TY  - JOUR
AU  - Milosavljević, Milutin M.
AU  - Vukicević, Ivan M.
AU  - Drmanić, Saša
AU  - Nikolić, Jasmina
AU  - Marinković, Aleksandar
AU  - Krstić, Sanja S.
AU  - Petrović, Slobodan
PY  - 2016
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3264
AB  - The present study reports a new facile methodology for the synthesis of symmetrical and asymmetrical thioureas by a one-pot reaction of the required amine, carbon disulfide and an oxidant, i.e., hydrogen peroxide, ethylenediaminetetraacetic acid (EDTA)/sodium percarbonate system or air. The structures of the synthesized compounds were confirmed by IR, H-1- and C-13-NMR and MS methods. A reaction mechanism is proposed based on the isolation of reaction intermediate and the determination of their structure. The synthetic benefits of the presented methods are reflected in the operational simplicity, mild reaction conditions, short reaction times, solvent recycling, high purity and yield of the products, absence of dangerous by-products and technological applicability on an industrial scale. Considering the commercial importance of thioureas, it should be emphasized that implementation of the optimal synthesis of thiourea determined in this study for industrial production could provide a concurrent alternative to the existing technologies in use.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Simple one-pot synthesis of thioureas from amines, carbon disulfide and oxidants in water
EP  - 231
IS  - 3
SP  - 219
VL  - 81
DO  - 10.2298/JSC150831087M
ER  - 

@article{
author = "Milosavljević, Milutin M. and Vukicević, Ivan M. and Drmanić, Saša and Nikolić, Jasmina and Marinković, Aleksandar and Krstić, Sanja S. and Petrović, Slobodan",
year = "2016",
abstract = "The present study reports a new facile methodology for the synthesis of symmetrical and asymmetrical thioureas by a one-pot reaction of the required amine, carbon disulfide and an oxidant, i.e., hydrogen peroxide, ethylenediaminetetraacetic acid (EDTA)/sodium percarbonate system or air. The structures of the synthesized compounds were confirmed by IR, H-1- and C-13-NMR and MS methods. A reaction mechanism is proposed based on the isolation of reaction intermediate and the determination of their structure. The synthetic benefits of the presented methods are reflected in the operational simplicity, mild reaction conditions, short reaction times, solvent recycling, high purity and yield of the products, absence of dangerous by-products and technological applicability on an industrial scale. Considering the commercial importance of thioureas, it should be emphasized that implementation of the optimal synthesis of thiourea determined in this study for industrial production could provide a concurrent alternative to the existing technologies in use.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Simple one-pot synthesis of thioureas from amines, carbon disulfide and oxidants in water",
pages = "231-219",
number = "3",
volume = "81",
doi = "10.2298/JSC150831087M"
}

Milosavljević, M. M., Vukicević, I. M., Drmanić, S., Nikolić, J., Marinković, A., Krstić, S. S.,& Petrović, S.. (2016). Simple one-pot synthesis of thioureas from amines, carbon disulfide and oxidants in water. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 81(3), 219-231.
https://doi.org/10.2298/JSC150831087M

Milosavljević MM, Vukicević IM, Drmanić S, Nikolić J, Marinković A, Krstić SS, Petrović S. Simple one-pot synthesis of thioureas from amines, carbon disulfide and oxidants in water. in Journal of the Serbian Chemical Society. 2016;81(3):219-231.
doi:10.2298/JSC150831087M .

Milosavljević, Milutin M., Vukicević, Ivan M., Drmanić, Saša, Nikolić, Jasmina, Marinković, Aleksandar, Krstić, Sanja S., Petrović, Slobodan, "Simple one-pot synthesis of thioureas from amines, carbon disulfide and oxidants in water" in Journal of the Serbian Chemical Society, 81, no. 3 (2016):219-231,
https://doi.org/10.2298/JSC150831087M . .

