human health and ecosystems and main textile industry problem when it comes to environment pollution with wastewaters. Traditional methods are inefficient, and in recent years, with a view to preserving the environment, the scientific community turns to the application of enzymes as the main catalysts in the removal of synthetic dyes. Based on the data available in the literature, HRP proved to be an enzyme with a high potential for the application of synthetic dyes removal by the mechanism of polymerization or ring opening. In this chapter well-studied enzyme is described with the focus on its promising use in colored wastewater treatment. C. I. Acid Violet 109 (AV 109) was used as a model dye in order to examine the feasibility of HRP application in removal of anthraquinone class of synthetic dyes. The reaction conditions were optimized in terms of dye, enzyme and H2O2 concentration as well as temperature and pH influence. It was established that the dye removal shows good agreement with two substrate ping-pong mechanism with substrate inhibition. The industrial application of this enzyme requires the economic feasibility. Accordingly, an expensive commercial preparation HRP was replaced with partially purified enzyme isolated from horseradish root which showed high efficiency in model dye removal. The next step towards the industrial application of this enzyme was the immobilization of various techniques (adsorption, covalent immobilization, cross-linked aggregates) to various carriers such as kaolin and the synthetic carrier Purolite® A109. Improvement in storage and operational stability after immobilization was confirmed and immobilized preparations were applied in different bioreactor configurations, batch and packed bed. HRP catalyzed removal of synthetic dyes appeared to be promising technique dye to high efficiency in dye removal and phytotoxicity and acute toxicity decrease, measured by Mung bean seeds and A. salina assays.
PB  - New York: Nova Science Publishers, Inc.
T2  - Horseradish peroxidase: Structure, Functions and Applications
T1  - Removal of Synthetic Dyes from Wastewaters Using Horseradish Peroxidase
EP  - 168
SP  - 112
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6269
ER  - 

@inbook{
author = "Šekuljica, Nataša and Prlainović, Nevena and Knežević-Jugović, Zorica and Mijin, Dušan",
year = "2019",
abstract = "Horseradish peroxidase is a heme-containing plant enzyme (HRP; EC 1.11.1.7) with a wide range of biotechnological and medical applications. In combination with hydrogen peroxide (H2O2) as an oxidant HRP can be used in the oxidation of various substrates (e.g. considered as toxic, muthagenic, recalcitrant and carcinogenic compounds with harmful impact on human health and ecosystems and main textile industry problem when it comes to environment pollution with wastewaters. Traditional methods are inefficient, and in recent years, with a view to preserving the environment, the scientific community turns to the application of enzymes as the main catalysts in the removal of synthetic dyes. Based on the data available in the literature, HRP proved to be an enzyme with a high potential for the application of synthetic dyes removal by the mechanism of polymerization or ring opening. In this chapter well-studied enzyme is described with the focus on its promising use in colored wastewater treatment. C. I. Acid Violet 109 (AV 109) was used as a model dye in order to examine the feasibility of HRP application in removal of anthraquinone class of synthetic dyes. The reaction conditions were optimized in terms of dye, enzyme and H2O2 concentration as well as temperature and pH influence. It was established that the dye removal shows good agreement with two substrate ping-pong mechanism with substrate inhibition. The industrial application of this enzyme requires the economic feasibility. Accordingly, an expensive commercial preparation HRP was replaced with partially purified enzyme isolated from horseradish root which showed high efficiency in model dye removal. The next step towards the industrial application of this enzyme was the immobilization of various techniques (adsorption, covalent immobilization, cross-linked aggregates) to various carriers such as kaolin and the synthetic carrier Purolite® A109. Improvement in storage and operational stability after immobilization was confirmed and immobilized preparations were applied in different bioreactor configurations, batch and packed bed. HRP catalyzed removal of synthetic dyes appeared to be promising technique dye to high efficiency in dye removal and phytotoxicity and acute toxicity decrease, measured by Mung bean seeds and A. salina assays.",
publisher = "New York: Nova Science Publishers, Inc.",
journal = "Horseradish peroxidase: Structure, Functions and Applications",
booktitle = "Removal of Synthetic Dyes from Wastewaters Using Horseradish Peroxidase",
pages = "168-112",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6269"
}

Šekuljica, N., Prlainović, N., Knežević-Jugović, Z.,& Mijin, D.. (2019). Removal of Synthetic Dyes from Wastewaters Using Horseradish Peroxidase. in Horseradish peroxidase: Structure, Functions and Applications
New York: Nova Science Publishers, Inc.., 112-168.
https://hdl.handle.net/21.15107/rcub_technorep_6269

Šekuljica N, Prlainović N, Knežević-Jugović Z, Mijin D. Removal of Synthetic Dyes from Wastewaters Using Horseradish Peroxidase. in Horseradish peroxidase: Structure, Functions and Applications. 2019;:112-168.
https://hdl.handle.net/21.15107/rcub_technorep_6269 .

Šekuljica, Nataša, Prlainović, Nevena, Knežević-Jugović, Zorica, Mijin, Dušan, "Removal of Synthetic Dyes from Wastewaters Using Horseradish Peroxidase" in Horseradish peroxidase: Structure, Functions and Applications (2019):112-168,
https://hdl.handle.net/21.15107/rcub_technorep_6269 .

