TY  - JOUR
AU  - Milosavljević, Milutin M.
AU  - Vukicević, Ivan M.
AU  - Serifi, Veis
AU  - Markovski, Jasmina
AU  - Stojiljković, Ivana
AU  - Mijin, Dušan
AU  - Marinković, Aleksandar
PY  - 2015
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3082
AB  - The optimized methods for N-alkyl and N,N-dialkyl substituted thioureas synthesis starting from ammonium thiocyanates, waste water constituent from the production of tetramethylthiuram monosulfide (TMTS), and alkyl amine, are presented in this work., Thioureas synthesis was developed in two ways: Method I-reaction of the thiocyanate and alkylamine in the presence of hydrochloric acid; Method II-reaction of the thiocyanate with benzoyl chloride following by amine addition in the first step, and base hydrolysis in the second step. The structure of the synthesized compounds was confirmed by IR, H-1- and C-13-NMR and MS instrumental methods, and purity was determined by high-performance liquid chromatography method. It is shown that the proposed methods offer a high degree of conversion and purity of product, absence of by-products and technological applicability at industrial scale. Considering the importance of the tetramethylthiuram disulfide (TMTD) and TMTS as vulcanization accelerators as well as thiourea as the pharmacologically active compounds, it can be said that application of the optimized methods of thiourea synthesis will provide significant improvement in sustainable development and implementation of eco-friendly production technology. The described environmentally benign process of thioureas synthesis represents a suitable option to existing methods. thioureas, industrial level, thiocyanate.
PB  - Savez hemijskih inženjera, Beograd
T2  - Chemical Industry & Chemical Engineering Quarterly
T1  - Optimization of the synthesis of n-alkyl and n,n-dialkyl thioureas from waste water containing ammonium thiocyanate
EP  - 510
IS  - 4
SP  - 501
VL  - 21
DO  - 10.2298/CICEQ141221006M
ER  - 

@article{
author = "Milosavljević, Milutin M. and Vukicević, Ivan M. and Serifi, Veis and Markovski, Jasmina and Stojiljković, Ivana and Mijin, Dušan and Marinković, Aleksandar",
year = "2015",
abstract = "The optimized methods for N-alkyl and N,N-dialkyl substituted thioureas synthesis starting from ammonium thiocyanates, waste water constituent from the production of tetramethylthiuram monosulfide (TMTS), and alkyl amine, are presented in this work., Thioureas synthesis was developed in two ways: Method I-reaction of the thiocyanate and alkylamine in the presence of hydrochloric acid; Method II-reaction of the thiocyanate with benzoyl chloride following by amine addition in the first step, and base hydrolysis in the second step. The structure of the synthesized compounds was confirmed by IR, H-1- and C-13-NMR and MS instrumental methods, and purity was determined by high-performance liquid chromatography method. It is shown that the proposed methods offer a high degree of conversion and purity of product, absence of by-products and technological applicability at industrial scale. Considering the importance of the tetramethylthiuram disulfide (TMTD) and TMTS as vulcanization accelerators as well as thiourea as the pharmacologically active compounds, it can be said that application of the optimized methods of thiourea synthesis will provide significant improvement in sustainable development and implementation of eco-friendly production technology. The described environmentally benign process of thioureas synthesis represents a suitable option to existing methods. thioureas, industrial level, thiocyanate.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Chemical Industry & Chemical Engineering Quarterly",
title = "Optimization of the synthesis of n-alkyl and n,n-dialkyl thioureas from waste water containing ammonium thiocyanate",
pages = "510-501",
number = "4",
volume = "21",
doi = "10.2298/CICEQ141221006M"
}

Milosavljević, M. M., Vukicević, I. M., Serifi, V., Markovski, J., Stojiljković, I., Mijin, D.,& Marinković, A.. (2015). Optimization of the synthesis of n-alkyl and n,n-dialkyl thioureas from waste water containing ammonium thiocyanate. in Chemical Industry & Chemical Engineering Quarterly
Savez hemijskih inženjera, Beograd., 21(4), 501-510.
https://doi.org/10.2298/CICEQ141221006M

Milosavljević MM, Vukicević IM, Serifi V, Markovski J, Stojiljković I, Mijin D, Marinković A. Optimization of the synthesis of n-alkyl and n,n-dialkyl thioureas from waste water containing ammonium thiocyanate. in Chemical Industry & Chemical Engineering Quarterly. 2015;21(4):501-510.
doi:10.2298/CICEQ141221006M .

Milosavljević, Milutin M., Vukicević, Ivan M., Serifi, Veis, Markovski, Jasmina, Stojiljković, Ivana, Mijin, Dušan, Marinković, Aleksandar, "Optimization of the synthesis of n-alkyl and n,n-dialkyl thioureas from waste water containing ammonium thiocyanate" in Chemical Industry & Chemical Engineering Quarterly, 21, no. 4 (2015):501-510,
https://doi.org/10.2298/CICEQ141221006M . .