TY  - JOUR
AU  - Milosavljević, Milutin M.
AU  - Vukicević, Ivan M.
AU  - Serifi, Veis
AU  - Markovski, Jasmina
AU  - Stojiljković, Ivana
AU  - Mijin, Dušan
AU  - Marinković, Aleksandar
PY  - 2015
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3082
AB  - The optimized methods for N-alkyl and N,N-dialkyl substituted thioureas synthesis starting from ammonium thiocyanates, waste water constituent from the production of tetramethylthiuram monosulfide (TMTS), and alkyl amine, are presented in this work., Thioureas synthesis was developed in two ways: Method I-reaction of the thiocyanate and alkylamine in the presence of hydrochloric acid; Method II-reaction of the thiocyanate with benzoyl chloride following by amine addition in the first step, and base hydrolysis in the second step. The structure of the synthesized compounds was confirmed by IR, H-1- and C-13-NMR and MS instrumental methods, and purity was determined by high-performance liquid chromatography method. It is shown that the proposed methods offer a high degree of conversion and purity of product, absence of by-products and technological applicability at industrial scale. Considering the importance of the tetramethylthiuram disulfide (TMTD) and TMTS as vulcanization accelerators as well as thiourea as the pharmacologically active compounds, it can be said that application of the optimized methods of thiourea synthesis will provide significant improvement in sustainable development and implementation of eco-friendly production technology. The described environmentally benign process of thioureas synthesis represents a suitable option to existing methods. thioureas, industrial level, thiocyanate.
PB  - Savez hemijskih inženjera, Beograd
T2  - Chemical Industry & Chemical Engineering Quarterly
T1  - Optimization of the synthesis of n-alkyl and n,n-dialkyl thioureas from waste water containing ammonium thiocyanate
EP  - 510
IS  - 4
SP  - 501
VL  - 21
DO  - 10.2298/CICEQ141221006M
ER  - 

@article{
author = "Milosavljević, Milutin M. and Vukicević, Ivan M. and Serifi, Veis and Markovski, Jasmina and Stojiljković, Ivana and Mijin, Dušan and Marinković, Aleksandar",
year = "2015",
abstract = "The optimized methods for N-alkyl and N,N-dialkyl substituted thioureas synthesis starting from ammonium thiocyanates, waste water constituent from the production of tetramethylthiuram monosulfide (TMTS), and alkyl amine, are presented in this work., Thioureas synthesis was developed in two ways: Method I-reaction of the thiocyanate and alkylamine in the presence of hydrochloric acid; Method II-reaction of the thiocyanate with benzoyl chloride following by amine addition in the first step, and base hydrolysis in the second step. The structure of the synthesized compounds was confirmed by IR, H-1- and C-13-NMR and MS instrumental methods, and purity was determined by high-performance liquid chromatography method. It is shown that the proposed methods offer a high degree of conversion and purity of product, absence of by-products and technological applicability at industrial scale. Considering the importance of the tetramethylthiuram disulfide (TMTD) and TMTS as vulcanization accelerators as well as thiourea as the pharmacologically active compounds, it can be said that application of the optimized methods of thiourea synthesis will provide significant improvement in sustainable development and implementation of eco-friendly production technology. The described environmentally benign process of thioureas synthesis represents a suitable option to existing methods. thioureas, industrial level, thiocyanate.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Chemical Industry & Chemical Engineering Quarterly",
title = "Optimization of the synthesis of n-alkyl and n,n-dialkyl thioureas from waste water containing ammonium thiocyanate",
pages = "510-501",
number = "4",
volume = "21",
doi = "10.2298/CICEQ141221006M"
}

Milosavljević, M. M., Vukicević, I. M., Serifi, V., Markovski, J., Stojiljković, I., Mijin, D.,& Marinković, A.. (2015). Optimization of the synthesis of n-alkyl and n,n-dialkyl thioureas from waste water containing ammonium thiocyanate. in Chemical Industry & Chemical Engineering Quarterly
Savez hemijskih inženjera, Beograd., 21(4), 501-510.
https://doi.org/10.2298/CICEQ141221006M

Milosavljević MM, Vukicević IM, Serifi V, Markovski J, Stojiljković I, Mijin D, Marinković A. Optimization of the synthesis of n-alkyl and n,n-dialkyl thioureas from waste water containing ammonium thiocyanate. in Chemical Industry & Chemical Engineering Quarterly. 2015;21(4):501-510.
doi:10.2298/CICEQ141221006M .

Milosavljević, Milutin M., Vukicević, Ivan M., Serifi, Veis, Markovski, Jasmina, Stojiljković, Ivana, Mijin, Dušan, Marinković, Aleksandar, "Optimization of the synthesis of n-alkyl and n,n-dialkyl thioureas from waste water containing ammonium thiocyanate" in Chemical Industry & Chemical Engineering Quarterly, 21, no. 4 (2015):501-510,
https://doi.org/10.2298/CICEQ141221006M . .