TY  - JOUR
AU  - Assaleh, Fathi H.
AU  - Marinković, Aleksandar
AU  - Nikolić, Jasmina
AU  - Prlainović, Nevena
AU  - Drmanić, Saša
AU  - Khan, Mohammad M.
AU  - Jovanović, Bratislav Ž.
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4115
AB  - Conformational stability of various 5-substituted orotic acid derivatives was studied by applying linear free energy relationships (LFER) to the C-13 NMR chemical shifts. The correlation analysis for the substituent-induced chemical shifts (SCS) with inductive (rI), and various resonance (rR) parameters were carried out through Single Substituent Parameter (SSP) and Dual Substituent Parameter (DSP) methods, and multiple regression analysis. Good Hammett correlations for all carbons were obtained, while electrophilic substituent constants better fitted for C2 carbon with electron-donor substituents. Conformational analysis of various derivatives using RB3LYP/6-311 ++G (3df,3dp) DFT method, together with C-13 NMR data suggests that most of the substituted orotic acid derivatives exist in planar conformation, except nitro and alkyl substituted derivatives. Internal rotation of carboxylic group showed significant impact on the extent of conjugative interaction making syn conformation more stable in all the derivatives studied. Further, of all 5-substituted orotic acid derivatives, diketo form proved to be the most stable form compared to zwitterionic and enol tautomeric forms. Optimized geometries and transmission effects of particular substituent through well-defined p-resonance units suggest that these units behave as isolated as well as conjugated fragments, depending on the type of substituent.
PB  - Elsevier, Amsterdam
T2  - Arabian Journal of Chemistry
T1  - Conformational stability of 5-substituted orotic acid derivatives analyzed by measuring C-13 NMR chemical shifts and applying linear free energy relationships
EP  - 3366
IS  - 8
SP  - 3357
VL  - 12
DO  - 10.1016/j.arabjc.2015.08.014
ER  - 

@article{
author = "Assaleh, Fathi H. and Marinković, Aleksandar and Nikolić, Jasmina and Prlainović, Nevena and Drmanić, Saša and Khan, Mohammad M. and Jovanović, Bratislav Ž.",
year = "2019",
abstract = "Conformational stability of various 5-substituted orotic acid derivatives was studied by applying linear free energy relationships (LFER) to the C-13 NMR chemical shifts. The correlation analysis for the substituent-induced chemical shifts (SCS) with inductive (rI), and various resonance (rR) parameters were carried out through Single Substituent Parameter (SSP) and Dual Substituent Parameter (DSP) methods, and multiple regression analysis. Good Hammett correlations for all carbons were obtained, while electrophilic substituent constants better fitted for C2 carbon with electron-donor substituents. Conformational analysis of various derivatives using RB3LYP/6-311 ++G (3df,3dp) DFT method, together with C-13 NMR data suggests that most of the substituted orotic acid derivatives exist in planar conformation, except nitro and alkyl substituted derivatives. Internal rotation of carboxylic group showed significant impact on the extent of conjugative interaction making syn conformation more stable in all the derivatives studied. Further, of all 5-substituted orotic acid derivatives, diketo form proved to be the most stable form compared to zwitterionic and enol tautomeric forms. Optimized geometries and transmission effects of particular substituent through well-defined p-resonance units suggest that these units behave as isolated as well as conjugated fragments, depending on the type of substituent.",
publisher = "Elsevier, Amsterdam",
journal = "Arabian Journal of Chemistry",
title = "Conformational stability of 5-substituted orotic acid derivatives analyzed by measuring C-13 NMR chemical shifts and applying linear free energy relationships",
pages = "3366-3357",
number = "8",
volume = "12",
doi = "10.1016/j.arabjc.2015.08.014"
}

Assaleh, F. H., Marinković, A., Nikolić, J., Prlainović, N., Drmanić, S., Khan, M. M.,& Jovanović, B. Ž.. (2019). Conformational stability of 5-substituted orotic acid derivatives analyzed by measuring C-13 NMR chemical shifts and applying linear free energy relationships. in Arabian Journal of Chemistry
Elsevier, Amsterdam., 12(8), 3357-3366.
https://doi.org/10.1016/j.arabjc.2015.08.014

Assaleh FH, Marinković A, Nikolić J, Prlainović N, Drmanić S, Khan MM, Jovanović BŽ. Conformational stability of 5-substituted orotic acid derivatives analyzed by measuring C-13 NMR chemical shifts and applying linear free energy relationships. in Arabian Journal of Chemistry. 2019;12(8):3357-3366.
doi:10.1016/j.arabjc.2015.08.014 .

Assaleh, Fathi H., Marinković, Aleksandar, Nikolić, Jasmina, Prlainović, Nevena, Drmanić, Saša, Khan, Mohammad M., Jovanović, Bratislav Ž., "Conformational stability of 5-substituted orotic acid derivatives analyzed by measuring C-13 NMR chemical shifts and applying linear free energy relationships" in Arabian Journal of Chemistry, 12, no. 8 (2019):3357-3366,
https://doi.org/10.1016/j.arabjc.2015.08.014 . .

TY  - JOUR
AU  - Rančić, Milica
AU  - Stojiljković, Ivana
AU  - Milošević, Milena D.
AU  - Prlainović, Nevena
AU  - Jovanović, Maja
AU  - Milčić, Miloš
AU  - Marinković, Aleksandar
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4139
AB  - The substituent and solvent effect on intramolecular charge transfer (ICT) in 5-aryli dene-3-methyl-2,4-thiazolidinediones (series 1) and 5-arylidene-3-phenyl-2,4-thiazolidinediones (series 2) was studied by using experimental and theoretical methodology. The effect of specific and non-specific solvent-solute interactions on the UV-vis absorption maxima shifts was evaluated by using the Kamlet-Taft and Catalan solvent parameter sets. Linear free energy relationships (LFERs) have been applied to the UV-vis and C-13 NMR data by using SSP (single substituent parameter) and DSP (dual substituent parameters). Comparative LFER analysis of 10 styrenic series was performed in order to distinguish contribution of structural and electronic substituent effect on extent of p-polarization in a side chain (vinyl) group. Furthermore, the experimental findings were interpreted with the aid of ab initio MP2 and time-dependent density functional (TD-DFT) methods. TD-DFT calculations are performed to quantify the efficiency of intramolecular charge transfer (ICT) allowing us to define the charge-transfer distance (DCT), amount of transferred charge (QCT), and difference of dipole moments between the ground and excited states (mu CT). It was found that both substituents and solvents influence electron density shift, i.e. extent of conjugation, and affect intramolecular charge transfer character in the course of excitation.
PB  - Elsevier, Amsterdam
T2  - Arabian Journal of Chemistry
T1  - Solvent and substituent effect on intramolecular charge transfer in 5-arylidene-3-substituted-2,4-thiazolidinediones: Experimental and theoretical study
EP  - 5161
IS  - 8
SP  - 5142
VL  - 12
DO  - 10.1016/j.arabjc.2016.12.013
ER  - 

@article{
author = "Rančić, Milica and Stojiljković, Ivana and Milošević, Milena D. and Prlainović, Nevena and Jovanović, Maja and Milčić, Miloš and Marinković, Aleksandar",
year = "2019",
abstract = "The substituent and solvent effect on intramolecular charge transfer (ICT) in 5-aryli dene-3-methyl-2,4-thiazolidinediones (series 1) and 5-arylidene-3-phenyl-2,4-thiazolidinediones (series 2) was studied by using experimental and theoretical methodology. The effect of specific and non-specific solvent-solute interactions on the UV-vis absorption maxima shifts was evaluated by using the Kamlet-Taft and Catalan solvent parameter sets. Linear free energy relationships (LFERs) have been applied to the UV-vis and C-13 NMR data by using SSP (single substituent parameter) and DSP (dual substituent parameters). Comparative LFER analysis of 10 styrenic series was performed in order to distinguish contribution of structural and electronic substituent effect on extent of p-polarization in a side chain (vinyl) group. Furthermore, the experimental findings were interpreted with the aid of ab initio MP2 and time-dependent density functional (TD-DFT) methods. TD-DFT calculations are performed to quantify the efficiency of intramolecular charge transfer (ICT) allowing us to define the charge-transfer distance (DCT), amount of transferred charge (QCT), and difference of dipole moments between the ground and excited states (mu CT). It was found that both substituents and solvents influence electron density shift, i.e. extent of conjugation, and affect intramolecular charge transfer character in the course of excitation.",
publisher = "Elsevier, Amsterdam",
journal = "Arabian Journal of Chemistry",
title = "Solvent and substituent effect on intramolecular charge transfer in 5-arylidene-3-substituted-2,4-thiazolidinediones: Experimental and theoretical study",
pages = "5161-5142",
number = "8",
volume = "12",
doi = "10.1016/j.arabjc.2016.12.013"
}

Rančić, M., Stojiljković, I., Milošević, M. D., Prlainović, N., Jovanović, M., Milčić, M.,& Marinković, A.. (2019). Solvent and substituent effect on intramolecular charge transfer in 5-arylidene-3-substituted-2,4-thiazolidinediones: Experimental and theoretical study. in Arabian Journal of Chemistry
Elsevier, Amsterdam., 12(8), 5142-5161.
https://doi.org/10.1016/j.arabjc.2016.12.013

Rančić M, Stojiljković I, Milošević MD, Prlainović N, Jovanović M, Milčić M, Marinković A. Solvent and substituent effect on intramolecular charge transfer in 5-arylidene-3-substituted-2,4-thiazolidinediones: Experimental and theoretical study. in Arabian Journal of Chemistry. 2019;12(8):5142-5161.
doi:10.1016/j.arabjc.2016.12.013 .

Rančić, Milica, Stojiljković, Ivana, Milošević, Milena D., Prlainović, Nevena, Jovanović, Maja, Milčić, Miloš, Marinković, Aleksandar, "Solvent and substituent effect on intramolecular charge transfer in 5-arylidene-3-substituted-2,4-thiazolidinediones: Experimental and theoretical study" in Arabian Journal of Chemistry, 12, no. 8 (2019):5142-5161,
https://doi.org/10.1016/j.arabjc.2016.12.013 . .

TY  - CONF
AU  - Banjanac, Katarina
AU  - Milivojević, Ana
AU  - Ćorović, Marija
AU  - Carević, Milica
AU  - Prlainović, Nevena
AU  - Marinković, Aleksandar
AU  - Bezbradica, Dejan
PY  - 2018
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6021
AB  - The objective of this research was to study the production of sunflower meal protein hydrolysate
(SMPH) from sunflower meal protein isolate (SMPI) prepared by sedimentation/flotation and isoelectric precipitation of sunflower meal (SM). SM is the main co-product formed during the industrial process of extracting oil from sunflower seed. By fractionation of SM, the crude protein content was increased from approximately 37.4 % in SM to 80.8 % in SMPI and represent a good source of protein for human consumption. The percentages of fiber, soluble sugars, polyphenols, lignocellulose fibers and residual lipids which may reduce the chemical and nutritive value of proteins in the SMPI were reduced to more than 92 % with respect to the SM.
Since functional properties of SMPI can be improved by enzymatic hydrolysis under controlled conditions, the hydrolysis of SMPI was carry out using endo-protease Alcalase covalently immobilized on epoxy modified silica nanoparticles (Alcalase-GFNS) and/or exo-protease Flavourzyme covalently immobilized on cyanuric chloride activated amino modified silica nanoparticles (Flavourzume-CCAFNS). Results showed that enzymatic hydrolysis of the SMPI should be performed using sequentially Alcalase-GFNS and Flavourzyme-CCAFNS since the achieved hydrolysis yield was greater by 1.5 and 3 times in comparison to the use of only Alcalase-GFNS or Flavourzyme-CCAFNS, respectively, during the same time. Also, it should be mentioned that Flavourzyme-CCAFNS was added in reaction mixture 2 h after the start of hydrolysis with Alcalase-GFNS. With the predigestion with Alcalase- GFNS, the number of N-terminal sites for the exoprotease activity of Flavourzyme-CCAFNS was increased which directly led to the increment of SMPI hydrolysis degree. Finally, it can be concluded that Alcalase-GFNS and Flavourzyme-CCAFNS have great prospects for usage in the hydrolysis of SMPI to produce SMPH with high nutritional value that can be used directly, for example, in the fortification of liquid foods or high energetic beverages.
PB  - University of Novi Sad, Institute of Food Technology
C3  - IV International congress of Food Technology, Quality and Safety, Proceedings
T1  - Production of sunflower meal protein hydrolysate by sequential hydrolysis with alcalase and flavourzyme immobilized on functionalized silica nanoparticles
EP  - 252
SP  - 247
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6021
ER  - 

@conference{
author = "Banjanac, Katarina and Milivojević, Ana and Ćorović, Marija and Carević, Milica and Prlainović, Nevena and Marinković, Aleksandar and Bezbradica, Dejan",
year = "2018",
abstract = "The objective of this research was to study the production of sunflower meal protein hydrolysate
(SMPH) from sunflower meal protein isolate (SMPI) prepared by sedimentation/flotation and isoelectric precipitation of sunflower meal (SM). SM is the main co-product formed during the industrial process of extracting oil from sunflower seed. By fractionation of SM, the crude protein content was increased from approximately 37.4 % in SM to 80.8 % in SMPI and represent a good source of protein for human consumption. The percentages of fiber, soluble sugars, polyphenols, lignocellulose fibers and residual lipids which may reduce the chemical and nutritive value of proteins in the SMPI were reduced to more than 92 % with respect to the SM.
Since functional properties of SMPI can be improved by enzymatic hydrolysis under controlled conditions, the hydrolysis of SMPI was carry out using endo-protease Alcalase covalently immobilized on epoxy modified silica nanoparticles (Alcalase-GFNS) and/or exo-protease Flavourzyme covalently immobilized on cyanuric chloride activated amino modified silica nanoparticles (Flavourzume-CCAFNS). Results showed that enzymatic hydrolysis of the SMPI should be performed using sequentially Alcalase-GFNS and Flavourzyme-CCAFNS since the achieved hydrolysis yield was greater by 1.5 and 3 times in comparison to the use of only Alcalase-GFNS or Flavourzyme-CCAFNS, respectively, during the same time. Also, it should be mentioned that Flavourzyme-CCAFNS was added in reaction mixture 2 h after the start of hydrolysis with Alcalase-GFNS. With the predigestion with Alcalase- GFNS, the number of N-terminal sites for the exoprotease activity of Flavourzyme-CCAFNS was increased which directly led to the increment of SMPI hydrolysis degree. Finally, it can be concluded that Alcalase-GFNS and Flavourzyme-CCAFNS have great prospects for usage in the hydrolysis of SMPI to produce SMPH with high nutritional value that can be used directly, for example, in the fortification of liquid foods or high energetic beverages.",
publisher = "University of Novi Sad, Institute of Food Technology",
journal = "IV International congress of Food Technology, Quality and Safety, Proceedings",
title = "Production of sunflower meal protein hydrolysate by sequential hydrolysis with alcalase and flavourzyme immobilized on functionalized silica nanoparticles",
pages = "252-247",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6021"
}

Banjanac, K., Milivojević, A., Ćorović, M., Carević, M., Prlainović, N., Marinković, A.,& Bezbradica, D.. (2018). Production of sunflower meal protein hydrolysate by sequential hydrolysis with alcalase and flavourzyme immobilized on functionalized silica nanoparticles. in IV International congress of Food Technology, Quality and Safety, Proceedings
University of Novi Sad, Institute of Food Technology., 247-252.
https://hdl.handle.net/21.15107/rcub_technorep_6021

Banjanac K, Milivojević A, Ćorović M, Carević M, Prlainović N, Marinković A, Bezbradica D. Production of sunflower meal protein hydrolysate by sequential hydrolysis with alcalase and flavourzyme immobilized on functionalized silica nanoparticles. in IV International congress of Food Technology, Quality and Safety, Proceedings. 2018;:247-252.
https://hdl.handle.net/21.15107/rcub_technorep_6021 .

Banjanac, Katarina, Milivojević, Ana, Ćorović, Marija, Carević, Milica, Prlainović, Nevena, Marinković, Aleksandar, Bezbradica, Dejan, "Production of sunflower meal protein hydrolysate by sequential hydrolysis with alcalase and flavourzyme immobilized on functionalized silica nanoparticles" in IV International congress of Food Technology, Quality and Safety, Proceedings (2018):247-252,
https://hdl.handle.net/21.15107/rcub_technorep_6021 .

TY  - CONF
AU  - Brkić, Dominik
AU  - Božić, Aleksandra
AU  - Prlainović, Nevena
AU  - Petrović, Predrag
AU  - Drmanić, Saša
AU  - Nikolić, Jasmina
PY  - 2018
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7314
AB  - Derivati izatina su se u novije vreme pokazali kao jedinjenja korisna u farmakologiji, jer
ispoljavaju širok spektar dejstava kao sto su antivirusna, antitumorna, antibakterijska,
antituberkulozna, antigljivična, antikonvulzivna. Reč je o jedinjenjima koja nastaju reakcijom
izatina i primarnih amina i spadaju u grupu Šifovih (Schiff) baza. Kao deo serije istraživanja
koje se bavi derivatima izatina, sintetisani su i njihovi kompleksi sa metalima. Ispitana je
njihova antimikrobna aktivnost, pomoću bujon - mikrodilucione metode, na kojoj se može
zasnovati i mogućnost njihove primene.
AB  - The isatin derivatives have recently shown the potential to be used in pharmaclogy because
of their activities such as antiviral, anticancer, antibacterial, antituberculosis, antifungal and
anticonvulsive. These compounds belong to the group of Schiff bases and they are
synthesized by the reaction of isatin and primary amines. As a part of the series of
investigation that deals with the isatin derivatives, their complexes with metals were
synthesized. Their antimicrobial activity was examined using the broth micro-dilution
method, which could provide the ground for the application of these compounds.
PB  - Beograd : Srpsko hemijsko društvo = Serbian Chemical Society
C3  - Kratki izvodi radova = Book of Abstracts / 55. savetovanje Srpskog hemijskog društva, Novi Sad 8. i 9. juni 2018 = 55th meeting of the Serbian chemical society, Novi Sad, Serbia, June 8-9, 2018
T1  - Kompleksi derivata izatina i njihovo antimikrobno dejstvo
T1  - The complexes of isatin derivatives and their antimicrobial acitivity
SP  - 67
UR  - https://hdl.handle.net/21.15107/rcub_technorep_7314
ER  - 

@conference{
author = "Brkić, Dominik and Božić, Aleksandra and Prlainović, Nevena and Petrović, Predrag and Drmanić, Saša and Nikolić, Jasmina",
year = "2018",
abstract = "Derivati izatina su se u novije vreme pokazali kao jedinjenja korisna u farmakologiji, jer
ispoljavaju širok spektar dejstava kao sto su antivirusna, antitumorna, antibakterijska,
antituberkulozna, antigljivična, antikonvulzivna. Reč je o jedinjenjima koja nastaju reakcijom
izatina i primarnih amina i spadaju u grupu Šifovih (Schiff) baza. Kao deo serije istraživanja
koje se bavi derivatima izatina, sintetisani su i njihovi kompleksi sa metalima. Ispitana je
njihova antimikrobna aktivnost, pomoću bujon - mikrodilucione metode, na kojoj se može
zasnovati i mogućnost njihove primene., The isatin derivatives have recently shown the potential to be used in pharmaclogy because
of their activities such as antiviral, anticancer, antibacterial, antituberculosis, antifungal and
anticonvulsive. These compounds belong to the group of Schiff bases and they are
synthesized by the reaction of isatin and primary amines. As a part of the series of
investigation that deals with the isatin derivatives, their complexes with metals were
synthesized. Their antimicrobial activity was examined using the broth micro-dilution
method, which could provide the ground for the application of these compounds.",
publisher = "Beograd : Srpsko hemijsko društvo = Serbian Chemical Society",
journal = "Kratki izvodi radova = Book of Abstracts / 55. savetovanje Srpskog hemijskog društva, Novi Sad 8. i 9. juni 2018 = 55th meeting of the Serbian chemical society, Novi Sad, Serbia, June 8-9, 2018",
title = "Kompleksi derivata izatina i njihovo antimikrobno dejstvo, The complexes of isatin derivatives and their antimicrobial acitivity",
pages = "67",
url = "https://hdl.handle.net/21.15107/rcub_technorep_7314"
}

Brkić, D., Božić, A., Prlainović, N., Petrović, P., Drmanić, S.,& Nikolić, J.. (2018). Kompleksi derivata izatina i njihovo antimikrobno dejstvo. in Kratki izvodi radova = Book of Abstracts / 55. savetovanje Srpskog hemijskog društva, Novi Sad 8. i 9. juni 2018 = 55th meeting of the Serbian chemical society, Novi Sad, Serbia, June 8-9, 2018
Beograd : Srpsko hemijsko društvo = Serbian Chemical Society., 67.
https://hdl.handle.net/21.15107/rcub_technorep_7314

Brkić D, Božić A, Prlainović N, Petrović P, Drmanić S, Nikolić J. Kompleksi derivata izatina i njihovo antimikrobno dejstvo. in Kratki izvodi radova = Book of Abstracts / 55. savetovanje Srpskog hemijskog društva, Novi Sad 8. i 9. juni 2018 = 55th meeting of the Serbian chemical society, Novi Sad, Serbia, June 8-9, 2018. 2018;:67.
https://hdl.handle.net/21.15107/rcub_technorep_7314 .

Brkić, Dominik, Božić, Aleksandra, Prlainović, Nevena, Petrović, Predrag, Drmanić, Saša, Nikolić, Jasmina, "Kompleksi derivata izatina i njihovo antimikrobno dejstvo" in Kratki izvodi radova = Book of Abstracts / 55. savetovanje Srpskog hemijskog društva, Novi Sad 8. i 9. juni 2018 = 55th meeting of the Serbian chemical society, Novi Sad, Serbia, June 8-9, 2018 (2018):67,
https://hdl.handle.net/21.15107/rcub_technorep_7314 .

TY  - JOUR
AU  - Milošević, Milena D.
AU  - Prlainović, Nevena
AU  - Milčić, Miloš
AU  - Nikolić, Vesna
AU  - Božić, Aleksandra R.
AU  - Bigović, Miljan
AU  - Marinković, Aleksandar
PY  - 2018
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3843
AB  - 15 symmetric 1-methyl-2,6-bis[2-(substituted phenyl)ethenyl]pyridinium iodides were synthesized in this work. Their structures were characterized using IR, H-1 and C-13 NMR, and UV-Vis spectroscopy. DFT calculations indicated that s-trans/s-trans conformation prevail in all compounds. The effects of specific and non-specific solvent-solute interactions on the UV-Vis absorption maxima shifts were evaluated using linear solvation-free energy relationships (LSER), i.e., Kamlet-Taft and Catalan models. A linear free energy relationship (LFER) in the form of single substituent parameter equations (SSP) was used to postulate quantitative structure-property relations of substituent effect on NMR data. TD-DFT results showed dependence of electronic transition on the substituent effects. The push-pull character of these compounds was analyzed by differences in C-13 chemical shift of the ethylenic double bond in 2- and 6-positions of cross-conjugated with pyridinum central ring. Also, the quotient of the occupations for the bonding pi and anti-bonding pi* orbitals of this bond was considered. Good correlations of the selected parameter between double bond lengths with pi*/pi and C-13 chemical shift differences of the bridging group proved them to be adequate descriptor of push-pull character. Synthesized compounds were screened for the antioxidant activity, using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical methods, and results demonstrated moderate antioxidant potential.
PB  - Springer, New York
T2  - Journal of the Iranian Chemical Society
T1  - Solvent, structural, quantum chemical study and antioxidative activity of symmetrical 1-methyl-2,6-bis[2-(substituted phenyl)ethenyl]pyridinium iodides
EP  - 2501
IS  - 11
SP  - 2483
VL  - 15
DO  - 10.1007/s13738-018-1437-5
ER  - 

@article{
author = "Milošević, Milena D. and Prlainović, Nevena and Milčić, Miloš and Nikolić, Vesna and Božić, Aleksandra R. and Bigović, Miljan and Marinković, Aleksandar",
year = "2018",
abstract = "15 symmetric 1-methyl-2,6-bis[2-(substituted phenyl)ethenyl]pyridinium iodides were synthesized in this work. Their structures were characterized using IR, H-1 and C-13 NMR, and UV-Vis spectroscopy. DFT calculations indicated that s-trans/s-trans conformation prevail in all compounds. The effects of specific and non-specific solvent-solute interactions on the UV-Vis absorption maxima shifts were evaluated using linear solvation-free energy relationships (LSER), i.e., Kamlet-Taft and Catalan models. A linear free energy relationship (LFER) in the form of single substituent parameter equations (SSP) was used to postulate quantitative structure-property relations of substituent effect on NMR data. TD-DFT results showed dependence of electronic transition on the substituent effects. The push-pull character of these compounds was analyzed by differences in C-13 chemical shift of the ethylenic double bond in 2- and 6-positions of cross-conjugated with pyridinum central ring. Also, the quotient of the occupations for the bonding pi and anti-bonding pi* orbitals of this bond was considered. Good correlations of the selected parameter between double bond lengths with pi*/pi and C-13 chemical shift differences of the bridging group proved them to be adequate descriptor of push-pull character. Synthesized compounds were screened for the antioxidant activity, using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical methods, and results demonstrated moderate antioxidant potential.",
publisher = "Springer, New York",
journal = "Journal of the Iranian Chemical Society",
title = "Solvent, structural, quantum chemical study and antioxidative activity of symmetrical 1-methyl-2,6-bis[2-(substituted phenyl)ethenyl]pyridinium iodides",
pages = "2501-2483",
number = "11",
volume = "15",
doi = "10.1007/s13738-018-1437-5"
}

Milošević, M. D., Prlainović, N., Milčić, M., Nikolić, V., Božić, A. R., Bigović, M.,& Marinković, A.. (2018). Solvent, structural, quantum chemical study and antioxidative activity of symmetrical 1-methyl-2,6-bis[2-(substituted phenyl)ethenyl]pyridinium iodides. in Journal of the Iranian Chemical Society
Springer, New York., 15(11), 2483-2501.
https://doi.org/10.1007/s13738-018-1437-5

Milošević MD, Prlainović N, Milčić M, Nikolić V, Božić AR, Bigović M, Marinković A. Solvent, structural, quantum chemical study and antioxidative activity of symmetrical 1-methyl-2,6-bis[2-(substituted phenyl)ethenyl]pyridinium iodides. in Journal of the Iranian Chemical Society. 2018;15(11):2483-2501.
doi:10.1007/s13738-018-1437-5 .

Milošević, Milena D., Prlainović, Nevena, Milčić, Miloš, Nikolić, Vesna, Božić, Aleksandra R., Bigović, Miljan, Marinković, Aleksandar, "Solvent, structural, quantum chemical study and antioxidative activity of symmetrical 1-methyl-2,6-bis[2-(substituted phenyl)ethenyl]pyridinium iodides" in Journal of the Iranian Chemical Society, 15, no. 11 (2018):2483-2501,
https://doi.org/10.1007/s13738-018-1437-5 . .

TY  - JOUR
AU  - Lović, Jelena
AU  - Stevanović, Sanja
AU  - Anđelković, Boban D.
AU  - Petrović, Slobodan
AU  - Vuković, Dragan
AU  - Prlainović, Nevena
AU  - Mijin, Dušan
AU  - Nikolić, Nebojša
AU  - Avramov-Ivić, Milka
PY  - 2018
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3907
AB  - Glucose biosensor containing cysteine (Cys), glutaraldehyde (GA) and glucose oxidase (GOx) onto gold electrode is constructed and already electrochemically tested. Now, the electrochemical behavior of biosensor in human serum is further investigated and supported by morphological characterization of layers for the first time. The morphology and microstructure of layers was examined by Fourier transformed infra red spectroscopy (FTIR), atomic force (AFM) and optical microscopy (OM). The electrochemical indication that the Cys-GA-GOx film on Au surface is not compact and that there were some bare regions which remain catalytically active is supported by AFM and OM results. The construction and the nature of bonding of Au-Cys-GA-GOx biosensor layers is confirmed by the FTIR study.
PB  - Electrochemical Science Group, Beograd
T2  - International Journal of Electrochemical Science
T1  - Electrochemical glucose biosensor with the characterization of surface morphology and content of glucose oxidase-glutaraldehyde-cysteine layers on gold electrode
EP  - 12348
IS  - 12
SP  - 12340
VL  - 13
DO  - 10.20964/2018.12.59
ER  - 

@article{
author = "Lović, Jelena and Stevanović, Sanja and Anđelković, Boban D. and Petrović, Slobodan and Vuković, Dragan and Prlainović, Nevena and Mijin, Dušan and Nikolić, Nebojša and Avramov-Ivić, Milka",
year = "2018",
abstract = "Glucose biosensor containing cysteine (Cys), glutaraldehyde (GA) and glucose oxidase (GOx) onto gold electrode is constructed and already electrochemically tested. Now, the electrochemical behavior of biosensor in human serum is further investigated and supported by morphological characterization of layers for the first time. The morphology and microstructure of layers was examined by Fourier transformed infra red spectroscopy (FTIR), atomic force (AFM) and optical microscopy (OM). The electrochemical indication that the Cys-GA-GOx film on Au surface is not compact and that there were some bare regions which remain catalytically active is supported by AFM and OM results. The construction and the nature of bonding of Au-Cys-GA-GOx biosensor layers is confirmed by the FTIR study.",
publisher = "Electrochemical Science Group, Beograd",
journal = "International Journal of Electrochemical Science",
title = "Electrochemical glucose biosensor with the characterization of surface morphology and content of glucose oxidase-glutaraldehyde-cysteine layers on gold electrode",
pages = "12348-12340",
number = "12",
volume = "13",
doi = "10.20964/2018.12.59"
}

Lović, J., Stevanović, S., Anđelković, B. D., Petrović, S., Vuković, D., Prlainović, N., Mijin, D., Nikolić, N.,& Avramov-Ivić, M.. (2018). Electrochemical glucose biosensor with the characterization of surface morphology and content of glucose oxidase-glutaraldehyde-cysteine layers on gold electrode. in International Journal of Electrochemical Science
Electrochemical Science Group, Beograd., 13(12), 12340-12348.
https://doi.org/10.20964/2018.12.59

Lović J, Stevanović S, Anđelković BD, Petrović S, Vuković D, Prlainović N, Mijin D, Nikolić N, Avramov-Ivić M. Electrochemical glucose biosensor with the characterization of surface morphology and content of glucose oxidase-glutaraldehyde-cysteine layers on gold electrode. in International Journal of Electrochemical Science. 2018;13(12):12340-12348.
doi:10.20964/2018.12.59 .

Lović, Jelena, Stevanović, Sanja, Anđelković, Boban D., Petrović, Slobodan, Vuković, Dragan, Prlainović, Nevena, Mijin, Dušan, Nikolić, Nebojša, Avramov-Ivić, Milka, "Electrochemical glucose biosensor with the characterization of surface morphology and content of glucose oxidase-glutaraldehyde-cysteine layers on gold electrode" in International Journal of Electrochemical Science, 13, no. 12 (2018):12340-12348,
https://doi.org/10.20964/2018.12.59 . .

TY  - JOUR
AU  - Prlainović, Nevena
AU  - Rančić, Milica
AU  - Stojiljković, Ivana
AU  - Nikolić, Jasmina
AU  - Drmanić, Saša
AU  - Ajaj, Ismail
AU  - Marinković, Aleksandar
PY  - 2018
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3968
AB  - The substituent and solvent effects on solvatochromism in 3-[(4-substituted) phenylamino] isobenzofuran-1(3H)-ones were studied using experimental and theoretical methodologies. The effect of specific and non-specific solvent-solute interactions on the shifts of UV-Vis absorption maxima were evaluated using the Kamlet-Taft and Catalan solvent parameter sets. The experimental results were studied by density functional theory (DT) and time-dependent density functional theory (TD-DFT). The HOMO/LUMO energies (EHOMO/ELUMO) and energy gap (E-gap) values, as well as the mechanism of electronic excitations and the changes in the electron density distribution in both ground and excited states of the investigated molecules were studied by calculation in the gas phase. The electronic excitations were calculated by the TD-DFT method in the solvent methanol. It was found that both substituents and solvents influence the degree of p-electron conjugation of the synthesized molecules and affect the intramolecular charge transfer character.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Experimental and theoretical study on solvent and substituent effects on the intramolecular charge transfer in 3-[(4-substituted)phenylamino]isobenzofuran-1(3H)-ones
EP  - 155
IS  - 2
SP  - 139
VL  - 83
DO  - 10.2298/JSC170408003P
ER  - 

@article{
author = "Prlainović, Nevena and Rančić, Milica and Stojiljković, Ivana and Nikolić, Jasmina and Drmanić, Saša and Ajaj, Ismail and Marinković, Aleksandar",
year = "2018",
abstract = "The substituent and solvent effects on solvatochromism in 3-[(4-substituted) phenylamino] isobenzofuran-1(3H)-ones were studied using experimental and theoretical methodologies. The effect of specific and non-specific solvent-solute interactions on the shifts of UV-Vis absorption maxima were evaluated using the Kamlet-Taft and Catalan solvent parameter sets. The experimental results were studied by density functional theory (DT) and time-dependent density functional theory (TD-DFT). The HOMO/LUMO energies (EHOMO/ELUMO) and energy gap (E-gap) values, as well as the mechanism of electronic excitations and the changes in the electron density distribution in both ground and excited states of the investigated molecules were studied by calculation in the gas phase. The electronic excitations were calculated by the TD-DFT method in the solvent methanol. It was found that both substituents and solvents influence the degree of p-electron conjugation of the synthesized molecules and affect the intramolecular charge transfer character.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Experimental and theoretical study on solvent and substituent effects on the intramolecular charge transfer in 3-[(4-substituted)phenylamino]isobenzofuran-1(3H)-ones",
pages = "155-139",
number = "2",
volume = "83",
doi = "10.2298/JSC170408003P"
}

Prlainović, N., Rančić, M., Stojiljković, I., Nikolić, J., Drmanić, S., Ajaj, I.,& Marinković, A.. (2018). Experimental and theoretical study on solvent and substituent effects on the intramolecular charge transfer in 3-[(4-substituted)phenylamino]isobenzofuran-1(3H)-ones. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 83(2), 139-155.
https://doi.org/10.2298/JSC170408003P

Prlainović N, Rančić M, Stojiljković I, Nikolić J, Drmanić S, Ajaj I, Marinković A. Experimental and theoretical study on solvent and substituent effects on the intramolecular charge transfer in 3-[(4-substituted)phenylamino]isobenzofuran-1(3H)-ones. in Journal of the Serbian Chemical Society. 2018;83(2):139-155.
doi:10.2298/JSC170408003P .

Prlainović, Nevena, Rančić, Milica, Stojiljković, Ivana, Nikolić, Jasmina, Drmanić, Saša, Ajaj, Ismail, Marinković, Aleksandar, "Experimental and theoretical study on solvent and substituent effects on the intramolecular charge transfer in 3-[(4-substituted)phenylamino]isobenzofuran-1(3H)-ones" in Journal of the Serbian Chemical Society, 83, no. 2 (2018):139-155,
https://doi.org/10.2298/JSC170408003P . .

TY  - JOUR
AU  - Brkić, Dominik R.
AU  - Božić, Aleksandra R.
AU  - Marinković, Aleksandar
AU  - Milčić, Miloš
AU  - Prlainović, Nevena
AU  - Assaleh, Fathi H.
AU  - Cvijetić, Ilija
AU  - Nikolić, Jasmina
AU  - Drmanić, Saša
PY  - 2018
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3971
AB  - The ratios of E/Z isomers of sixteen synthesized 1,3-dihydro-3-(substituted phenylimino)-2H-indol-2-one were studied using experimental and theoretical methodology. Linear solvation energy relationships (LSER) rationalized solvent influence of the solvent-solute interactions on the UV-Vis absorption maxima shifts (v(max)) of both geometrical isomers using the Kamlet-Taft equation. Linear free energy relationships (LEER) in the form of single substituent parameter equation (SSP) was used to analyze substituent effect on pK(a), NMR chemical shifts and v(max) values. Electron charge density was obtained by the use of Quantum Theory of Atoms in Molecules, i.e. Bader's analysis. The substituent and solvent effect on intramolecular charge transfer (ICT) were interpreted with the aid of time-dependent density functional (TD-DFT) method. Additionally, the results of TD-DFT calculations quantified the efficiency of ICT from the calculated charge-transfer distance (D-CT) and amount of transferred charge (Q(CT)). The antimicrobial activity was evaluated using broth microdilution method. 3D QSAR modeling was used to demonstrate the influence of substituents effect as well as molecule geometry on antimicrobial activity.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy
T1  - Detailed solvent, structural, quantum chemical study and antimicrobial activity of isatin Schiff base
EP  - 30
SP  - 16
VL  - 196
DO  - 10.1016/j.saa.2018.01.080
ER  - 

@article{
author = "Brkić, Dominik R. and Božić, Aleksandra R. and Marinković, Aleksandar and Milčić, Miloš and Prlainović, Nevena and Assaleh, Fathi H. and Cvijetić, Ilija and Nikolić, Jasmina and Drmanić, Saša",
year = "2018",
abstract = "The ratios of E/Z isomers of sixteen synthesized 1,3-dihydro-3-(substituted phenylimino)-2H-indol-2-one were studied using experimental and theoretical methodology. Linear solvation energy relationships (LSER) rationalized solvent influence of the solvent-solute interactions on the UV-Vis absorption maxima shifts (v(max)) of both geometrical isomers using the Kamlet-Taft equation. Linear free energy relationships (LEER) in the form of single substituent parameter equation (SSP) was used to analyze substituent effect on pK(a), NMR chemical shifts and v(max) values. Electron charge density was obtained by the use of Quantum Theory of Atoms in Molecules, i.e. Bader's analysis. The substituent and solvent effect on intramolecular charge transfer (ICT) were interpreted with the aid of time-dependent density functional (TD-DFT) method. Additionally, the results of TD-DFT calculations quantified the efficiency of ICT from the calculated charge-transfer distance (D-CT) and amount of transferred charge (Q(CT)). The antimicrobial activity was evaluated using broth microdilution method. 3D QSAR modeling was used to demonstrate the influence of substituents effect as well as molecule geometry on antimicrobial activity.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy",
title = "Detailed solvent, structural, quantum chemical study and antimicrobial activity of isatin Schiff base",
pages = "30-16",
volume = "196",
doi = "10.1016/j.saa.2018.01.080"
}

Brkić, D. R., Božić, A. R., Marinković, A., Milčić, M., Prlainović, N., Assaleh, F. H., Cvijetić, I., Nikolić, J.,& Drmanić, S.. (2018). Detailed solvent, structural, quantum chemical study and antimicrobial activity of isatin Schiff base. in Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy
Pergamon-Elsevier Science Ltd, Oxford., 196, 16-30.
https://doi.org/10.1016/j.saa.2018.01.080

Brkić DR, Božić AR, Marinković A, Milčić M, Prlainović N, Assaleh FH, Cvijetić I, Nikolić J, Drmanić S. Detailed solvent, structural, quantum chemical study and antimicrobial activity of isatin Schiff base. in Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy. 2018;196:16-30.
doi:10.1016/j.saa.2018.01.080 .

Brkić, Dominik R., Božić, Aleksandra R., Marinković, Aleksandar, Milčić, Miloš, Prlainović, Nevena, Assaleh, Fathi H., Cvijetić, Ilija, Nikolić, Jasmina, Drmanić, Saša, "Detailed solvent, structural, quantum chemical study and antimicrobial activity of isatin Schiff base" in Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy, 196 (2018):16-30,
https://doi.org/10.1016/j.saa.2018.01.080 . .